Article
Microbiology
Emily McKloud, Christopher Delaney, Leighann Sherry, Ryan Kean, Shanice Williams, Rebecca Metcalfe, Rachael Thomas, Riina Richardson, Konstantinos Gerasimidis, Christopher J. Nile, Craig Williams, Gordon Ramage
Summary: This study identified changes in vaginal microbiome in RVVC, showing a reduction in Lactobacillus crispatus and an increase in Lactobacillus iners. The presence of Candida albicans biofilm formation and interactions with Lactobacillus species were also highlighted, suggesting potential mechanisms for RVVC and the importance of understanding these interactions for developing effective therapies.
Article
Infectious Diseases
Rodrigo L. Fabri, Jhamine C. O. Freitas, Ari S. O. Lemos, Lara M. Campos, Irley O. M. Diniz, Nicolas C. C. Pinto, Thiago P. Silva, Cinthia Palazzi, Paula Marchesini, Caio Monteiro, Alan F. Barbosa, Mario G. Carvalho, Luciana M. Chedier, Marcelo G. F. Araujo, Ana Carolina M. Apolonio, Vinicius N. Rocha, Rossana C. N. Melo, Priscila F. Pinto
Summary: This study evaluated the antifungal activity of spilanthol against Candida albicans ATCC (R) 10231 (TM), a multidrug-resistant fungal strain. The findings showed that spilanthol(AcO) has the potential to be considered for the therapeutical treatment of vulvovaginal candidiasis caused by C. albicans.
Article
Public, Environmental & Occupational Health
Oluwatosin Goje, Ryan Sobel, Paul Nyirjesy, Steven R. R. Goldstein, Mark Spitzer, Brooke Faught, Shelagh Larson, Thomas King, Nkechi E. E. Azie, David Angulo, Jack D. D. Sobel
Summary: This study aimed to evaluate the effectiveness of Ibrexafungerp in different patient subgroups, and the results showed that this treatment had significant clinical cure and mycological cure rates for acute vulvovaginal candidiasis, and was not affected by race, BMI, baseline VSS score, and Candida species.
JOURNAL OF WOMENS HEALTH
(2023)
Article
Mycology
Qiuyu Pang, Weida Liu, Fan Cui, Siyue Kan, Xiaofang Li
Summary: This study investigated the genotypes and drug resistance of Candida albicans strains causing different conditions of vulvovaginal candidiasis (VVC). Results showed that C. albicans was the main pathogen of VVC, but non-albicans Candida (NAC) infection and mixed infection cases were increasing. Some C. albicans strains exhibited resistance to multiple drugs. The genotypes of RVVC and drug-resistant C. albicans strains were different from those of uncomplicated VVC. These findings have significant diagnostic and therapeutic implications for VVC.
Article
Microbiology
Jian Miao, Jessica Regan, Chun Cai, Glen E. Palmer, David L. Williams, Michael D. Kruppa, Brian M. Peters
Summary: This study characterizes the glycogen metabolism pathways in Candida albicans and shows that glycogen metabolism is important for the long-term survival and virulence of the fungus.
Article
Infectious Diseases
Aina Mesquida, Teresa Vicente, Elena Reigadas, Maria Palomo, Carlos Sanchez-Carrillo, Patricia Munoz, Jesus Guinea, Pilar Escribano
Summary: The study demonstrated that Ibrexafungerp has good in vitro activity against Candida albicans from vaginal samples, including isolates with reduced susceptibility to fluconazole. Population structure analysis revealed two genotype populations, with some genotypes showing reduced susceptibility to fluconazole.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Paul Vandecruys, Silke Baldewijns, Mart Sillen, Wouter Van Genechten, Patrick Van Dijck
Summary: Recurrent vulvovaginal candidiasis (RVVC) is a widespread condition that significantly impacts women's quality of life. The traditional maintenance treatment using fluconazole has limitations due to azole resistance and high recurrence rates. However, the introduction of oteseconazole (VT-1161) as a novel antifungal therapy shows promise in effectively managing RVVC with low recurrence rates.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Xiuyi Liang, Agata J. Pacula-Miszewska, Magdalena Obieziurska-Fabisiak, Richa Vartak, Ganming Mao, Ketankumar Patel, Natalya U. Fedosova, Jacek Scianowski, Blase Billack
Summary: In this study, a series of novel organoselenium compounds were evaluated for their antifungal activity. CHB4 and CHB6 exhibited strong inhibitory effects against Candida albicans and showed selectivity towards fungi. They also demonstrated low cytotoxicity and skin irritation. In a mouse model, CHB4 and CHB6 effectively reduced yeast colonization, alleviated mucosal injury, and decreased inflammatory response.
Article
Biochemistry & Molecular Biology
Lei Chen, Fei Wang, Su Qu, Xiaona He, Yongxin Zhu, Yi Zhou, Kunlong Yang, Yong-Xin Li, Man Liu, Xue Peng, Jun Tian
Summary: This study revealed that C. albicans infection increased the expression of NOX2 and the content of MDA. PAE restored the activity of antioxidant enzymes in the vagina and inhibited ROS accumulation through Keap1-Nrf2 pathway. PAE also inhibited apoptosis of vaginal cells via Caspase 9-Caspase 7-PARP pathway and prevented IL-1 beta release in VVC mice.
Article
Obstetrics & Gynecology
Ali Khaksar Baniasadi, Seyyed Amin Ayatollahi Mosavi, Iraj Sharifi, Mehdi Bamorovat, Samira Salari, Atefeh Ahmadi, Azam Amanizadeh, Setareh Agha Kuchak Afshari
Summary: This study examined the molecular identification and antifungal susceptibility profile of Candida species causing vulvovaginal candidiasis (VVC) in southeast Iran. The majority of VVC cases were found to be caused by non-albicans Candida species and exhibited resistance to certain antifungal drugs. The results highlight the importance of periodic epidemiological studies to monitor changes in species distribution and the need to evaluate the susceptibility profiles of Candida species isolated from VVC patients.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Infectious Diseases
Angela Fernandes, Nuno Azevedo, Andreia Valente, Marisol Dias, Ana Gomes, Cristina Nogueira-Silva, Mariana Henriques, Sonia Silva, Bruna Goncalves
Summary: This study highlights the importance of understanding the epidemiology, microbiology, antifungal susceptibility, and risk factors of VVC, in order to improve prevention and treatment strategies for this globally significant infection.
Article
Infectious Diseases
Xinzheng Li, Shi Chen, Xiangcai Lyu, Jiyun Tian
Summary: The virulence of strains from recurrent vulvovaginal candidiasis is stronger than that from vulvovaginal candidiasis and asymptomatic carrier, but the drug resistance rates are opposite. Virulence is one of the mechanisms of the relapse of RVVC, rather than drug resistance.
Article
Mycology
Siyue Kan, Nana Song, Qiuyu Pang, Huan Mei, Hailin Zheng, Dongmei Li, Fan Cui, Guixia Lv, Ruifang An, Ping Li, Zhengai Xiong, Shangrong Fan, Mengzhen Zhang, Yanhong Chen, Qiao Qiao, Xudong Liang, Manhua Cui, Dongyan Li, Qinping Liao, Xiaofang Li, Weida Liu
Summary: Vulvovaginal candidiasis is a global public health issue, and the optimal treatment for recurrent VVC has not been established. In vitro antifungal susceptibility profiling of VVC isolates from different regions of China can provide significant improvements for the control and treatment of this disease.
Review
Integrative & Complementary Medicine
Sun Fu-Juan, Li Min, Gu Liang, Wang Ming-Ling, Yang Ming-Hua
Summary: Candida is a difficult-to-eradicate life-threatening pathogen causing major morbidity and mortality in immunocompromised individuals. The rapid spread of drug-resistant fungi has highlighted the urgent need for new anti-Candida agents. Researchers have made important progress in discovering novel antifungal agents from nature to combat this medical challenge.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Review
Infectious Diseases
Martha F. Mushi, Ronald Olum, Felix Bongomin
Summary: The aim of this study was to comprehensively investigate the prevalence, antifungal susceptibility, and etiology of vulvovaginal candidiasis (VVC) in sub-Saharan Africa (SSA). The study found that approximately one-third of women in SSA have VVC, mainly caused by Candida albicans.
Article
Oncology
Hosein Rostamian, Mohammad Khakpoor-Koosheh, Leila Jafarzadeh, Elham Masoumi, Keyvan Fallah-Mehrjardi, Mohammad Javad Tavassolifar, John M. Pawelek, Hamid Reza Mirzaei, Jamshid Hadjati
Summary: Lactic acid produced by tumors can suppress the activation and function of T cells in the tumor microenvironment, while Dichloroacetate (DCA) can limit the tumor-derived lactic acid and improve T cell proliferation and cytokine production. Accumulation of lactic acid in the tumor microenvironment restricts T cell responses and DCA supports anti-tumor responses of T cells by metabolic reprogramming of tumor cells.
