Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Review
Medicine, General & Internal
Mihaela Fadgyas Stanculete, Abdulrahman Ismaiel, Stefan-Lucian Popa, Octavia Oana Capatina
Summary: Irritable bowel syndrome (IBS) is a disorder characterized by altered gut-brain interaction and dysfunction of the brain-gut-microbiota axis. Prior studies have shown significant impairments in the health-related quality of life of patients with IBS. Resilience, as a psychosocial ability, plays a crucial role in promoting health and enhancing stress response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Grace L. Burns, Nicholas J. Talley, Simon Keely
Summary: Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction characterized by chronic abdominal pain and altered defaecation. Research has found that small intestinal mechanosensation, altered barrier functions, and microbial imbalance are associated with IBS. The current literature suggests that the pathogenesis of IBS may involve dysfunction of the entire intestinal tract.
Review
Medicine, General & Internal
Daniel Paramythiotis, Eleni Karlafti, Matthaios Didagelos, Maria Fafouti, Kalliopi Veroplidou, Adonis A. Protopapas, Georgia Kaiafa, Smaro Netta, Antonios Michalopoulos, Christos Savopoulos
Summary: The emergence of post-COVID-19 syndrome (PCS) has raised concerns within the medical community. This review analyzes the gastrointestinal (GI) involvement and prolonged symptoms of COVID-19 infection as part of PCS, focusing on the potential development of post-infection IBS (PI-IBS). The review highlights the need for more research on PI-IBS and potential treatment options.
MEDICINA-LITHUANIA
(2023)
Article
Gastroenterology & Hepatology
Tadayuki Oshima, Kewin Tien Ho Siah, Takanori Yoshimoto, Ko Miura, Toshihiko Tomita, Hirokazu Fukui, Hiroto Miwa
Summary: This study investigated the impact of the COVID-19 pandemic on gastrointestinal and psychological symptoms of functional dyspepsia (FD) and irritable bowel syndrome (IBS). Results showed that during the pandemic, respondents with FD-IBS overlap syndrome had the worst symptoms, followed by IBS-alone and FD-alone respondents. 11.9% reported deterioration and 2.8% reported improvement of gastrointestinal symptoms.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Anna Nazarewska, Konrad Lewandowski, Magdalena Kaniewska, Mariusz Rosolowski, Wojciech Marlicz, Grazyna Rydzewska
Summary: Gastrointestinal symptoms following COVID-19 can persist, and the Rome IV criteria may not fully capture these symptoms.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2022)
Letter
Gastroenterology & Hepatology
Cong Dai, Yu-Hong Huang, Min Jiang
Summary: This article is connected to the papers of Marasco et al. To access these papers, visit and
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Medicine, General & Internal
Sofia D. Shaikh, Natalie Sun, Andrew Canakis, William Y. Park, Horst Christian Weber
Summary: Irritable Bowel Syndrome (IBS) is a functional disorder of the gastrointestinal tract characterized by abdominal pain and altered bowel habits. It has a high prevalence and disease burden, affecting the quality of life, work productivity and healthcare utilization and costs. IBS is associated with various conditions, including psychiatric comorbidities. The pathophysiology involves dysregulation of the brain-gut axis, leading to changes in intestinal motility, gut permeability, visceral hypersensitivity and gut microbiota composition. This article aims to explore the role of gut microbiota in the pathophysiology of IBS, factors influencing the gut microbiome, and the potential of microbiome as a treatment target.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Sik Yu So, Tor C. Savidge
Summary: Irritable bowel syndrome (IBS) is more common in females, and sex steroids play a critical role in disease onset and symptom severity by regulating visceral sensitivity, gut motility, and psychological conditions.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Gastroenterology & Hepatology
Carlo Romano Settanni, Gianluca Ianiro, Francesca Romana Ponziani, Stefano Bibbo, Jonathan Philip Segal, Giovanni Cammarota, Antonio Gasbarrini
Summary: COVID-19, caused by SARS-CoV-2, can result in a wide range of symptoms from mild to severe, including fever, cough, and gastrointestinal issues. Long-term consequences may include respiratory problems and fatigue. Research speculates that COVID-19 may trigger irritable bowel syndrome.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Letter
Gastroenterology & Hepatology
Giovanni Marasco, Marcello Maida, Cesare Cremon, Maria Raffaella Barbaro, Vincenzo Stanghellini, Giovanni Barbara
Summary: This article is connected to Marasco et al papers. To view these articles, visit and...
