DGAT2 Inhibition Potentiates Lipid Droplet Formation To Reduce Cytotoxicity in APOL1 Kidney Risk Variants

Lack of APOL1 in proximal tubules of normal human kidneys and proteinuric APOL1 transgenic mouse kidneys

(2021) Natalya A. Blessing et al.   PLoS One

AIM2 Suppresses Inflammation and Epithelial Cell Proliferation during Glomerulonephritis

(2021) Hyunjae Chung et al.   JOURNAL OF IMMUNOLOGY

TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells

(2020) Cyril Corbet et al.   Nature Communications

Treatment of human skeletal muscle cells with inhibitors of diacylglycerol acyltransferases 1 and 2 to explore isozyme-specific roles on lipid metabolism

(2020) Nils G. Løvsletten et al.   Scientific Reports

Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes

(2020) Suzie J. Scales et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Domain-Specific Antibodies Reveal Differences in the Membrane Topologies of Apolipoprotein L1 in Serum and Podocytes

(2020) Nidhi Gupta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity

(2019) Justin Chun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advances in our understanding of genetic kidney disease using kidney organoids

(2019) Melissa H. Little et al.   PEDIATRIC NEPHROLOGY

Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network

(2019) Jian Hui Low et al.   Cell Stem Cell

APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice

(2019) Jung-Hwa Ryu et al.   PLoS One

APOL1 Kidney Risk Variants Induce Cell Death via Mitochondrial Translocation and Opening of the Mitochondrial Permeability Transition Pore

(2019) Shrijal S. Shah et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Apolipoprotein L1 (APOL1) risk variant toxicity depends on the haplotype background

(2019) Herbert Lannon et al.   KIDNEY INTERNATIONAL

APOL1 and Kidney Disease: From Genetics to Biology

(2019) David J. Friedman et al.   Annual Review of Physiology

Glucometabolic consequences of acute and prolonged inhibition of fatty acid oxidation

(2019) Anne-Marie Lundsgaard et al.   JOURNAL OF LIPID RESEARCH

Generation of infant- and pediatric-derived urinary induced pluripotent stem cells competent to form kidney organoids

(2019) Jaap Mulder et al.   PEDIATRIC RESEARCH

APOL1 Risk Variants Cause Podocytes Injury through Enhancing Endoplasmic Reticulum Stress

(2018) Hongxiu Wen et al.   BIOSCIENCE REPORTS

Organoids from Nephrotic Disease-Derived iPSCs Identify Impaired NEPHRIN Localization and Slit Diaphragm Formation in Kidney Podocytes

(2018) Shunsuke Tanigawa et al.   Stem Cell Reports

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome

(2018) Jaye M. Platnich et al.   Cell Reports

Identification and characterization of a novelDGAT1missense mutation associated with congenital diarrhea

(2017) Nina L. Gluchowski et al.   JOURNAL OF LIPID RESEARCH

Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease

(2017) Nelly M. Cruz et al.   NATURE MATERIALS

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

(2017) Pazit Beckerman et al.   NATURE MEDICINE

Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development

(2017) Yong Kyun Kim et al.   STEM CELLS

APOL1-G0 or APOL1-G2 Transgenic Models Develop Preeclampsia but Not Kidney Disease

(2016) L. A. Bruggeman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Generation of kidney organoids from human pluripotent stem cells

(2016) Minoru Takasato et al.   Nature Protocols

Knockdown of ApoL1 in Zebrafish Larvae Affects the Glomerular Filtration Barrier and the Expression of Nephrin

(2016) Ahmed M. Kotb et al.   PLoS One

Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects

(2015) M. G. Sampson et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Nephron organoids derived from human pluripotent stem cells model kidney development and injury

(2015) Ryuji Morizane et al.   NATURE BIOTECHNOLOGY

Metabolic functions of FABPs—mechanisms and therapeutic implications

(2015) Gökhan S. Hotamisligil et al.   Nature Reviews Endocrinology

APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases

(2015) Opeyemi A. Olabisi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

(2015) Benjamin S. Freedman et al.   Nature Communications

KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas

(2015) Matthias S. Roost et al.   Stem Cell Reports

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Regulation of lipid droplet size and phospholipid composition by stearoyl-CoA desaturase

(2013) Xun Shi et al.   JOURNAL OF LIPID RESEARCH

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

GeneMANIA Cytoscape plugin: fast gene function predictions on the desktop

(2010) J. Montojo et al.   BIOINFORMATICS

Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene

(2010) Shay Tzur et al.   HUMAN GENETICS

Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans

(2010) G. Genovese et al.   SCIENCE

Biochemical and physiological function of stearoyl-CoA desaturase

(2008) Chad M. Paton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Thematic Review Series: Glycerolipids.DGAT enzymes and triacylglycerol biosynthesis

(2008) Chi-Liang Eric Yen et al.   JOURNAL OF LIPID RESEARCH