Article
Biochemistry & Molecular Biology
Chun-Hung Chiu, Ming-Yao Chen, Jun-Jie Lieu, Chin-Chu Chen, Chun-Chao Chang, Charng-Cherng Chyau, Robert Y. Peng
Summary: Styrylpyrone-enriched extract (SPEE) from Phellinus linteus can ameliorate lipid accumulation, decrease inflammation and oxidative stress through the activation of SIRT1/AMPK/PGC1-alpha pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Bhavimani Guru, Akhilesh K. Tamrakar, S. N. Manjula, B. R. Prashantha Kumar
Summary: Insulin resistance is a characteristic of type 2 diabetes, closely associated with non-alcoholic fatty liver disease. Novel dual PPAR alpha/gamma agonists G4 and G5 have shown promising results in improving insulin sensitivity, lipid metabolism, and reducing side effects, offering potential for the treatment of NAFLD and insulin resistance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jingyi Luo, Pengbo Sun, Yangyang Wang, Yang Chen, Yaoyun Niu, Yipei Ding, Naihan Xu, Yaou Zhang, Weidong Xie
Summary: The study found that DAPA significantly suppressed fat accumulation in liver tissues of mice and cells, and regulated the expression levels of proteins related to lipid synthesis and genes associated with fatty acid oxidation. Moreover, DAPA activated AMPK phosphorylation and inhibited mTOR phosphorylation, ameliorating hepatic steatosis through the AMPK/mTOR pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jun H. Heo, Sang R. Lee, Seong Lae Jo, Je-Won Ko, Hyo-Jung Kwon, Eui-Ju Hong
Summary: The incidence of non-alcoholic fatty liver disease (NAFLD) increases in males aged >45 years, which indicates that androgens are associated with the development and/or progression of NAFLD, although excess dietary intake is the primary causative factor. Our study demonstrates that testosterone can influence the development of NAFLD by increasing the expression of AMP-activated protein kinase (AMPK) and LKB1 and modulating the AMPK-ACC signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Medicinal
Navid Omidkhoda, Sina Mahdiani, A. Wallace Hayes, Gholamreza Karimi
Summary: This article summarizes in vitro and in vivo studies on the effect of natural bioactive compounds on NAFLD through the LKB1/AMPK signaling pathway, providing clues for finding new therapeutic agents for NAFLD management.
PHYTOTHERAPY RESEARCH
(2023)
Review
Medicine, Research & Experimental
Liwei Wu, Jingjing Li, Jiao Feng, Jie Ji, Qiang Yu, Yan Li, Yuanyuan Zheng, Weiqi Dai, Jianye Wu, Chuanyong Guo
Summary: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder in both China and worldwide, posing a significant health burden to society. The microbiota and PPARs play crucial roles in the development of NAFLD, offering important insights for prevention and treatment strategies.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Rongrong Li, Yuqi Li, Xueling Yang, Yaorui Hu, Haining Yu, Yana Li
Summary: This study found that VEGFB can participate in lipid metabolism and insulin resistance in NAFLD through the AMPK signaling pathway, further confirming the importance of VEGFB in the pathogenesis of fatty liver disease.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Liuran Li, Qinghua Li, Wenbin Huang, Yibing Han, Huiting Tan, Min An, Qianru Xiang, Rui Zhou, Li Yang, Yanzhen Cheng
Summary: The study showed that dapagliflozin can alleviate hepatocyte steatosis by reducing lipogenic enzyme, inducing fatty acid oxidation enzyme, and autophagy, which may be associated with AMPK activation. The results also indicate that dapagliflozin induces autophagy via the AMPK-mTOR pathway, revealing a novel clinical application and functional mechanism in the treatment of NAFLD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Yaxu Liang, Zhen Zhang, Jiayu Tu, Zhibo Wang, Xiaoxiao Gao, Kaiping Deng, M. A. El-Samahy, Peihua You, Yixuan Fan, Feng Wang
Summary: The study revealed that GLA can protect AML-12 cells from lipid metabolism disorder caused by PA by balancing autophagy and apoptosis mediated by the LKB1-AMPK-mTOR pathway, thus preventing and treating NAFLD.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Fangfang Tie, Jin Ding, Na Hu, Qi Dong, Zhi Chen, Honglun Wang
Summary: Kaempferol and kaempferide were found to attenuate lipid accumulation and oxidative stress in HepG2 cells through regulating the expression of lipogenesis-related proteins and adipogenic transcription factors, as well as reducing the expression of heme oxygenase-1. This suggests that these natural compounds may have potential therapeutic benefits for treating NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Bart Staels, Laura Butruille, Sven Francque
Summary: The pathophysiology of non-alcoholic steatohepatitis (NASH) involves various metabolic, inflammatory, vascular, and fibrogenic pathways. Peroxisome proliferator-activated receptors (PPARs) play a significant role in regulating NASH development.
