Article
Pathology
Xiaoding Liu, Xianglin Yin, Dongmei Li, Kaimi Li, Hui Zhang, Junliang Lu, Liangrui Zhou, Jie Gao, Jing Wang, Huanwen Wu, Zhiyong Liang
Summary: This study investigated fusion genes in 76 cases of PMTs using RNA-based next-generation sequencing. It was found that 68.4% of the cases had fusion genes, and the most common fusion was FN1::FGFR1. Moreover, novel fusion genes were also identified. These findings are important for understanding the genetic basis of PMTs.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mohsin A. M. Hussein, Francesco Pio Cafarelli, Maria Teresa Paparella, Winston J. Rennie, Giuseppe Guglielmi
Summary: Phosphaturic mesenchymal tumors (PMTs) are rare neoplasms of soft tissue or bone origin that often result in tumor-induced osteomalacia. They exhibit polymorphic features on radiological and histological examinations, leading to challenges in differential diagnosis with other mesenchymal tumors.
Article
Endocrinology & Metabolism
J. C. Horng, E. Van Eperen, S. Tutton, R. Singh, J. L. Shaker, A. N. Wooldridge
Summary: Phosphaturic mesenchymal tumors (PMTs) can cause vague symptoms of diffuse bone pain and pathologic fractures, leading to delayed diagnosis. This type of tumor can result in tumor-induced osteomalacia (TIO), characterized by gradual muscle weakness and delayed diagnosis. In cases where wide surgical excision is not possible, image-guided ablation can be an alternative therapeutic option for treating PMTs.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Veronica Abate, Anita Vergatti, Gianpaolo De Filippo, Vincenzo Damiano, Ciro Menale, Lanfranco D'Elia, Domenico Rendina
Summary: This study compares the clinical characteristics of benign and malignant PMTs inducing TIO. It finds that patients with malignant PMTs are younger and more likely to experience bone pain, functional impairment, and bone deformities. Malignant PMTs also have higher levels of intact FGF23 and a higher mortality rate.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Yupeng Liu, Hongbo He, Can Zhang, Hao Zeng, Xiaopeng Tong, Qing Liu
Summary: This study evaluated our experience in the diagnosis and treatment of phosphaturic mesenchymal tumors (PMT) and provided a research basis for accurate and standardized treatment. The results showed that accurate diagnosis and standardized surgical treatment are crucial for achieving a clinical cure for PMT. Combining clinical manifestations, biochemical examinations, imaging characteristics, and pathological findings is an effective way to accurately diagnose PMT.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Junho Jung, Minah Kim, So-Woon Kim, Joo-Young Ohe
Summary: Phosphaturic mesenchymal tumor (PMT) is strongly associated with tumor-induced osteomalacia (TIO), resulting in various skeletal problems including bone deformities, gait disturbance, and multiple bone fractures. The overexpression of fibroblast growth factor 23 by the tumor causes hypophosphatemia and leads to oncogenic osteomalacia, a rare paraneoplastic syndrome. PMT in the oral and maxillofacial regions is extremely rare, and this case emphasizes the importance of understanding the mechanisms by which local lesions can affect systemic conditions, as well as the significance of combining physical examinations, laboratory investigations, and radiologic investigations for an accurate diagnosis.
APPLIED SCIENCES-BASEL
(2023)
Article
Medicine, General & Internal
Michael J. Econs, Daryl J. Selen, Rene Balza, Omar Zurkiya, Henry M. Kronenberg, Yin P. Hung
Summary: A 29-year-old woman presented with recurrent fractures and hypophosphatemia, and the cause is yet to be determined.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Bo Abrahamsen, Christopher D. Smith, Salvatore Minisola
Summary: This study conducted an observational cohort study using national Danish health registers for the period 2008 to 2018 to investigate the rare condition of tumor-induced osteomalacia (TIO) and found that the incidence of TIO in Denmark is low. Future research should focus on centralized management of patients with TIO.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Taiki Takaoka, Natsuo Tomita, Yoji Shido, Satoshi Baba, Mayu Fukushima, Chikao Sugie, Yuta Shibamoto
Summary: PMT is a rare neoplasm causing oncogenic osteomalacia, with surgery being the main treatment option. However, this case report demonstrated successful treatment of PMT with a combination of radiotherapy and activated vitamin D supplementation. The patient experienced near-complete resolution of symptoms, normalization of laboratory values, and no regrowth of the irradiated tumor during a 5-year follow-up.
Review
Clinical Neurology
Chaitanya Dev Pannu, David Baxter, Hanny Anwar
Summary: This article provides a comprehensive review of the management challenges associated with Spinal Phosphaturic Mesenchymal tumors (PMTs) and evaluates the surgical management outcomes for this rare entity linked to Tumor-induced osteolysis. The study aims to enhance the familiarity of treating physicians with the clinical features, diagnosis, and treatment options for Spinal PMTs. The retrospective analysis of electronic medical records reveals that surgical management of Spinal PMTs can effectively alleviate symptoms and restore phosphate levels. A multidisciplinary approach and continued vigilance are essential for early diagnosis, effective treatment, and long-term monitoring of patients affected by spinal PMTs.
EUROPEAN SPINE JOURNAL
(2023)
Article
Otorhinolaryngology
Davis P. Argersinger, Catherine T. Haring, John E. Hanks, Kevin J. Kovatch, S. Ahmed Ali, Jonathan B. McHugh, Melissa A. Pynnonen, Erin L. McKean
Summary: In this study, 4 cases of sinonasal and skull base PMT were reviewed, and all patients underwent complete surgical resection with successful outcomes. The presentation of skull base PMT is variable, and complete surgical resection with negative margins may potentially be curative.
