Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors

Progress toward B-Cell Lymphoma 6 BTB Domain Inhibitors for the Treatment of Diffuse Large B-Cell Lymphoma and Beyond

(2021) Yong Ai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket

(2021) Matthew G. Lloyd et al.   JOURNAL OF MEDICINAL CHEMISTRY

Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders

(2020) Benjamin R. Bellenie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Germinal center‐derived lymphomas: The darkest side of humoral immunity

(2019) Coraline Mlynarczyk et al.   IMMUNOLOGICAL REVIEWS

Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations

(2018) Robert J. Young et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design

(2018) Huimin Cheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Transcriptional Regulation of Germinal Center Formation

(2018) Shuang Song et al.   Frontiers in Immunology

Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6

(2018) William McCoull et al.   ACS Chemical Biology

Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors

(2017) William McCoull et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a B-Cell Lymphoma 6 Protein–Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach

(2017) Yusuke Kamada et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6

(2017) Nina Kerres et al.   Cell Reports

Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma

(2016) Mariano G. Cardenas et al.   JOURNAL OF CLINICAL INVESTIGATION

Roles of BCL6 in normal and transformed germinal center B cells

(2012) Katia Basso et al.   IMMUNOLOGICAL REVIEWS

Tautomer Enumeration and Stability Prediction for Virtual Screening on Large Chemical Databases

(2009) Francesca Milletti et al.   Journal of Chemical Information and Modeling

Microwave-assisted Aromatic C–O Bond Formation: A Rapid and Efficient Method for the Synthesis of Aryl Ethers

(2008) Boyan Xu et al.   CHEMISTRY LETTERS

Structure of a BCOR Corepressor Peptide in Complex with the BCL6 BTB Domain Dimer

(2008) Alexandru F. Ghetu et al.   MOLECULAR CELL