Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons

Non-cell-autonomous pathogenic mechanisms in amyotrophic lateral sclerosis

(2021) Alexandra C.M. Van Harten et al.   TRENDS IN NEUROSCIENCES

Neurotoxic reactive astrocytes induce cell death via saturated lipids

(2021) Kevin A. Guttenplan et al.   NATURE

Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response

(2021) Bàrbara Samper-Martín et al.   Cell Reports

Methods for the Analysis of Polyphosphate in the Life Sciences

(2020) Jonas Johannes Christ et al.   ANALYTICAL CHEMISTRY

Inorganic polyphosphate in mammals: where's Wally?

(2020) Yann Desfougères et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice

(2020) Nur Jury et al.   Clinical Epigenetics

Inorganic polyphosphate is produced and hydrolyzed in F0F1-ATP synthase of mammalian mitochondria

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Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model

(2020) Kevin A. Guttenplan et al.   Nature Communications

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease

(2019) Angelique di Domenico et al.   Stem Cell Reports

Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS

(2019) André Varcianna et al.   EBioMedicine

Inorganic Polyphosphate Regulates AMPA and NMDA Receptors and Protects Against Glutamate Excitotoxicity via Activation of P2Y Receptors

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Genetics and molecular mechanisms of frontotemporal lobar degeneration: an update and future avenues

(2019) Ferrari Raffaele et al.   NEUROBIOLOGY OF AGING

Ppn2 endopolyphosphatase overexpressed in Saccharomyces cerevisiae: Comparison with Ppn1, Ppx1, and Ddp1 polyphosphatases

(2019) Nadeshda Andreeva et al.   BIOCHIMIE

Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity

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Large SOD1 aggregates, unlike trimeric SOD1, do not impact cell viability in a model of amyotrophic lateral sclerosis

(2018) Cheng Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signal transduction in astrocytes: Localization and release of inorganic polyphosphate

(2018) Plamena R. Angelova et al.   GLIA

Analytical polyphosphate extraction from Saccharomyces cerevisiae

(2018) Jonas Johannes Christ et al.   ANALYTICAL BIOCHEMISTRY

Inorganic polyphosphate, a multifunctional polyanionic protein scaffold

(2018) Lihan Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic infusion of SOD1G93A astrocyte-secreted factors induces spinal motoneuron degeneration and neuromuscular dysfunction in healthy rats

(2017) Uri N. Ramírez-Jarquín et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Simple Silica Column–Based Method to Quantify Inorganic Polyphosphates in Cartilage and Other Tissues

(2017) Whitaik David Lee et al.   Cartilage

Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo

(2017) Kun Qian et al.   Stem Cell Reports

Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein

(2017) Anna-Lena Hallmann et al.   Scientific Reports

Prolonged AT1R activation induces CaV1.2 channel internalization in rat cardiomyocytes

(2017) Tamara Hermosilla et al.   Scientific Reports

Adeno-associated virus-delivered artificial microRNA extends survival and delays paralysis in an amyotrophic lateral sclerosis mouse model

(2016) Lorelei Stoica et al.   ANNALS OF NEUROLOGY

High glucocorticoid levels during gestation activate the inflammasome in hippocampal oligodendrocytes of the offspring

(2016) Carola J. Maturana et al.   Developmental Neurobiology

Polyphosphate: A Conserved Modifier of Amyloidogenic Processes

(2016) Claudia M. Cremers et al.   MOLECULAR CELL

Effect of Terminal Groups of Dendrimers in the Complexation with Antisense Oligonucleotides and Cell Uptake

(2016) Valeria Márquez-Miranda et al.   Nanoscale Research Letters

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Pathophysiological and diagnostic implications of cortical dysfunction in ALS

(2016) Nimeshan Geevasinga et al.   Nature Reviews Neurology

Cell-specific restoration of stimulus preference after monocular deprivation in the visual cortex

(2016) T. Rose et al.   SCIENCE

Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection

(2016) Linda Labberton et al.   Nature Communications

Effect of Terminal Groups of Dendrimers in the Complexation with Antisense Oligonucleotides and Cell Uptake

(2016) Valeria Márquez-Miranda et al.   Nanoscale Research Letters

Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan

(2015) Cara M. Weismann et al.   HUMAN MOLECULAR GENETICS

An Innovative Method for Obtaining Consistent Images and Quantification of Histochemically Stained Specimens

(2015) Michael A. Linden et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice

(2015) Owen M. Peters et al.   NEURON

Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability

(2015) Anna-Claire Devlin et al.   Nature Communications

The Regulatory Machinery of Neurodegeneration in In Vitro Models of Amyotrophic Lateral Sclerosis

(2015) Burcin Ikiz et al.   Cell Reports

In Situ Investigation of Mammalian Inorganic Polyphosphate Localization Using Novel Selective Fluorescent Probes JC-D7 and JC-D8

(2014) Plamena R. Angelova et al.   ACS Chemical Biology

Nontoxic polyphosphate inhibitors reduce thrombosis while sparing hemostasis

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Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

(2014) Diane B. Re et al.   NEURON

Comparison of the Gene Expression Profiles of Human Fetal Cortical Astrocytes with Pluripotent Stem Cell Derived Neural Stem Cells Identifies Human Astrocyte Markers and Signaling Pathways and Transcription Factors Active in Human Astrocytes

(2014) Nasir Malik et al.   PLoS One

Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress

(2014) Fabiola Rojas et al.   Frontiers in Cellular Neuroscience

Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons

(2014) Brian J. Wainger et al.   Cell Reports

Inorganic polyphosphate regulates neuronal excitability through modulation of voltage-gated channels

(2014) Stephanie C Stotz et al.   Molecular Brain

Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats

(2013) Jianbin Tong et al.   EMBO JOURNAL

Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability

(2013) Elsa Fritz et al.   JOURNAL OF NEUROPHYSIOLOGY

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

Downregulation of MicroRNA-9 in iPSC-Derived Neurons of FTD/ALS Patients with TDP-43 Mutations

(2013) Zhijun Zhang et al.   PLoS One

A Secreted PTEN Phosphatase That Enters Cells to Alter Signaling and Survival

(2013) B. D. Hopkins et al.   SCIENCE

Efficient Generation of Astrocytes from Human Pluripotent Stem Cells in Defined Conditions

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Signalling properties of inorganic polyphosphate in the mammalian brain

(2013) Kira M. Holmström et al.   Nature Communications

Human Stem Cell-Derived Spinal Cord Astrocytes with Defined Mature or Reactive Phenotypes

(2013) Laurent Roybon et al.   Cell Reports

Fluorometric Quantification of Polyphosphate in Environmental Plankton Samples: Extraction Protocols, Matrix Effects, and Nucleic Acid Interference

(2012) Patrick Martin et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation

(2012) S. A. Smith et al.   BLOOD

Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72

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Induced Pluripotent Stem Cell Models of Progranulin-Deficient Frontotemporal Dementia Uncover Specific Reversible Neuronal Defects

(2012) Sandra Almeida et al.   Cell Reports

Glial nuclear aggregates of superoxide dismutase-1 are regularly present in patients with amyotrophic lateral sclerosis

(2011) Karin Forsberg et al.   ACTA NEUROPATHOLOGICA

Amyloid  -Induced Death in Neurons Involves Glial and Neuronal Hemichannels

(2011) J. A. Orellana et al.   JOURNAL OF NEUROSCIENCE

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

Selective Neuronal Vulnerability in Neurodegenerative Diseases: from Stressor Thresholds to Degeneration

(2011) Smita Saxena et al.   NEURON

Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo

(2011) S. T. Papadeas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice

(2010) L. Wang et al.   HUMAN MOLECULAR GENETICS

Differential Roles of NMDA Receptor Subtypes NR2A and NR2B in Dendritic Branch Development and Requirement of RasGRF1

(2010) Fernando J. Sepulveda et al.   JOURNAL OF NEUROPHYSIOLOGY

Inorganic Polyphosphate: Essential for Growth and Survival

(2009) Narayana N. Rao et al.   Annual Review of Biochemistry

Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo

(2009) Felicitas Müller et al.   CELL

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

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ADrosophilaModel for Amyotrophic Lateral Sclerosis Reveals Motor Neuron Damage by Human SOD1

(2008) Melanie R. Watson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Sensitivity, Quantitative Measurements of Polyphosphate Using a New DAPI-Based Approach

(2008) Roozbeh Aschar-Sobbi et al.   JOURNAL OF FLUORESCENCE

Neonatal Neuronal Circuitry Shows Hyperexcitable Disturbance in a Mouse Model of the Adult-Onset Neurodegenerative Disease Amyotrophic Lateral Sclerosis

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Focal transplantation–based astrocyte replacement is neuroprotective in a model of motor neuron disease

(2008) Angelo C Lepore et al.   NATURE NEUROSCIENCE

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

(2008) Koji Yamanaka et al.   NATURE NEUROSCIENCE