Review
Biochemical Research Methods
Helena R. Moreira, Alexandra P. Marques
Summary: This review discusses the strategies of regulating vascularization in cutaneous wound healing through biomaterial-based and cell-based approaches, highlighting the importance of considering the temporal features of the healing process and different types of wounds beyond the contribution to regulate vascularization.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Neha Tiwari, Ernesto Rafael Osorio-Blanco, Ana Sonzogni, David Esporrin-Ubieto, Huiyi Wang, Marcelo Calderon
Summary: Nanosized carrier systems offer a promising alternative for improving skin penetration of therapeutic molecules with minimal damage to the skin's natural barrier. The use of nanoparticles for delivering drugs, genetic material, and vaccines into the skin is discussed, along with the importance of nanotoxicology studies and recent clinical developments in shedding light on their potential for market translation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Biochemistry & Molecular Biology
Dinesh Kumar Chellappan, Richie R. Bhandare, Afzal B. Shaik, Krishna Prasad, Nurfatihah Azlyna Ahmad Suhaimi, Wei Sheng Yap, Arpita Das, Pradipta Banerjee, Nandini Ghosh, Tanner Guith, Amitava Das, Sarannya Balakrishnan, Mayuren Candasamy, Jayashree Mayuren, Kishneth Palaniveloo, Gaurav Gupta, Sachin Kumar Singh, Kamal Dua
Summary: Diabetes, a globally prevalent endocrinological disorder, has become a significant contributor to morbidity and mortality among young and middle-aged individuals. Recent advancements in understanding the autoimmune responses causing diabetes have raised concerns regarding the potential use of immunomodulatory agents for prevention. The mechanism of action of vaccines, including the removal of autoreactive T cells and inhibition of immune cell interactions, varies greatly. While diabetes vaccines have been tested in animal models, only a few human trials have shown positive outcomes. This review explores ongoing clinical trial studies for the development of a prototype diabetes vaccine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Marc Oliva, Nuria Mulet-Margalef, Maria Ochoa-De-Olza, Stefania Napoli, Joan Mas-Lloret, Berta Laquente, Laia Alemany, Eric J. Duell, Paolo Nuciforo, Victor Moreno
Summary: The study of the human microbiome in oncology is an expanding and rapidly evolving field, with increasing research showing associations between microbiome and cancer. The gut microbiome plays a crucial role in antitumor immune responses, while tumor-associated microbiome interactions impact cancer progression and treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Respiratory System
Mario Cazzola, Clive P. Page, Maria Gabriella Matera, Paola Rogliani, Nicola A. Hanania
Summary: Current guidelines and strategies for asthma treatment primarily focus on improving lung function and reducing symptoms. However, they fail to address the underlying mechanisms of this heterogeneous disease. It is necessary to re-evaluate the current one-size-fits-all approach and develop more personalized asthma management.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Oncology
Alvaro Moreira, Lucie Heinzerling, Nina Bhardwaj, Philip Friedlander
Summary: This manuscript discusses recent updates on melanoma-related clinical trial data, including new therapeutic agents, long-term efficacy and safety data, breakthroughs related to management after resistance, and clinical trials for non-cutaneous melanoma. Groundbreaking research in immunology and cancer biology has led to the development of novel therapeutics, revolutionizing the clinical care of patients with metastatic melanoma.
Article
Biochemistry & Molecular Biology
Constanze Banz-Jansen, Laureen P. Helweg, Barbara Kaltschmidt
Summary: Endometrial cancer is a common malignant disease in women, and targeting cancer stem cells and immunotherapy could improve prognosis and prevent cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Konstantinos Georgiou, Blagoi Marinov, Ammad Ahmad Farooqi, Maria Gazouli
Summary: The gut microbiota is a powerful organ that can influence the metabolic, nutritional, physiological, and immunological processes of the human body. While the lung microbiota is less understood, there may exist a complex relationship between the human microbiome and lung cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Andreas Liampas, Panagiotis Zis, Georgios Hadjigeorgiou, George D. Vavougios
Summary: Stroke is the second most common cause of death worldwide and can cause long-term morbidity. Selenium, a trace element, has various effects on human health. Lower selenium levels are associated with increased stroke risk and poorer outcomes. However, higher selenium levels are associated with glucose metabolism disturbances and high blood pressure, both of which are also risk factors for stroke. In addition, selenium deficiency can impair immune fitness and contribute to inflammation and infection, which can further worsen stroke outcomes. This complex interrelationship between selenium, stroke, and infection has important implications for human health and disease.
