Article
Pathology
Lijiang Wang, Supaporn Kulthinee, John Slate-Romano, Thomas Zhao, Hamsa Shanmugam, Patrycja M. Dubielecka, Ling X. Zhang, Gangjian Qin, Shougang Zhuang, Y. Eugene Chin, Ting C. Zhao
Summary: The study investigated the role of Integrin alpha v beta 5 in modulating the protective effect of Irisin during hemorrhage. It was found that Integrin alpha v beta 5 plays an important role in regulating Irisin's protective effect.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Minshu Li, Xiuping Li, Dan Wang, Xiaolin Gao, Shiyao Li, Xiaojing Cheng, Yiming Shen, Shenghui Li, Qiang Jia, Qiang Liu
Summary: Inhibition of exosome release exacerbates neuroinflammation and ICH injury by increasing leukocyte infiltration into the brain and barrier disruption. However, exosomes extracted from the ICH brain can reduce ICH injury in recipient mice, showing potential neuroprotective effects. Further investigation into the impact of exosomes released from the ICH brain on the immune system is warranted.
Review
Biochemistry & Molecular Biology
Ewa Brzozowska, Sameer Deshmukh
Summary: Integrins are crucial for cell adhesion, migration, and positioning. Studies have shown that the expression levels of Integrin αVβ6 are closely related to malignant diseases and patient prognosis. It plays a significant role in cancer progression and the activation of transforming growth factor β(TGF-β). While essential for normal function in healthy individuals, it can also be a target for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Travis C. Jackson, Kiersten Gorse, Jeremy R. Herrmann, Patrick M. Kochanek
Summary: New research has found that integrin-alpha V and integrin-beta 5 show different expression levels in human brain tissues across various age groups, while GFRAL protein is less expressed in the hippocampus and cortex. These findings suggest a potentially larger impact of irisin on the developing brain and implications for Zika virus infection in infants and young children.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Immunology
Siqi Xia, Yonghe Zheng, Feng Yan, Gao Chen
Summary: Intracerebral hemorrhage is the most common subtype of hemorrhagic stroke, with neuroinflammation being closely related to secondary brain injury and functional recovery. MicroRNAs have been found to play crucial roles in regulating the pathophysiological process of ICH, offering potential new directions for therapeutic interventions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Chaoran Xu, Huaijun Chen, Shengjun Zhou, Chenjun Sun, Xiaolong Xia, Yucong Peng, Jianfeng Zhuang, Xiongjie Fu, Hanhai Zeng, Hang Zhou, Yang Cao, Qian Yu, Yin Li, Libin Hu, Guoyang Zhou, Feng Yan, Gao Chen, Jianru Li
Summary: The pharmacological activation of RXR-alpha accelerates hematoma clearance, alleviates neurological dysfunction after ICH, and reduces neuroinflammation by repolarizing microglia/macrophages, indicating a promising therapeutic target for ICH.
NEUROSCIENCE BULLETIN
(2021)
Article
Nanoscience & Nanotechnology
Liu Zi, Wencheng Zhou, Jiake Xu, Junshu Li, Ning Li, Jianguo Xu, Chao You, Chengwei Wang, Meng Tian
Summary: This study developed rosuvastatin-loaded nanomicelles to target neuroinflammation in a mouse model of ICH, which significantly reduced neuron degeneration, inhibited inflammatory cell infiltration, reduced brain edema, and improved neurological deficits. The nanomicelles also promoted the polarization of microglia/macrophages to M2 phenotype and down-regulated proinflammatory cytokines while up-regulating anti-inflammatory cytokines, suggesting potential clinical application for promoting nerve functional recovery in ICH.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Wenjun Yan, Youhu Chen, Yongzhen Guo, Yunlong Xia, Congye Li, Yunhui Du, Chen Lin, Xiaoming Xu, Tingting Qi, Miaomiao Fan, Fuyang Zhang, Guangyu Hu, Erhe Gao, Rui Liu, Chunxu Hai, Ling Tao
Summary: Irisin pretreatment enhances the engraftment of adipose tissue-derived MSCs in the injured myocardium and improves their therapeutic effects for ischemic heart injury. The study identifies CSF2RB as a cytokine receptor that facilitates the chemotaxis of irisin-treated MSCs. Irisin pretreatment also reduces apoptosis and enhances the paracrine proangiogenic effect of MSCs through specific pathways and receptors. These findings provide compelling evidence for the optimization of intravenously delivered MSCs through irisin pretreatment as a therapy for ischemic heart injury.
