Review
Medicine, General & Internal
Masaki Kuwatani, Kazumichi Kawakubo, Naoya Sakamoto
Summary: The poor prognosis of biliary tract cancer is due to the challenges in detecting cancer lesions and the lack of standard screening methods. Genomic analysis has shown promise in improving the accuracy of diagnosis for biliary tract cancer, and future diagnosis and treatment should be based on molecular and genetic analysis.
Article
Oncology
Rahman Shafique, Furqan Rustam, Gyu Sang Choi, Isabel de la Torre Diez, Arif Mahmood, Vivian Lipari, Carmen Lili Rodriguez Velasco, Imran Ashraf
Summary: Breast cancer is a common and deadly disease in women. Automated detection methods are crucial for timely treatment. This study investigates the impact of different feature selection techniques on improving the performance of machine learning methods for breast cancer detection. The results show that using appropriate features leads to highly accurate predictions.
Article
Gastroenterology & Hepatology
Joseph R. Habib, Yayun Zhu, Lingdi Yin, Ammar A. Javed, Ding Ding, Jonathan Tenior, Michael Wright, Syed Z. Ali, Richard A. Burkhart, William Burns, Christopher L. Wolfgang, Eunji Shin, Jun Yu, Jin He
Summary: Targeted next-generation sequencing (NGS) can detect KRAS mutations from EUS-FNA samples, showing high concordance with primary tumors and ctDNA. This suggests that targeted NGS of EUS-FNA samples may enhance diagnostic accuracy in PDAC and enable preoperative ctDNA prognostication.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Oncology
Isabela Panzeri Carlotti Buzatto, Francisco Jose Candido dos Reis, Jurandyr Moreira de Andrade, Tamara Cristina Gomes Ferraz Rodrigues, Jessica Maria Camargo Borba, Amanda Homse Netto, Marina Sconzo Polydoro, Daniel Guimaraes Tiezzi
Summary: The study demonstrated that axillary ultrasound coupled with fine-needle aspiration cytology is effective in evaluating axillary involvement in breast cancer patients. Ultrasound combined with FNAC showed high specificity in accurately predicting clinically relevant node metastasis in patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Hongki Gwak, Sang Seok Woo, Se Jeong Oh, Jee Ye Kim, Hee-Chul Shin, Hyun Jo Youn, Jung Whan Chun, Dasom Lee, Seong Hwan Kim
Summary: This study investigated the prognosis and application criteria of core needle biopsy (CNB) and fine needle aspiration (FNA) in breast cancer diagnosis. The results showed that patients diagnosed using FNA had significantly worse survival rates than those diagnosed using CNB. Under specific conditions, FNA showed particularly poor survival rates.
Article
Oncology
Shujun Xia, Yilai Chen, Weiwei Zhan, Wei Zhou
Summary: This study compared the effectiveness of ultrasound-guided fine-needle aspiration and capillary sampling with different gauge needles for cervical lymph node biopsy. Results showed that 22G fine-needle aspiration and 22G capillary sampling were more effective in sampling adequacy and diagnostic efficiency compared to 25G fine-needle aspiration. The study suggests that 22G fine-needle aspiration and 22G capillary sampling may be more suitable for diagnosing cervical lymph nodes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Carolla El Chamieh, Philippe Vielh, Sylvie Chevret
Summary: Statistical issues in evaluating the diagnostic accuracy of fine needle aspiration cytology for breast cancer, such as suspect test results and verification bias, were addressed using various methods including conditional estimates, Begg and Greenes method, multivariate imputation by chained equations, and a Bayesian approach. The FNAC test demonstrated high specificity, always above 94%, and performed better as a rule-in test for breast cancer diagnosis.
BMC MEDICAL RESEARCH METHODOLOGY
(2022)
Article
Oncology
Huang Chen, Aiping Song, Ye Wang, Yifan He, Jie Tong, Jinxi Di, Chun Li, Zhongren Zhou, Xiaopin Cai, Dingrong Zhong, Jiping Da
Summary: The study demonstrated that combining fine-needle aspiration cytology with BRAF(V600E) mutation testing can improve the accuracy of papillary thyroid cancer diagnosis, especially for thyroid nodules with indeterminate or nondiagnostic cytology.
Review
Medicine, General & Internal
Galab M. Hassan, Louise Laporte, Sarto C. Paquin, Charles Menard, Anand Sahai, Benoit Masse, Helen Trottier
Summary: A systematic review and meta-analysis compared the diagnostic accuracy of EUS-guided FNA and FNB for pancreatic cancer. The meta-analysis showed that EUS-FNB had superior diagnostic accuracy compared to EUS-FNA for pancreatic cancer.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Anke Werner, Philipp Seifert, Bernhard Theis, Martin Freesmeyer, Theresa Leder
Summary: For patients with metastatic castration-resistant prostate cancer, PSMA PET/CT can provide valuable information for subsequent treatment. Fine-needle aspiration cytology can be used to evaluate BRCA mutations and guide the selection of appropriate therapeutic options.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Celia Dupain, Julien Masliah-Planchon, Celine Gu, Elodie Girard, Pierre Gestraud, Pauline Du Rusquec, Edith Borcoman, Diana Bello, Francesco Ricci, Segolene Hescot, Marie-Paule Sablin, Patricia Tresca, Alexandre de Moura, Delphine Loirat, Maxime Frelaut, Anne Vincent-Salomon, Charlotte Lecerf, Celine Callens, Samantha Antonio, Coralie Franck, Odette Mariani, Ivan Bieche, Maud Kamal, Christophe Le Tourneau, Vincent Servois
Summary: This study aimed to evaluate the potential of fine-needle aspiration (FNA) compared to core needle biopsies (CNB) in detecting molecular alterations in various tumor types, with a high concordance of 80% between FNA and CNB. Comparative analysis showed that FNA and CNB have similar high concordance in terms of variants and copy number variations (CNVs) identified.
MOLECULAR ONCOLOGY
(2021)
Review
Biology
Masataka Taniuchi, Tetsuya Terada, Ryo Kawata
Summary: Fine-needle aspiration cytology is widely used for preoperative evaluation of parotid tumors, with core needle biopsy and liquid-based cytology improving reliability of immunostaining and molecular testing.
Article
Gastroenterology & Hepatology
Stefania Bunduc, Bianca Varzaru, Razvan Andrei Iacob, Andrei Sorop, Ioana Manea, Andreea Spiridon, Raluca Chelaru, Adina Emilia Croitoru, Gabriel Becheanu, Mona Dumbrava, Simona Dima, Irinel Popescu, Cristian Gheorghe
Summary: This study assessed the adequacy of DNA yielded from EUS-FNA pancreatic adenocarcinoma (PDAC) samples for next generation sequencing (NGS). The results showed that DNA concentration and purity in EUS-FNA samples were suitable for NGS. There was no significant difference in DNA yield between 22G and 19G needles, but DNA purity parameters may vary with needle size.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Luai Sallout, Mohamed Tashkandi, Amani Moqnas, Hebah AlMajed, Abdulrhman Al-Naeem, Yazeed Alwelaie
Summary: The study found that axillary lymph node fine-needle aspiration biopsy could be a potential alternative to SLNB in newly diagnosed breast cancer patients. When axillary lymph node FNAB results are negative, a standard SLNB should be considered, especially in nodes with abnormal imaging findings.
CANCER CYTOPATHOLOGY
(2023)
Review
Oncology
Haining Zheng, Rui Zhao, Wei Wang, Xiaona Liu, Xiaoqing Wang, Chaoyang Wen, Yubo Ren
Summary: This study evaluates the diagnostic accuracy of ultrasound-guided fine needle aspiration (US-FNA) and core needle biopsy (US-CNB) for detecting axillary lymph nodes in women with breast cancer. The results indicate that both US-FNA and US-CNB have high accuracy for suspicious axillary lymph nodes.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Doo-Ho Lee, Woongchang Yoon, Areum Lee, Youngmin Han, Yoonhyeong Byun, Jae Seung Kang, Hongbeom Kim, Wooil Kwon, Young-Ah Suh, Yonghwan Choi, Junghyun Namkung, Sangjo Han, Sung Gon Yi, Jin Seok Heo, In Woong Han, Joon Oh Park, Joo Kyung Park, Song Cheol Kim, Eunsung Jun, Chang Moo Kang, Woo Jin Lee, Hyeon Kook Lee, Huisong Lee, Seungyeoun Lee, Seung-Yong Jeong, Kyu Eun Lee, Wonshik Han, Taesung Park, Jin-Young Jang
Summary: This study developed a prediction model using a multi-marker panel as a diagnostic screening tool for pancreatic ductal adenocarcinoma and demonstrated its significant diagnostic performance in distinguishing pancreatic ductal adenocarcinoma from normal and benign pancreatic disease states, as well as patients with other cancers.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Multidisciplinary Sciences
