Review
Neurosciences
Rimi Hazra, Enrico M. M. Novelli, Xiaoming Hu
Summary: In ischemic brain, lack of oxygen causes mitochondrial dysfunction, limited energy production, and activation of astrocytes. However, most studies on mitochondrial dysfunction in cerebral ischemia have focused on neurons. This review emphasizes the importance of the diverse morphology, molecules, and functions of astrocytes in their role in brain injuries, and explores how activated astrocytes exhibit calcium imbalance, excessive reactive oxygen species, and apoptosis. Additionally, it specifically focuses on the role of mitochondrial protein frataxin in activated astrocytes during ischemia and its potential role in the pharmacological management of cerebral ischemia.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Ana Dunatov Huljev, Nela Kelam, Benjamin Benzon, Violeta Soljic, Natalija Filipovic, Valdi Pesutic Pisac, Merica Glavina Durdov, Katarina Vukojevic
Summary: Clear cell renal cell carcinoma (ccRCC) is the deadliest neoplasm of the urinary tract. The expression of Sonic Hedgehog (SHH) was found to be higher in grade 1 tumors and decreased with tumor progression. PTCH expression was lower in grades 1 and 2 compared to the control and grade 4, while SMO expression was higher in grade 4 than in other grades and the control. High PTCH and low SMO expression were associated with better survival rates in ccRCC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Developmental Biology
Wenguang Yin, Andreas Liontos, Janine Koepke, Maroua Ghoul, Luciana Mazzocchi, Xinyuan Liu, Chunyan Lu, Haoyu Wu, Athanasios Fysikopoulos, Alexandros Sountoulidis, Werner Seeger, Clemens Ruppert, Andreas Gunther, Didier Y. R. Stainier, Christos Samakovlis
Summary: The tracheal epithelium is a crucial element in pulmonary diseases, and its understanding of cell proliferation and differentiation is limited. The Hedgehog (HH) signaling pathway plays a role in communication between epithelial and mesenchymal cells in the lung, affecting stromal cell proliferation, differentiation, and epithelial signaling. This study discovered an autocrine HH signaling function in airway epithelial cells, with its inhibition leading to defects in cell proliferation and differentiation. Additionally, HH function is mediated by transcriptional activation, as inhibition of HH signaling downregulates cell type-specific transcription factor genes in both mouse trachea and human airway epithelial cells. These findings provide new insights into the role of HH signaling in epithelial cell proliferation and differentiation during airway development.
Article
Neurosciences
Dexu Sun, Jiaxin Deng, Yifan Wang, Jinyu Xie, Xiaocui Li, Xiangyang Li, Xiaotian Wang, Feng Zhou, Suping Qin, Xiaomei Liu
Summary: Anxiety, a prevalent and disabling psychiatric disorder, is associated with mitochondrial dysfunction caused by a high-fat diet. This study investigates the protective role of the Sonic hedgehog (SHH) signaling pathway in anxiety through regulation of mitochondrial homeostasis. The administration of a SHH signaling agonist, SAG, effectively decreased anxiety-like behavior in high-fat diet-fed mice by rectifying the imbalanced expression of Mfn2 and Drp1 and alleviating mitochondrial fragmentation. These findings suggest that SHH signal is neuroprotective in obesity and can relieve anxiety-like behavior through reducing mitochondrial fragmentation.
BRAIN RESEARCH BULLETIN
(2023)
Review
Cell Biology
Wanchen Wang, Ryo Shiraishi, Daisuke Kawauchi
Summary: The sonic hedgehog (SHH) pathway plays a crucial role in regulating the development of the central nervous system in vertebrates, and aberrant regulation can lead to neurodevelopmental diseases and brain tumors. Research on the mechanisms of SHH in the cerebellum has shed light on structural abnormalities and medulloblastoma, with current clinical trials exploring novel therapeutic approaches.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Diana C. Yanez, Eleftheria Papaioannou, Mira M. Chawda, Jasmine Rowell, Susan Ross, Ching-In Lau, Tessa Crompton
Summary: Pharmacological inhibition of smoothened reduces Th2 cell infiltration and alleviates the severity of allergic asthma by decreasing the induction of Shh, IL-4, and IL-13, as well as lowering serum IgE levels and expression of inflammation-related genes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Alexia Tiberi, Nicola Maria Carucci, Giovanna Testa, Caterina Rizzi, Paola Pacifico, Giulia Borgonovo, Ivan Arisi, Mara D'Onofrio, Rossella Brandi, Wen-Biao Gan, Simona Capsoni, Antonino Cattaneo
Summary: Nerve growth factor (NGF) has been shown to have a critical role in neuronal physiology. However, this study reveals that astrocytes in the central nervous system are also affected by changes in NGF levels, leading to astrocytic atrophy and proinflammatory responses. Additionally, inhibition of NGF leads to increased calcium activity in layer I astrocytes, which can be reversed by acute administration of NGF.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biology
Rachana Deven Somaiya, Katelyn Stebbins, Ellen C. Gingrich, Hehuang Xie, John N. Campbell, A. Denise R. Garcia, Michael A. Fox
Summary: Axons of retinal ganglion cells induce astrocytes in the visual thalamus to generate Fgf15, which influences the migration of interneurons. The release of SHH from retinal axons is crucial for the recruitment of interneurons.
Article
Pediatrics
Vien Nguyen, Manideep Chavali, Amara Larpthaveesarp, Srikirti Kodali, Ginez Gonzalez, Robin J. M. Franklin, David H. Rowitch, Fernando Gonzalez
Summary: The Sonic hedgehog agonist SAG demonstrated neuroprotective effects in neonatal stroke and adult white matter injury, reducing brain damage and improving long-term behavioral outcomes. This study expands the potential use of Sonic hedgehog in treating developing brain injury, adding to previous research in models of Down syndrome and cerebellar injury.
PEDIATRIC RESEARCH
(2021)
Review
Oncology
Hongping Wang, Qun Lai, Dayong Wang, Jian Pei, Baogang Tian, Yunhe Gao, Zhaoguo Gao, Xiang Xu
Summary: This study reviewed the role of the HH signaling pathway in the occurrence and progression of GBM, as well as the effectiveness of drugs that target the HH pathway. The findings highlight the key role of HH signaling in the occurrence, development, and treatment of GBM.
Article
Cell Biology
Yan Guo, Di Wu, QingJian Xu, Weihui Chen
Summary: The mandible is an important part of the craniofacial skeleton and its development involves multiple signaling pathways. The function of the hedgehog signaling pathway is crucial for mandibular development.
Article
Cell Biology
Yuqing Wang, Shanshan Lu, Yifei Chen, Liang Li, Xia Li, Zhongwei Qu, Junbo Huang, Liu Fan, Chao Yuan, Nan Song, Jun Zhang, Wendong Xu, Shenglian Yang, Yizheng Wang
Summary: The study demonstrated that the SHH-SMO-GLT-1 pathway can control extracellular glutamate and reduce ischemic brain damage by inhibiting SMO. It was found that under ischemic conditions, regulating the SHH-SMO-GLT-1 pathway can decrease the release of extracellular glutamate, thereby protecting neurons.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Environmental Sciences
Kuan Liu, Zhiqi Liu, Zhuofan Liu, Zhuo Ma, Yunfei Jia, Yu Deng, Wei Liu, Bin Xu
Summary: This study found that manganese poisoning can cause impairment of mitochondrial biogenesis. Further investigation revealed that S-nitrosylation of PINK1 and subsequent ZNF746 protein degradation are crucial signaling processes involved in the impairment of mitochondrial biogenesis caused by manganese poisoning.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Ophthalmology
Jing-Yu Qu, Yu-Ting Xiao, Ying-Ying Zhang, Hua-Tao Xie, Ming-Chang Zhang
Summary: The Hedgehog signaling pathway plays an important role in regulating proliferation and differentiation of RMGECs, potentially offering a therapeutic approach for treating meibomian gland dysfunction (MGD).
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Environmental Sciences
Hong Cheng, Bobo Yang, Tao Ke, Shaojun Li, Xiaobo Yang, Michael Aschner, Pan Chen
Summary: Metals play important roles in physiological activities, but metal overload can lead to neurotoxicity by increasing reactive oxygen species and oxidative stress. Mitochondria, crucial for energy production, are major targets of metal toxicity, and dysfunction can disrupt brain function, causing neuronal cell death and neurological disorders.
Article
Neurosciences
Frida Loria, Javier Diaz-Nido
NEUROBIOLOGY OF DISEASE
(2015)
Article
Biochemistry & Molecular Biology
Saida Abounit, Luc Bousset, Frida Loria, Seng Zhu, Fabrice de Chaumont, Laura Pieri, Jean-Christophe Olivo-Marin, Ronald Melki, Chiara Zurzolo
Article
Biotechnology & Applied Microbiology
Yurika Katsu-Jimenez, Frida Loria, Juan Carlos Corona, Javier Diaz-Nido
Article
Immunology
Fernando Correa, Miriam Hernangomez-Herrero, Leyre Mestre, Frida Loria, Fabian Docagne, Carmen Guaza
BRAIN BEHAVIOR AND IMMUNITY
(2011)
Article
Neurosciences
Miriam Hernangomez, Leyre Mestre, Fernando G. Correa, Frida Loria, Miriam Mecha, Paula M. Inigo, Fabian Docagne, Richard O. Williams, Jose Borrell, Carmen Guaza
Article
Immunology
Leyre Mestre, Paula M. Inigo, Miriam Mecha, Fernando G. Correa, Miriam Hernangomez-Herrero, Frida Loria, Fabian Docagne, Jose Borrell, Carmen Guaza
JOURNAL OF NEUROINFLAMMATION
(2011)
Article
Neurosciences
F. Loria, S. Petrosino, M. Hernangomez, L. Mestre, A. Spagnolo, F. Correa, V. Di Marzo, F. Docagne, C. Guaza
NEUROBIOLOGY OF DISEASE
(2010)
Article
Neurosciences
Miguel Moreno-Martet, Leyre Mestre, Frida Loria, Carmen Guaza, Javier Fernandez-Ruiz, Eva de Lago
NEUROSCIENCE LETTERS
(2012)
Article
Biochemistry & Molecular Biology
Jessica Y. Vargas, Frida Loria, Yuan-Ju Wu, Gonzalo Cordova, Takashi Nonaka, Sebastien Bellow, Sylvie Syan, Masato Hasegawa, Geeske M. van Woerden, Capucine Trollet, Chiara Zurzolo
Article
Biochemistry & Molecular Biology
Sara Perez-Luz, Frida Loria, Yurika Katsu-Jimenez, Daniel Oberdoerfer, Oscar-Li Yang, Filip Lim, Jose Luis Munoz-Blanco, Javier Diaz-Nido
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Pharmacology & Pharmacy
Andres Vicente-Acosta, Maria Ceprian, Pilar Sobrino, Maria Ruth Pazos, Frida Loria
Summary: Stroke is a major cause of death and neurological damage, and glial cells have emerged as potential therapeutic targets for improving brain recovery in ischemic stroke. The pharmacological modulation of the endocannabinoid system in these cells has shown promising neuroprotective effects in various neurological diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Frida Loria, Jessica Y. Vargas, Luc Bousset, Sylvie Syan, Audrey Salles, Ronald Melki, Chiara Zurzolo
ACTA NEUROPATHOLOGICA
(2017)
Article
Pharmacology & Pharmacy
Miriam Hernangomez, Francisco J. Carrillo-Salinas, Miriam Mecha, Fernando Correa, Leyre Mestre, Frida Loria, Ana Feliu, Fabian Docagne, Carmen Guaza
CURRENT PHARMACEUTICAL DESIGN
(2014)