Article
Oncology
Yao Xu, Fanqi Shi, Yanting Zhang, Mengfan Yin, Xiuxin Han, Jinyan Feng, Guowen Wang
Summary: This study aimed to update the recent epidemiologic estimates of malignant bone tumors. The results showed differences in incidence and mortality rates across tumor types and demographic variables, providing potential suggestions for further adjustment of medical resources.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Jing Wang, Xiang-zhi Ni, Ming-lei Yang, Xing Huang, Shu-ming Hou, Cheng Peng, Jia-shi Cao, Tie-Long Liu
Summary: This study comprehensively analyzed the demographic features, clinicopathologic characteristics and prognosis factors of spinal osteosarcoma using the SEER database. The results showed that male gender, high tumor grade, regional and metastasis stage, as well as radiotherapy, were independent predictors of poor survival in spinal osteosarcoma patients. The clinical treatment of spinal osteosarcoma still faces serious challenges.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cell Biology
Tarek Assi, Sarah Watson, Bachar Samra, Elie Rassy, Axel Le Cesne, Antoine Italiano, Olivier Mir
Summary: Osteosarcoma is the most common primary tumor of the bones in young adults, with poor prognosis in relapsed or metastatic cases. However, advancements in targeted therapy, particularly focusing on angiogenesis, have shown promise in enhancing anti-tumor activity in osteosarcoma patients.
Article
Medicine, Research & Experimental
Zimao Wang, Jinhua Liu, Jingjing Han, Zheng Yang, Qiying Wang
Summary: This study constructed and validated a nomogram for predicting the 3-year and 5-year overall survival (OS) in patients with undifferentiated pleomorphic sarcoma (UPS). The nomogram showed good discrimination, accuracy, and clinical practicability, providing a reference for better clinical decisions.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Oncology
Sarah Cole, D. Matthew Gianferante, Bin Zhu, Lisa Mirabello
Summary: Using a large database, this study thoroughly evaluates osteosarcoma incidence and survival patterns and identifies important differences, particularly for the youngest children, ethnic minorities, and subsequent osteosarcoma cases.
Article
Clinical Neurology
Runyi Jiang, Shaohui He, Haitao Sun, Haiyi Gong, Xinghai Yang, Xiaopan Cai, Haifeng Wei, Jianru Xiao
Summary: This retrospective analysis study included 371 patients and found that the metastasis of PSES patients is associated with the year of diagnosis, tumor size, and lymph node invasion. A nomogram based on age, tumor extent, tumor size, and surgical treatments was developed to predict survival for PSES patients.
Article
Cardiac & Cardiovascular Systems
Kanhua Yin, Rongkui Luo, Yaguang Wei, Fenglei Wang, Yiwen Zhang, Karl J. Karlson, Zhiqi Zhang, Michael J. Reardon, Nikola Dobrilovic
Summary: The study evaluated survival outcomes of primary cardiac sarcoma in a US nationwide cancer database. It found that overall survival for patients with primary cardiac sarcoma is poor, with surgery and chemotherapy associated with improved survival. Increasing age at diagnosis was linked to worse survival outcomes.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Liyuan Tang, Binbin Liu
Summary: Osteosarcoma is a malignant tumor that rarely shows simultaneous lung and bone metastases. Factors such as female sex, tumor size, specific types of osteosarcoma, lymph node involvement, other metastatic sites, and treatments (surgery, radiotherapy, and chemotherapy) were significantly associated with lung metastases. Factors such as age, tumor stage, presence of lung metastases, liver metastases, and treatments were significantly associated with bone metastases. Both lung and bone metastases were significantly associated with specific types of osteosarcoma, tumor stage, other metastatic sites, and treatments. Metastases, radiotherapy, and surgery at the primary site were significantly correlated with lung and/or bone metastases. Chemotherapy at the primary site was effective in improving the survival rate of patients with lung and/or bone metastases. Older age, bone metastases, no surgery, and no chemotherapy were harmful to the survival of osteosarcoma patients with lung metastases. Similarly, in patients with bone metastases, factors such as lymph node involvement, no surgery, and no chemotherapy were harmful for survival. In patients with both lung and bone metastases, older age and no chemotherapy were harmful for survival.