Joo Heung Kim, Sunggyun Park, Hyung Seok Park, Ji Soo Park, Seung-Tae Lee, Sung-Won Kim, Jong Won Lee, Min Hyuk Lee, Sue K. Park, Woo-Chul Noh, Doo Ho Choi, Wonshik Han, Sung Hoo Jung
Summary: Genetic testing for BRCA1 and BRCA2 is crucial in diagnosing hereditary breast and ovarian cancer syndromes, but VUS results pose challenges to clinicians. A study of 676 breast cancer patients in Korea found numerous VUS on BRCA mutation tests, some of which were reclassified in the ClinVar database. Utilizing updated ClinVar information and calculating odds ratios can aid in the reclassification of VUSs in BRCA1/2.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Ju Hee Kim, Eun-Shin Lee, Jihui Yun, Han Suk Ryu, Hong Kyu Kim, Young Wook Ju, Kwangsoo Kim, Jong-Il Kim, Hyeong-Gon Moon
Summary: CASQ2, a newly identified breast cancer-related gene, has been found to potentially regulate tumor-microenvironment interactions by promoting a more aggressive phenotype and altering epithelial-mesenchymal transition (EMT) markers in breast cancer cells. Overexpression of CASQ2 also induces cancer-associated fibroblast characteristics and increases hypoxia-inducible factor 1 alpha (HIF1 alpha) expression in stromal fibroblasts, leading to accelerated tumorigenesis, collagen structure remodeling, and distant metastasis in vivo. CASQ2 may confer more metaplastic features to triple-negative breast cancer cells, suggesting its key role in breast cancer tumorigenesis and metastasis through modulating various aspects of tumor-microenvironment interactions.
MOLECULAR ONCOLOGY
(2022)
Letter
Surgery
Jong-Ho Cheun, Hong Kyu Kim, Han-Byoel Lee, Wonshik Han, Hyeong-Gon Moon
Article
Biochemical Research Methods
Jaeyong Choi, Woochan Lee, Jung-Ki Yoon, Sun Mi Choi, Chang-Hoon Lee, Hyeong-Gon Moon, Sukki Cho, Jin-Haeng Chung, Han-Kwang Yang, Jong-Il Kim
Summary: The study evaluated misalignment errors and exonic multi-mapping events in mixed human and mouse single-cell data analysis, and developed a new bioinformatics pipeline to minimize errors. Results showed that the clustering effect of data processed using this pipeline was good compared to unmixed data, effectively identified false-positive signals caused by ambient RNA, and successfully applied to the analysis of multispecies multisample single-cell libraries.
BMC BIOINFORMATICS
(2022)
Article
Oncology
Hye-Young Min, Ho Jin Lee, Young-Ah Suh, Honglan Pei, Hyukjin Kwon, Hyun-Ji Jang, Hye Jeong Yun, Hyeong-Gon Moon, Ho-Young Lee
Summary: This study highlights the pivotal role of EGFR signaling-mediated G6PD expression in paclitaxel resistance and suggests that targeting EGFR could be a potential therapeutic strategy to overcome paclitaxel resistance in TNBC and NSCLC cells overexpressing G6PD.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
ByulA Jee, Eunjeong Seo, Kyunghee Park, Yi Rang Kim, Sun-ju Byeon, Sang Min Lee, Jae Hoon Chung, Wan Song, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Se Hoon Park, Woong-Yang Park, Minyong Kang
Summary: This study analyzed the genomic and transcriptomic features of metastatic ccRCC patients treated with ICIs, identified three molecular subtypes, and determined specific features associated with response and survival rates. Additionally, the research revealed a novel gene, GATM, associated with PBRM1 mutation and having tumor suppressive features in ccRCC.
Article
Oncology
Yong Jae Lee, Ha Young Woo, Yoo-Na Kim, Junsik Park, Eun Ji Nam, Sang Wun Kim, Sunghoon Kim, Young Tae Kim, Eunhyang Park, Je-Gun Joung, Jung-Yun Lee
Summary: Neoadjuvant chemotherapy (NAC) induces changes in the tumor immune microenvironment (TIME), increasing immune infiltration and enhancing CD8 T cell activity. However, this increased immune activity does not translate into a survival benefit due to concomitant immunosuppression caused by an increase in regulatory T cells. These findings may help improve the effectiveness of immunotherapies in ovarian cancer.
