Lesions without symptoms: understanding resilience to Alzheimer disease neuropathological changes

Donanemab in Early Alzheimer’s Disease

(2021) Mark A. Mintun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tau-PET and in vivo Braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals

(2021) Davina Biel et al.   Alzheimers Research & Therapy

ATN status in amnestic and non-amnestic Alzheimer’s disease and frontotemporal lobar degeneration

(2020) Katheryn A Q Cousins et al.   BRAIN

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

(2020) Simon Dujardin et al.   NATURE MEDICINE

CSF biomarkers in Olmsted County

(2020) Argonde C. Van Harten et al.   NEUROLOGY

Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE), ADNC Pathology, and Cognitive Decline in Aging

(2020) Alifiya Kapasi et al.   NEUROLOGY

Genetic variants and functional pathways associated with resilience to Alzheimer’s disease

(2020) Logan Dumitrescu et al.   BRAIN

Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer’s Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers

(2020) Ayush Singh et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s Disease Neuropathological Comorbidities are Common in the Younger-Old

(2020) Thomas G. Beach et al.   JOURNAL OF ALZHEIMERS DISEASE

Vascular dysfunction—The disregarded partner of Alzheimer's disease

(2019) Melanie D. Sweeney et al.   Alzheimers & Dementia

Systemic and CNS inflammation crosstalk: implications for Alzheimer’s Disease

(2019) Evi Paouri et al.   Current Alzheimer Research

Longitudinal neuroanatomical and cognitive progression of posterior cortical atrophy

(2019) Nicholas C Firth et al.   BRAIN

Vascular Cognitive Impairment and Dementia

(2019) Costantino Iadecola et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging–Alzheimer’s Association Research Framework

(2019) Clifford R. Jack et al.   JAMA Neurology

Alzheimer’s disease frequency peaks in the tenth decade and is lower afterwards

(2019) Jose M. Farfel et al.   Acta Neuropathologica Communications

Efficacy and Safety of Lanabecestat for Treatment of Early and Mild Alzheimer Disease

(2019) Alette M. Wessels et al.   JAMA Neurology

Non-Alzheimer’s contributions to dementia and cognitive resilience in The 90+ Study

(2018) John L. Robinson et al.   ACTA NEUROPATHOLOGICA

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease

(2018) Lawrence S. Honig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Postsynaptic Proteome of Non-Demented Individuals with Alzheimer’s Disease Neuropathology

(2018) Olga Zolochevska et al.   JOURNAL OF ALZHEIMERS DISEASE

Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease

(2018) Eric McDade et al.   NEUROLOGY

Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies

(2018) Patricia A. Boyle et al.   ANNALS OF NEUROLOGY

Distinct cytokine profiles in human brains resilient to Alzheimer's pathology

(2018) Isabel Barroeta-Espar et al.   NEUROBIOLOGY OF DISEASE

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

(2018) Borislav Dejanovic et al.   NEURON

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

The Neuropathology of Older Persons with and Without Dementia from Community versus Clinic Cohorts

(2017) Julie A. Schneider et al.   JOURNAL OF ALZHEIMERS DISEASE

Microinfarcts are common and strongly related to dementia in the oldest-old: The 90+ study

(2016) María M. Corrada et al.   Alzheimers & Dementia

Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria

(2016) Bruno Dubois et al.   Alzheimers & Dementia

Genomic variants, genes, and pathways of Alzheimer's disease: An overview

(2016) Adam C. Naj et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Vascular contributions to cognitive impairment, clinical Alzheimer's disease, and dementia in older persons

(2016) A. Kapasi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TDP-43 stage, mixed pathologies, and clinical Alzheimer’s-type dementia

(2016) Bryan D. James et al.   BRAIN

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

A systematic review of the diagnostic test accuracy of brief cognitive tests to detect amnestic mild cognitive impairment

(2016) Seline Ozer et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

(2016) Clifford R. Jack et al.   NEUROLOGY

The Evolution of Genetics: Alzheimer’s and Parkinson’s Diseases

(2016) Andrew Singleton et al.   NEURON

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Alzheimer's disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes

(2015) Shobana Sekar et al.   NEUROBIOLOGY OF AGING

Multiple pathologies are common and related to dementia in the oldest-old

(2015) Claudia H. Kawas et al.   NEUROLOGY

Disease-related microglia heterogeneity in the hippocampus of Alzheimer’s disease, dementia with Lewy bodies, and hippocampal sclerosis of aging

(2015) Adam D Bachstetter et al.   Acta Neuropathologica Communications

TDP-43 is a key player in the clinical features associated with Alzheimer’s disease

