Review
Cell Biology
Kyu Hwan Kwack, Hyeon-Woo Lee
Summary: Dental caries is a common disease that causes damage to teeth and pulp tissue. Dental pulp stem cells have multipotency, high proliferation rate, and immunosuppressive properties, making them ideal for regenerating damaged pulp tissue.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sahng G. Kim
Summary: Despite the recent surge in studies on dental pulp regeneration using tissue engineering strategies, the translation of these findings into therapeutic applications remains a challenge. This scoping review systematically reviewed the efficacy of mesenchymal stem cell transplantation for dental pulp regeneration, showing potential for vascularized pulp-like tissue regeneration and successful regeneration of vital tissue in clinical trials. More high-quality studies are needed to further evaluate the safety and efficacy of stem cell transplantation for dental pulp regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Giulia Brunello, Federica Zanotti, Martina Trentini, Ilaria Zanolla, Elham Pishavar, Vittorio Favero, Riccardo Favero, Lorenzo Favero, Eriberto Bressan, Massimo Bonora, Stefano Sivolella, Barbara Zavan
Summary: This study found that EXOs derived from dental pulp stem cells of different age donors have varying effects on MSCs. The younger donor group showed a more significant influence on proliferation and commitment ability.
Review
Biotechnology & Applied Microbiology
Yun-Feng Zhou, Di Zhang, Wan-Ting Yan, Kai Lian, Zheng-Zheng Zhang
Summary: This article reviews the therapeutic potential of multipotent stromal cells (MSCs) in repairing meniscal injuries and discusses the avenues for utilizing these cells. The current progress on biomaterial implants is also reviewed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Martyna Smeda, Kerstin M. Galler, Melanie Woelflick, Andreas Rosendahl, Christoph Moehle, Beate Lenhardt, Wolfgang Buchalla, Matthias Widbiller
Summary: Both dental pulp and apical papilla are potential sources of stem cells for regenerative endodontic treatments. This study compared the molecular characteristics of dental pulp stem cells (DPSC) and stem cells from the apical papilla (SCAP). The results showed that both cell types expressed similar mesenchymal stem cell markers and had the ability to differentiate into various lineages. However, differences were observed in the profiles of secreted molecules and gene regulation. Overall, both DPSC and SCAP are suitable for dental pulp tissue engineering from a molecular biological perspective.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Tyler T. Cooper, Stephen E. Sherman, Gillian I. Bell, Thamara Dayarathna, Danielle M. McRae, Jun Ma, Francois Lagugne-Labarthet, Stephen H. Pasternak, Gilles A. Lajoie, David A. Hess
Summary: The study demonstrates that intrapancreatic injection of concentrated CM produced by MSCs can support islet regeneration and glycemic control. Using Panc-MSC as biofactories, the research shows potential applications for regenerative medicine by enriching tissue regenerative stimuli housed within the secretome.
STEM CELLS AND DEVELOPMENT
(2021)
Review
Pharmacology & Pharmacy
Dayanand Deo, Misty Marchioni, Prakash Rao
Summary: Organ transplantation is crucial for saving lives, but faces challenges such as organ shortage and rejection. Cellular therapy using MSC can address these issues, and advances in tissue engineering and regenerative medicine offer potential solutions for generating new organs and improving organ availability.
Article
Emergency Medicine
Courtney Premer, Ivonne H. Schulman, Jennifer S. Jackson
Summary: MSCs show promising potential in treating acute diseases, with clinical trials demonstrating safety but inconsistent efficacy data, necessitating further research.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Cell & Tissue Engineering
Bahareh Sadri, Mohammad Hassanzadeh, Abolfazl Bagherifard, Javad Mohammadi, Mehdi Alikhani, Kasra Moeinabadi-Bidgoli, Hoda Madani, Dylana Diaz-Solano, Shahedeh Karimi, Mohammad Mehrazmay, Mehdi Mohammadpour, Massoud Vosough
Summary: This study aimed to evaluate the therapeutic effect of adipose-derived mesenchymal stromal cells (AD-MSCs) in knee osteoarthritis (KOA). The results showed that the thickness of articular cartilage increased in patients treated with AD-MSCs, and there was a significant improvement in clinical evaluation.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Zafer C. Cehreli, Gizem Erbas Unverdi, Elif Ballikaya
Summary: This case series demonstrates the clinical and radiographic outcomes of regenerative endodontic treatment (RET) using deciduous pulp autotransplantation in traumatized, necrotic young permanent incisors. Follow-up observations at 12 and 24 months showed radiographic evidence of complete periapical healing, slight increase in dentinal wall thickness, and continued apical closure in all patients.