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Integrative & Complementary Medicine
Kiangyada Yaklai, Sintip Pattanakuhar, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: IBS is a chronic dysfunction of the gastrointestinal tract characterized by symptoms such as abdominal pain and discomfort, which significantly affect patients' quality of life. Treatment mainly focuses on symptom management through standard and complementary therapies, including acupuncture. Studies have shown that acupuncture can be effective in treating IBS and research is ongoing to understand its mechanisms of action.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Giovanni Marasco, Marcello Maida, Cesare Cremon, Maria Raffaella Barbaro, Vincenzo Stanghellini, Giovanni Barbara
Summary: This meta-analysis aimed to estimate the incidence of post-COVID-19 functional dyspepsia (FD) and irritable bowel syndrome (IBS). The analysis found that COVID-19 survivors are at a higher risk of developing IBS compared to controls, while data for FD are inconclusive.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Immunology
Lin Xiao, Qin Liu, Mei Luo, Lishou Xiong
Summary: Research has identified the significant roles that microbiota-derived metabolites play in the development of IBS symptoms in patients, shedding light on the complex interplay between gut microbiota and IBS.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kexin Wang, Huan Liu, Jingjing Liu, Liyuan Han, Zheng Kang, Libo Liang, Shengchao Jiang, Nan Meng, Peiwen Chen, Qiao Xu, Qunhong Wu, Yanhua Hao
Summary: This study investigated the prevalence and influencing factors of IBS and its subtypes in adult participants in the UK. The results showed that somatization and coeliac disease are primary risk factors for IBS. Differences were found among subtypes and sexes. The prevalence of PI-IBS in IBS patients was relatively high and characterized by diarrhea, fever, bloody diarrhea, and vomiting.
FRONTIERS IN PHARMACOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Aditi Kumar, Gaurav B. Nigam, Dipesh Harshvadan Vasant, Anjan Dhar
FRONTLINE GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Christopher J. Black, Peter A. Paine, Anurag Agrawal, Imran Aziz, Maria P. Eugenicos, Lesley A. Houghton, Pali Hungin, Ross Overshott, Dipesh H. Vasant, Sheryl Rudd, Richard C. Winning, Maura Corsetti, Alexander C. Ford
Summary: This research aims to review and summarize the current evidence on functional dyspepsia, provide a practical framework for evidence-based diagnosis and treatment of patients, and provide specific recommendations based on the GRADE system. The study also considers the development of novel treatment methods and highlights areas of unmet need and priorities for future research.
Article
Gastroenterology & Hepatology
Umair Akbani, Dipesh Harshvadan Vasant
Summary: This study investigated the perceptions of foundation doctors towards gastroenterology and identified gender differences in specialty selection factors. The results showed that female doctors value patient-centred care and good mentorship, while male doctors prioritize income and length of training. Female doctors had negative perceptions of the male dominant existing workforce and the requirement to be a medical registrar in gastroenterology. Increasing flexibility in training and providing more exposure and mentorship during the foundation years may improve diversity in the specialty.
