Synthesis of Secondary Trifluoromethylated Alkyl Bromides Using 2-Bromo-3,3,3-trifluoropropene as a Radical Acceptor

Csp3–H Trifluoromethylation of Unactivated Aliphatic Systems

(2021) Jiachen He et al.   ORGANIC LETTERS

Lewis Acid Activation of Fragment-Coupling Reactions of Tertiary Carbon Radicals Promoted by Visible-Light Irradiation of EDA Complexes

(2021) Spencer P. Pitre et al.   ORGANIC LETTERS

Single Electron Transfer-Induced Redox Processes Involving N-(Acyloxy)phthalimides

(2021) Sushanta Kumar Parida et al.   ACS Catalysis

Diverse Synthesis of Chiral Trifluoromethylated Alkanes via Nickel‐Catalyzed Asymmetric Reductive Cross‐Coupling Fluoroalkylation

(2021) Yue Min et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Late‐Stage Alkylation of Heterocycles Using N‐(Acyloxy)phthalimides

(2021) Sushanta Kumar Parida et al.   Chemistry-An Asian Journal

Utilization of C(sp3)‐Carboxylic Acids and Their Redox‐Active Esters in Decarboxylative Carbon‒Carbon Bond Formation

(2021) Sukhen Karmakar et al.   ADVANCED SYNTHESIS & CATALYSIS

Remote Regioselective Radical C–H Functionalization of Unactivated C–H Bonds in Amides: The Synthesis of gem-Difluoroalkenes

(2021) Qu-Ping Hu et al.   ORGANIC LETTERS

Selective C–F Bond Allylation of Trifluoromethylalkenes

(2021) Chuan Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Electrochemical Installation of CFH 2 −, CF 2 H−, CF 3 −, and Perfluoroalkyl Groups into Small Organic Molecules

(2021) Camila M. Kisukuri et al.   CHEMICAL RECORD

Dual Nickel- and Photoredox-Catalyzed Reductive Cross-Coupling to Access Chiral Trifluoromethylated Alkanes

(2021) Pan Zhou et al.   ORGANIC LETTERS

Recent Advances in the Synthesis of Difluorinated Architectures from Trifluoromethyl Groups

(2021) Feng Zhao et al.   ADVANCED SYNTHESIS & CATALYSIS

Regioselective Synthesis of 3-Trifluoromethylpyrazole by Coupling of Aldehydes, Sulfonyl Hydrazides, and 2-Bromo-3,3,3-trifluoropropene

(2020) Chuanle Zhu et al.   ORGANIC LETTERS

New Visible Light‐triggered Photocatalytic Trifluoromethylation Reactions of Carbon‐carbon Multiple Bonds and (Hetero)aromatic Compounds

(2020) SEBASTIAN BARATA-VALLEJO et al.   CHEMISTRY-A EUROPEAN JOURNAL

Trifluoromethylation of Alkyl Radicals: Breakthrough and Challenges †

(2020) Lin Zhu et al.   CHINESE JOURNAL OF CHEMISTRY

One-Electron Reduction of Redox-Active Esters to Generate Carbon-Centered Radicals

(2020) Pengfei Niu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Progress in Electrochemical Trifluoromethylation Reactions

(2020) Rasmi P. Bhaskaran et al.   ADVANCED SYNTHESIS & CATALYSIS

Direct C(sp 3 )−H Trifluoromethylation of Unactivated Alkanes Enabled by Multifunctional Trifluoromethyl Copper Complexes

(2020) Geunho Choi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Late-Stage Benzylic C(sp3)–H Trifluoromethylation

(2019) Haiwen Xiao et al.   Chem

Photocatalytic decarboxylative alkylations mediated by triphenylphosphine and sodium iodide

(2019) Ming-Chen Fu et al.   SCIENCE

Copper-Catalyzed Trifluoromethylation of Alkyl Bromides

(2019) David J. P. Kornfilt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalyst‐free Decarboxylation and Decarboxylative Giese Additions of Alkyl Carboxylates through Photoactivation of Electron Donor‐Acceptor Complex

