Aging Enables Ca2+ Overload and Apoptosis Induced by Amyloid-β Oligomers in Rat Hippocampal Neurons: Neuroprotection by Non-Steroidal Anti-Inflammatory Drugs and R-Flurbiprofen in Aging Neurons

A new procedure for amyloid β oligomers preparation enables the unambiguous testing of their effects on cytosolic and mitochondrial Ca 2+ entry and cell death in primary neurons

(2016) Erica Caballero et al.   NEUROSCIENCE LETTERS

Susceptibility to excitotoxicity in aged hippocampal cultures and neuroprotection by non-steroidal anti-inflammatory drugs: role of mitochondrial calcium

(2015) María Calvo et al.   JOURNAL OF NEUROCHEMISTRY

Non-steroidal anti-inflammatory drugs (NSAIDs) and neuroprotection in the elderly: a view from the mitochondria

(2015) Carlos Villalobos et al.   Neural Regeneration Research

Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

(2015) Takayuki Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease

(2014) Alison Hamilton et al.   Molecular Brain

On the Interaction of β-Amyloid Peptides and α7-Nicotinic Acetylcholine Receptors in Alzheimer’s Disease

(2013) Murat Oz et al.   Current Alzheimer Research

Mitochondrial dysfunction in long-term neuronal cultures mimics changes with aging

(2013) Weiguo Dong et al.   MEDICAL SCIENCE MONITOR

Increased NR2A:NR2B ratio compresses long-term depression range and constrains long-term memory

(2013) Zhenzhong Cui et al.   Scientific Reports

Molecular Mechanisms and Therapeutic Application of NSAIDs and Derived Compounds in Alzheimers Disease

(2012) M. T. Heneka et al.   Current Alzheimer Research

Age-related loss of calcium buffering and selective neuronal vulnerability in Alzheimer’s disease

(2011) David Riascos et al.   ACTA NEUROPATHOLOGICA

Amyloid β peptide oligomers directly activate NMDA receptors

(2011) Laura Texidó et al.   CELL CALCIUM

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

Cellular stress from excitatory neurotransmission contributes to cholesterol loss in hippocampal neurons aging in vitro

(2010) Alejandro O. Sodero et al.   NEUROBIOLOGY OF AGING

Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer DiseaseA Randomized Controlled Trial

(2009) Robert C. Green   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Calcium hypothesis of Alzheimer’s disease

(2009) Michael J. Berridge   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

Mitochondrial Ca2+ Overload Underlies Aβ Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs

(2008) Sara Sanz-Blasco et al.   PLoS One