Article
Microbiology
Mahyar Keymaram, Mehraban Falahati, Shirin Farahyar, Ensieh Lotfali, Sara Abolghasemi, Shahram Mahmoudi, Fatemeh Sadeghi, Halala Khalandi, Reza Ghasemi, Sina Shamsaei, Omid Raiesi
Summary: Oral candidiasis, mainly caused by Candida albicans, is prevalent among hematologic malignancy patients. Eucalyptol, either alone or in combination with antifungal drugs, shows promising inhibitory activity against Candida biofilm formation.
ARCHIVES OF MICROBIOLOGY
(2022)
Correction
Microbiology
Mahyar Keymaram, Mehraban Falahati, Shirin Farahyar, Ensieh Lotfali, Sara Abolghasemi, Shahram Mahmoudi, Fatemeh Sadeghi, Halala Khalandi, Reza Ghasemi, Sina Shamsaei, Omid Raiesi
ARCHIVES OF MICROBIOLOGY
(2022)
Review
Mycology
Hasti Kamali Sarvestani, Amirreza Seifi, Mahsa Falahatinejad, Shahram Mahmoudi
Summary: Otomycosis is a fungal infection that primarily affects the external auditory canal. The main causes of this disease are Aspergillus species and Candida. Recent studies have shown that Aspergillus section Nigri comprises multiple morphologically similar species, and not all black Aspergillus isolates are Aspergillus niger.
JOURNAL DE MYCOLOGIE MEDICALE
(2022)
Article
Medical Laboratory Technology
Shima Aboutalebian, Shahram Mahmoudi, Arezoo Charsizadeh, Bahram Nikmanesh, Mahnaz Hosseini, Hossein Mirhendi
Summary: A new multiplex assay called YEAST PLEX is described in this study, which can rapidly and inexpensively identify pathogenic yeasts. The method shows high specificity, 100% agreement with PCR-sequencing/MALDI-TOF, and the ability to identify mixed yeast colonies.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Review
Dermatology
Alireza Izadi, Sanaz Aghaei Gharehbolagh, Fatemeh Sadeghi, Meysam Talebi, Kimia Darmiani, Ali Zarrinnia, Fateme Zarei, Fatemeh Peymaeei, Shaghayegh Khojasteh, Andrew M. Borman, Shahram Mahmoudi
Summary: Candida auris is a drug-resistant pathogen and finding alternative drugs through repurposing approaches would be clinically beneficial. A systematic search found several drugs/compounds that can inhibit both the planktonic and biofilm forms of C. auris.
Article
Immunology
Mohammad Soleimani, Alireza Izadi, Sadegh Khodavaisy, Claudy Oliveira dos Santos, Marlou C. C. Tehupeiory-Kooreman, Roshanak Daie Ghazvini, Seyed Jamal Hashemi, Seyed Amin Ayatollahi Mousavi, Farzad Aala, Mahsa Abdorahimi, Mehdi Aminizadeh, Zohre Abedinifar, Shahram Mahmoudi, Afsaneh Mohamadi, Sara Rezaie, Paul E. E. Verweij
Summary: This study aimed to investigate the clinical features and predisposing factors of fungal keratitis (FK) in Tehran, Iran. The fungal etiology of corneal ulcers was confirmed in 7.23% of cases, with Fusarium spp., Aspergillus spp., and Candida spp. being the predominant species. The study also found that different antifungal agents may be effective in treating FK caused by different fungal species.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Editorial Material
Immunology
Renato Kovacs, Shahram Mahmoudi
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Microbiology
Fereshteh Zarei, Shahram Mahmoudi, Azam Amanizadeh, Setareh Agha Kuchak Afshari
Summary: This article presents a rare case of nondermatophytic onychomycosis caused by Phoma glomerata in a 27-year-old Iranian female patient, emphasizing the importance of reliable laboratory identification for choosing appropriate treatment. It also provides a literature review on human infections caused by Phoma species.
REVIEWS AND RESEARCH IN MEDICAL MICROBIOLOGY
(2023)
Review
Infectious Diseases
Hasti Kamali Sarvestani, Bahram Ahmadi, Mohsen Gerami Shoar, Muhammad Getso, Zahra Rafat, Shahram Mahmoudi, Mahmoud Khansari, Faeze Salahshour, Ladan Fatahi, Mohammadreza Salehi, Saham Ansari
Summary: This article reports a case of A. flavus mycetoma in a 38-year-old male farmer with a history of type 2 diabetes mellitus. The importance of wearing footwear to prevent skin trauma as the main risk factor for patient involvement is emphasized.