JOURNAL OF HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Peng Cao, Yi Wang, Cong Zhang, Mitchell A. Sullivan, Wen Chen, Xiang Jing, Huifan Yu, Fei Li, Qu Wang, Zhongshi Zhou, Qi Wang, Wen Tian, Zhenpeng Qiu, Lianxiang Luo
Summary: This study aims to further elucidate the potential mechanism of action of quercetin in alleviating nonalcoholic fatty liver disease (NAFLD). It was found that quercetin prevents NAFLD through AMPK-mediated mitophagy, suggesting that promoting mitophagy via an upregulation of AMPK may be a promising therapeutic strategy against NAFLD.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Seung Yeon Park, Hyun Jung Lee, Jin-Ho Song, Yong Kyoo Shin, A. M. Abd El-Aty, Amer Ramadan, A. Hacimuftuoglu, Ji Hoon Jeong, Tae Woo Jung
Summary: In summary, DITA treatment attenuated palmitate-induced impairment of insulin signaling and inflammation in C2C12 myocytes by enhancing AMPK phosphorylation, PPAR delta expression, and FGF21 secretion. This study suggests that targeting the AMPK/FGF21/PPAR delta pathway may alleviate insulin resistance in skeletal muscle cells.
Article
Multidisciplinary Sciences
Eric M. Desjardins, Brennan K. Smith, Emily A. Day, Serge Ducommun, Matthew J. Sanders, Joshua P. Nederveen, Rebecca J. Ford, Stephen L. Pinkosky, Logan K. Townsend, Robert M. Gutgesell, Rachel Lu, Kei Sakamoto, Gregory R. Steinberg
Summary: This study demonstrates the important physiological role of AMPK ss 1 Ser108 phosphorylation in promoting fatty acid oxidation, mitochondrial biogenesis, and autophagy under conditions of high lipid availability.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Tomomi Yamazaki, Megumi Ihato
Summary: PPAR-alpha prevents fatty liver caused by excessive sucrose intake through regulating SREBP-1c target gene expression and liver TG accumulation. Gender differences may be related to the expression level of PPAR-gamma.
Review
Biochemistry & Molecular Biology
C. R. Sruthi, K. G. Raghu
Summary: The critical roles of advanced glycation endproducts (AGEs) in diabetes and diabetic complications have been widely recognized, with various adverse effects on organ functions. Autophagy, a cellular process that maintains homeostasis, may serve as a potential therapeutic strategy against AGEs-induced problems.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
C. R. Sruthi, K. G. Raghu
Summary: This study reveals the potential of methylglyoxal (MGO) in promoting cancer in HepG2 cells through the Warburg effect and glycation. MGO reduces the expression of GLO 1 and GLO 2, weakening the innate detoxification system, and increases the expression of RAGE and AGEs. Additionally, MGO induces hypoxia, surplus reactive oxygen species (ROS), and enhances glycolysis. The upregulation of HIF-1α further promotes cancer development.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)