Article
Multidisciplinary Sciences
Norbert Pardi, Juan Manuel Carreno, George O'Dell, Jessica Tan, Csaba Bajusz, Hiromi Muramatsu, Willemijn Rijnink, Shirin Strohmeier, Madhumathi Loganathan, Dominika Bielak, Molly M. H. Sung, Ying K. Tam, Florian Krammer, Meagan McMahon
Summary: This study focuses on the development of a universal influenza B virus vaccine using the lipid nanoparticle-encapsulated nucleoside-modified mRNA (mRNA-LNP) platform. Vaccine candidates based on different target antigens are evaluated for their ability to protect against ancestral and recent influenza B viruses. The findings show that a pentavalent vaccine with multiple antigens can protect mice from morbidity even at a very low dose.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Siriruk Changrob, Peter J. Halfmann, Hejun Liu, Jonathan L. Torres, Joshua J. C. McGrath, Gabriel Ozorowski, Lei Li, G. Dewey Wilbanks, Makoto Kuroda, Tadashi Maemura, Min Huang, Nai-Ying Zheng, Hannah L. Turner, Steven A. Erickson, Yanbin Fu, Atsuhiro Yasuhara, Gagandeep Singh, Brian Monahan, Jacob Mauldin, Komal Srivastava, Viviana Simon, Florian Krammer, D. Noah Sather, Andrew B. Ward, Ian A. Wilson, Yoshihiro Kawaoka, Patrick C. Wilson
Summary: In this study, a broadly neutralizing antibody (bnAb) called S728-1157 was identified, which can neutralize various SARS-CoV-2 variants, including Omicron. The antibody showed therapeutic potential in animal models and may be useful for vaccine design against future SARS-CoV-2 variants.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Immunology
Bin Ju, Qi Zhang, Ziyi Wang, Zhen Qin Aw, Peng Chen, Bing Zhou, Ruoke Wang, Xiangyang Ge, Qining Lv, Lin Cheng, Rui Zhang, Yi Hao Wong, Huixin Chen, Haiyan Wang, Sisi Shan, Xuejiao Liao, Xuanling Shi, Lei Liu, Justin Jang Hann Chu, Xinquan Wang, Zheng Zhang, Linqi Zhang
Summary: Researchers found that antibodies isolated from COVID-19 convalescent patients have broad neutralizing activity against all SARS-CoV-2 variants tested, including omicron, which can enhance antibody immunity against variant strains.
Article
Biochemistry & Molecular Biology
Xiangyang Chi, Yingying Guo, Guanying Zhang, Hancong Sun, Jun Zhang, Min Li, Zhengshan Chen, Jin Han, Yuanyuan Zhang, Xinghai Zhang, Pengfei Fan, Zhe Zhang, Busen Wang, Xiaodong Zai, Xuelian Han, Meng Hao, Ting Fang, Jinghan Xu, Shipo Wu, Yi Chen, Yingying Fang, Yunzhu Dong, Bingjie Sun, Jinlong Zhang, Jianmin Li, Guangyu Zhao, Changming Yu, Qiang Zhou, Wei Chen
Summary: This study developed a panel of broadly neutralizing antibodies (bnAbs) against the SARS-CoV-2 Omicron variant and other variants of concern. It demonstrated the evolution of bnAbs over time following vaccination and identified a monoclonal antibody (mAb) named ZWD12 that exhibited potent and broad neutralization against multiple variants. The study also determined the epitope bound by ZWD12 and suggested it as a rational target for the design of broadly protective vaccines.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Medicine, General & Internal
Matthew S. Parsons, Anne B. Kristensen, Kevin J. Selva, Wen Shi Lee, Thakshila Amarasena, Robyn Esterbauer, Adam K. Wheatley, Benjamin R. Bavinton, Anthony D. Kelleher, Andrew E. Grulich, Georges Khoury, Jennifer A. Juno, Stephen J. Kent
Summary: The study found that passively infused anti-HIV-1 neutralizing antibody provides protection at semen exposed mucosae, demonstrating a positive effect on rectal SHIVSF162P3 challenge.
