Cyclophilin D Promotes Brain Mitochondrial F1FO ATP Synthase Dysfunction in Aging Mice

Familial Alzheimer’s Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds

(2016) Sarah Veugelen et al.   NEURON

Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer’s disease

(2016) Simon J. Beck et al.   Nature Communications

Assembly of F1F0-ATP synthases

(2015) Thilo Rühle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM

(2015) Anna Zhou et al.   eLife

Proteome analysis in the assessment of ageing

(2014) Esther Nkuipou-Kenfack et al.   AGEING RESEARCH REVIEWS

The Oligomycin-Sensitivity Conferring Protein of Mitochondrial ATP Synthase: Emerging New Roles in Mitochondrial Pathophysiology

(2014) Manuela Antoniel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

(2014) K. N. Alavian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The C Ring of the F1Fo ATP Synthase Forms the Mitochondrial Permeability Transition Pore: A Critical Appraisal

(2014) Andrew P. Halestrap   Frontiers in Oncology

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-dependent dissociation of ATP synthase dimers and loss of inner-membrane cristae in mitochondria

(2013) B. Daum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Energy Metabolism and Redox Signaling in Brain Aging and Neurodegeneration

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Mitochondrial Permeability Transition Pore Component Cyclophilin D Distinguishes Nigrostriatal Dopaminergic Death Paradigms in the MPTP Mouse Model of Parkinson's Disease

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Brain aging, Alzheimer's disease, and mitochondria

(2011) Russell H. Swerdlow   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aging Neural Progenitor Cells Have Decreased Mitochondrial Content and Lower Oxidative Metabolism

(2011) Elizabeth A. Stoll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of the mitochondrial permeability transition by cyclophilin D: Moving closer to F0–F1 ATP synthase?

(2011) Christos Chinopoulos et al.   MITOCHONDRION

Ageing alters the supramolecular architecture of OxPhos complexes in rat brain cortex

(2010) Monika Frenzel et al.   EXPERIMENTAL GERONTOLOGY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue elasticity and the ageing elastic fibre

(2009) Michael J. Sherratt   AGE

The Alzheimer's disease mitochondrial cascade hypothesis: An update

(2009) Russell H. Swerdlow et al.   EXPERIMENTAL NEUROLOGY

Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria

(2009) Shankar J. Chinta et al.   FREE RADICAL BIOLOGY AND MEDICINE

Elevated neuronal nitric oxide synthase expression during ageing and mitochondrial energy production

(2009) Philip Y. Lam et al.   FREE RADICAL RESEARCH

Cyclophilin D Modulates Mitochondrial F0F1-ATP Synthase by Interacting with the Lateral Stalk of the Complex

(2009) Valentina Giorgio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model

(2009) Heng Du et al.   NEUROBIOLOGY OF AGING

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE