Article
Oncology
Jian-Wei Yang, Ling-Ling Yuan, Yan Gao, Xu-Sheng Liu, Yu-Jiao Wang, Lu-Meng Zhou, Xue-Yan Kui, Xiao-Hui Li, Chang-Bin Ke, Zhi-Jun Pei
Summary: The study found a correlation between the expression levels of EIF2S2 gene and F-18-FDG PET/CT metabolic parameters in CRC patients, and a positive correlation between EIF2S2 and GLUT1 expression. Overexpression of EIF2S2 in CRC can promote glycolysis.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jin Qi, Elizabeth Kurian, Orhan K. oez
Summary: Hibernomas are rare benign tumors originating from fetal brown adipose tissue. They can occur in various parts of the body, with thigh, shoulder, back, and neck being the most common locations, and are rarely found in the abdominal cavity, retroperitoneum, breast, bones, scrotum, and perirectum. We present a case of a 58-year-old woman with a mediastinal mass, who was incidentally found to have an FDG-avid fat-containing lesion in the omentum abutting the stomach.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Neurosciences
Yanxiao Li, Yee Ling Ng, Manish D. Paranjpe, Qi Ge, Fengyun Gu, Panlong Li, Shaozhen Yan, Jie Lu, Xiuying Wang, Yun Zhou
Summary: This study aimed to improve the statistical power in detecting changes in brain glucose metabolism, amyloid, and tau deposition in Alzheimer's disease studies by using a reference tissue-based quantification approach. The results showed that the tracer-specific reference tissue improved the detection of PET SUVR changes, which is beneficial for early diagnosis, disease progression monitoring, and therapeutic response in Alzheimer's disease.
HUMAN BRAIN MAPPING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Ryul Shim, Seong-Jang Kim
Summary: This study evaluated the diagnostic accuracies of F-18-FDG PET or PET/CT for Merkel cell carcinoma (MCC) through a systematic review and meta-analysis. The results showed that F-18-FDG PET/CT had excellent performance in diagnosing MCC and could be useful for exclusion and confirmation of the disease. Further large multicenter studies are needed to validate its diagnostic accuracy.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yun Chen, Shan Zheng, Zenan Wu, Yanmin Lin, Weibing Miao
Summary: A 76-year-old man with yellowish discoloration of sclera and skin for 2 months was referred for F-18-FDG PET/CT to characterize a mass in the pancreas. PET/CT images showed intense FDG uptake in the head of the pancreas, with a lymph nodal mass in the hepatic hilar region, consistent with pancreatic malignancy. Histopathologic findings confirmed diffuse large B-cell lymphoma with no evidence of adenocarcinoma.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Geriatrics & Gerontology
Pedro J. M. R. Pinho, Laiss Bertola, Ari Alex Ramos, Matheus Ghossain Barbosa, Wendell Rabelo, Erico Castro-Costa, Maria Fernanda Lima-Costa, Cleusa Pinheiro Ferri
Summary: Subjective memory complaints (SMCs) are common in the Brazilian older population and are associated with health and sociodemographic factors. Different patterns exist between men and women.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Abarnaa Sivapathasundaram, Nicolas Golse, Alina Pascale, Emmanuel Durand, Mylene Sebagh, Florent L. Besson
Summary: Contrary to common belief, F-18-FDG/F-18-choline dual-tracer PET behavior is not a relevant surrogate of tumor differentiation in hepatocellular carcinoma (HCC). Future multitracer PET studies are necessary to improve our understanding of their biological significance in this field.
CLINICAL NUCLEAR MEDICINE
(2023)
Review
Oncology
Domenico Albano, Giorgio Treglia, Francesco Dondi, Anna Calabro, Alessio Rizzo, Salvatore Annunziata, Luca Guerra, Silvia Morbelli, Alessandra Tucci, Francesco Bertagna
Summary: The new biomarker Dmax, which measures the maximal distance between the two farthest hypermetabolic PET lesions, has shown high accuracy as a prognostic factor in lymphoma patients. Most studies have demonstrated the significant predictive value of Dmax in predicting progression-free survival and overall survival.
Article
Psychiatry
Andrea Vergallo, Simone Lista, Yuhai Zhao, Pablo Lemercier, Stefan J. Teipel, Marie-Claude Potier, Marie-Odile Habert, Bruno Dubois, Walter J. Lukiw, Harald Hampel
Summary: The study identified brain-enriched miRNAs in a cohort of cognitively normal individuals with subjective memory complaints. It investigated the impact of age, sex, and the APOE epsilon 4 allele on miRNA plasma concentrations and explored associations with brain metabolic uptake using PET imaging. The results suggest potential associations between miRNA concentrations and neuroimaging biomarkers of AD pathophysiology.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
David J. Liesker, Stijn Legtenberg, Paola A. Erba, Andor W. J. M. Glaudemans, Clark J. Zeebregts, Jean-Paul P. M. De Vries, Nabil Chakfe, Ben R. Saleem, Riemer H. J. A. Slart
Summary: This study aimed to assess the variability of [F-18]FDG-PET/LDCT reporting in suspected VGEI using a standardized reporting format. The results showed that less than half of the reports met all the pre-selected criteria, and the incompleteness of reports led to lower sensitivity and specificity.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Lidija Antunovic, Alessia Artesani, Alessandro Vigano, Arturo Chiti, Armando Santoro, Martina Sollini, Silvia D. Morbelli, Rita De Sanctis
Summary: This study aimed to examine brain metabolic patterns on [F-18]Fluorodeoxyglucose ([F-18]FDG) positron emission tomography (PET) in breast cancer (BC), comparing patients with tension-type headache (TTH), migraine (MiG), and those without headache. The results showed that headache patients exhibited hypometabolism in specific brain regions before neoadjuvant chemotherapy (NAC) and headache patients with a good response to NAC showed hypermetabolic brain regions in the anterior medial frontal cortex.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sang Woo Lee, Seong-Jang Kim
Summary: The systematic review and meta-analysis showed that F-18-FDG PET/CT has good diagnostic performance in detecting lymph node metastasis in penile cancer patients, with similar accuracy in detecting inguinal and pelvic lymph node metastasis.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Halil Komek, Canan Can, Ihsan Kaplan, Cihan Gundogan, Ferat Kepenek, Huseyin Karaoglan, Aykut Demirkiran, Senar Ebinc, Yunus Guzel, Ebubekir Gundes
Summary: [(68) Ga]Ga-DOTA-FAPI-04 PET/CT demonstrates higher sensitivity and specificity in the evaluation of primary lesions and metastases in patients with colorectal cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Gastroenterology & Hepatology
Dae-Weung Kim, Soon-Ah Park, Myoung Hyoun Kim
Summary: A 77-year-old woman underwent F-18 FDG PET/CT for evaluation of fever focus. Diffuse and intense hepatosplenic uptake was noted, suggesting lymphoma or tuberculosis. Liver biopsy revealed chronic granulomatous inflammation with Langerhans-type giant cells and necrosis. A follow-up PET/CT after anti-tuberculosis treatment showed resolution of hepatosplenic uptake.
LIVER INTERNATIONAL
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Falko Ensle, Jan A. Schaab, Florentia Dimitriou, Martin W. Huellner, Alexander Maurer
Summary: We report the F-18-FDG PET/CT findings of an internal thoracic vein tumor thrombus in a 76-year-old woman with melanoma. The restaging F-18-FDG PET/CT revealed disease progression with an internal thoracic vein tumor thrombus associated with sternal bone metastasis. Although cutaneous malignant melanoma can metastasize to any organ, direct tumor invasion of veins leading to tumor thrombus formation is an extremely rare complication.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Clinical Neurology
Pratishtha Chatterjee, Steve Pedrini, James D. Doecke, Rohith Thota, Victor L. Villemagne, Vincent Dore, Abhay K. Singh, Penghao Wang, Stephanie Rainey-Smith, Christopher Fowler, Kevin Taddei, Hamid R. Sohrabi, Mark P. Molloy, David Ames, Paul Maruff, Christopher C. Rowe, Colin L. Masters, Ralph N. Martins
Summary: This study investigated the changes in several blood biomarkers across the AD continuum and their associations with cognitive decline and brain Aβ-PET load. The results showed that plasma Aβ1-42/Aβ1-40 ratio decreased, p-tau181 and GFAP increased in predicting the β-amyloid positive/negative status across the AD continuum.