Review
Virology
Kaito A. Nagashima, Jarrod J. Mousa
Summary: Influenza virus is a highly mutable respiratory pathogen causing significant disease annually. Despite efforts to improve vaccine effectiveness against circulating strains, limitations exist, and research into broader neutralizing antibodies has shown progress.
Article
Multidisciplinary Sciences
Dean Follmann, Meagan P. O'Brien, Jonathan Fintzi, Michael P. Fay, David Montefiori, Allyson Mateja, Gary A. Herman, Andrea T. Hooper, Kenneth C. Turner, Kuo- Chen Chan, Eduardo Forleo-Neto, Flonza Isa, Lindsey R. Baden, Hana M. El Sahly, Holly Janes, Nicole Doria-Rose, Jacqueline Miller, Honghong Zhou, Weiping Dang, David Benkeser, Youyi Fong, Peter B. Gilbert, Mary Marovich, Myron S. Cohen
Summary: This study demonstrates the correlation between neutralizing antibody titers and the efficacy of monoclonal antibodies and vaccines in providing protection against COVID-19. It shows that a certain level of neutralizing antibody titer is associated with high protective efficacy (92-97%). These findings suggest that neutralizing antibody titers can serve as surrogate endpoints for authorizing new monoclonal antibodies.
NATURE COMMUNICATIONS
(2023)
Article
Infectious Diseases
Craig Fenwick, Priscilla Turelli, Yoan Duhoo, Kelvin Lau, Cecile Herate, Romain Marlin, Myriam Lamrayah, Jeremy Campos, Line Esteves-Leuenberger, Alex Farina, Charlene Raclot, Vanessa Genet, Flurin Fiscalini, Julien Cesborn, Laurent Perez, Nathalie Dereuddre-Bosquet, Vanessa Contreras, Kyllian Lheureux, Francis Relouzat, Rana Abdelnabi, Pieter Leyssen, Yves Levy, Florence Pojer, Roger Le Grand, Didier Trono, Giuseppe Pantaleo
Summary: This study isolated a potent neutralizing antibody that can neutralize various variants of SARS-CoV-2 and potentially provide prophylactic protection for immunocompromised patients.
JOURNAL OF INFECTION
(2023)
Article
Multidisciplinary Sciences
Simone Conti, Kevin J. Kaczorowski, Ge Song, Katelyn Porter, Raiees Andrabi, Dennis R. Burton, Arup K. Chakraborty, Martin Karplus
Summary: Developing a vaccine that can generate broadly neutralizing antibodies against HIV is crucial in combating the HIV epidemic, but it requires at least three stages. The challenge lies in designing an optimal panel of antigens that can elicit such antibodies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Simone Conti, Kevin J. Kaczorowski, Ge Song, Katelyn Porter, Raiees Andrabi, Dennis R. Burton, Arup K. Chakraborty, Martin Karplus
Summary: Research has shown that a vaccine capable of eliciting broadly neutralizing antibodies against HIV has potential to protect against the virus, involving at least three separate stages. This vaccine may require immunization with a mixture of Envs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Andrea R. Shiakolas, Kevin J. Kramer, Daniel Wrapp, Simone Richardson, Alexandra Schafer, Steven Wall, Nianshuang Wang, Katarzyna Janowska, Kelsey A. Pilewski, Rohit Venkat, Robert Parks, Nelia P. Manamela, Nagarajan Raju, Emilee Friedman Fechter, Clinton M. Holt, Naveenchandra Suryadevara, Rita E. Chen, David R. Martinez, Rachel S. Nargi, Rachel E. Sutton, Julie E. Ledgerwood, Barney S. Graham, Michael S. Diamond, Barton F. Haynes, Priyamvada Acharya, Robert H. Carnahan, James E. Crowe, Ralph S. Baric, Lynn Morris, Jason S. McLellan, Ivelin S. Georgiev
Summary: Research identifies antibodies from a recovered SARS-CoV donor sample that cross-react with the spike proteins of highly pathogenic SARS-CoV and SARS-CoV-2, as well as other coronaviruses. These antibodies mediate phagocytosis in vitro and reduce hemorrhagic pathology in murine lungs in vivo.
