期刊
JOURNAL OF ANIMAL BREEDING AND GENETICS
卷 133, 期 6, 页码 452-462出版社
WILEY-BLACKWELL
DOI: 10.1111/jbg.12217
关键词
Accuracy; genomic prediction; genome sharing; identity by descent; SNP
资金
- Agriculture and Food Research Initiative Competitive Grant from the USDA National Institute of Food and Agriculture [2010-65205-20342]
- National Pork Board [11-042]
- US Pig Genome Coordination Program
- CONICET [PIP 2013-00833]
- ANPCyT from Argentina [PICT 2013-1661]
- Saint-Exupery Scholarship Program (MinCyT Argentina-French Embassy)
- NIFA [2010-65205-20342, 581200] Funding Source: Federal RePORTER
Accurate prediction of breeding values depends on capturing the variability in genome sharing of relatives with the same pedigree relationship. Here, we compare two approaches to set up genomic relationship matrices for precision of genomic relationships (GR) and accuracy of estimated breeding values (GEBV). Real and simulated data (pigs, 60k SNP) were analysed, and GR were estimated using two approaches: (i) identity by state, corrected with either the observed (G(VR-O)) or the base population (G(VR-B)) allele frequencies and (ii) identity by descent using linkage analysis (G(IBD-L)). Estimators were evaluated for precision and empirical bias with respect to true pedigree IBD GR. All three estimators had very low bias. G(IBD-L) displayed the lowest sampling error and the highest correlation with true genome-shared values. G(VR-B) approximated G(IBD-L)'s correlation and had lower error than G(VR-O). Accuracy of GEBV for selection candidates was significantly higher when G(IBD-L) was used and identical between G(VR-O) and G(VR-B). In real data, G(IBD-L)'s sampling standard deviation was the closest to the theoretical value for each pedigree relationship. Use of pedigree to calculate GR improved the precision of estimates and the accuracy of GEBV.
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