期刊
NATURE METHODS
卷 19, 期 4, 页码 418-428出版社
NATURE PORTFOLIO
DOI: 10.1038/s41592-022-01453-y
关键词
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资金
- Bill and Melinda Gates Foundation [INV-037420]
- NIDDK [R01 DK124463, DP3 DK111907-01, R01 DK116075-01A1, R01 DK119667-01A1]
- Irma Hirschl Trust Research Award
- NICHD [1F32HD096810-01]
- Weill Cornell Medicine Research Assistance for Primary Parents Award
- Bill and Melinda Gates Foundation [INV-037420] Funding Source: Bill and Melinda Gates Foundation
Organoid models provide a powerful tool for studying COVID-19, including SARS-CoV-2 tropism, host response, drug discovery, and vaccine development. However, there are remaining challenges and unmet needs in the context of SARS-CoV-2 research using organoid technology.
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS-CoV-2 not only infects the respiratory tract, but also causes damage to many organs. Organoids, which can self-renew and recapitulate the various physiology of different organs, serve as powerful platforms to model COVID-19. In this Perspective, we overview the current effort to apply both human pluripotent stem cell-derived organoids and adult organoids to study SARS-CoV-2 tropism, host response and immune cell-mediated host damage, and perform drug discovery and vaccine development. We summarize the technologies used in organoid-based COVID-19 research, discuss the remaining challenges and provide future perspectives in the application of organoid models to study SARS-CoV-2 and future emerging viruses. This Perspective discusses the use of organoid technology, its current limitations and unmet needs in the context of SARS-CoV-2 research.
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