期刊
MARINE DRUGS
卷 20, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/md20030197
关键词
low molecular weight fucoidan (LMWF); dendritic cells; immune stimulation; Undaria pinnatifida; New Zealand
资金
- New Zealand Ministry of Education, New Zealand-China Tripartite Partnership Fund
- Royal Society of New Zealand Catalyst Seeding Fund [21-AUT-005-CSG]
- National Natural Science Foundation of China [U1803381]
The study demonstrated that low molecular weight fucoidan can modulate dendritic cells by stimulating their maturation and migration, as well as promoting T cell proliferation. This immune promoting activity is activated through TLR4 and its downstream signaling pathways, and has shown a strong immunological boosting effect in a mouse model.
Low molecular weight fucoidan (LMWF) has been reported to have immunomodulation effects through the increase of the activation and function of macrophages. In this study, the regulating effect of LMWF from Undaria pinnatifida grown in New Zealand on dendritic cells (DCs) was investigated. We discovered that LMWF could stimulate DCs' maturation and migration, as well as CD4+ and CD8+ T cells' proliferation in vitro. We proved that this immune promoting activity is activated through TLR4 and its downstream MAPK and NF-kappa B signaling pathways. Further in vivo (mouse model) investigation showed that LMWF has a strong immunological boosting effect, such as facilitating the proliferation of immune cells and increasing the index of immune organs. These findings suggest that LMWF has a positive immunomodulatory effect and is a promising candidate to supplement cancer immunotherapy.
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