Article
Oncology
Marcos R. Gonzalez, Daniel Karczewski, Angad D. S. Bedi, Hayley Denwood, Santiago A. Lozano-Calderon
Summary: A study of 770 patients undergoing pelvic sarcoma surgery found that the incidence of soft tissue complications within 30 days after surgery was 12.6%. Risk factors for soft tissue complications included age over 30, hematocrit less than 30%, and longer operative time.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Shengnan Zhou, Shitao Jiang, Weijie Chen, Haixin Yin, Liangbo Dong, Hao Zhao, Shaoqi Han, Xiaodong He
Summary: This study investigated prognostic factors for biliary neuroendocrine neoplasms (NENs) and developed a nomogram to predict overall survival. Age, tumor size, pathological classification, SEER stage, and surgery were identified as independent variables associated with survival. The developed nomogram showed good calibration and discrimination abilities, making it a useful tool for clinicians to estimate individual survival among biliary NENs patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Yu Huang, Chengxin Xie, Qinglong Li, Xiao Huang, Wenwen Huang, Dong Yin
Summary: A prognostic nomogram was constructed to predict the overall survival of patients with bone-metastatic bladder cancer (BMBC) based on data from the Surveillance, Epidemiology, and End Results database. Six independent prognostic factors were identified and included in the nomogram construction. The nomogram showed good predictive accuracy and could serve as a useful tool for predicting overall survival in BMBC patients and guiding treatment decisions.
Article
Orthopedics
Jinkui Wang, Mujie Li, Peng Guo, Dawei He
Summary: This study analyzes the factors affecting chemotherapy in patients with osteosarcoma and explores the challenges and survival benefits of chemotherapy. The results show that older patients benefit significantly from chemotherapy, but there have been no significant changes in the chemotherapy treatment rate and 5-year survival rate of osteosarcoma patients.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Zunaira Shoaib, Timothy M. Fan, Joseph M. K. Irudayaraj
Summary: Osteosarcoma, a common primary bone tumor, is influenced by mechanobiology in its pathogenesis. Mechanobiology-driven therapies can curb tumor progression by altering the physical microenvironment or inhibiting proteins associated with metastasis.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Ahmed K. Awad, Anas Elgenidy, Ahmed M. Afifi, Michel Pompe Sa, Basel Ramlawi
Summary: Primary malignant cardiac tumors, especially cardiac sarcoma, have a poor prognosis compared to other cardiac or extracardiac tumors. This retrospective study analyzed the clinical data of 235 patients and found that tumor-directed surgery, chemotherapy, and radiotherapy were the most common treatment methods. In addition, other associated cancers with cardiac sarcoma were rare.
JOURNAL OF CARDIAC SURGERY
(2022)
Article
Oncology
Muhammad U. Jawad, Saif Farhan, Max R. Haffner, Hai Van Le, Steven W. Thorpe, Eric O. Klineberg, R. Lor Randall
Summary: Primary sarcomas originating from the mobile spine have a particularly poor prognosis. The incidence of spinal sarcoma in 2017 was 0.019 per 100,000 persons and has not significantly changed since 2000. Survival and prognostic factors vary by histologic subtypes, with osteosarcoma having the worst 5-year survival at 39% and chondrosarcoma having the best at 69%. Factors affecting survival include age, grade, and stage, with stage being an independent predictor for every histologic subtype.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Orthopedics
Trevor R. Gulbrandsen, Zain M. Khazi, Matthew Bollier, Brian Wolf, Christopher Larson, Kyle Duchman, Qiang An, Robert W. Westermann
Summary: This study aimed to establish the preoperative validity of PROMIS PF-CT in meniscal root tears patients. The results showed a strong correlation between PROMIS PF-CT and other established PROMs, without floor or ceiling effects. PROMIS PF-CT is proven to be a valuable tool for assessing preoperative patient-reported physical function in patients with MRT.