CELL REPORTS MEDICINE
(2021)
Review
Immunology
Sharana Mahomed, Nigel Garrett, Cheryl Baxter, Quarraisha Abdool Karim, Salim S. Abdool Karim
Summary: Passive immunization with bnAbs shows potential in reducing global HIV infections, with newly developed highly potent bnAbs showing promise for HIV prevention. Published data indicate these antibodies are safe and effective, and if proven to be successful, could have a positive impact on HIV vaccine development.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Chenchen Jiao, Bo Wang, Pucheng Chen, Yongping Jiang, Jinxiong Liu
Summary: By analyzing more than 70 types of broadly neutralizing antibodies targeting the HA of influenza A viruses, this review identifies five regions of HA as highly conserved protective epitopes. The findings provide valuable insights for the design of universal influenza vaccines and targeted therapeutic agents.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Endeshaw Chekol Abebe, Tadesse Asmamaw Dejenie
Summary: Neutralizing antibodies (NAbs) play a central role in the immune response against SARS-CoV-2 by neutralizing viral antigens and collaborating with immune cells to combat the virus. They have various clinical applications, including COVID-19 diagnosis, severity evaluation, prognosis assessment, and identification of suitable plasma donors. However, their use in clinical settings can present challenges. This review discusses the functions, mechanisms, and clinical applications of NAbs, as well as the challenges and solutions associated with antibody-based prophylaxis, therapy, and vaccination in COVID-19.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Daniel J. Sheward, Tandile Hermanus, Ben Murrell, Nigel Garrett, Salim S. Abdool Karim, Lynn Morris, Penny L. Moore, Carolyn Williamson
Summary: The development of broadly neutralizing antibodies (bNAbs) to HIV and other diverse pathogens may require the use of multiple immunogens. This study characterizes the antibody responses in individuals coinfected with multiple HIV variants, revealing interference and the potential role of conserved neutralizing epitopes in guiding broad antibody responses.
JOURNAL OF VIROLOGY
(2022)
Article
Chemistry, Physical
Panpan Zhou, Ziming Cao, Xuezhang Xiao, Liujun Zhan, Jiahuan He, Yuyuan Zhao, Li Wang, Mi Yan, Zhinian Li, Lixin Chen
Summary: This study evaluates the potential application of AB5 and AB2 alloys in hydrogen storage technology. La0.45Ce0.35Ca0.2Ni5 alloy exhibits excellent volumetric capacity (126.65 kg H2/m3), while Ti0.88Zr0.12Mn1.2Cr0.6V0.2 alloy performs better in gravimetric capacity (1.67 wt% H2). Both alloys have the potential to be qualified candidates for hydrogen feeding systems.
MATERIALS TODAY ENERGY
(2023)
Article
Chemistry, Physical
Ziming Cao, Mingyuan Piao, Xuezhang Xiao, Liujun Zhan, Panpan Zhou, Zhinian Li, Shumao Wang, Lijun Jiang, Fen Xu, Lixian Sun, Lixin Chen
Summary: In this study, three series of alloys were prepared and their crystal structural characteristics and hydrogen storage properties were investigated. The results showed that a single C14-Laves phase with homogeneous element distribution existed in all alloys. The hydrogen absorption/desorption plateau of the alloys increased as the Fe, Mn, or Ti content increased. The hydrogen storage capacity of the alloys also correlated negatively with the hydrogen affinity of interstitial sites. Ti0.935Zr0.085Cr1.3Mn0.3Fe0.4 alloy exhibited saturated hydrogenation under 8 MPa at 293 K and dehydrogenation around 24.91 MPa pressure at 363 K with a hydrogen capacity of 1.74 wt%, as well as excellent cycling performance and mere hysteresis. Ti0.92Zr0.10Cr1.0Mn0.6Fe0.4 alloy showed promising hydrogen capacity of 1.86 wt% at 283 K and a dehydrogenation pressure of 27.94 MPa at 363 K, along with satisfactory cycling durability. This study can guide the compositional design of AB2-type hydrogen storage alloys for hydrogen compression application.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Yuming Wang, Panpan Zhou, Weicheng Zhou, Shun Huang, Chengrong Peng, Dunhai Li, Genbao Li
Summary: The epiphytic bacterial communities on Cladophora in Qinghai Lake were different in different life stages. Chemoheterotrophic and aerobic microorganisms were enriched in the attached stage, phototrophic bacteria were more abundant in the floating stage, and a variety of bacteria showed vertical heterogeneity in the decomposing stage. Sulfur cycle-associated bacteria played an important role in the development of Cladophora.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Chemistry, Physical
Linlin Chen, Zhi Chen, Li Chen, Panpan Zhou, Jing Wang, Huiyong Yang, Zhijun Feng, Xibao Li, Juntong Huang
Summary: MoS2@C nanosheets are obtained by a three-roller grinder, where the bulk MoS2 can be thinned and a carbon layer can be formed on the surface. As the anode for KIBs, the MoS2@C electrode exhibits highly reversible discharge capacity of 382 mAh/g at 0.1 A/g after 50 cycles. This efficient preparation method opens a new path for high-performance K+ storage applications.
