期刊
JOURNAL OF ENDOCRINOLOGY
卷 252, 期 3, 页码 R71-R82出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/JOE-21-0335
关键词
thyroid hormone; metabolism; heart; regeneration; polyploid
资金
- CSUPERB New Investigator Award
- SJSU RSCA seed grant
- NIH diversity supplement [R01HL13845604S1]
- UCSF spark award
- NIH [R01HL138456]
- March of Dimes Basil O'Conner Scholar Award
- American Heart Association
- American Federation for Aging Research
- Department of Defense Discovery Award [W81XWH1910206]
- American Heart Beginning
- U.S. Department of Defense (DOD) [W81XWH1910206] Funding Source: U.S. Department of Defense (DOD)
The regenerative capacity of hearts varies across different animals, with adult zebrafish and newborn mice possessing a strong ability for heart regeneration. This ability is generally lost in adult mammals. Recent research suggests that thyroid hormones play a role in controlling both animal metabolism and the regenerative potential of cardiomyocytes, potentially explaining the evolutionary tradeoff between endothermy and loss of heart regenerative capacity.
While adult zebrafish and newborn mice possess a robust capacity to regenerate their hearts, this ability is generally lost in adult mammals. The logic behind the diversity of cardiac regenerative capacity across the animal kingdom is not well understood. We have recently reported that animal metabolism is inversely correlated to the abundance of mononucleated diploid cardiomyocytes in the heart, which retain proliferative and regenerative potential. Thyroid hormones are classical regulators of animal metabolism, mitochondrial function, and thermogenesis, and a growing body of scientific evidence demonstrates that these hormonal regulators also have direct effects on cardiomyocyte proliferation and maturation. We propose that thyroid hormones dually control animal metabolism and cardiac regenerative potential through distinct mechanisms, which may represent an evolutionary tradeoff for the acquisition of endothermy and loss of heart regenerative capacity. In this review, we describe the effects of thyroid hormones on animal metabolism and cardiomyocyte regeneration and highlight recent reports linking the loss of mammalian cardiac regenerative capacity to metabolic shifts occurring after birth.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据