Mitochondrial uncouplers induce proton leak by activating AAC and UCP1

Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice

(2020) Stephanie J. Alexopoulos et al.   Nature Communications

Patch-Clamp Analysis of the Mitochondrial H+ Leak in Brown and Beige Fat

(2020) Ambre M. Bertholet et al.   Frontiers in Physiology

BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control

(2020) Christopher L Axelrod et al.   EMBO Molecular Medicine

The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier

(2019) Jonathan J. Ruprecht et al.   CELL

OPLS3e: Extending Force Field Coverage for Drug-Like Small Molecules

(2019) Katarina Roos et al.   Journal of Chemical Theory and Computation

H+ transport is an integral function of the mitochondrial ADP/ATP carrier

(2019) Ambre M. Bertholet et al.   NATURE

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential

(2017) Elizabeth S. Childress et al.   JOURNAL OF MEDICINAL CHEMISTRY

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis

(2015) J Cho et al.   CELL DEATH AND DIFFERENTIATION

Human Brown Adipose Tissue: What We Have Learned So Far

(2015) Matthias J. Betz et al.   DIABETES

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

(2015) R. J. Perry et al.   SCIENCE

Membrane Protein Properties Revealed through Data-Rich Electrostatics Calculations

(2015) Frank V. Marcoline et al.   STRUCTURE

Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism

(2014) J. J. Ruprecht et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler

(2013) Rachel J. Perry et al.   Cell Metabolism

Rapid parameterization of small molecules using the force field toolkit

(2013) Christopher G. Mayne et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane

(2013) Brandon M. Kenwood et al.   Molecular Metabolism

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Constant electric field simulations of the membrane potential illustrated with simple systems

(2011) James Gumbart et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKaPredictions

(2011) Mats H. M. Olsson et al.   Journal of Chemical Theory and Computation

MDAnalysis: A toolkit for the analysis of molecular dynamics simulations

(2011) Naveen Michaud-Agrawal et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

The Regulation and Physiology of Mitochondrial Proton Leak

(2011) Ajit S. Divakaruni et al.   PHYSIOLOGY

A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu

(2010) Stefan Grimme et al.   JOURNAL OF CHEMICAL PHYSICS

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The ADP and ATP transport in mitochondria and its carrier

(2008) Martin Klingenberg   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Binding of ADP in the Mitochondrial ADP/ATP Carrier Is Driven by an Electrostatic Funnel

(2008) François Dehez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY