A pharmacokinetic–pharmacodynamic model characterizing the emergence of resistantEscherichia colisubpopulations during ertapenem exposure

A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants

(2015) David D. Khan et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

High Fitness Costs and Instability of Gene Duplications Reduce Rates of Evolution of New Genes by Duplication-Divergence Mechanisms

(2014) M. Adler et al.   MOLECULAR BIOLOGY AND EVOLUTION

Frequent emergence of porin-deficient subpopulations with reduced carbapenem susceptibility in ESBL-producing Escherichia coli during exposure to ertapenem in an in vitro pharmacokinetic model

(2013) T. Tangden et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Comparative Pharmacokinetics, Pharmacodynamics, and Tolerability of Ertapenem 1 Gram/Day Administered as a Rapid 5-Minute Infusion versus the Standard 30-Minute Infusion in Healthy Adult Volunteers

(2013) Dora E. Wiskirchen et al.   PHARMACOTHERAPY

Clinical Outcomes With Extended or Continuous Versus Short-term Intravenous Infusion of Carbapenems and Piperacillin/Tazobactam: A Systematic Review and Meta-analysis

(2012) Matthew E. Falagas et al.   CLINICAL INFECTIOUS DISEASES

Influence of acquired  -lactamases on the evolution of spontaneous carbapenem resistance in Escherichia coli

(2012) M. Adler et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Emergence of Ertapenem Resistance in an Escherichia coli Clinical Isolate Producing Extended-Spectrum β-Lactamase AmpC

(2011) Hélène Guillon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetic-Pharmacodynamic Model for Gentamicin and Its Adaptive Resistance with Predictions of Dosing Schedules in Newborn Infants

(2011) Ami F. Mohamed et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Does prolonged β-lactam infusions improve clinical outcomes compared to intermittent infusions? A meta-analysis and systematic review of randomized, controlled trials

(2011) Pranita D Tamma et al.   BMC INFECTIOUS DISEASES

Transfer of an Escherichia coli ST131 multiresistance cassette has created a Klebsiella pneumoniae-specific plasmid associated with a major nosocomial outbreak

(2011) Linus Sandegren et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Attenuation of Colistin Bactericidal Activity by High Inoculum of Pseudomonas aeruginosa Characterized by a New Mechanism-Based Population Pharmacodynamic Model

(2010) J. B. Bulitta et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Handling Data Below the Limit of Quantification in Mixed Effect Models

(2009) Martin Bergstrand et al.   AAPS Journal

Ertapenem Resistance among Extended-Spectrum- -Lactamase-Producing Klebsiella pneumoniae Isolates

(2009) A. Leavitt et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Development and Qualification of a Pharmacodynamic Model for the Pronounced Inoculum Effect of Ceftazidime against Pseudomonas aeruginosa

(2008) J. B. Bulitta et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

CTX-M Expression and Selection of Ertapenem Resistance in Klebsiella pneumoniae and Escherichia coli

(2008) D. Girlich et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacodynamic Modeling of Aminoglycosides against Pseudomonas aeruginosa and Acinetobacter baumannii: Identifying Dosing Regimens To Suppress Resistance Development

(2008) V. H. Tam et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY