期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 137, 期 1, 页码 68-+出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2015.05.033
关键词
Blood lipids; asthma; child; respiratory function tests; inflammation
资金
- COPSAC
- Lundbeck Foundation [R16-A1694]
- Ministry of Health [903516]
- Danish Council for Strategic Research
- Capital Region Research Foundation
- Thrasher Research Award
Background: Studies of children's blood lipid profiles in relation to asthma are few, and the results are ambiguous. Objective: We sought to examine whether the lipid profile is associated with concurrent asthma, altered lung function, and allergic sensitization in children. Methods: High-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglyceride levels were measured at ages 5 to 7 years in the Copenhagen Prospective Studies on Asthma in Childhood(2000) at-risk birth cohort. Asthma and allergic rhinitis were diagnosed based on predefined algorithms at age 7 years along with assessments of lung function, bronchial responsiveness, fraction of exhaled nitric oxide (FENO), and allergic sensitization. Associations between lipid levels and clinical outcomes were adjusted for sex, passive smoking, and body mass index. Results: High levels of low-density lipoprotein cholesterol were associated with concurrent asthma (adjusted odds ratio [aOR], 1.93; 95% CI, 1.06-3.55; P=.03) and airway obstruction: 50% of forced expiratory flow (a beta coefficient, -0.13 L/s; 95% CI, -0.24 to -0.03 L/s; P = .01) and specific airway resistance (a beta coefficient, 0.06 kPa/s; 95% CI, 0.00-0.11 kPa/s; P = .05). High levels of high-density lipoprotein cholesterol were associated with improved specific airway resistance (a beta coefficient, -0.11 kPa/s; 95% CI, -0.21 to -0.02; P = .02), decreased bronchial responsiveness (a beta coefficient, 0.53 log-mu mol; 95% CI, 0.00-1.60 log-mmol; P = .05), decreased risk of aeroallergen sensitization aOR, 0.27; 95% CI, 0.01-0.70; P = .01), and a trend of reduced FENO levels (a beta coefficient, -0.22 log-ppb; 95% CI, -0.50 to 0.01 log-ppb; P = .06). High triglyceride levels were associated with aeroallergen sensitization (aOR, 2.01; 95% CI, 1.14-3.56; P=.02) and a trend of increased FENO levels (a beta coefficient, 0.14 log-ppb; 95% CI, -0.02 to 0.30 log-ppb; P = .08). Conclusion: The blood lipid profile is associated with asthma, airway obstruction, bronchial responsiveness, and aeroallergen sensitization in 7-year-old children. These findings suggest that asthma and allergy are systemic disorders with commonalities with other chronic inflammatory disorders.
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