Review
Oncology
Kinga Krawiec, Piotr Strzalka, Magdalena Czemerska, Aneta Wisnik, Izabela Zawlik, Agnieszka Wierzbowska, Agnieszka Pluta
Summary: Genetic mutations in patients with acute myeloid leukemia (AML) can lead to evasion of regulated cell death (RCD), causing excessive cell proliferation. Apoptosis, the best-known form of RCD, plays a crucial role in the development and progression of AML. Understanding the mechanisms of apoptosis is essential for personalized AML therapy.
Article
Medicine, Research & Experimental
Georgia B. Nikolopoulou, Helena C. Maltezou
Summary: From the beginning of the COVID-19 pandemic, it has been observed that children infected with SARS-CoV-2 are mostly asymptomatic or mildly symptomatic. The true prevalence of asymptomatic cases in children is likely underestimated and serologic surveys indicate that half of infected children show no symptoms. Children with COVID-19 have lower risk of hospitalization and severe complications.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Review
Clinical Neurology
Robyn Whitney, Kevin C. Jones, Suvasini Sharma, Rajesh RamachandranNair
Summary: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related death, but many neurologists do not inform patients and their families about it, despite recommendations. Some argue that patients have a right to know, while others believe it may cause unnecessary stress.
Article
Clinical Neurology
Ralph G. G. Andrzejak, Hitten P. P. Zaveri, Andreas Schulze-Bonhage, Marc G. G. Leguia, William C. C. Stacey, Mark P. P. Richardson, Levin Kuhlmann, Klaus Lehnertz
Summary: Significant progress has been made recently in seizure forecasting. Wearable and implantable devices that record various signals have provided valuable data for analyzing seizure dynamics. Network science approaches have also contributed to understanding the pre-ictal dynamics of epileptic brains. A key challenge now is to effectively communicate the results of seizure-forecasting algorithms to patients, caretakers, and clinicians.
Review
Medicine, General & Internal
David Lukanovic, Marija Batkoska, Gorazd Kavsek, Mirjam Druskovic
Summary: Intraamniotic infection, also known as chorioamnionitis, is an inflammatory infection that can affect the amniotic fluid, placenta, fetus, fetal membranes, umbilical cord, or decidua. The treatment of chorioamnionitis varies widely due to different bacterial causes and limited evidence-based guidelines. Antibiotic therapy alone is not sufficient to cure chorioamnionitis, and delivery may be necessary for complete recovery.
FRONTIERS IN MEDICINE
(2023)
Review
Oncology
Dennis A. Eichenauer, Michael Fuchs
Summary: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare B cell-derived lymphoma entity accounting for approximately 5% of all Hodgkin lymphoma cases. Recently, B-cell non-Hodgkin lymphoma (B-NHL) directed treatment strategies have been increasingly used for NLPHL, despite limited data. The overall prognosis of NLPHL patients is excellent, with low excess mortality compared to the general population. Future research aims to identify strategies to reduce treatment intensity and define the optimal use of HL-directed and B-NHL-directed approaches.
Article
Public, Environmental & Occupational Health
Ruxandra Calin, Anna Belkacem, Pauline Caraux-Paz, Mathilde Wagner, Heene Guillot, Nicolas Veziris, Stephane Jaureguiberry, Eric Caumes, Olivier Patey, Valerie Pourcher
Summary: Abdominal tuberculosis (ATB) is a rare disease and mainly affects young males of African descent. It is often characterized by lymph node and peritoneal involvement, with good treatment outcomes. The use of steroids in treatment remains controversial, with bacteriological confirmation being more common in diagnosis.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Letter
Respiratory System
Nicolas Veziris, Isabelle Bonnet, Florence Morel, Lorenzo Guglielmetti, Thomas Maitre, Laure Fournier Le Ray, Wladimir Sougakoff, Jerome Robert, Alexandra Aubry
EUROPEAN RESPIRATORY JOURNAL
(2021)
Letter
Respiratory System
Thomas Maitre, Lorenzo Guglielmetti, Nicolas Veziris
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Respiratory System
Rechana Vongthilath-Moeung, Jerome Plojoux, Antoine Poncet, Gesuele Renzi, Nicolas Veziris, Jacques Schrenzel, Jean-Paul Janssens
Summary: NTM strains in Western Switzerland exhibit geographical variability, predominantly affecting female patients with a median age of 62 and low BMI. Specific treatment was administered in 19% of patients with positive NTM cultures.
Letter
Respiratory System
Lorenzo Guglielmetti, Gunar Guenther, Claude Leu, Daniela Cirillo, Raquel Duarte, Alberto L. Garcia-Basteiro, Delia Goletti, Mateja Jankovic, Liga Kuksa, Florian P. Maurer, Frederic Mechai, Simon Tiberi, Frank van Leth, Nicolas Veziris, Christoph Lange
EUROPEAN RESPIRATORY JOURNAL
(2022)
Editorial Material
Respiratory System
Sophia B. Georghiou, Timothy C. Rodwell, Alexei Korobitsyn, Said H. Abbadi, Kanchan Ajbani, Jan-Willem Alffenaar, David Alland, Nataly Alvarez, Sonke Andres, Elisa Ardizzoni, Alexandra Aubry, Rossella Baldan, Marie Ballif, Ivan Barilar, Erik C. Bottger, Soumitesh Chakravorty, Pauline M. Claxton, Daniela M. Cirillo, Inaki Comas, Chris Coulter, Claudia M. Denkinger, Brigitta Derendinger, Edward P. Desmond, Jurriaan E. M. de Steenwinkel, Keertan Dheda, Andreas H. Diacon, David L. Dolinger, Kelly E. Dooley, Matthias Egger, Maha R. Farhat, Lanfranco Fattorini, Iris Finci, Laure Fournier Le Ray, Victoria Furio, Ramona Groenheit, Tawanda Gumbo, Scott K. Heysell, Doris Hillemann, Harald Hoffmann, Po-Ren Hsueh, Yi Hu, Hairong Huang, Alamdar Hussain, Farzana Ismail, Kiyohiko Izumi, Tomasz Jagielski, John L. Johnson, Priti Kambli, Kone Kaniga, G. H. R. Eranga Karunaratne, Meenu Kaushal Sharma, Peter M. Keller, Ellis C. Kelly, Margarita Kholina, Mikashmi Kohli, Katharina Kranzer, Ian F. Laurenson, Jason Limberis, S-Y Grace Lin, Yongge Liu, Alexandre Lopez-Gavin, Anna Lyander, Diana Machado, Elena Martinez, Faisal Masood, Satoshi Mitarai, Nomonde R. Mvelase, Stefan Niemann, Vladyslav Nikolayevskyy, Florian P. Maurer, Matthias Merker, Paolo Miotto, Shaheed Omar, Ralf Otto-Knapp, Moises Palaci, Juan Jose Palacios Gutierrez, Sharon J. Peacock, Charles A. Peloquin, Jennifer Perera, Catherine Pierre-Audigier, Suporn Pholwat, James E. Posey, Therdsak Prammananan, Leen Rigouts, Jaime Robledo, Neesha Rockwood, Camilla Rodrigues, Max Salfinger, Marcos C. Schechter, Marva Seifert, Sarah Sengstake, Thomas Shinnick, Natalia Shubladze, Vitali Sintchenko, Frederick Sirgel, Sulochana Somasundaram, Timothy R. Sterling, Andrea Spitaleri, Elizabeth Streicher, Philip Supply, Erik Svensson, Elisa Tagliani, Sabira Tahseen, Akiko Takaki, Grant Theron, Gabriela Torrea, Armand Van Deun, Annelies Van Rie, Dick van Soolingen, Roger Vargas, Amour Venter, Nicolas Veziris, Cristina Villellas, Miguel Viveiros, Robin Warren, Shu'an Wen, Jim Werngren, Robert J. Wilkinson, Caie Yang, Tingting Zhang, Danila Zimenkov, Nazir Ismail, Thomas Schon, Claudio U. Koser, Soudeh Ehsani, Jakko van Ingen, F. Ferda Yilmaz
EUROPEAN RESPIRATORY JOURNAL
(2022)
Letter
Infectious Diseases
Simone Tunesi, Damien Le Du, Gina Gualano, Joan-Pau Millet, Aliaksandr Skrahin, Graham Bothamley, Xavier Casas, Delia Goletti, Christoph Lange, Maria Musso, Fabrizio Palmieri, Valerie Pourcher, Christophe Rioux, Alena Skrahina, Nicolas Veziris, Dzmitry Viatushka, Mathilde Jachym-Frechet, Lorenzo Guglielmetti, Dhiba Marigot-Outtandy, Xavier Lescure, Marie Dubert, Yazdan Yazdanpanah, Eric Caumes, Pascaline Choinier, Elie Haddad, Jakub Kowalczyk, Helene Laurichesse, Olivier Lesens, Alexandra Aubry, Isabelle Bonnet, Florence Morel
JOURNAL OF INFECTION
(2022)
Article
Microbiology
Aurelie Schnuriger, Sophie Vimont, Alexandre Godmer, Joel Gozlan, Salah Gallah, Muriel Mace, Valerie Lalande, Kenda Saloum, Marine Perrier, Nicolas Veziris, Laurence Morand-Joubert
Summary: Based on our comparative analysis, we propose an algorithm for the use of both syndromic and specific assays, for an optimal care of the meningitis/encephalitis threat in adult and pediatric patients.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
N. De Castro, F. Mechai, D. Bachelet, A. Canestri, V Joly, M. Vandenhende, D. Boutoille, M. Kerjouan, N. Veziris, J. M. Molina, N. Grall, P. Tattevin, C. Laouenan, Y. Yazdanpanah
Summary: The study shows that a combination of isoniazid, rifampicin, and pyrazinamide, based on early detection of isoniazid resistance using molecular testing, is noninferior to the recommended 4-drug regimen for tuberculosis treatment.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Microbiology
Thomas Maitre, Florence Morel, Florence Brossier, Wladimir Sougakoff, Jeremy Jaffre, Sokleaph Cheng, Nicolas Veziris, Alexandra Aubry
Summary: This study assessed the detection of ETH-R in 497 MDR-TB isolates and found a high mutation rate. The results do not support the association between ethR mutations and ETH resistance. The positive predictive value of the genotypic strategy to diagnose ETH-R can be improved by considering variants included in the WHO catalogue and other databases.
