Structure–Activity Relationships of 8-Hydroxyquinoline-Derived Mannich Bases with Tertiary Amines Targeting Multidrug-Resistant Cancer
出版年份 2022 全文链接
标题
Structure–Activity Relationships of 8-Hydroxyquinoline-Derived Mannich Bases with Tertiary Amines Targeting Multidrug-Resistant Cancer
作者
关键词
-
出版物
JOURNAL OF MEDICINAL CHEMISTRY
Volume -, Issue -, Pages -
出版商
American Chemical Society (ACS)
发表日期
2022-05-26
DOI
10.1021/acs.jmedchem.2c00076
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Relation of Metal-Binding Property and Selective Toxicity of 8-Hydroxyquinoline Derived Mannich Bases Targeting Multidrug Resistant Cancer Cells
- (2021) Veronika F.S. Pape et al. Cancers
- Insights of 8-hydroxyquinolines: A novel target in medicinal chemistry
- (2021) Rohini Gupta et al. BIOORGANIC CHEMISTRY
- Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines
- (2020) Haythem A. Saadeh et al. MOLECULES
- Identification of anticancer OATP2B1 substrates by an in vitro triple-fluorescence-based cytotoxicity screen
- (2019) Tímea Windt et al. ARCHIVES OF TOXICOLOGY
- 8‐Hydroxyquinoline‐2‐Carboxanilides as Antiviral Agents Against Avian Influenza Virus
- (2019) Jiri Kos et al. ChemistrySelect
- Design, synthesis and preliminary bioactivity evaluations of 8-hydroxyquinoline derivatives as matrix metalloproteinase (MMP) inhibitors
- (2019) Chen Chen et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Unshielding Multidrug Resistant Cancer through Selective Iron Depletion of P-Glycoprotein–Expressing Cells
- (2019) Mihály Cserepes et al. CANCER RESEARCH
- Anticancer Thiosemicarbazones: Chemical Properties, Interaction with Iron Metabolism, and Resistance Development
- (2018) Petra Heffeter et al. ANTIOXIDANTS & REDOX SIGNALING
- Synthesis of 8-hydroxyquinoline glycoconjugates and preliminary assay of their β1,4-GalT inhibitory and anti-cancer properties
- (2018) Monika Krawczyk et al. BIOORGANIC CHEMISTRY
- Design, synthesis and biological evaluation of thiosemicarbazones, hydrazinobenzothiazoles and arylhydrazones as anticancer agents with a potential to overcome multidrug resistance
- (2016) Veronika F.S. Pape et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- 8-Hydroxyquinolines in medicinal chemistry: A structural perspective
- (2016) Valentina Oliveri et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Cancer chemoresistance; biochemical and molecular aspects: a brief overview
- (2016) Saeed Kachalaki et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Identification and Validation of Compounds Selectively Killing Resistant Cancer: Delineating Cell Line–Specific Effects from P-Glycoprotein–Induced Toxicity
- (2016) András Füredi et al. MOLECULAR CANCER THERAPEUTICS
- Acquired Resistance to Clinical Cancer Therapy: A Twist in Physiological Signaling
- (2016) Andreas Wicki et al. PHYSIOLOGICAL REVIEWS
- Mechanisms of tumor cell resistance to the current targeted-therapy agents
- (2016) Gholamreza Khamisipour et al. TUMOR BIOLOGY
- Mannich bases in medicinal chemistry and drug design
- (2015) Gheorghe Roman EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- 8-Hydroxyquinoline: a privileged structure with a broad-ranging pharmacological potential
- (2015) Yu'ning Song et al. MedChemComm
- Targeting the Achilles Heel of Multidrug-Resistant Cancer by Exploiting the Fitness Cost of Resistance
- (2014) Gergely Szakács et al. CHEMICAL REVIEWS
- Chemistry: Chemical con artists foil drug discovery
- (2014) Jonathan Baell et al. NATURE
- 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation
- (2013) Richard J. Hopkinson et al. Chemical Science
- Reversal of ATP-binding cassette drug transporter activity to modulate chemoresistance: why has it failed to provide clinical benefit?
- (2012) Man Yu et al. CANCER AND METASTASIS REVIEWS
- CellMiner: A Web-Based Suite of Genomic and Pharmacologic Tools to Explore Transcript and Drug Patterns in the NCI-60 Cell Line Set
- (2012) W. C. Reinhold et al. CANCER RESEARCH
- Gluconjugates of 8-hydroxyquinolines as potential anti-cancer prodrugs
- (2012) Valentina Oliveri et al. DALTON TRANSACTIONS
- Collateral sensitivity as a strategy against cancer multidrug resistance
- (2012) Kristen M. Pluchino et al. DRUG RESISTANCE UPDATES
- Targeting MDR in breast and lung cancer: Discriminating its potential importance from the failure of drug resistance reversal studies
- (2012) Laleh Amiri-Kordestani et al. DRUG RESISTANCE UPDATES
- Investigational ABC transporter inhibitors
- (2012) Marco Falasca et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Modern Phenotypic Drug Discovery Is a Viable, Neoclassic Pharma Strategy
- (2012) Jonathan A. Lee et al. JOURNAL OF MEDICINAL CHEMISTRY
- Circumventing Cancer Drug Resistance in the Era of Personalized Medicine
- (2012) Levi A. Garraway et al. Cancer Discovery
- Cancer drug pan-resistance: pumps, cancer stem cells, quiescence, epithelial to mesenchymal transition, blocked cell death pathways, persisters or what?
- (2012) P. Borst Open Biology
- The controversial role of ABC transporters in clinical oncology
- (2011) Akina Tamaki et al. Essays in Biochemistry
- Linear free energy relationships for metal–ligand complexation: Bidentate binding to negatively-charged oxygen donor atoms
- (2011) Richard F. Carbonaro et al. GEOCHIMICA ET COSMOCHIMICA ACTA
- Synthesis and Structure–Activity Evaluation of Isatin-β-thiosemicarbazones with Improved Selective Activity toward Multidrug-Resistant Cells Expressing P-Glycoprotein
- (2011) Matthew D. Hall et al. JOURNAL OF MEDICINAL CHEMISTRY
- Utilization of an In Vivo Reporter for High Throughput Identification of Branched Small Molecule Regulators of Hypoxic Adaptation
- (2010) Natalya A. Smirnova et al. CHEMISTRY & BIOLOGY
- Synthesis and structure-activity relationship study of 8-hydroxyquinoline-derived Mannich bases as anticancer agents
- (2010) Arthur Y. Shaw et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
- (2010) Jonathan B. Baell et al. JOURNAL OF MEDICINAL CHEMISTRY
- Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors
- (2010) Oliver N. F. King et al. PLoS One
- Regioselectivity in isoquinoline alkaloid synthesis
- (2010) Rodolfo Quevedo et al. TETRAHEDRON LETTERS
- Identification of Compounds Selectively Killing Multidrug-Resistant Cancer Cells
- (2009) D. Turk et al. CANCER RESEARCH
- Synthesis, Activity, and Pharmacophore Development for Isatin-β-thiosemicarbazones with Selective Activity toward Multidrug-Resistant Cells
- (2009) Matthew D. Hall et al. JOURNAL OF MEDICINAL CHEMISTRY
- Is resistance useless? Multidrug resistance and collateral sensitivity
- (2009) Matthew D. Hall et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ
- (2008) Paul A. Adlard et al. NEURON
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started