ALZHEIMERS & DEMENTIA
(2023)
Article
Psychology, Clinical
Joan Chan, Rodrigo Becerra, Michael Weinborn, David Preece
Summary: This study examines the cross-cultural validity and application of the alexithymia construct by assessing the psychometric properties and measurement invariance of two alexithymia measures, the Perth Alexithymia Questionnaire (PAQ) and Toronto Alexithymia Scale-20 (TAS-20), in samples from Singapore and Australia. The results suggest that both measures have good utility and support the validity of the alexithymia construct across cultures, although the PAQ may provide a more detailed facet-level profile. The findings also highlight differences in the experience of positive emotions between the Singaporean and Australian samples.
JOURNAL OF PERSONALITY ASSESSMENT
(2023)
Article
Clinical Neurology
Cathryn McKenzie, Romola S. Bucks, Michael Weinborn, Pierrick Bourgeat, Olivier Salvado, Brandon E. Gavett
Summary: The study found that brain reserve and cognitive reserve can predict slower decline in executive function in older adults. When Alzheimer's disease pathology is low, only brain reserve can attenuate decline. Education is not independently associated with cognitive decline.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Clinical Neurology
Kelsey R. R. Sewell, Stephanie R. R. Rainey-Smith, Jeremiah Peiffer, Hamid R. R. Sohrabi, Kevin Taddei, David Ames, Paul Maruff, Colin L. L. Masters, Christopher C. C. Rowe, Ralph N. N. Martins, Kirk I. I. Erickson, Belinda M. M. Brown
Summary: This study examined the association between objectively measured physical activity and cognition in older adults over 8 years. The results showed that higher energy expenditure, physical activity intensity, and total activity were associated with better episodic recall memory and global cognition. These findings suggest that physical activity may preserve cognitive function, with activity intensity playing a significant role.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Pratishtha Chatterjee, Lisa Vermunt, Brian A. Gordon, Steve Pedrini, Lynn Boonkamp, Nicola J. Armstrong, Chengjie Xiong, Abhay K. Singh, Yan Li, Hamid R. Sohrabi, Kevin Taddei, Mark Molloy, Tammie L. S. Benzinger, John C. Morris, Celeste Karch, Sarah Berman, Jasmeer Chhatwal, Carlos Cruchaga, Neill R. Graff-Radford, Gregory S. Day, Martin Farlow, Nick Fox, Alison Goate, Jason Hassenstab, Jae-Hong Lee, Johannes Levin, Eric McDade, Hiroshi Mori, Richard Perrin, Raquel Sanchez-Valle, Peter R. Schofield, Allan Levey, Mathias Jucker, Colin L. Masters, Anne M. Fagan, Randall J. Bateman, Ralph N. Martins, Charlotte Teunissen
Summary: This study found that plasma GFAP levels increase a decade before symptom onset in AD and are associated with Aβ load, neurodegeneration, and cognitive decline.
ALZHEIMERS & DEMENTIA
(2023)
Article
Behavioral Sciences
Kelsey R. Sewell, Stephanie R. Rainey-Smith, Victor L. Villemagne, Jeremiah Peiffer, Hamid R. Sohrabi, Kevin Taddei, David Ames, Vincent Dore, Paul Maruff, Simon M. Laws, Colin L. Masters, Christopher C. Rowe, Ralph N. Martins, Kirk Erickson, Belinda M. Brown
Summary: The study suggests that physical activity may play a moderating role in the relationship between sleep, cognitive function, and brain A beta burden.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Nutrition & Dietetics
Carolina B. Castro, Cintia B. Dias, Heidi Hillebrandt, Hamid R. Sohrabi, Pratishtha Chatterjee, Tejal M. Shah, Stephanie J. Fuller, Manohar L. Garg, Ralph N. Martins
Summary: This systematic review and meta-analysis examined the effects of medium-chain fatty acid (MCFA) supplementation on circulating ketone bodies and cognition in individuals with cognitive decline and Alzheimer's disease. The results showed that MCFA supplementation increases blood ketone levels and enhances brain energy metabolism. However, the effects on cognition varied and further research is needed to determine if MCFA-mediated increase in brain energy metabolism can improve cognition.
