Article
Multidisciplinary Sciences
Leona S. Alizadeh, Vitali Koch, Leon D. Gruenewald, Ibrahim Yel, Daniel Mathies, Dominic Rauschning, Thomas J. Vogl, Christian Booz
Summary: Truncus arteriosus (TA) is a rare congenital anomaly that has complex cardiovascular anatomy and is associated with severe complications and pathologies. Understanding and treating TA and its complications are crucial for the survival and outcome of patients.
Article
Cardiac & Cardiovascular Systems
Phillip S. Naimo, Douglas Bell, Tyson A. Fricke, Yves d'Udekem, Christian P. Brizard, Nelson Alphonso, Igor E. Konstantinov
Summary: Truncus arteriosus repair in neonates presents significant surgical challenges, but survival beyond the first year following repair is associated with excellent outcomes. Neonatal surgery and low operative weight are risk factors for early mortality, while a coronary artery anomaly is a risk factor for late mortality.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Carlos Bonilla-Ramirez, Christopher Ibarra, Ziyad M. Binsalamah, Iki Adachi, Jeffrey S. Heinle, E. Dean McKenzie, Christopher A. Caldarone, Michiaki Imamura
Summary: Coronary artery lesions are associated with increased mortality after truncus repair, with surgical intervention potentially improving survival for patients with fewer lesions. Patients with the most complex anomalies have poor survival outcomes and require ongoing study for repair techniques.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Yifan Zhu, Qi Jiang, Wen Zhang, Renjie Hu, Wei Dong, Hao Zhang, Haibo Zhang
Summary: A retrospective study of TA patients undergoing repair at Shanghai Children's Medical Center between 2009 and 2021 revealed that PHC was more common in patients with late referral, especially those with higher sum of Z-score of pre-operative bilateral pulmonary artery diameters. Prolonged CPB duration may lead to early mortality, while valved reconstruction of RVOT was associated with early reinterventions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Pediatrics
Antonio F. Corno, Tina O. Findley, Jorge D. Salazar
Summary: This article reviews the changes in management strategies and innovations for patients with functionally single ventricle physiology. By analyzing a series of innovations in methods, diagnosis, and treatment from fetal to adult life, it is found that these last 40 years have indeed changed the natural history of patients with congenital single ventricle. However, there is still much left unexplored and room for improvement, which requires collaboration among different institutions and specialties.
TRANSLATIONAL PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Syed Shahyan Bakhtiyar, Sara Sakowitz, Konmal Ali, Nikhil L. Chervu, Arjun Verma, Ming-Sing Si, David D'Alessandro, Peyman Benharash
Summary: The study evaluates the survival rate after heart transplantation in adults with single and biventricular CHD and compares it to that of non-CHD transplant recipients. Single-ventricle physiology is associated with higher short-term mortality, but 10-year conditional survival is similar for biventricular CHD patients and most single-ventricle CHD patients, and notably better for biventricular CHD patients compared to non-CHD heart transplant recipients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Genetics & Heredity
Alistair T. Pagnamenta, Adam Jackson, Rahat Perveen, Glenda Beaman, Gemma Petts, Asheeta Gupta, Zerin Hyder, Brian Hon-Yin Chung, Anita Sik-Yau Kan, Ka Wang Cheung, Wilhelmina S. Kerstjens-Frederikse, Kristin M. Abbott, Orly Elpeleg, Jenny C. Taylor, Siddharth Banka, Asaf Ta-Shma
Summary: This study confirms the genetic basis of SHDRA, expands its known mutational spectrum, and clarifies its clinical features. SHDRA is a severe condition associated with substantial mortality in early childhood, characterized by congenital cardiac malformations with a variable renal phenotype.
Article
Cardiac & Cardiovascular Systems
Phillip S. Naimo, Igor E. Konstantinov
Summary: Surgery for truncus arteriosus has a high early mortality rate and long-term survival challenge, but the long-term outcomes of truncus arteriosus repair are good, with many patients enjoying a quality of life comparable to the general population.