APPLIED SURFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Bernadeta Dadonaite, Katharine H. D. Crawford, Caelan E. Radford, Ariana G. Farrell, Timothy C. Yu, William W. Hannon, Panpan Zhou, Raiees Andrabi, Dennis R. Burton, Lihong Liu, David D. Ho, Helen Y. Chu, Richard A. Neher, Jesse D. Bloom
Summary: This study describes a deep mutational scanning platform to understand the impact of emerging mutations in the spike protein of SARS-CoV-2 on antibody neutralization and pseudovirus infection. The platform can be extended to study entry proteins of other viruses.
Article
Chemistry, Multidisciplinary
Yunping Zhoujin, Yuping Li, Peng-Yu Liang, Pan-Pan Zhou, Sean Parkin, Tonglei Li, Faquan Yu, Sihui Long
Summary: We synthesized a series of phenylalkylamino-nicotinic acids (1-4) by altering the linker length between the pyridine and benzene rings, and investigated their polymorphism. Compound 1 and 2 had one crystal form, compound 3 had three forms, and compound 4 had two forms under the same crystallization conditions. Conformational analysis revealed that the polymorphism of 3 and 4 was caused by the anti and/or gauche conformation of specific sigma bonds within them. However, there was no correlation between the number of polymorphs and sigma bonds, and the rotation of which sigma bond(s) was responsible for the polymorphism could not be predicted. Phase behavior studies by DSC showed a phase transition from 4-I to 4 II with a change in asymmetric unit. Computational studies including Hirshfeld surface analysis and IGM analyses were performed to determine the significant intermolecular interactions in the crystals.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Immunology
Panpan Zhou, Ge Song, Hejun Liu, Meng Yuan, Wan-ting He, Nathan Beutler, Xueyong Zhu, Longping V. Tse, David R. Martinez, Alexandra Schafer, Fabio Anzanello, Peter Yong, Linghang Peng, Katharina Dueker, Rami Musharrafieh, Sean Callaghan, Tazio Capozzola, Oliver Limbo, Mara Parren, Elijah Garcia, Stephen A. Rawlings, Davey M. Smith, David Nemazee, Joseph G. Jardine, Yana Safonova, Bryan Briney, Thomas F. Rogers, Ian A. Wilson, Ralph S. Baric, Lisa E. Gralinski, Dennis R. Burton, Raiees Andrabi
Summary: Research finds that specific neutralizing antibodies play a key role in developing broadly protective vaccines against novel pandemic coronaviruses and effectively responding to SARS-CoV-2 variants. A panel of broadly neutralizing antibodies targeting a conserved S2 region in the betacoronavirus spike fusion machinery was isolated from vaccinated-recovered donors. These antibodies showed broad in vivo protection against three deadly betacoronaviruses and provided insights for developing pan-betacoronavirus vaccines.
