Article
Biochemistry & Molecular Biology
Ioannis Tsialtas, Achilleas Georgantopoulos, Maria E. Karipidou, Foteini D. Kalousi, Aikaterini G. Karra, Demetrios D. Leonidas, Anna-Maria G. Psarra
Summary: Estrogens play a crucial role in regulating both reproductive and non-reproductive system physiology, with a particular impact on the nervous system. The presence of mitochondrial estrogen receptor beta (mtER beta) has been shown to directly participate in neuronal physiology maintenance. Overexpression of mtER beta in N2A cells enhances resistance to apoptotic stimuli, suggesting its potential as a therapeutic target for degenerative diseases associated with mitochondrial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Pu Xu, Shaoyun Li, Qing Wu, Luxi Yang, Na Zheng, Chao Zhu, Peng Liu, Ning Li, Libo Zou
Summary: With the increasing incidence of Alzheimer's disease (AD), there is a lack of effective therapeutic drugs for treatment. Phytoestrogens (PEs), similar to endogenous estrogens, have potential in AD treatment due to their neuroprotective properties. The active ingredient loureirin C from Chinese Dragon's Blood shows partial agonistic activity on ER alpha. However, it is still unclear if loureirin C has estrogenic effects in the body and if it exerts anti-AD effects through ER alpha.
Review
Biochemistry & Molecular Biology
Victor Valverde-Salazar, Daniel Ruiz-Gabarre, Vega Garcia-Escudero
Summary: Alzheimer's disease (AD) is a common form of dementia characterized by memory decline, cognitive impairment, and several pathological changes in the brain. Oxidative stress and inflammation play important roles in the development of AD. Green tea and its active compound EGCG have shown potential therapeutic effects in modulating AD through their antioxidative and anti-inflammatory properties. EGCG can regulate inflammatory processes, reduce protein aggregation, and promote neuronal survival pathways, making it a suitable candidate for the treatment of neurodegenerative disorders involving oxidative stress and inflammation.
Article
Chemistry, Organic
Madhu Ramesh, Kolla Rajasekhar, Kavya Gupta, Vardhaman Babagond, Deepak Kumar Saini, Thimmaiah Govindaraju
Summary: Mitochondria are crucial for cellular energy production and metabolism regulation, with dynamic processes like fission, fusion, biogenesis, and mitophagy maintaining their normal function. The study introduces a far-red fluorescent probe (Mito-TG) for monitoring mitochondrial dysfunction and disease conditions, showing excellent stability and targeting capabilities in live cells.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Clinical Neurology
Yutong Shang, Xiaoyan Sun, Xiaoqin Chen, Quanqiu Wang, Evan J. Wang, Emiko Miller, Rong Xu, Andrew A. Pieper, Xin Qi
Summary: This study reveals that CHCHD6 mechanistically connects APP processing and mitochondrial dysfunction in Alzheimer's disease through a circular feedback loop. Reduced CHCHD6 enhances APP accumulation on mitochondria-associated ER membranes, accelerates APP processing, and induces mitochondrial dysfunction and neuronal cholesterol accumulation, promoting amyloid pathology in Alzheimer's disease.
ACTA NEUROPATHOLOGICA
(2022)
Review
Biochemistry & Molecular Biology
Lucia Gallego Villarejo, Lisa Bachmann, David Marks, Maite Brachthaeuser, Alexander Geidies, Thorsten Mueller
Summary: Intracellular amyloid beta (iAβ) plays a crucial role in neurodegeneration and serves as a pathological marker. Modulating iAβ through pharmacological treatment has shown beneficial effects on cognitive properties. Future research should focus on the impact of viral infections on iAβ generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lauren Y. Shields, Huihui Li, Kevin Nguyen, Hwajin Kim, Zak Doric, Joseph H. Garcia, T. Michael Gill, Dominik Haddad, Keith Vossel, Meredith Calvert, Ken Nakamura
Summary: The loss of central mitochondrial fission protein Drp1 worsens learning and memory in mice expressing mutant hAPP in neurons, leading to mitochondrial Ca2+ overload. This suggests a potential mechanism by which mitochondrial fission protects against hAPP-driven pathology.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Kenta Yoh, Kazuhiro Ikeda, Kuniko Horie, Satoshi Inoue
Summary: Estrogen is an essential hormone that primarily functions in the female reproductive system and has pleiotropic effects in various tissues and organs. Low estrogen levels, such as in postmenopausal women, can lead to disorders like cardiovascular disease, dementia, metabolic syndrome, osteoporosis, sarcopenia, and frailty. Estrogen receptors (ERs) and estrogen-related receptors (ERRs) play crucial roles in muscle physiology, including muscle mass maintenance, exercise physiology, and regeneration, particularly in relation to mitochondrial function and metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Haiyan Chi, Ran Yao, Chao Sun, Bing Leng, Tengqun Shen, Tong Wang, Shukun Zhang, Mengfan Li, Yachao Yang, Hairong Sun, Zhenguang Li, Jinbiao Zhang
Summary: There is evidence that mitochondrial dysfunction is linked to the role of diabetes in the progression of Alzheimer's disease. This study found that levels of mitochondrial proteins in plasma exosomes could predict cognitive decline and brain injury in participants with diabetes, suggesting their potential as diagnostic and prognostic biomarkers for early stage Alzheimer's disease.
Article
Pharmacology & Pharmacy
Adam Olaitan Abdulkareem, Priya Tiwari, Zahid Rasool Lone, Hina Iqbal, Satish Gupta, Rajesh Kumar Jha, Debabrata Chanda, Kumaravelu Jagavelu, Kashif Hanif
Summary: This study investigated the ameliorative effects of ormeloxifene, a selective estrogen receptor modulator, in pulmonary hypertension. The results showed that ormeloxifene promoted the synthesis of 17β-estradiol, alleviated inflammation, and improved the NOX4/HO1/Nrf/PPAR gamma/PGC-1 alpha axis, thereby attenuating pulmonary hypertension.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Iwona Szydlowska, Marta Grabowska, Jolanta Nawrocka-Rutkowska, Malgorzata Piasecka, Andrzej Starczewski
Summary: The results of the study suggest that a good response to UPA treatment in fibroids may be associated with a decrease in fibrosis, ER/PR and PCNA and Ki67 immunoexpression, as well as an increase in cell apoptosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Sayali Chandrashekhar Deolankar, Mohd Altaf Najar, Poornima Ramesh, Anagha Kanichery, Avinash K. Kudva, Shamprasad Varija Raghu, T. S. Keshava Prasad
Summary: Accumulation of A beta(42) peptides forming plaque in various regions of the brain is a characteristic of Alzheimer's disease progression. However, there is currently no effective management strategy for attenuating the early-stage toxicity induced by A beta(42). This study investigated the neuroprotective effects of aqueous extracts from Bacopa monnieri and Centella asiatica (both commonly known as Brahmi) using a Drosophila melanogaster model. Through quantitative proteomics analysis, the study found that the Brahmi extract restored the expression of a significant portion of differentially expressed proteins in A beta(42)-expressing flies, which are involved in neuronal pathways associated with cell cycle re-entry, apoptosis, and mitochondrial dynamics. The neuroprotective effect of Brahmi was also confirmed by negative geotaxis behavioral analysis. These findings provide a platform for developing novel therapies for Alzheimer's disease by elucidating the molecular targets of neuroprotection conferred by the aqueous extracts of Bacopa monnieri or Centella asiatica.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Chemistry, Medicinal
Ravindran Vini, Vishnu Sunil Jaikumar, Viji Remadevi, Swathy Ravindran, Juberiya M. Azeez, Anjana Sasikumar, Shankar Sundaram, Sreeharshan Sreeja
Summary: 27-hydroxycholesterol (27-HC) is an endogenous selective estrogen receptor modulator (SERM) that has adverse effects on breast cancer. Pomegranate extract, which contains ellagitannins and ellagic acid, can compete with 27-HC. Urolithins, especially urolithin A (UA) and urolithin B (UB), derived from pomegranate, have antiproliferative and estrogenic activities, and UA can act as an antagonist to 27-HC in breast cancer cells, making it a potential SERM.