(2014) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Genetic Modulation of Soluble A  Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease

(2014) S. W. Fowler et al.   JOURNAL OF NEUROSCIENCE

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dissecting phenotypic traits linked to human resilience to Alzheimer’s pathology

(2013) Beatriz G. Perez-Nievas et al.   BRAIN

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

A Population-Based Clinicopathological Study in the Oldest-Old: The 90+ Study

(2013) Maria M. Corrada et al.   Current Alzheimer Research

Memantine Rescues Transient Cognitive Impairment Caused by High-Molecular-Weight A  Oligomers But Not the Persistent Impairment Induced by Low-Molecular-Weight Oligomers

(2013) C. P. Figueiredo et al.   JOURNAL OF NEUROSCIENCE

Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease

(2013) Willem Kamphuis et al.   NEUROBIOLOGY OF AGING

Life-span cognitive activity, neuropathologic burden, and cognitive aging

(2013) R. S. Wilson et al.   NEUROLOGY

Brain  -amyloid load approaches a plateau

(2013) C. R. Jack et al.   NEUROLOGY

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo

(2013) K. V. Kuchibhotla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

(2012) Hwan-Ching Tai et al.   AMERICAN JOURNAL OF PATHOLOGY

Amyloid deposition, hypometabolism, and longitudinal cognitive decline

(2012) Susan M. Landau et al.   ANNALS OF NEUROLOGY

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn2+ in cognitively intact aged individuals with Alzheimer’s disease neuropathology

(2012) Nicole L Bjorklund et al.   Molecular Neurodegeneration

Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice

(2012) J H Ledo et al.   MOLECULAR PSYCHIATRY

Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's disease

(2012) Steven E. Arnold et al.   NEUROBIOLOGY OF AGING

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Soluble forms of tau are toxic in Alzheimer’s disease

(2012) Katherine Kopeikina et al.   Translational Neuroscience

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Relationship Between Education and Dementia

(2011) Emily Schoenhofen Sharp et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain

(2011) Katherine J. Kopeikina et al.   AMERICAN JOURNAL OF PATHOLOGY

Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease

(2011) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

Alzheimer Disease Pathology in Subjects Without Dementia in 2 Studies of Aging: The Nun Study and the Adult Changes in Thought Study

(2011) Karen S. SantaCruz et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study

(2011) Melissa E Murray et al.   LANCET NEUROLOGY

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype

(2011) Julie E. Simpson et al.   NEUROBIOLOGY OF AGING

The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia

(2010) Jessica M. Mc Donald et al.   BRAIN

Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease

(2010) Sudha Seshadri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cell-Mediated Neuroprotection in a Mouse Model of Human Tauopathy

(2010) D. W. Hampton et al.   JOURNAL OF NEUROSCIENCE

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease

(2010) M. Coma et al.   NEUROBIOLOGY OF DISEASE

Vascular Factors and Markers of Inflammation in Offspring With a Parental History of Late-Onset Alzheimer Disease

(2009) Eric van Exel et al.   ARCHIVES OF GENERAL PSYCHIATRY

Diagnosis and staging of mild cognitive impairment, using a modification of the clinical dementia rating scale: the mCDR

(2009) Ranjan Duara et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Tangle-Bearing Neurons Survive Despite Disruption of Membrane Integrity in a Mouse Model of Tauopathy

(2009) Alix de Calignon et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

(2009) Jennifer L. Tomic et al.   NEUROBIOLOGY OF DISEASE

The Nun Study: Clinically silent AD, neuronal hypertrophy, and linguistic skills in early life

(2009) D. Iacono et al.   NEUROLOGY

Epidemiological Pathology of Dementia: Attributable-Risks at Death in the Medical Research Council Cognitive Function and Ageing Study

(2009) Fiona E. Matthews et al.   PLOS MEDICINE

Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly

(2008) Howard Jay Aizenstein et al.   ARCHIVES OF NEUROLOGY

Oligomers of the amyloid-β protein disrupt working memory: Confirmation with two behavioral procedures

(2008) Alan Poling et al.   BEHAVIOURAL BRAIN RESEARCH

Modeling the Association between 43 Different Clinical and Pathological Variables and the Severity of Cognitive Impairment in a Large Autopsy Cohort of Elderly Persons

(2008) Peter T. Nelson et al.   BRAIN PATHOLOGY

Neuronal Hypertrophy in Asymptomatic Alzheimer Disease

(2008) Diego Iacono et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain

(2008) J.E. Simpson et al.   NEUROBIOLOGY OF AGING