Article
Microbiology
Isabelle Bonnet, Elie Haddad, Lorenzo Guglielmetti, Pascale Bemer, Louis Bernard, Anne Bourgoin, Rachel Brault, Gaud Catho, Eric Caumes, Lelia Escaut, Eric Fourniols, Mathilde Frechet-Jachym, Alice Gaudart, Helene Guillot, Barthelemy Lafon-Desmurs, Jean-Philippe Lanoix, Philippe Lanotte, Adrien Lemaignen, Benedicte Lemaire, Nadine Lemaitre, Christophe Michau, Philippe Morand, Faiza Mougari, Dhiba Marigot-Outtandy, Solene Patrat-Delon, Thomas Perpoint, Caroline Piau, Valerie Pourcher, Virginie Zarrouk, Valerie Zeller, Nicolas Veziris, Stephane Jaureguiberry, Alexandra Aubry
Summary: This study evaluated the diagnosis, management, and outcomes of multidrug-resistant tuberculosis strains (MDR-OATB) causing osteoarticular infection in France. Among 23 reported MDR-OATB cases, 91% of patients successfully completed treatment. However, further research is needed to determine the optimal treatment for MDR-OATB.
Article
Multidisciplinary Sciences
A. Godmer, J. Bigot, Q. Giai Gianetto, Y. Benzerara, N. Veziris, A. Aubry, J. Guitard, C. Hennequin
Summary: This study evaluated the contribution of Machine Learning (ML) approach in interpreting intercalating dye-based quantitative PCR (IDqPCR) signals for the diagnosis of mucormycosis. The results showed that the ML-based approach could accurately interpret IDqPCR curves, making the diagnosis of mucormycosis available for non-specialists in molecular diagnosis.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Milene Chaptal, Claire Andrejak, Timothee Bonifay, Emmanuel Beillard, Genevieve Guillot, Stephanie Guyomard-Rabenirina, Magalie Demar, Sabine Trombert-Paolantoni, Veronique Jacomo, Emilie Mosnier, Nicolas Veziris, Felix Djossou, Loic Epelboin
Summary: This study is the first epidemiological study on non-tuberculous mycobacteria (PNTM) infections in French Guiana. The incidence of these infections in French Guiana is similar to that of other countries and metropolitan France, and is mainly caused by MAC and M.abscessus.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Immunology
Raphael Chiron, Wouter Hoefsloot, Jakko Van Ingen, Helene Marchandin, Laurent Kremer, Helene Morisse-Pradier, Jeremy Charriot, Jean-Pierre Mallet, Jean-Louis Herrmann, Davide Caimmi, Johan Moreau, Yann Dumont, Sylvain Godreuil, Anne Bergeron, Margot Drevait, Elodie Bouzat-Rossigneux, Nicolas Terrail, Claire Andrejak, Nicolas Veziris, Dominique Grenet, Alexandre Coudrat, Emilie Catherinot
Summary: This study investigated the safety and efficacy of ALIS as an adjunct treatment for M abscessus lung infection. Among 26 patients with long-term follow-up data, a sputum culture conversion rate of 54% was achieved, and there was a significant association between patient treatment compliance and culture conversion and clinical outcomes.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Review
Infectious Diseases
Thomas Maitre, Alain Baulard, Alexandra Aubry, Nicolas Veziris
Summary: Antibiotic-resistant tuberculosis poses a major threat to global tuberculosis control. Recent research has produced promising compounds that have the potential to change the game in treating multi-drug resistant tuberculosis. However, there are still obstacles preventing these molecules from being used as first-line drugs. Alternative strategies are being evaluated to optimize the utilization of existing antituberculosis agents, with a focus on enhancing the effectiveness of antibiotics against bacterial targets.
INFECTIOUS DISEASES NOW
(2024)