PHYTOTHERAPY RESEARCH
(2023)
Article
Medicine, Research & Experimental
Sara Soleimani Asl, Alireza Gharebaghi, Siamak Shahidi, Simin Afshar, Fereshte Kalhori, Kimia Amiri, Fatemeh Mirzaei
Summary: Preconditioning stem cells with deferoxamine before transplantation can enhance the neuroprotective effects of stem cells, increase antioxidant capacity, and improve cell homing efficiency.
Review
Cell Biology
Martin Picard, Orian S. Shirihai
Summary: Mitochondria, as living and dynamic organelles, play a crucial role in processing and transmitting signals to regulate cellular and organismal functions and adaptation. Understanding mitochondrial signal transduction is of great significance for studying mitochondrial biology and human health.
Article
Neurosciences
Nora E. Gray, Jonathan A. Zweig, Charles Murchison, Maya Caruso, Donald G. Matthews, Colleen Kawamoto, Christopher J. Harris, Joseph F. Quinn, Amala Soumyanath
NEUROSCIENCE LETTERS
(2017)
Article
Cell Biology
Nora E. Gray, Jonathan A. Zweig, Donald G. Matthews, Maya Caruso, Joseph F. Quinn, Amala Soumyanath
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2017)
Article
Behavioral Sciences
Nora E. Gray, Jonathan A. Zweig, Maya Caruso, Marjoen D. Martin, Jennifer Y. Zhu, Joseph F. Quinn, Amala Soumyanath
BRAIN AND BEHAVIOR
(2018)
Article
Neurosciences
Nora E. Gray, Jonathan A. Zweig, Maya Caruso, Jennifer Y. Zhu, Kirsten M. Wright, Joseph F. Quinn, Amala Soumyanath
MOLECULAR AND CELLULAR NEUROSCIENCE
(2018)
Article
Psychology, Clinical
Krista Specketer, Cyrus P. Zabetian, Karen L. Edwards, Lu Tian, Joseph F. Quinn, Amie L. Peterson-Hiller, Kathryn A. Chung, Shu-Ching Hu, Thomas J. Montine, Brenna A. Cholerton
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2019)
Article
Geriatrics & Gerontology
Jonathan A. Zweig, Maya Caruso, Mikah S. Brandes, Nora E. Gray
EXPERIMENTAL GERONTOLOGY
(2020)
Article
Genetics & Heredity
Christopher J. Harris, Brett A. Davis, Jonathan A. Zweig, Kimberly A. Nevonen, Joseph F. Quinn, Lucia Carbone, Nora E. Gray
FRONTIERS IN GENETICS
(2020)
Article
Pharmacology & Pharmacy
Kirsten M. Wright, Armando Alcazar Magana, Ronald M. Laethem, Caroline L. Moseley, Troy T. Banks, Claudia S. Maier, Jan F. Stevens, Joseph F. Quinn, Amala Soumyanath
DRUG METABOLISM AND DISPOSITION
(2020)
Article
Biochemistry & Molecular Biology
Lee E. Neilson, Joseph F. Quinn, Nora E. Gray
Summary: NRF2, a transcription factor critical in maintaining cellular redox balance, has been identified as a therapeutic target in various human diseases. PBMCs can serve as a convenient source of biomarkers to monitor NRF2 activation and disease progression in clinical trials, indicating their potential as exploratory markers for targeting NRF2 activation.