ANNALS OF THORACIC SURGERY
(2021)
Article
Obstetrics & Gynecology
J. S. Abel, C. Berg, A. Geipel, U. Gembruch, U. Herberg, J. Breuer, K. Brockmeier, I. Gottschalk
Summary: This study found that prenatal diagnosis of truncus arteriosus communis (TAC) was accurate, but TAC was often associated with chromosomal and extra-cardiac anomalies, leading to high rates of pregnancy termination and perioperative mortality. The prevalence of repeated interventions due to recurrent stenosis associated with TAC was also high.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
J. S. Abel, C. Berg, A. Geipel, U. Gembruch, U. Herberg, J. Breuer, K. Brockmeier, I Gottschalk
Summary: Truncus arteriosus communis is a rare and complex cardiac anomaly that can be diagnosed prenatally with high precision. TAC is frequently associated with chromosomal and extra-cardiac anomalies, leading to a high intrauterine and postnatal loss rate due to terminations and perioperative mortality. Without severe extra-cardiac anomalies, postoperative health status is excellent, independent of the subtype of TAC, but the prevalence of repeated interventions due to recurrent stenosis is high.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Engineering, Biomedical
Ze-Wei Tao, Dillon K. Jarrell, Andrew Robinson, Elizabeth M. Cosgriff-Hernandez, Jeffrey G. Jacot
Summary: The study improved the acellular fibrin patch material, prevascularized it, and used stem cells to develop a new treatment that effectively promotes heart defect repair and improves heart function.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Cardiac & Cardiovascular Systems
Emilie Laflamme, Rachel M. Wald, S. Lucy Roche, Candice K. Silversides, Sara A. Thorne, Jack M. Colman, Lee Benson, Mark Osten, Eric Horlick, Erwin Oechslin, Rafael Alonso-Gonzalez
Summary: In a study of 215 patients with pulmonary valve stenosis (PVS) who underwent surgical valvotomy or balloon valvuloplasty, it was found that the majority of patients remained asymptomatic after a median follow-up of 38.6 years. Predictors of reinterventions and complications included RVOT intervention, presence of associated defects, and older age at the time of first repair.
Article
Cardiac & Cardiovascular Systems
Yoonjin Kang, Jae Gun Kwak, Jooncheol Min, Jae Hong Lim, Woong-han Kim
Summary: This study evaluated the long-term outcomes after repair of truncus arteriosus, showing that most patients require conduit-related reoperations, and younger age and methods of right ventricular outflow tract reconstruction are risk factors for conduit-related reoperations.
PEDIATRIC CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sisca Natalia Siagian, Radityo Prakoso, Bayushi Eka Putra, Yovi Kurniawati, Olfi Lelya, Aditya Agita Sembiring, Indriwanto Sakidjan Atmosudigdo, Poppy Surwianti Roebiono, Anna Ulfah Rahajoe, Ganesja Moelia Harimurti, Brian Mendel, Christianto Christianto, Moira Setiawan, Oktavia Lilyasari
Summary: This study aimed to explore the feasibility and safety of percutaneous closure of patent ductus arteriosus (PDA) under echocardiography guidance. The study results showed that all patients had successful PDA closure, and there was no significant difference in procedural time between the fluoroscopy and echocardiography groups.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Henry Chubb, Anica Bulic, Douglas Mah, Jeremy P. Moore, Jan Janousek, Jennifer Fumanelli, S. Yukiko Asaki, Andreas Pflaumer, Allison C. Hill, Carolina Escudero, Sit Yee Kwok, Jasveer Mangat, Luis A. Ochoa Nunez, Seshadri Balaji, Eric Rosenthal, William Regan, Michaela Horndasch, Hiroko Asakai, Ronn Tanel, Richard J. Czosek, Ming-Lon Young, David J. Bradley, Thomas Paul, Peter Fischbach, Lindsey Malloy-Walton, Doff B. McElhinney, Anne M. Dubin
