期刊
MOLECULAR PHARMACEUTICS
卷 19, 期 4, 页码 1033-1046出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.1c00960
关键词
ionic liquids; drug delivery; solubility; stability
资金
- National Natural Science Foundation of China [81872734]
- Research & Development Project in Key Areas of Guangdong Province [2019B020203003]
Ionic liquids (ILs) are nonmolecular compounds composed only of ions, which have a wide range of applications in various fields including pharmaceuticals. ILs have advantages such as wide chemical space, adjustable structures, and high thermal stability, making them potential candidates for drug delivery systems.
Ionic liquids (ILs) are a class of nonmolecular compounds composed only of ions. Compared with traditional organic solvents, ILs have the advantages of wide chemical space, diverse and flexible structures, negligible vapor pressure, and high thermal stability, which make them widely used in many fields of modern science, such as chemical synthesis and catalytic decomposition, electrochemistry, biomass conversion, and biotransformation biotechnology. Because of their special characteristics, ILs have been favored in the pharmaceutical field recently, especially for the development of efficient drug delivery systems. So far, ILs have been successfully designed to promote the dissolution of poorly soluble drugs and the destruction of physiological barriers, such as the tight junction between the stratum corneum and the intestinal epithelium. In addition, ILs can also be combined with other drug strategies to stabilize the structure of small molecules. This Review mainly introduces the application of ILs in drug delivery, emphasizes the potential mechanism of ILs, and presents the key research directions of ILs in the future.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据