Article
Mathematics
Pau Fonseca i Casas
Summary: The correctness and proper use of a model depend on its assumptions. This study aims to propose a methodology for defining and using assumptions in the modeling process, including a simulation project process, an assumptions taxonomy, and a simplified method for handling assumptions. The traditional Validation, Verification, and Accreditation processes can be expanded to include eight phases that cover the entire lifecycle of a model.
Article
Pharmacology & Pharmacy
Feroz Jameel, Alina Alexeenko, Akhilesh Bhambhani, Gregory Sacha, Tong Zhu, Serguei Tchessalov, Puneet Sharma, Ehab Moussa, Lavanya Iyer, Sumit Luthra, Jayasree Srinivasan, Ted Tharp, Joseph Azzarella, Petr Kazarin, Mehfouz Jalal
Summary: This study showcases the cutting edge of lyophilization validation, integrating community-based opinion and industrial perspective. It covers various aspects of process design, process qualification, and continued process verification, including batch size determination, sampling strategies, statistical models, and determining the number of PPQ runs.
Article
Engineering, Chemical
Damien van de Berg, Thomas Savage, Panagiotis Petsagkourakis, Dongda Zhang, Nilay Shah, Ehecatl Antonio del Rio-Chanona
Summary: This study investigates the application of derivative-free optimization algorithms in process engineering, comparing model-based and direct-search DFO algorithms for efficiency in mathematical optimization problems and five chemical engineering applications, addressing challenges such as constraint satisfaction, uncertainty, problem dimension, and evaluation cost.
CHEMICAL ENGINEERING SCIENCE
(2022)
Article
Computer Science, Information Systems
Pablo Parra, Oscar R. Polo, Javier Fernandez, Antonio da Silva, Sebastian Sanchez, Agustin Martinez
Summary: This work describes a platform-aware model-driven engineering process for building component-based embedded software systems using annotated analysis models. The process is supported by a framework called MICOBS, enabling analysis of non-functional properties based on principles of composability and compositionality. Various actors, such as Framework Architect, Component Provider, Component Tester, and Application Architect, play important roles in the process.
IEEE TRANSACTIONS ON EMERGING TOPICS IN COMPUTING
(2021)
Article
Biochemical Research Methods
Willow Carretero Chavez, Marcus Krantz, Edda Klipp, Irina Kufareva
Summary: The kboolnet toolkit is proposed in this study, which integrates with the rxncon software to provide a complete workflow for the verification, validation, and visualization of rxncon models. The toolkit is also cloud-enabled, allowing for easy collaborative development. The application of this toolkit will enable the creation of larger, more comprehensive, and more rigorous models of cell signaling using the rxncon formalism in the future.
BMC BIOINFORMATICS
(2023)
Review
Computer Science, Interdisciplinary Applications
Maolin Yang, Pingyu Jiang, Tianshuo Zang, Yuhao Liu
Summary: Data-driven intelligent computational design (DICD) is a research hotspot that utilizes deep learning algorithms to extract and represent design features hidden in design process data for design solution retrieval, generation, optimization, and evaluation. Although DICD has drawn attention, unexplored issues such as specific dataset building and systematic methods for DICD implementation limit its development. To address these issues, a systematic and operable road map for DICD implementation is established, including the workflow, framework, mechanisms, calculation principles, and case scenarios.
JOURNAL OF COMPUTATIONAL DESIGN AND ENGINEERING
(2023)
Article
Engineering, Electrical & Electronic
Zhizhen Zhao, Jong Chul Ye, Yoram Bresler
Summary: Physics-informed generative modeling is a rapidly growing field in computational imaging, with various methods and applications. This review focuses on generative modeling techniques, such as variational autoencoders (VAEs) and generative adversarial networks (GANs), and recent advancements in score-based generative models. Through different imaging applications, the review demonstrates how these generative modeling techniques effectively incorporate the physics of the imaging problem to solve inverse problems.
IEEE SIGNAL PROCESSING MAGAZINE
(2023)
Article
Engineering, Environmental
Yeongryeol Choi, Bhavana Bhadriaju, Hyungtae Cho, Jongkoo Lim, In-Su Han, Il Moon, Joseph Sang-Il Kwon, Junghwan Kim
Summary: This work presents a data-driven modeling approach using clustering and feature selection techniques to develop a predictive model for multimode industrial processes. The method involves extracting steady-state operation data from raw data using K-means clustering, applying feature selection using Pearson's correlation coefficient, and training an LSTM model to predict steady-state operation. The validity and effectiveness of the approach are demonstrated using real-world 2,3-Butanediol distillation process dataset.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Christoph Oefner, Sven Herrmann, Maeruan Kebbach, Hans-E. Lange, Daniel Kluess, Matthias Woiczinski
Summary: Finite element analysis (FEA) is a fundamental tool in biomechanical investigations, yet challenges in verification and validation processes as well as in FEA setup and evaluation persist. This study introduces a checklist and report form for FEA in Orthopedic and Trauma biomechanics to address these challenges, with the aim of improving credibility in clinical applications and scientific exchange in the community.
MEDICAL ENGINEERING & PHYSICS
(2021)
Article
Computer Science, Artificial Intelligence
Debaditya Chakraborty, Hakan Basagaoglu, James Winterle
Summary: This study compared the predictive capabilities of interpretable and noninterpretable machine learning models, revealing that tree-based ensemble models can perform similarly to deep learning models in structured hydro-climatological datasets. Using a newly developed sequential transfer-learning technique, the tree-based ensemble model was able to impute missing climate data at various levels. The eXML framework quantified the global importance of hydro-climatic variables and identified transition points of climate variables for daily ETo rates.
EXPERT SYSTEMS WITH APPLICATIONS
(2021)
Article
Electrochemistry
Jacob C. Hamar, Simon V. Erhard, Christoph Zoerr, Andreas Jossen
Summary: Three anode estimation methods are proposed and evaluated for their accuracy and storage requirements. A novel random forest model shows the lowest estimation error and reduced memory demand, making it suitable for a lithium plating warning detection system during fast charging.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Editorial Material
Environmental Sciences
Anargiros I. Delis, Ioannis K. Nikolos
Summary: This special issue focuses on the latest advances in hydraulic modeling based on non-linear shallow water equations (NSWEs) and their applications in practical engineering. NSWEs play a critical role in predicting tides, storm surge levels, coastline changes, and have attracted great attention for research on effective and accurate numerical methods for their solutions.
Article
Computer Science, Artificial Intelligence
Angelina Espinoza, Ernesto Del-Moral, Alfonso Martinez-Martinez, Nour Ali
Summary: Designing an ontology that meets end-users' needs is crucial for data reasoning support. However, there is a lack of standard process in knowledge engineering to guide ontology design. The proposed CQ-Driven Ontology Design Process (CODEP) validates and verifies the incremental ontology design through metrics based on defined CQs, demonstrating its feasibility for delivering ontologies with similar requirements in other contexts.
Article
Materials Science, Multidisciplinary
C. Hensley, K. Sisco, S. Beauchamp, A. Godfrey, H. Rezayat, T. McFalls, D. Galicki, F. List, K. Carver, C. Stover, D. W. Gandy, S. S. Babu
Summary: This research evaluated three pathways for qualification of 316 L stainless steel components made by laser powder bed fusion additive manufacturing, exploring comprehensive process flows with computational modeling, in-situ measurements, ex-situ characterization, and mechanical testing. The role of post-process hot isostatic pressing (HIP) was found to minimize scatter in AM properties, meeting industry standards; alternative qualification methodologies were also explored for applications where HIP may not be feasible.
JOURNAL OF NUCLEAR MATERIALS
(2021)
Article
Engineering, Civil
Ran Tian, Nan Li, Ilya Kolmanovsky, Yildiray Yildiz, Anouck R. Girard
Summary: Applying game theory to simulate vehicle interactions for testing, evaluation, and parameter optimization of autonomous vehicles.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2022)