FRONTLINE GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Alexander O'Connor, Caroline M. Byrne, Dipesh H. Vasant, Abhiram Sharma, Donghua Liao, Niels Klarskov, Edward S. Kiff, Karen Telford
Summary: This review presents the current and potential future applications of AAR and FLIP techniques, highlighting the unanswered questions associated with these novel technologies.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Editorial Material
Gastroenterology & Hepatology
Sophia Agwaonye, Dipesh H. Vasant
BMJ OPEN GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Dipesh H. Vasant, Gaurav B. Nigam, Sebastian Bate, Shaheen Hamdy, Jimmy K. Limdi
Summary: Despite advances in UC therapies, a proportion of patients experience fecal incontinence (FI) in the absence of active inflammation. In a prospective study, the prevalence and impact of FI in UC were estimated.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Hussain Jaafari, Lesley A. Houghton, Robert M. West, Anurag Agrawal, Imran Aziz, Christopher J. Black, Maura Corsetti, Farag Shuweihdi, Maria Eugenicos, Peter A. Paine, Alexander C. Ford, Peter J. Whorwell, Shrikant I. Bangdiwala, Olafur S. Palsson, Ami D. Sperber, Dipesh H. Vasant
Summary: This study compared the prevalence of disorders of gut brain interaction (DGBI) in the UK with other countries and found that the proportion of DGBI participants was lower in the UK. The prevalence of 14 out of 22 Rome IV DGBI was similar between the UK and other countries, while some specific DGBI were more prevalent in the UK. Differences in opioid prescribing, cultural, dietary, and lifestyle factors may contribute to variations in the prevalence of DGBI between the UK and other countries.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Johann P. Hreinsson, Reuben K. M. Wong, Jan Tack, Peter Whorwell, Marc A. Benninga, Viola Andresen, Bruno Bonaz, Suck Chei Choi, Enrico S. Corazziari, Javier Santos, Shin Fukudo, Motoyori Kanazawa, Xuicai Fang, Shrikant I. Bangdiwala, Ami D. Sperber, Olafur S. Palsson, Magnus Simren
Summary: This study compared the prevalence of gut-brain interaction disorders (DGBI) between Asia and Western Europe, and found that DGBI is generally more prevalent in Western Europe, which is associated with severe psychological and non-GI somatic symptoms.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Syed S. Hasan, Sarah Ballou, Laurie Keefer, Dipesh H. Vasant
Summary: Gut-directed hypnotherapy (GDH) is a highly effective behavioral therapy recommended for the treatment of irritable bowel syndrome (IBS). GDH has been recognized as a valuable addition to integrated care alongside medical and dietary approaches. Recent innovations, such as smartphone app-delivered GDH, have improved access to this therapy despite low adherence rates.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Multidisciplinary Sciences
Huw Purssell, Lucy Bennett, Oliver Street, Karen Piper Hanley, Neil Hanley, Dipesh H. Vasant, Varinder S. Athwal
Summary: The study evaluated the prevalence and burden of Rome IV irritable bowel syndrome (IBS) in patients with non-alcoholic fatty liver disease (NAFLD). It found that 55.6% of NAFLD patients had Rome IV bowel disorders of gut brain interaction (DGBI), with 35.2% meeting the criteria for IBS. Rome IV bowel DGBI, such as IBS, are associated with impaired quality-of-life (QoL) and psychosocial distress.
SCIENTIFIC REPORTS
(2023)
Article
Psychology, Clinical
Syed Shariq Hasan, Dipesh Vasant
Summary: Remote hypnotherapy is increasingly used internationally, especially after the COVID-19 pandemic. Video-based remote hypnotherapy is more popular and effective compared to telephone therapy, improving access to treatment. Patient satisfaction and practical considerations should be taken into account when deciding on the mode of delivery.
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL HYPNOSIS
(2023)
Article
Gastroenterology & Hepatology
Jade Devenney, Syed S. Hasan, Julie Morris, Peter J. Whorwell, Dipesh H. Vasant
Summary: This study conducted a secondary analysis of gut-directed hypnotherapy outcomes in patients with refractory IBS and found that patients with a higher burden of gastrointestinal and extraintestinal symptoms are most likely to benefit from this treatment. Clinical assessment of gastrointestinal, somatic, and psychological symptom profiles may play a role in selecting patients for gut-directed hypnotherapy.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Ayodele Sasegbon, Yuying Luo, Laurie A. Keefer, Dipesh H. Vasant
Summary: Despite the high prevalence and burden of disorders of gut-brain interaction (DGBI), there is limited teaching on this topic in medical curricula. This study evaluated the exposure and comfort levels of UK gastroenterology trainees in diagnosing and managing DGBI. Findings suggest that most trainees lack confidence in dealing with DGBI.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Karuna Sapru, Peter Barry, Andrew Jones, John Walmsley, Javaid Iqbal, Dipesh H. Vasant
Summary: Patients with cystic fibrosis (pwCF) have a high incidence of early colorectal cancer (CRC). This study evaluated the utility and outcomes of colonoscopy and CRC at a large UK CF centre. The results showed that the uptake of colonoscopy among pwCF was low, but it was highly effective for detecting premalignant lesions in patients over 40 years old.
BMJ OPEN GASTROENTEROLOGY
(2023)