Article
Oncology
Dongmei Chen, Keith M. Wirth, Scott Kizy, Joseph M. Muretta, Todd W. Markowski, Peter Yong, Adam Sheka, Hisham Abdelwahab, Ann V. Hertzel, Sayeed Ikramuddin, Masato Yamamoto, David A. Bernlohr
Summary: FABP4 is a secreted adipokine associated with obesity and cancer progression. It has been found that obesity increases extracellular FABP4 levels, and eFABP4 can stimulate proliferation of breast cancer cells and interact with specific proteins.
MOLECULAR CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Ellen Young, Boyd Yount, Petraleigh Pantoja, Sandra Henein, Rita M. Meganck, Jennifer McBride, Jennifer E. Munt, Thomas J. Baric, Deanna Zhu, Trevor Scobey, Stephanie Dong, Longping V. Tse, Melween I. Martinez, Armando G. Burgos, Rachel L. Graham, Laura White, Aravinda DeSilva, Carlos A. Sariol, Ralph S. Baric
Summary: The four dengue virus serotypes circulate globally and cause significant human disease. Current dengue vaccines induce balanced protective immunity. By employing chimeric viruses, researchers have successfully developed a live chimeric DENV2/4 EDII virus that replicates efficiently in primates and elicits neutralizing antibodies for both DENV2 and DENV4, providing a simplified vaccine strategy.
NATURE COMMUNICATIONS
(2023)
Article
Environmental Sciences
Duo Feng, Panpan Zhou, Dongyan Wang, Pu Shi
Summary: This study aimed to reconstruct the ecological restoration pattern by establishing an ecosystem health assessment model and identified four restoration zones in a black soil region. The results provide insights into ecosystem health and can guide restoration efforts in similar regions.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2023)
Article
Chemistry, Physical
Jiapeng Bi, Panpan Zhou, Xuezhang Xiao, Zhaoqing Liang, Jiacheng Qi, Yajie Zhang, Huaqin Kou, Tao Tang, Lixin Chen
Summary: In this study, the poisoning resistance behaviors and mechanism of ZrCo in H2+CO2 mixed gas were systematically investigated. Even trace amounts of CO2 can strongly deteriorate hydrogenation kinetics of ZrCo, but this phenomenon can be mitigated by further increasing the inputting pressure of the mixed gas. In-situ surface reconstruction strategy by high-temperature treatment was proposed, which enhanced the CO2 poisoning tolerance of ZrCo through the formation of metallic Co nanoclusters on ZrCo surface.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Cell Biology
Longping V. Tse, Yixuan J. Hou, Elizabeth Mcfadden, Rhianna E. Lee, Trevor D. Scobey, Sarah R. Leist, David R. Martinez, Rita M. Meganck, Alexandra Schafer, Boyd L. Yount, Teresa Mascenik, John M. Powers, Scott H. Randell, Yi Zhang, Lingshu Wang, John Mascola, Jason S. Mclellan, Ralph S. Baric
Summary: This research studied the characteristics and genetic features of Middle East respiratory syndrome (MERS)-related coronaviruses and evaluated the impact of currently available treatments. The study found that certain broad-spectrum coronavirus antivirals had potent inhibitory effects on this virus, and identified monoclonal antibodies with neutralizing activity.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Oscar L. Rodriguez, Yana Safonova, Catherine A. Silver, Kaitlyn Shields, William S. Gibson, Justin T. Kos, David Tieri, Hanzhong Ke, Katherine J. L. Jackson, Scott D. Boyd, Melissa L. Smith, Wayne A. Marasco, Corey T. Watson
Summary: Variation in the antibody response is linked to disease outcomes, vaccine and therapeutic responsiveness. Polymorphisms within the immunoglobulin heavy chain locus have an impact on the antibody repertoire, indicating genetic predisposition. Understanding IGH genetics can help comprehend the regulation, function, and dynamics of the antibody response.
NATURE COMMUNICATIONS
(2023)
Article
Biodiversity Conservation
Hanqing Tang, Keke Niu, Panpan Zhou, Yanbing Gong, Can Dai
Summary: Habitat fragmentation and population declines lead to increased population edges. This study found that edge plants have longer pollination distances and enjoy higher reproductive success compared to interior plants. These results indicate that edge effects play an important role in promoting gene exchange and population recovery.
GLOBAL ECOLOGY AND CONSERVATION
(2023)