Review
Audiology & Speech-Language Pathology
Naomi de Kleine, Miranda L. Rose, Michael Weinborn, Robert Knox, Nicolas Fay
Summary: This study assessed the impact of gesture on the communication success of people with aphasia through a systematic review. The results showed that gesture can improve the communication success of people with aphasia beyond spoken language alone. However, the severity of apraxia can hinder the effectiveness of gesture, while aphasia severity and semantic processing deficits do not have a significant impact.
Article
Neurosciences
Hadeel Y. Tarawneh, Dona M. P. Jayakody, Shipra Verma, Vincent Dore, Ying Xia, Wilhelmina H. A. M. Mulders, Ralph N. Martins, Hamid R. Sohrabi
Summary: This study investigated whether auditory event-related potentials (AERPs) can be used to objectively identify older adults with subjective memory complaints (SMCs) who are at high risk of developing Alzheimer's disease (AD). The results suggest that P50 latencies may be a useful tool for identifying individuals at higher risk of developing measurable cognitive decline.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Multidisciplinary Sciences
Paul L. McIlhiney, Gilles Gignac, Ullrich K. H. S. Ecker, Briana S. Kennedy, Michael S. Weinborn
Summary: This study found that susceptibility to the continued influence effect (CIE) can be predicted by executive function (EF), specifically the factor of working-memory updating. These results further our understanding of the cognitive antecedents of CIE and provide potential directions for real-world CIE intervention.
Article
Nutrition & Dietetics
Anjana Rajendra, Nicola P. Bondonno, Kevin Murray, Liezhou Zhong, Stephanie R. Rainey-Smith, Samantha L. Gardener, Lauren C. Blekkenhorst, David Ames, Paul Maruff, Ralph N. Martins, Jonathan M. Hodgson, Catherine P. Bondonno
Summary: This study aimed to investigate the association between dietary nitrate intake from natural sources and cognitive function and decline. The results showed that in APOE ε4 carriers, intake of vegetable-derived and total nitrate was associated with better memory. However, there was no evidence of an association between dietary nitrate intake and rate of cognitive decline.
CLINICAL NUTRITION
(2023)
Article
Geriatrics & Gerontology
Kelsey R. Sewell, Stephanie R. Rainey-Smith, Jeremiah Peiffer, Hamid R. Sohrabi, James Doecke, Natalie J. Frost, Shaun J. Markovic, Kirk Erickson, Belinda M. Brown
Summary: The study found that individuals with poorer sleep efficiency showed greater improvements in episodic memory and global cognition following a moderate intensity exercise intervention. This suggests that poor sleep may enhance the cognitive benefits of exercise interventions.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Clinical Neurology
Emma A. Koemans, Jasmeer P. Chhatwal, Susanne J. van Veluw, Ellis S. van Etten, Matthias J. P. van Osch, Marianne A. A. van Walderveen, Hamid R. Sohrabi, Mariel G. Kozberg, Zahra Shirzadi, Gisela M. Terwindt, Mark A. van Buchem, Eric E. Smith, David J. Werring, Ralph N. Martins, Marieke J. H. Wermer, Steven M. Greenberg
Summary: Cerebral amyloid angiopathy, a common age-related small vessel pathology, is associated with intracerebral haemorrhage and cognitive impairment. By studying individuals with different forms of the disease and using mouse models, researchers have identified key stages in the progression of cerebral amyloid angiopathy, which may help in developing interventions for this and other cerebral small vessel diseases.
Article
Geriatrics & Gerontology
Jun Yuan, Steve Pedrini, Rohith Thota, James Doecke, Pratishtha Chatterjee, Hamid R. Sohrabi, Charlotte E. Teunissen, Inge M. W. Verberk, Erik Stoops, Hugo Vanderstichele, Bruno P. Meloni, Christopher Mitchell, Stephanie Rainey-Smith, Kathryn Goozee, Andrew Chi Pang Tai, Nicholas Ashton, Henrik Zetterberg, Kaj Blennow, Junjie Gao, Delin Liu, Frank Mastaglia, Charles Inderjeeth, Minghao Zheng, Ralph N. Martins
Summary: This study investigated the association between plasma SOST levels and brain amyloid-beta load in older individuals. The results showed that plasma SOST levels were higher in individuals with brain amyloid-beta load, and the combination of plasma SOST and Aβ 42/Aβ40 ratio improved the predictive accuracy for preclinical Alzheimer's disease.