期刊
NANO TODAY
卷 44, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2022.101477
关键词
Aggregation-induced emission; Vermiculite; Photodynamic therapy; Oxygen self-sufficient; Ferroptosis; Tumor microenvironment
资金
- National Key R&D Programs (China) [2019YFE0198700, 2021YFA0910001]
- Shenzhen Basic Research (key project) (China) [JCYJ20210324120011030, JCYJ20210324115804013]
- China Postdoctoral Science Foundation [2021TQ0344]
- Shenzhen Science and Technology Program (China) [JCYJ20200109114616534, SGDX2020110309280301]
- ShenzhenMacao Technology Plan (China) [SGDX2020110309280301]
- K.C. Wong Education Foundation (China) [GJTD-2018-14]
- National Natural Science Foundation of China [22105057, 81901906, 32000982]
- Guangdong Province International Scientific and Technological Cooperation Projects (China) [2020A0505100047]
- Guangdong Basic and Applied Basic Research Fund Project (China) [2019A1515110222, 2021A1515110699]
- Guangdong Province Natural Science Fund (China) [2020B1111540001]
- UNSW-CAS Collaborative Research Seed Fund Program (China) [172644KYSB20190059]
- Zhuhai Innovation and Entrepreneurship Team Project [ZH01110405180056PWC]
- SIAT Innovation Program for Excellent Young Researchers [201920]
- CAS-CNR Bilateral Project 2020-2022
A bonsai-inspired oxygen self-sufficient photodynamic cancer therapeutic system was developed using AIEgen/vermiculite nanohybrid, which effectively improved the efficiency of radiation therapy in the hypoxic tumor microenvironment and induced ferroptosis for enhanced therapeutic effect.
Oxygen-dependent photodynamic therapy (PDT) for cancer treatment based on aggregation-induced emission luminogen (AIEgen) photosensitizer shows limited efficiency in the hypoxic tumor micro environment (TME). To overcome tumor hypoxia-induced PDT resistance, a bonsai-inspired oxygen selfsufficient photodynamic cancer therapeutic system was developed based on AIEgen/vermiculite nanohybrid. Ultrathin nanosheets (NSs) were synthesized by lithium-ion intercalation from potting soil vermiculite for AIEgen photosensitizer (DCPy) loading through electrostatic attraction to produce NSs@DCPy (nano bonsai). When NSs@DCPy was absorbed by hypoxic the tumor and exposed to white light radiation, the NSs@DCPy could not only produce O-1(2) and center dot OH but also catalyze the H2O2 to generate O-2 for alleviating hypoxia significantly improving PDT efficacy. Surprisingly, NSs@DCPy could induce ferroptosis of the tumor by iron overload and depleting glutathione (GSH). Therefore, we provide a bonsai-inspired AIEgen-vermiculite nanohybrid platform for ferroptosis-assisted oxygen self-sufficient photodynamic cancer therapy.(c) 2022 Published by Elsevier Ltd.
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