Summary: This study aimed to quantify the risk of permanent ventricular pacing (PPMv) in patients with single ventricle (SV) and identify modifiable risk factors. The results showed that PPMv was associated with an increased risk of heart transplantation and death. Higher ventricular pacing percentage (Vp), higher QRS z-score, and nonapical ventricular lead position were all associated with a higher risk of adverse outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Bo Hu, Qing Zhou, Nan Jiang, Lei Hu, Zhen Zhou, Rui-qiang Guo
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2016)
Review
Cell Biology
Jingyuan Sun, Hongping Deng, Zhen Zhou, Xiaoxing Xiong, Ling Gao
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Physiology
Tamara Darwiche, Scott D. Collum, Weizhen Bi, Julia O. Reynolds, Cory Wilson, Nancy Wareing, Adriana M. Hernandez, Tinne C. J. Mertens, Zhen Zhou, Lavannya M. Pandit, Harry Karmouty-Quintana
EXPERIMENTAL PHYSIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Tingting Xie, Changhan Chen, Zhangzhe Peng, Benjamin C. Brown, Julie A. Reisz, Ping Xu, Zhen Zhou, Anren Song, Yujin Zhang, Mikhail V. Bogdanov, Rodney E. Kellems, Angelo D'Alessandro, Weiru Zhang, Yang Xia
CIRCULATION RESEARCH
(2020)
Article
Hematology
William G. Robichaux, Fang C. Mei, Wenli Yang, Hui Wang, Hua Sun, Zhen Zhou, Dianna M. Milewicz, Ba-Bie Teng, Xiaodong Cheng
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Antonio F. Corno, Forest B. Trager, Rebecca Sam, Jorge D. Salazar
Summary: This retrospective study evaluates the safety of using absorbable sutures as purse strings for arterial and venous cannulation in pediatric heart surgery. The study concludes that the use of absorbable sutures is safe and does not result in bleeding, deaths, or complications in a large population of pediatric patients.
JOURNAL OF CARDIAC SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Antonio F. Corno, Dilachew A. Adebo, Damien J. LaPar, Jorge D. Salazar
Summary: The importance and role of interatrial communication in cardiovascular physiopathology, and its impact on modern heart diseases, have been discussed. The evolving utility and indications for closure, maintenance, or creation of interatrial communication have also been highlighted.
JOURNAL OF CARDIAC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Ana L. Vasquez Choy, Dilachew A. Adebo, Sheba John, Christopher E. Greenleaf, Jorge D. Salazar, Antonio F. Corno
Summary: This study retrospectively evaluated the imaging results of 13 infants who underwent repair for total anomalous pulmonary venous connection (TAPVC) associated with single ventricle (SV). The results showed that cardiac computed tomography (CT) plays a crucial role in evaluating pre- and postoperative TAPVC in SV, aiding in surgical decision making and long-term follow-up.
JOURNAL OF CARDIAC SURGERY
(2022)
Article
Hematology
Abhijnan Chattopadhyay, Pujun Guan, Suravi Majumder, Kaveeta Kaw, Zhen Zhou, Chen Zhang, Siddharth K. Prakash, Anita Kaw, L. Maximillian Buja, Callie S. Kwartler, Dianna M. Milewicz
Summary: This study reveals that hypercholesterolemia drives complex phenotypic modulation of vascular smooth muscle cells (SMCs) and leads to atherosclerotic plaque formation. Deficiency of Perk in SMCs reduces plaque formation and prevents migration of SMCs from the medial layer of the aorta.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Anita Kaw, Albert J. Pedroza, Abhijnan Chattopadhyay, Amelie Pinard, Dongchuan Guo, Kaveeta Kaw, Zhen Zhou, Rohan Shad, Michael P. Fischbein, Callie S. Kwartler, Dianna M. Milewicz
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Review
Genetics & Heredity
Zhen Zhou, Alana C. Cecchi, Siddharth K. Prakash, Dianna M. Milewicz
Summary: This article discusses the main risk factors associated with thoracic aortic aneurysms and dissections (TAD), including genetic variants and environmental conditions, and explores the underlying mechanisms leading to TAD.
Meeting Abstract
Hematology
Zhen Zhou, Andrew M. Peters, Shanzhi Wang, Jiyuan Chen, Erin Arthur, Dianna M. Milewicz
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2018)
Article
Surgery
Bowen Li, Zhiwei Wang, Zhipeng Hu, Min Zhang, Zongli Ren, Zhen Zhou, Jizhen Huang, Xiaoping Hu
ANNALS OF VASCULAR SURGERY
(2017)