Review
Immunology
Ruiyi Zhang, V. Wee Yong, Mengzhou Xue
Summary: Intracerebral hemorrhage (ICH) is a subtype of stroke with a poor prognosis. Despite numerous pre-clinical studies and clinical trials, effective treatment for ICH patients is still lacking. Minocycline, a neuroprotective pharmaceutical, shows promise in alleviating secondary brain injury after ICH. This review discusses the protective mechanisms, limitations, and clinical trial perspectives of minocycline in ICH, aiming to facilitate further research.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Neurosciences
Rentang Bi, Zhi Fang, Mingfeng You, Quanwei He, Bo Hu
Summary: Small glial cells play a crucial role in both tissue damage and repair processes after ICH, with the proportion of glial cell phenotypes determining the progression of brain tissue damage or repair.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Immunology
Yihao Chen, Shengpan Chen, Jianbo Chang, Junji Wei, Ming Feng, Renzhi Wang
Summary: PHE is considered a promising therapeutic target for ICH, but existing research results are conflicting. Therefore, it is necessary to classify, compare, and summarize existing studies on PHE.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jiachen Liu, Lirong Liu, Xiaoyu Wang, Rundong Jiang, Qinqin Bai, Gaiqing Wang
Summary: Research suggests that microglia may shift towards a pro-inflammatory phenotype following intracerebral hemorrhage, while anti-inflammatory microglia with neuroprotective effects are suppressed. Driving microglia towards an anti-inflammatory phenotype could potentially restrict inflammation and engulf cellular debris.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Geriatrics & Gerontology
Noah Watson, Frederick Bonsack, Sangeetha Sukumari-Ramesh
Summary: Intracerebral hemorrhage (ICH) is a severe type of stroke with high mortality and morbidity rates. Advanced age is a major risk factor for ICH, but the molecular changes in the aging brain after ICH are largely unknown. This limits the translation of preclinical studies into potential human treatments.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Immunology
Yang Wu, Qing Hu, Xiaoliang Wang, Hongbo Cheng, Jiegang Yu, Yang Li, Jianing Luo, Qingjiu Zhang, Jianliang Wu, Gengshen Zhang
Summary: Pterostilbene attenuates neuroinflammation and brain injury after intracerebral hemorrhage (ICH) in mice, potentially through regulating microglial mitochondrial dynamics.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Honglei Ren, Yan Pan, Danni Wang, Hongying Hao, Ranran Han, Caiyun Qi, Wenjun Zhang, Wenyan He, Fu-Dong Shi, Qiang Liu
Summary: The upregulation of CD22 in microglia plays a crucial role in intracerebral hemorrhage (ICH) and its blockade leads to reduced neurological deficits, brain lesion, and hematoma volume. CD22 blockade enhances the phagocytosis activity and alternative activation markers in microglia after ICH. Its protective effects are dependent on microglial activity and the involvement of SYK pathway.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Peng-Fei Zhang, Xu Pei, Ke-Sang Li, Li-Na Jin, Fei Wang, Jing Wu, Xue-Mei Zhang
Article
Cardiac & Cardiovascular Systems
Xu Pei, Shu-Qiang Zhu, Xiang Long, Bai-Quan Qiu, Kun Lin, Feng Lu, Jian-Jun Xu, Yong-Bing Wu
HEART LUNG AND CIRCULATION
(2020)
Article
Cell Biology
Xu Pei, Shi-Wei Chen, Xiang Long, Shu-Qiang Zhu, Bai-Quan Qiu, Kun Lin, Feng Lu, Jian-Jun Xu, Peng-Fei Zhang, Yong -Bing Wu
Article
Biochemistry & Molecular Biology
Shi-Wei Chen, Shu-Qiang Zhu, Xu Pei, Bai-Quan Qiu, Dian Xiong, Xiang Long, Kun Lin, Feng Lu, Jian-Jun Xu, Yong-Bing Wu
Summary: In human non-small cell lung cancer (NSCLC) tissues, high expression levels of circUSP7 are associated with poor clinical prognosis and dysfunction of CD8(+) T cells. CircUSP7 found in NSCLC patient plasma is mainly secreted by NSCLC cells via exosomes, inhibiting CD8(+) T cell function by upregulating SHP2 expression. Additionally, circUSP7 may contribute to resistance to anti-PD1 immunotherapy in NSCLC patients.
Article
Oncology
Xu-Dong Ye, Bai-Quan Qiu, Dian Xiong, Xu Pei, Na Jie, Hua Xu, Shu-Qiang Zhu, Xiang Long, Zheng Xu, Hai-Bo Wu, Jian-Jun Xu, You-Sheng Huang, Yong-Bing Wu