Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase

Accurate prediction of protein structures and interactions using a three-track neural network

(2021) Minkyung Baek et al.   SCIENCE

SuperPlots: Communicating reproducibility and variability in cell biology

(2020) Samuel J. Lord et al.   JOURNAL OF CELL BIOLOGY

PI3K isoforms in cell signalling and vesicle trafficking

(2019) Benoit Bilanges et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Salmonella Outer Protein B Suppresses Colitis Development via Protecting Cell From Necroptosis

(2019) Gui-Qiu Hu et al.   Frontiers in Cellular and Infection Microbiology

Optical control of protein phosphatase function

(2019) Taylor M. Courtney et al.   Nature Communications

Genome variation and molecular epidemiology of Salmonella Typhimurium pathovariants

(2018) Priscilla Branchu et al.   INFECTION AND IMMUNITY

Minimal SPI1-T3SS effector requirement for Salmonella enterocyte invasion and intracellular proliferation in vivo

(2018) Kaiyi Zhang et al.   PLoS Pathogens

Quantitative Lipid Imaging Reveals a New Signaling Function of Phosphatidylinositol-3,4-Bisphophate: Isoform- and Site-Specific Activation of Akt

(2018) Shu-Lin Liu et al.   MOLECULAR CELL

A high-avidity biosensor reveals plasma membrane PI(3,4)P2 is predominantly a class I PI3K signaling product

(2018) Brady D. Goulden et al.   JOURNAL OF CELL BIOLOGY

Multiphasic dynamics of phosphatidylinositol 4-phosphate during phagocytosis

(2017) Roni Levin et al.   MOLECULAR BIOLOGY OF THE CELL

PI(3,4,5)P 3 Engagement Restricts Akt Activity to Cellular Membranes

(2017) Michael Ebner et al.   MOLECULAR CELL

PTEN Regulates PI(3,4)P 2 Signaling Downstream of Class I PI3K

(2017) Mouhannad Malek et al.   MOLECULAR CELL

Cirtical role for Salmonella effector SopB in regulating inflammasome activation

(2017) Gui-Qiu Hu et al.   MOLECULAR IMMUNOLOGY

A second wave of Salmonella T3SS1 activity prolongs the lifespan of infected epithelial cells

(2017) Ciaran E. Finn et al.   PLoS Pathogens

Emerging evidence of signalling roles for PI(3,4)P2 in Class I and II PI3K-regulated pathways

(2016) P. T. Hawkins et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The structure of phosphoinositide phosphatases: Insights into substrate specificity and catalysis

(2015) FoSheng Hsu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Phosphoinositides and host–pathogen interactions

(2015) Javier Pizarro-Cerdá et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma

(2015) Tiziana Scanu et al.   Cell Host & Microbe

Salmonellae interactions with host processes

(2015) Doris L. LaRock et al.   NATURE REVIEWS MICROBIOLOGY

Bacterial Type III Secretion Systems: Specialized Nanomachines for Protein Delivery into Target Cells

(2014) Jorge E. Galán et al.   Annual Review of Microbiology

A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi

(2014) Gerald R.V. Hammond et al.   JOURNAL OF CELL BIOLOGY

Genetically Encoded Optochemical Probes for Simultaneous Fluorescence Reporting and Light Activation of Protein Function with Two-Photon Excitation

(2014) Ji Luo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate

(2013) York Posor et al.   NATURE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

(2013) Tamas Balla   PHYSIOLOGICAL REVIEWS

Multiple Host Kinases Contribute to Akt Activation during Salmonella Infection

(2013) Bernhard Roppenser et al.   PLoS One

Salmonella Transforms Follicle-Associated Epithelial Cells into M Cells to Promote Intestinal Invasion

(2012) Amin Tahoun et al.   Cell Host & Microbe

Protective Role of Akt2 in Salmonella enterica Serovar Typhimurium-Induced Gastroenterocolitis

(2011) Winnie W. S. Kum et al.   INFECTION AND IMMUNITY

Interaction of the Salmonella Typhimurium effector protein SopB with host cell Cdc42 is involved in intracellular replication

(2011) Isabel Rodríguez-Escudero et al.   MOLECULAR MICROBIOLOGY

Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry

(2011) Jonathan Clark et al.   NATURE METHODS

Activation of Akt by the Bacterial Inositol Phosphatase, SopB, is Wortmannin Insensitive

(2011) Kendal G. Cooper et al.   PLoS One

Phosphoproteomic Analysis of Salmonella-Infected Cells Identifies Key Kinase Regulators and SopB-Dependent Host Phosphorylation Events

(2011) L. D. Rogers et al.   Science Signaling

Insulin-feedback via PI3K-C2α activated PKBα/Akt1 is required for glucose-stimulated insulin secretion

(2010) Barbara Leibiger et al.   FASEB JOURNAL

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling

(2009) Christina Gewinner et al.   CANCER CELL

Quantitative Comparison of Spot Detection Methods in Fluorescence Microscopy

(2009) I. Smal et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Films of Agarose Enable Rapid Formation of Giant Liposomes in Solutions of Physiologic Ionic Strength

(2009) Kim S. Horger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mammalian phosphoinositide kinases and phosphatases

(2009) Takehiko Sasaki et al.   PROGRESS IN LIPID RESEARCH

Salmonella Typhimurium Type III Secretion Effectors Stimulate Innate Immune Responses in Cultured Epithelial Cells

(2009) Vincent M. Bruno et al.   PLoS Pathogens

Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion

(2008) G. N. Schroeder et al.   CLINICAL MICROBIOLOGY REVIEWS

SopB promotes phosphatidylinositol 3-phosphate formation onSalmonellavacuoles by recruiting Rab5 and Vps34

(2008) Gustavo V. Mallo et al.   JOURNAL OF CELL BIOLOGY

The Identification of 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer†

(2008) Adrian J. Folkes et al.   JOURNAL OF MEDICINAL CHEMISTRY

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN

(2008) M. Rahdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA