Article
Nanoscience & Nanotechnology
Saeedeh Ahmadi, Mahmoud Seraj, Mohsen Chiani, Seyedayin Hosseini, Saba Bazzazan, Iman Akbarzadeh, Samaneh Saffar, Ebrahim Mostafavi
Summary: In this study, an optimized formulation of letrozole-loaded niosome was developed and its anticancer effect on breast cancer cell lines was assessed. The results showed that niosomes could be a promising drug carrier for delivering letrozole to breast cancer cells.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Elham Jamshidifar, Faten Eshrati Yeganeh, Mona Shayan, Mohammad Tavakkoli Yaraki, Mahsa Bourbour, Ali Moammeri, Iman Akbarzadeh, Hassan Noorbazargan, Nikoo Hossein-Khannazer
Summary: The study presents a magnetic niosomal nanocarrier for co-delivery of curcumin and letrozole into breast cancer cells, demonstrating high cytotoxicity and pH-dependent release behavior for potential cancer treatment applications. The nanocarriers showed low cellular uptake in non-tumorigenic cells and high uptake in cancer cell lines, leading to enhanced synergistic chemotherapeutic effects. The findings suggest the potential of magnetic niosomal formulations for targeted and simultaneous delivery of hydrophobic and hydrophilic drugs in cancer cells, indicating advances in nanomedicine and theranostic agent development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Sara Karimifard, Niloufar Rezaei, Elham Jamshidifar, Shahryar Moradi Falah Langeroodi, Mohammadreza Abdihaji, Afsoun Mansouri, Mahshid Hosseini, Nima Ahmadkhani, Ziba Rahmati, Maryam Heydari, Massoud Vosough, Iman Akbarzadeh, Ebrahim Mostafavi
Summary: In this study, a chitosan-adorned niosome-based nanocarrier was developed for co-delivery of doxorubicin and vincristine in breast cancer treatment. The nanocarrier exhibited pH-responsive drug release, with lower release rate in acidic pH. The results showed that DOX+VIN/Nio/CS had the lowest IC50 value and could inhibit cell migration and increase apoptosis in breast cancer cells.
ACS APPLIED NANO MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Shaghayegh Saharkhiz, Atefeh Zarepour, Negar Nasri, Marco Cordani, Ali Zarrabi
Summary: This study introduces and evaluates a smart pH-responsive niosomal formulation capable of delivering Doxorubicin (DOX) and Curcumin (CUR) individually or in combination, demonstrating effective anticancer efficacy.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Hanzhang Zhu, Weijiang Zhou, Yafeng Wan, Jun Lu, Ke Ge, Changku Jia
Summary: This study investigated the application of Adriamycin-loaded niosomes in the treatment of liver cancer. The results demonstrated that Adriamycin-loaded niosomes improved cellular uptake of Adriamycin, enhanced its anti-cancer effect in vivo, and reduced the toxicity to normal cells and mortality in tumor-bearing mice through responsive release under acidic conditions.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Hamideh Karbalaeiheidar, Fatemeh Ashrafi
Summary: In the face of increasing antibiotic-resistant bacteria, it is crucial to find alternatives to conventional antibiotics to combat the serious threat they pose to humanity and the financial burden they impose on communities. This study developed a co-encapsulated formulation of Vancomycin and Gingerol in niosomes and evaluated its effectiveness as an antibacterial agent against carbapenem-resistant Klebsiella pneumoniae strains. The optimized formulation showed sustained drug release, great stability, and enhanced antibacterial and antibiofilm activity against CRKP strains, making it a promising candidate for targeted drug delivery.
BIOMEDICAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Farnaz Khodabakhsh, Mahsa Bourbour, Mohammad Tavakkoli Yaraki, Saina Bazzazan, Haleh Bakhshandeh, Reza Ahangari Cohan, Yen Nee Tan
Summary: In this study, a PEGylated niosomal formulation of cyclophosphamide was prepared and characterized. The prepared nanocarrier showed controlled drug release and improved stability. It induced apoptosis in cancer cells by regulating gene expression and inhibited cell cycle and migration. These results suggest that the developed nanocarrier could be an effective and targeted drug delivery system for gastric cancer therapy.
Article
Pharmacology & Pharmacy
Shaghayegh Saharkhiz, Atefeh Zarepour, Ali Zarrabi
Summary: Smart nanotheranostics, composed of doxorubicin-loaded pH-responsive stealth niosomes and CdSe/ZnS quantum dots, were fabricated and evaluated for their physicochemical properties, drug release behavior, and biological activities. The results showed that the nanoparticles had a round shape with an average size of about 100 +/- 10 nm, -2 mV surface charge, and 87% entrapment efficiency. The drug release profile exhibited pH-responsive behavior, with 80%, 60%, and 40% drug release at pH 4, 6.5, and 7.4, respectively. The nanoparticles also showed cytotoxicity effects and were taken up by cells, indicating their potential for future cancer theranostic applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Golchin Shafiei, Davoud Jafari-Gharabaghlou, Mahdi Farhoudi-Sefidan-Jadid, Effat Alizadeh, Marziyeh Fathi, Nosratollah Zarghami
Summary: In recent years, researchers have discovered and synthesized various nanoparticles (NPs) for targeted therapy of cancer cells. This study designed silibinin-loaded magnetic niosomes nanoparticles (MNNPs) and investigated their cytotoxicity in colorectal cancer cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xi Ye, Xin Chen, Ruixi He, Wangyang Meng, Weidong Chen, Fengling Wang, Xiangyun Meng
Summary: This study developed a novel liposome, CUR-DTX-L, to address multidrug resistance and low efficacy in breast cancer treatment. The liposome showed sustained release and better antitumor efficacy compared to free drugs, and promising pharmacokinetic properties, making it a potential drug delivery system for synergistic treatment of breast cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yanhong Liu, Meiyan Wang, Wanru Liu, Jili Jing, Hongshuang Ma
Summary: In this study, olaparib and doxorubicin were co-loaded on disulfide bond cross-linked polypeptide nanogels for the treatment of breast cancer in mouse models. The dual-drug-co-loaded nanogels showed the best anti-cancer effect and excellent biological safety, making them a promising approach for anti-cancer treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Ali Moammeri, Masoumeh Mirzaei Chegeni, Hamidreza Sahrayi, Robabehbeygom Ghafelehbashi, Farkhondeh Memarzadeh, Afsoun Mansouri, Iman Akbarzadeh, Maryam Sadat Abtahi, Faranak Hejabi, Qun Ren
Summary: The advancement of nanotechnology has sparked interest in nanocarriers as efficient and safe drug delivery systems. Niosomes, a newer generation of nano-scale vesicles composed of non-ionic surfactants along with cholesterol or other amphiphilic molecules, offer a multilamellar carrier for bioactive substances. Compared to liposomes, niosomes are considered more chemically and physically stable, and have more economical preparation methods. They have various technological applications and are beneficial in terms of pharmacokinetics, toxicity reduction, drug solvability enhancement, and bioavailability improvement.
MATERIALS TODAY BIO
(2023)
Article
Pharmacology & Pharmacy
Tahereh Rezaei, Mehdi Rezaei, Sara Karimifard, Farzaneh Mahmoudi Beram, Mohammad Sedigh Dakkali, Maryam Heydari, Soheil Afshari-Behbahanizadeh, Ebrahim Mostafavi, Dmitry Olegovich Bokov, Mohammad Javed Ansari, Bahareh Farasati Far, Iman Akbarzadeh, Chaiyavat Chaiyasut
Summary: Breast cancer, the most common invasive cancer in women, can be effectively targeted through the use of bioactive molecule-decorated nanoniosomes. Among the different modifications, folate-functionalized niosomes demonstrated the highest cellular uptake and showed reduced cell migration and invasion. The study also confirmed the sustained drug release characteristics of the decorated nanoniosomes, which induced cell apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Rasoul Shahbazi, Davoud Jafari-Gharabaghlou, Zohreh Mirjafary, Hamid Saeidian, Nosratollah Zarghami
Summary: In this study, PEGylated niosomal nanoparticles loaded with ART-MET were synthesized and characterized. The results showed that these nanoparticles can inhibit the growth of A549 lung cancer cells and induce apoptotic gene expression.
PHARMACOLOGICAL REPORTS
(2023)
Article
Nanoscience & Nanotechnology
Fen Qiu, Long Xi, Shengshuang Chen, Yonghua Zhao, Zhenping Wang, Ying Zheng
Summary: Cel Nio gel achieved the anti-psoriatic effect by inhibiting inflammation and hyperproliferation of keratinocytes in the skin, further suppressing systemic inflammation. The gel demonstrated significant local and systemic therapeutic effects in treating psoriasis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mahdieh Rahimivand, Farzaneh Tafvizi, Hassan Noorbazargan
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Chemistry, Inorganic & Nuclear
Roghayeh Shiripoure Ganjineh Ketab, Farzaneh Tafvizi, Parvin Khodarahmi
Summary: The study demonstrated that biosynthesized AgNPs using Satureja rechingeriJamzad have potential as anti-cancer agents for gastric cancer treatment, showing significant inhibitory effects on AGS cancer cells through inducing apoptosis, regulating the cell cycle, and modulating the expression of apoptotic-related genes.
JOURNAL OF CLUSTER SCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Shahrzad Aslany, Farzaneh Tafvizi, Vahid Naseh
MATERIALS TODAY COMMUNICATIONS
(2020)
Article
Energy & Fuels
Sepideh Shahriary, Farzaneh Tafvizi, Parvin Khodarahmi, Masoud Shaabanzadeh
Summary: The study found that green-synthesized CuO nanoparticles have potential in treating cisplatin-resistant ovarian cancer cells. The results showed that these synthesized nanoparticles could induce apoptosis in cancer cells and have minimal toxicity on normal cells. Therefore, biogenic synthesized CuO nanoparticles could be further studied as a potential approach for cancer treatment.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Pharmacology & Pharmacy
Soheila Rostami, Farzaneh Tafvizi, Hamid Reza Kheiri Manjili
Summary: The study synthesized TMX-loaded L-lysine coated magnetic iron oxide nanoparticles and demonstrated their significant anti-proliferative and apoptosis-inducing effects on MCF-7 cancer cells in vitro. Furthermore, the nanoparticles were shown to have an impact on the cell cycle progression.
Article
Environmental Sciences
Sahar Sadeghi Asl, Farzaneh Tafvizi, Hassan Noorbazargan
Summary: In this study, gold nanoparticles with anticancer activity were successfully synthesized using Serach rechingeri Jamzad aqueous leaf extract. These nanoparticles showed inhibitory effects on cisplatin-resistant ovarian cancer cells by promoting apoptosis and cell cycle arrest.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Masoumeh Dolati, Farzaneh Tafvizi, Masoud Salehipour, Tahereh Komeili Movahed, Parvaneh Jafari
Summary: The study examined the anticancer capabilities of Bacillus coagulans supernatant-produced copper oxide nanoparticles (BC-CuONPs) on breast cancer cells. The results showed that BC-CuONPs had significant cytotoxic effects on cancer cells, induced apoptosis, inhibited cell proliferation, and demonstrated anti-metastatic and anticancer properties. These findings suggest that BC-CuONPs could be a potential therapeutic strategy in cancer management.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Mahdi Bahrami Parsa, Farzaneh Tafvizi, Vahid Chaleshi, Mostafa Ebadi
Summary: This article describes a method of using liposomes loaded with cisplatin and doxorubicin for the treatment of ovarian cancer. This approach enhances drug efficacy, reduces toxicity, and improves drug delivery versatility. The experimental results show that the liposomal formulation has significant cytotoxicity against ovarian cancer cells and can induce apoptosis and cell cycle arrest.
Article
Multidisciplinary Sciences
Adel Abedi, Farzaneh Tafvizi, Neda Akbari, Parvaneh Jafari
Summary: The current study evaluated the cytotoxic activity and apoptosis induction of cell-free supernatants (CFS) from Lactobacillus buchneri on AGS gastric cancer cell line. The CFS inhibited cancer cell proliferation, induced apoptosis, and caused cell cycle arrest in a time-dependent manner. This study suggests that L. buchneri supernatant can be used as a biological anticancer agent in the treatment of gastric cancer.
IRANIAN JOURNAL OF SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Fatemeh Mirzaee Rad, Farzaneh Tafvizi, Hassan Noorbazargan, Alireza Iranbakhsh
Summary: Artemisia turcomanica extract was used to synthesize Ag, ZnO, and Ag-doped ZnO nanoparticles. The anticancer activity of these nanoparticles against AGS gastric cancer cells was evaluated. The Ag-doped ZnO nanoparticles showed significant anticancer activity and induced apoptosis and cell cycle arrest. Rating: 8 out of 10.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Najme Dehghani, Farzaneh Tafvizi, Parvaneh Jafari
Summary: The supernatant of probiotic Lactobacillus rhamnosus showed potential in inhibiting the growth of HT-29 cancer cells and inducing apoptosis. Treatment with the supernatant led to apoptotic cell death, up-regulation of pro-apoptotic genes, down-regulation of anti-apoptotic genes, and arrest of cancer cells in the G0/G1 phase of the cell cycle. Moreover, a significant decrease in cyclin D1 protein expression was observed during treatment with the bacterial supernatant.
Article
Genetics & Heredity
Reza Amiri, Farzaneh Tafvizi, Alireza Ghanadan
Article
Agricultural Engineering
Sara Mosafer Haghighi, Farzaneh Tafvizi, Amir Mirzaie
INDUSTRIAL CROPS AND PRODUCTS
(2020)
Article
Genetics & Heredity
Sara Asgharzadeh, Farzaneh Tafvizi, Vahid Chaleshi, Shahrokh Iravani
Article
Pharmacology & Pharmacy
Xueliang Xiu, Shichao Ma, Zhiyong Li, Zhipeng Li, Xuemei Li, Yangtao Ruan, Dezhao Li, Jianwei Wang, Fengsen Ma
Summary: Liposomes are promising delivery vehicles for drugs and vaccines. The use of microfluidic chips for liposome preparation is an effective method. However, traditional liposome preparation technologies hinder their industrial production and clinical application. This study presents a novel three-dimensional integrated microfluidic device for continuous liposome preparation and purification, which shows potential for industrial production of nano-pharmaceutical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2024)