JOURNAL OF ENDODONTICS
(2022)
Article
Health Care Sciences & Services
Mohammed Mashyakhy, Ahmed Alkahtani, Abdulaziz S. Abumelha, Reham Jamal Sharroufna, Mazen F. Alkahtany, Mohamed Jamal, Ali Robaian, Sultan Binalrimal, Hitesh Chohan, Vikrant R. Patil, A. Thirumal Raj, Shilpa Bhandi, Rodolfo Reda, Luca Testarelli, Shankargouda Patil
Summary: The study investigated the effects of taurine on DPSC chondrogenic differentiation, demonstrating a significant increase in the expression of chondrogenesis-related genes and an increase in glycosaminoglycan production by the cells.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell & Tissue Engineering
Alison J. Wilson, Emma Rand, Andrew J. Webster, Paul G. Genever
Summary: Many clinical trials involving mesenchymal stem/stromal cells lack comprehensive characterization data of the cellular population, including details on surface marker expression, viability, and differentiation. Functional assessment is very limited and does not always correlate with the likely mechanism of action.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Pharmacology & Pharmacy
Jeremy Boulestreau, Marie Maumus, Christian Jorgensen, Daniele Noel
Summary: Osteoarthritis is associated with a high number of senescent cells in joint tissues, which release senescence-associated secretory phenotype (SASP) factors contributing to the disease progression. Targeting senescent cells has shown improvement in OA features in mouse models. MSCs and MSC-EVs are promising treatments for OA, but their functions are affected by aging.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Medicine, Research & Experimental
Raquel Cabrera-Perez, Alexis Rafols-Mitjans, Angela Roig-Molina, Silvia Beltramone, Joaquim Vives, Laura Batlle-Morera
Summary: Our study investigated the osteogenic commitment of hard-to-handle MSC,WJ in different bone microenvironments. Co-culture experiments showed that MSC,WJ could efficiently differentiate into bone cells in the presence of osteogenic stimuli from MSC,BM. In vivo experiments demonstrated successful bone formation in the medullar cavity of tibias in mice treated with MSC,WJ. The presence of human cells in various organs indicated the potential systemic effects of engineered MSC,WJ. Overall, our findings support the use of off-the-shelf allogeneic MSC,WJ products in bone repair and regeneration.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Pedram Iranmanesh, Mahmoud Torabinejad, Masoud Saatchi, Davood Toghraie, Sayed Mohammad Razavi, Abbasali Khademi
Summary: This study aimed to evaluate the effect of the duration of root canal infection on the ability of dentin-pulp complex regeneration. The results showed that long-term root canal infection decreased the ability of the body to regenerate the dentin-pulp complex.
JOURNAL OF ENDODONTICS
(2022)
Review
Dentistry, Oral Surgery & Medicine
J. Caviedes-Bucheli, J. F. Gomez-Sosa, M. M. Azuero-Holguin, M. Ormeno-Gomez, V. Pinto-Pascual, H. R. Munoz
INTERNATIONAL ENDODONTIC JOURNAL
(2017)
Article
Dentistry, Oral Surgery & Medicine
J. F. Gomez-Sosa, J. Caviedes-Bucheli, L. E. Diaz-Barrera, H. R. Munoz
INTERNATIONAL ENDODONTIC JOURNAL
(2019)
Article
Dentistry, Oral Surgery & Medicine
Javier Caviedes-Bucheli, Nestor Rios-Osorio, Diana Usme, Cristian Jimenez, Adriana Pinzon, Jorge Rincon, Maria M. Azuero-Holguin, Alvaro Zubizarreta-Macho, Jose F. Gomez-Sosa, Hugo R. Munoz
Summary: The study aimed to evaluate changes in canal volume after root canal preparation using 3 different single-file techniques. Results showed that Reciproc-Blue had the highest increase in canal volume, followed by WaveOne-Gold, while XP-EndoShaper did not significantly increase canal volume during preparation.
Article
Dentistry, Oral Surgery & Medicine
Javier Caviedes-Bucheli, Luis Fernando Lopez-Moncayo, Hernan Dario Munoz-Alvear, Jose Francisco Gomez-Sosa, Luis Eduardo Diaz-Barrera, Hernando Curtidor, Hugo Roberto Munoz
Summary: The study found that there is a significant increase in the expressions of SP, CGRP, and VEGF in human dental pulps when stimulated by occlusal trauma combined with moderate orthodontic forces, compared to these two stimuli applied independently.
Article
Dentistry, Oral Surgery & Medicine
Gisbeli Brea, Francisco Gomez, Jose Francisco Gomez-Sosa
Summary: This study used CBCT to evaluate the presence of C-shaped configurations in mandibular premolars, finding a prevalence of 19.2%. The study observed slight differences in C-shaped root canal system prevalence between male and female patients. The presence of C-shaped anatomical systems was found to be higher in mandibular first premolars.
Article
Dentistry, Oral Surgery & Medicine
Francisco Gomez, Gisbeli Brea, Jose Francisco Gomez-Sosa
Summary: The study aimed to identify anatomical variations of mandibular second molars' root canal system using CBCT. Results showed a variety of root and root canal configurations, with two roots, three root canals, and two apical foramina being the most prevalent. Additionally, C-shaped root canal systems and extra roots were also observed.
Review
Dentistry, Oral Surgery & Medicine
Javier Caviedes-Bucheli, Hernan D. Munoz-Alvear, Luis F. Lopez-Moncayo, Angela Narvaez-Hidalgo, Lorena Zambrano-Guerrero, Jose F. Gavino-Orduna, Ricardo Portigliatti, Jose F. Gomez-Sosa, Hugo R. Munoz
Summary: This umbrella review assessed the success of scaffold and regenerative materials used for the treatment of immature necrotic permanent teeth with a periapical lesion. The results showed that blood clot was the most commonly used scaffold, and Mineral Trioxide Aggregate (MTA) and Biodentine were the most commonly used regenerative materials. Tooth length increase and widening of root canal walls were considered as success indicators.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Review
Dentistry, Oral Surgery & Medicine
Jose Francisco Gomez-Sosa, Jose E. Cardier, Javier Caviedes-Bucheli
Summary: This review analyzed the role of hypoxia-dependent angiogenic processes in dental pulp and discussed their effects on tooth maturation and homeostasis. The study found that the angiogenesis process plays a crucial role in regulating oxygen concentration, mineralization, and defense mechanisms against chronic stimuli in dental pulp.
JOURNAL OF ORAL BIOSCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Javier Caviedes-Bucheli, Luis F. Lopez-Moncayo, Hernan Dario Munoz-Alvear, Francisco Hernandez-Acosta, Melissa Pantoja-Mora, Angie S. Rodriguez-Guerrero, Alexander Lopez-Ordonez, Luis E. Diaz, Jose Francisco Gomez-Sosa, Hugo R. Munoz
Article
Dentistry, Oral Surgery & Medicine
Jose Francisco Gomez-Sosa, Javier Caviedes-Buchell, Juan Goncalves-Pereira
ENDO-ENDODONTIC PRACTICE TODAY
(2018)
Article
Dentistry, Oral Surgery & Medicine
Jose Francisco Gomez Sosa, Juan Norberto Goncalves Pereira, Eliana Burguera
ENDO-ENDODONTIC PRACTICE TODAY
(2014)
Article
Dentistry, Oral Surgery & Medicine
Jose Francisco Gomez Sosa, Juan Norberto Goncalves Pereira
ENDO-ENDODONTIC PRACTICE TODAY
(2014)
Article
Dentistry, Oral Surgery & Medicine
Jose Francisco Gomez Sosa, Enrique Jose Padron Zambrano
ENDO-ENDODONTIC PRACTICE TODAY
(2013)
Article
Dentistry, Oral Surgery & Medicine
Jose Francisco Gomez Sosa
ENDO-ENDODONTIC PRACTICE TODAY
(2012)