JOURNAL OF KNEE SURGERY
(2021)
Article
Orthopedics
Alan G. Shamrock, James R. Hall, Christina J. Hajewski, Qiang An, Kyle R. Duchman
Summary: The purpose of this study was to investigate the pattern of meniscus and cartilage pathology in multiligament knee injuries (MLKIs) and determine the relationship between surgical timing and injury mechanism with degree of intra-articular injury. The study found that delayed surgical intervention was associated with increased meniscus and cartilage pathology.
JOURNAL OF KNEE SURGERY
(2022)
Article
Medicine, General & Internal
Patricia Schneider, Victoria Giglio, Dana Ghanem, David Wilson, Robert Turcotte, Marc Isler, Sophie Mottard, Benjamin Miller, James Hayden, Yee-Cheen Doung, Kenneth Gundle, R. Lor Randall, Kevin Jones, Roberto Velez, Michelle Ghert
Summary: This study investigated the willingness of extremity sarcoma patients from Canada, the USA, and Spain to participate in a randomized controlled trial, with the majority of patients expressing willingness. Patients' motivations included helping future patients, while barriers included the overwhelming burden of a cancer diagnosis.
Editorial Material
Oncology
Jeffrey D. Rytlewski, Nicholas Scalora, Keith Garcia, Munir Tanas, Fatima Toor, Benjamin Miller, Bryan Allen, Mohammed Milhem, Varun Monga
Summary: Advanced sarcomas have not seen the improved outcomes observed in other cancer subtypes. Verteporfin has the potential to bring about significant changes in sarcoma treatment due to its anti-proliferative properties, including inhibition of the Hippo pathway and photodynamic therapy. Studies suggest that verteporfin could be incorporated into standard sarcoma treatment protocols, leveraging its ability to inhibit the Hippo pathway and induce necrosis through oxidative damage with photodynamic therapy.
Article
Biochemical Research Methods
Eric Larson, Madeline Hines, Munir Tanas, Benjamin Miller, Mitchell Coleman, Fatima Toor
JOURNAL OF BIOMEDICAL OPTICS
(2021)
Article
Oncology
Mary Kate Skalitzky, Trevor R. Gulbrandsen, Olivier Q. Groot, Aditya Karhade, Jorrit-Jan Verlaan, Joseph H. Schwab, Benjamin J. Miller
Summary: The study validated the SORG machine-learning algorithm for predicting 90-day and 1-year survival in patients with metastatic long-bone disease, showing good discrimination, calibration, overall performance, and decision curve analysis. The developed ML algorithms were found to be effective in predicting survival and may assist clinicians in making informed decisions regarding treatment.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Michelle Ghert, Patricia Schneider, Gordon Guyatt, Lehana Thabane, Roberto Velez, Timothy O'Shea, R. Lor Randall, Robert Turcotte, David Wilson, Jay S. Wunder, Andre Mathias Baptista, Edward Y. Cheng, Yee-Cheen Doung, Peter C. Ferguson, Victoria Giglio, James Hayden, Diane Heels-Ansdell, Shah Alam Khan, Venkatesan Sampath Kumar, Paula McKay, Benjamin Miller, Michiel van de Sande, Juan P. Zumarraga, Mohit Bhandari
Summary: This randomized clinical trial compared the effectiveness of a 5-day regimen of postoperative intravenous antibiotics with a 1-day regimen in preventing surgical site infections after surgery for lower extremity bone tumors. The study found no significant difference in the rate of surgical site infections between the two regimens. However, the 5-day regimen group had significantly more antibiotic-related complications.
Article
Oncology
Trevor Robert Gulbrandsen, Mary Kate Skalitzky, Alan Gregory Shamrock, Burke Gao, Obada Hasan, Benjamin James Miller
Summary: This study evaluated the readability, understandability, and actionability of web-based osteosarcoma resources. The results showed that these resources scored poorly in terms of readability, understandability, and actionability, failing to meet the recommended reading level. Only a few resources were considered understandable by the general public. Authors of patient resources should improve these web-based resources to support patient understanding.
Article
Oncology
Emma L. Herbach, Bradley D. McDowell, Elizabeth A. Chrischilles, Benjamin J. Miller
Summary: The volume of surgeries performed at hospitals for bone metastatic disease (MDB) does not significantly affect patient outcomes, while medical school affiliation is associated with lower mortality rates. However, being treated at Commission on Cancer accredited hospitals is linked to higher risk of death after surgery.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2022)
Article
Orthopedics
Lukas M. Nystrom, Nathan W. Mesko, Yuxuan Jin, Chirag Shah, Andre Spiguel, Jeremy White, Benjamin J. Miller
Summary: Surgical wound-healing complications after tumor resections in preoperatively radiated tissue are a significant clinical problem, and there is currently no reliable method to predict these complications. Transcutaneous oximetry has been suggested as a potential predictor, but the evidence is inconclusive. This study found that transcutaneous oximetry cannot reliably predict wound-healing complications, and alternative approaches should be explored.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Article
Engineering, Biomedical
Joshua E. Johnson, Jessica E. Goetz, Marc J. Brouillette, Benjamin J. Miller
Summary: Computational mechanical tools can assist in decision-making for non-surgical management of appropriate patients with femur metastatic bone disease, reducing unnecessary surgical treatment in some patients.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
(2022)
Review
Oncology
Emily Z. Keung, Kate J. Krause, Jessica Maxwell, Carol D. Morris, Aimee M. Crago, Matthew T. Houdek, John Kane, Valerae Lewis, Dario Callegaro, Benjamin Miller, Alexander J. Lazar, Rebecca Gladdy, Chandrajit P. Raut, Nicola Fabbri, Waddah Al-Refaie, Mark Fairweather, Sandra L. Wong, Christina L. Roland
Summary: Regional lymph node metastasis (RLNM) is uncommon in patients with soft tissue sarcoma (STS), although certain STS subtypes are more prone to RLNM. The impact of node-positive disease on patient survival is still controversial. There is ongoing debate about the benefits of sentinel lymph node biopsy (SLNB) in STS patients. Further multicenter prospective studies are needed to determine the true incidence and potential benefits of SLNB in patients with clinically occult RLNM.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Emily Z. Keung, Kate J. Krause, Jessica Maxwell, Carol D. Morris, Aimee M. Crago, Matthew T. Houdek, John Kane, Valerae Lewis, Dario Callegaro, Benjamin Miller, Alexander J. Lazar, Rebecca Gladdy, Chandrajit P. Raut, Nicola Fabbri, Waddah Al-Refaie, Mark Fairweather, Sandra L. Wong, Christina L. Roland
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Psychology, Multidisciplinary
Jonathan R. Day, Benjamin Miller, Bradley T. Loeffler, Sarah L. Mott, Munir Tanas, Melissa Curry, Jonathan Davick, Mohammed Milhem, Varun Monga
Summary: This study retrospectively analyzed young adult patients with sarcoma and found that their overall quality of life improved at 12 months post-diagnosis, especially in terms of physical and functional wellbeing. Factors such as clinical characteristics and comorbidities had a significant impact on physical and social wellbeing.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Oncology
Emma L. Herbach, Bradley D. D. McDowell, Mary Charlton, Benjamin J. J. Miller
Summary: Patients with metastatic disease of the bone (MDB) often require surgical stabilization, but there is no consensus on the subsequent adjuvant treatment. This study aimed to examine the utilization of perioperative adjuvant treatment among MDB patients. The results showed that patients treated at major medical schools or high-volume facilities had higher odds of receiving radiation and chemotherapy, while patients treated at CoC-accredited institutions had higher odds of receiving radiation and bisphosphonates. The use of chemotherapy and bisphosphonates increased over the study period, while the use of radiation declined.