(2019) Chao Zheng et al.   ADVANCED SYNTHESIS & CATALYSIS

Copper-Catalyzed Highly Stereoselective Trifluoromethylation and Difluoroalkylation of Secondary Propargyl Sulfonates

(2018) Xing Gao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metal-Free C(sp3)–H Allylation via Aryl Carboxyl Radicals Enabled by Donor–Acceptor Complex

(2018) Yang Li et al.   ORGANIC LETTERS

Rapid access to diverse, trifluoromethyl-substituted alkenes using complementary strategies

(2018) James P. Phelan et al.   Chemical Science

N -(Acyloxy)phthalimides as Redox-Active Esters in Cross-Coupling Reactions

(2018) Sandip Murarka   ADVANCED SYNTHESIS & CATALYSIS

Catalytic enantioconvergent coupling of secondary and tertiary electrophiles with olefins

(2018) Zhaobin Wang et al.   NATURE

Trifluoromethylation of Alkyl Radicals in Aqueous Solution

(2017) Haigen Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silver-Catalyzed Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids

(2017) Xinqiang Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Synthesis of 3-Trifluoromethyl-Substituted 1,3-Butadienes by Means of Directed C–H Bond Functionalization

(2017) Qun Zhao et al.   ORGANIC LETTERS

Fine Design of Photoredox Systems for Catalytic Fluoromethylation of Carbon–Carbon Multiple Bonds

(2016) Takashi Koike et al.   ACCOUNTS OF CHEMICAL RESEARCH

18F-Labeling of Arenes and Heteroarenes for Applications in Positron Emission Tomography

(2016) Sean Preshlock et al.   CHEMICAL REVIEWS

Nickel-Catalyzed Alkyl-Alkyl Cross-Couplings of Fluorinated Secondary Electrophiles: A General Approach to the Synthesis of Compounds having a Perfluoroalkyl Substituent

(2015) Yufan Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Aromatic CH Trifluoromethylation via an Electron-Donor-Acceptor Complex

(2015) Yuanzheng Cheng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fragment Coupling and the Construction of Quaternary Carbons Using Tertiary Radicals Generated From tert-Alkyl N-Phthalimidoyl Oxalates By Visible-Light Photocatalysis

(2015) Gregory L. Lackner et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereoconvergent Negishi Arylations of Racemic Secondary Alkyl Electrophiles: Differentiating between a CF3 and an Alkyl Group

(2015) Yufan Liang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photo-organocatalytic Enantioselective Perfluoroalkylation of β-Ketoesters

(2015) Łukasz Woźniak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Reductive Cross-Coupling of (Hetero)Aryl Iodides with Fluorinated Secondary Alkyl Bromides

(2015) Xuefei Li et al.   ORGANIC LETTERS

Oxidative Trifluoromethylation and Trifluoromethylthiolation Reactions Using (Trifluoromethyl)trimethylsilane as a Nucleophilic CF3 Source

(2014) Lingling Chu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Metal-Free Photochemical Aromatic Perfluoroalkylation of α-Cyano Arylacetates

(2014) Manuel Nappi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Direct Construction of Quaternary Carbons from Tertiary Alcohols via Photoredox-Catalyzed Fragmentation of tert-Alkyl N-Phthalimidoyl Oxalates

(2013) Gregory L. Lackner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and Metal-Catalyzed Reactions of gem-Dihalovinyl Systems

(2011) Giorgio Chelucci   CHEMICAL REVIEWS

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Iron-Catalyzed Cross-Coupling Reactions between Arylzinc Reagents and Alkyl Halides Bearing β-Fluorines

(2011) Xiaowei Lin et al.   ORGANOMETALLICS

C−F Bond Activation in Organic Synthesis

(2009) Hideki Amii et al.   CHEMICAL REVIEWS

Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments

(2008) Kenneth L. Kirk   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS