What Is Ne, Anyway?

Few doubt that effective population size (N-e) is one of the most important parameters in evolutionary biology, but how many can say they really understand the concept? N-e is the evolutionary analog of the number of individuals (or adults) in the population, N. Whereas ecological consequences of population size depend on N, evolutionary consequences (rates of loss of genetic diversity and increase in inbreeding; relative effectiveness of selection) depend on N-e. Formal definitions typically relate effective size to a key population genetic parameter, such as loss of heterozygosity or variance in allele frequency. However, for practical application to real populations, it is more useful to define N-e in terms of 3 demographic parameters: number of potential parents (adult N), and mean and variance in offspring number. Defined this way, N-e determines the rate of random genetic drift across the entire genome in the offspring generation. Other evolutionary forces (mutation, migration, selection)-together with factors such as variation in recombination rate-can also affect genetic variation, and this leads to heterogeneity across the genome in observed rates of genetic change. For some, it has been convenient to interpret this heterogeneity in terms of heterogeneity in N-e, but unfortunately, this has muddled the concepts of genetic drift and effective population size. A commonly repeated misconception is that N-e is the number of parents that actually contribute genes to the next generation (N-P). In reality, N-P can be smaller or larger than N-e, and the N-P/N-e ratio depends on the sex ratio, the mean and variance in offspring number, and whether inbreeding or variance N-e is of interest.

Automated summary

Effective population size (N-e) is a crucial parameter in evolutionary biology, influencing rates of loss of genetic diversity, increase in inbreeding, and the effectiveness of selection. N-e is typically defined in relation to key population genetic parameters, but a more practical definition involves demographic parameters such as the number of potential parents, mean, and variance in offspring number. N-e determines the rate of genetic drift in the offspring generation.