Article
Oncology
Hyun Ae Jung, Keon-Uk Park, Sanghee Cho, Jinyeong Lim, Keun-Wook Lee, Min Hee Hong, Tak Yun, Ho Jung An, Woong-Yang Park, Sergio Pereira, Chan-Young Ock, Bhumsuk Keam
Summary: Nivolumab plus gemcitabine showed promising efficacy with favorable toxicity profiles in patients with advanced NPC in whom platinum-based combination chemotherapy failed.
CLINICAL CANCER RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Jinzhuang Dou, Yukun Tan, Kian Hong Kock, Jun Wang, Xuesen Cheng, Le Min Tan, Kyung Yeon Han, Chung-Chau Hon, Woong-Yang Park, Jay W. Shin, Haijing Jin, Yujia Wang, Han Chen, Li Ding, Shyam Prabhakar, Nicholas Navin, Rui Chen, Ken Chen
Summary: Monopogen is a computational tool for identifying single-nucleotide variants (SNVs) from single-cell sequencing data. It can accurately identify 100K to 3M germline SNVs with a genotyping accuracy of 95%, as well as hundreds of putative somatic SNVs. Monopogen enables global and local ancestry inference, identification of admixed samples, and detection of variants associated with cellular processes such as cardiomyocyte metabolism and epigenomic programs. It also improves the detection of putative somatic SNVs and enables clonal lineage tracing in primary human clonal hematopoiesis.
NATURE BIOTECHNOLOGY
(2023)
Article
Oncology
Young-jin Lee, Jae Ho Jeong, Jinhong Jung, Tae-Kyung Yoo, Sae Byul Lee, Jisun Kim, Beom Seok Ko, Hee Jeong Kim, Jong Won Lee, Byung Ho Son, Il Yong Chung
Summary: This study aimed to analyze the waiting time for initial treatment after breast cancer diagnosis and determine the factors influencing treatment delay in South Korea. The study found that waiting times for initial treatment have increased across all regions in South Korea, with particularly long wait times for patients traveling to Seoul.
JOURNAL OF BREAST CANCER
(2023)
Article
Surgery
Yoon Ju Bang, Won Kyung Kwon, Jong-Won Kim, Jeong Eon Lee, Boo Yeon Jung, Mina Kim, Jisun Kim, Jeongshin An, Seung Pil Jung, Hong-Kyu Kim, Zisun Kim, Hyun Jo Youn, Jai Min Ryu, Sung-Won Kim
Summary: We provide clinical evidence for the reclassification of the BRCA1: c.5017_5019del variant as a likely pathogenic variant (LPV) based on the analysis of clinicopathological characteristics and family history of 17 patients.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jin-Mi Oh, Minae An, Dae-Soon Son, Jinhyuk Choi, Yong Beom Cho, Chang Eun Yoo, Woong-Yang Park
Summary: There are differences in the proportions of cell types between single-cell RNA sequencing (scRNA-seq) and single-nucleus RNA sequencing (snRNA-seq). The proportion of immune cells is relatively high in scRNA-seq, while the proportion of epithelial cells in the colon and hepatocytes in the liver is relatively high in snRNA-seq.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Oncology
Tae-Kyung Yoo, Woo Seung Lee, Jisun Kim, Min Kyoon Kim, In-Ae Park, Ju Han Kim, Wonshik Han
Summary: This study investigated the association between kinome gene alterations and disease outcomes in triple-negative breast cancer (TNBC). The significantly mutated genes included TP53, PIK3CA, BRCA2, and ATM. Higher occurrence of PIK3CA gene mutations was observed in Asian patients. Tumors with high tumor mutational burden showed longer progression-free survival. Kinome gene alterations in the Wnt pathway were associated with poor survival.
JOURNAL OF BREAST CANCER
(2022)
Article
Biochemistry & Molecular Biology
Taemook Kim, Sungwook Han, Yujin Chun, Hyeokjun Yang, Hyesung Min, Sook Young Jeon, Jang-il Kim, Hyeong-Gon Moon, Daeyoup Lee
Summary: This study investigated the 3D chromatin organization in different subtypes of breast cancer using in situ Hi-C technology. The results showed that the 3D architectures were significantly disrupted in breast cancer, especially in the triple-negative subtype. The disrupted structures were associated with perturbed chromatin accessibility and transcriptional dysregulation. The study also observed 3D chromatin disorganization in TNBC tissues. Furthermore, distinct tissue-specific chromatin loops were discovered by comparing normal and TNBC tissues.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)