Article
Spectroscopy
Elena Ryzhikova, Nicole M. Ralbovsky, Vitali Sikirzhytski, Oleksandr Kazakov, Lenka Halamkova, Joseph Quinn, Earl A. Zimmerman, Igor K. Lednev
Summary: The current diagnostics for Alzheimer's disease relies on clinical assessments, imaging, and neuropsychological tests which are only efficient in the advanced stages of the disease. Early diagnosis of AD is crucial for preventive treatment and disease-modifying drug development. Cerebrospinal fluid (CSF) is the most promising body fluid for AD diagnostic test development due to its reflective changes associated with the disease. The novel method using NIR Raman spectroscopy combined with machine learning analysis shows potential for early AD detection with high sensitivity and specificity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Geriatrics & Gerontology
Jonathan A. Zweig, Mikah S. Brandes, Barbara H. Brumbach, Maya Caruso, Kirsten M. Wright, Joseph F. Quinn, Amala Soumyanath, Nora E. Gray
Summary: The study demonstrates that loss of NRF2 results in accelerated age-related cognitive decline and worsened mitochondrial deficits in aged mice. Long-term CAW treatment did not affect cognitive and mitochondrial function in NRF2KO mice, indicating that NRF2 is required for the cognitive enhancing effects of CAW during aging.
NEUROBIOLOGY OF AGING
(2021)
Article
Psychology, Clinical
Brenna A. Cholerton, Kathleen L. Poston, Laurice Yang, Liana S. Rosenthal, Ted M. Dawson, Alexander Pantelyat, Karen L. Edwards, Lu Tian, Joseph F. Quinn, Kathryn A. Chung, Amie L. Hiller, Shu-Ching Hu, Thomas J. Montine, Cyrus P. Zabetian
Summary: The study found that patients diagnosed with PD show significant decline in processing speed and semantic verbal fluency, even without evident cognitive impairment or dementia. This suggests that specific cognitive domains may experience subtle decline in PD patients, emphasizing the importance of early awareness of potential cognitive impacts in PD even in the absence of mild cognitive impairment or dementia.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2021)
Article
Medicine, Research & Experimental
Valerie C. Anderson, Ian J. Tagge, Aaron Doud, Xin Li, Charles S. Springer, Joseph F. Quinn, Jeffrey A. Kaye, Katherine Wild, William D. Rooney
Summary: Metabolic deficits at brain-fluid barriers, including reduced water efflux rate constant at the blood-cerebrospinal fluid barrier, are associated with cognitive decline in older adults. Significant associations were observed between water efflux rate constant and cognitive dysfunction, indicating a potential biomarker for cognitive impairment in later life.
Article
Biochemistry & Molecular Biology
Nathan Hwangbo, Xinyu Zhang, Daniel Raftery, Haiwei Gu, Shu-Ching Hu, Thomas J. Montine, Joseph F. Quinn, Kathryn A. Chung, Amie L. Hiller, Dongfang Wang, Qiang Fei, Lisa Bettcher, Cyrus P. Zabetian, Elaine R. Peskind, Ge Li, Daniel E. L. Promislow, Marie Y. Davis, Alexander Franks
Summary: Metabolomics has been utilized to analyze human cerebrospinal fluid samples and found strong separation between PD and AD patients and healthy controls in the metabolome. Key metabolites associated with PD and AD classification were identified, along with metabolic pathways linked to these neurodegenerative diseases.
Article
Clinical Neurology
Delaram Safarpour, Barbara H. Brumbach, Monica Arena, Joseph Quinn, Sarah Diamond, Jay G. Nutt, RonaldF. Pfeiffer
Summary: This study aimed to investigate whether altered segmental gastrointestinal transit time (GITT) correlates with clinical response and plasma levodopa concentration (PLC) variability in patients with Parkinson's disease. The results showed no significant difference in GITT between typical and erratic responders. Additionally, Small Intestinal Bacterial Overgrowth (SIBO) was positive in half of the erratic responders and negative in most typical responders.
MOVEMENT DISORDERS
(2022)