Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19

No higher infectivity but immune escape of SARS-CoV-2 501Y.V2 variants

(2021) Qianqian Li et al.   CELL

The Variant Gambit: COVID’s Next Move

(2021) Jessica A. Plante et al.   Cell Host & Microbe

DP1 prostanoid receptor activation increases the severity of an acute lower respiratory viral infection in mice via TNF-α-induced immunopathology

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Q493K and Q498H substitutions in Spike promote adaptation of SARS-CoV-2 in mice

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Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study

(2021) Thomas M Drake et al.   Lancet Rheumatology

Antiplatelet therapy and outcome in COVID-19: the Health Outcome Predictive Evaluation Registry

(2021) Francesco Santoro et al.   HEART

Does aspirin save lives in patients with COVID-19?

(2021) Dinesh Voruganti et al.   HEART

Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

(2021) Obbina Abani et al.   LANCET

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

(2021) Shihui Sun et al.   Nature Communications

Pathogenesis of SARS-CoV-2 in transgenic mice expressing human angiotensin-converting enzyme 2

(2020) Ren-Di Jiang et al.   CELL

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

(2020) Shi-Hui Sun et al.   Cell Host & Microbe

Viral and host factors related to the clinical outcome of COVID-19

(2020) Xiaonan Zhang et al.   NATURE

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

(2020) Linlin Bao et al.   NATURE

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chronic Hypersensitivity Pneumonitis, an Interstitial Lung Disease with Distinct Molecular Signatures

(2020) Haruhiko Furusawa et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding

(2020) Tyler N. Starr et al.   CELL

Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment

(2020) Jing Sun et al.   CELL

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

(2020) Ahmed O. Hassan et al.   CELL

Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy

(2020) Hongjing Gu et al.   SCIENCE

Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J mice

(2020) Jinliang Wang et al.   Protein & Cell

A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice

(2020) Sarah R. Leist et al.   CELL

A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures

(2020) Kenneth H. Dinnon et al.   NATURE

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

(2020) Emma S. Winkler et al.   NATURE IMMUNOLOGY

Age-related susceptibility to coronavirus infections: role of impaired and dysregulated host immunity

(2020) Rudragouda Channappanavar et al.   JOURNAL OF CLINICAL INVESTIGATION

Severe Acute Respiratory Syndrome Coronavirus 2–Induced Immune Activation and Death of Monocyte-Derived Human Macrophages and Dendritic Cells

(2020) Jian Zheng et al.   JOURNAL OF INFECTIOUS DISEASES

Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

(2020) Ioanna-Evdokia Galani et al.   NATURE IMMUNOLOGY

Principles and approaches for reproducible scoring of tissue stains in research

(2018) David K. Meyerholz et al.   LABORATORY INVESTIGATION

Prostaglandin D2 receptor antagonists in allergic disorders: safety, efficacy, and future perspectives

(2018) Giancarlo Marone et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Dual Roles of Group IID Phospholipase A2in Inflammation and Cancer

(2016) Yoshimi Miki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Genotype-Tissue Expression (GTEx) Project

(2015) Latarsha J. Carithers et al.   BIOPRESERVATION AND BIOBANKING

Effect of the potent and selective DP1 receptor antagonist, asapiprant (S-555739), in animal models of allergic rhinitis and allergic asthma

(2015) Go Takahashi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Critical role of phospholipase A2group IID in age-related susceptibility to severe acute respiratory syndrome–CoV infection

(2015) Rahul Vijay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4

(2015) Kun Li et al.   JOURNAL OF INFECTIOUS DISEASES

The Genotype-Tissue Expression (GTEx) Project

(2015) Latarsha J. Carithers et al.   Biopreservation and Biobanking

Lymphoid tissue phospholipase A2group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators

(2013) Yoshimi Miki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Engineering a Replication-Competent, Propagation-Defective Middle East Respiratory Syndrome Coronavirus as a Vaccine Candidate

(2013) F. Almazan et al.   mBio

Collaboration gets the most out of software

(2013) Andrew Morin et al.   eLife

Prostanoid DP receptor antagonists suppress symptomatic asthma-like manifestation by distinct actions from a glucocorticoid in rats

(2011) Yosuke Hirano et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice

(2011) Jincun Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells to Severe Acute Respiratory Syndrome-Associated Coronavirus Infection

(2010) Tomoki Yoshikawa et al.   PLoS One

Highly Specific and Broadly Potent Inhibitors of Mammalian Secreted Phospholipases A2

(2008) Rob C. Oslund et al.   JOURNAL OF MEDICINAL CHEMISTRY