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
(2022)
Review
Clinical Neurology
Daijiro Kojima, Shigeo Ohba, Masato Abe, Atsushi Suzuki, Seiji Horibe, Ichiro Tateya, Mitsuhiro Hasegawa, Yuichi Hirose
Summary: This paper presents a case of rare intracranial osteomalacia-inducing tumor (OIT) and provides a review of previous cases. Intracranial OIT is difficult to diagnose and treat. Previous studies have shown that intracranial OIT usually occurs in patients aged 8-69 years, with bone and muscle pain as the main symptoms. Detection of FGF23 and STAT6 can help distinguish PMTs from HPCs.
Article
Endocrinology & Metabolism
Agnes Linglart, Erik A. Imel, Michael P. Whyte, Anthony A. Portale, Wolfgang Hogler, Annemieke M. Boot, Raja Padidela, William Van't Hoff, Gary S. Gottesman, Angel Chen, Alison Skrinar, Mary Scott Roberts, Thomas O. Carpenter
Summary: In children with XLH, treatment with burosumab for 160 weeks improved phosphate homeostasis, reduced rickets severity, and showed good tolerability.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Rawan E. Hudairy, Abdelrazak Meliti, Ghadeer Mokhtar, Maram Alanazi
Summary: Phosphaturic mesenchymal tumor (PMT) is a rare tumor that often leads to tumor-induced osteomalacia (TIO). Most cases occur in the extremities. We present a case of PMT arising in the left upper thigh.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Oncology
Andrea Montanari, Maria Giulia Pirini, Ludovica Lotrecchiano, Lorenzo Di Prinzio, Guido Zavatta
Summary: Phosphaturic mesenchymal tumors (PMTs) can cause tumor-induced osteomalacia (TIO) due to phosphate metabolism derangement. Locating these tumors is crucial for a cure. Some tumors may not produce symptoms until they become large enough. FGF-23 can be produced by both benign and malignant PMTs. A multidisciplinary team is necessary to assess the metabolism, radiology, and histology of these rare tumors and improve patients' quality of life. This review provides insights into the endocrine, radiological, and histological features of PMTs, as well as surgical and interventional strategies for management.
Article
Medicine, General & Internal
Leonardo Bencivenga, Klara Komici, Stefania Paolillo, Carmela Nappi, Paola Gargiulo, Roberta Assante, Giuseppina Gambino, Fabio Santillo, Grazia Daniela Femminella, Grazia Maria Corbi, Nicola Ferrara, Alberto Cuocolo, Pasquale Perrone-Filardi, Giuseppe Rengo
Summary: The study found a weak association between cardiac sympathetic innervation and risk scores for predicting mortality in patients with heart failure. Therefore, it is recommended to integrate tools indicative of both arrhythmic and general mortality risks when evaluating patients eligible for device implantation.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Valeria Cantoni, Roberta Green, Emilia Zampella, Adriana D'Antonio, Alberto Cuocolo
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Emilia Zampella, Teresa Mannarino, Adriana D'Antonio, Roberta Assante, Valeria Gaudieri, Pietro Buongiorno, Mariarosaria Panico, Valeria Cantoni, Roberta Green, Carmela Nappi, Parthiban Arumugam, Mario Petretta, Alberto Cuocolo, Wanda Acampa
Summary: The study assessed the prognostic value of cardiac Rb-82 positron emission tomography (PET)/computed tomography (CT) imaging in patients with myocardial ischemia of nonobstructive coronary arteries. The results showed that increased total perfusion defect (TPD) and reduced myocardial flow reserve (MFR) were predictors of cardiac events in these patients. The combined evaluation of myocardial perfusion and coronary vascular function by Rb-82 PET/CT can identify patients at higher risk of cardiac events.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mario Petretta, Rosario Megna, Roberta Assante, Emilia Zampella, Carmela Nappi, Valeria Gaudieri, Teresa Mannarino, Roberta Green, Valeria Cantoni, Adriana D'Antonio, Mariarosaria Panico, Wanda Acampa, Alberto Cuocolo
Summary: An external validation of the J-ACCESS model showed that it underestimated the risk of major adverse cardiac events within three-year follow-up in our study population. The recalibrations and updates of the model slightly improved its performance, but limitations still exist.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Nutrition & Dietetics
Anita Vergatti, Veronica Abate, Aquilino Flavio Zarrella, Fiore Manganelli, Stefano Tozza, Rosa Iodice, Gianpaolo De Filippo, Lanfranco D'Elia, Pasquale Strazzullo, Domenico Rendina
Summary: This meta-analysis found a significant association between 25(OH)D levels <= 8.5 ng/mL at the first stroke and an increased risk of recurrent stroke.
Editorial Material
Cardiac & Cardiovascular Systems
Mario Petretta, Mariarosaria Panico, Ciro Gabriele Mainolfi, Alberto Cuocolo
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Teresa Mannarino, Adriana D'Antonio, Roberta Assante, Emilia Zampella, Valeria Gaudieri, Mario Petretta, Alberto Cuocolo, Wanda Acampa
Summary: Advancements in preventing and treating cardiovascular disease have reduced mortality rates, but atherosclerosis leading to coronary artery disease and stroke is still a leading cause of death worldwide. Imaging tests have proven useful in identifying individuals at high risk and informing risk factor modification. This article aims to analyze the latest techniques in combined imaging for assessing cardiovascular disease risk, with the goal of providing clinicians with additional prognostic information for better patient management and reducing adverse events.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Review
Nutrition & Dietetics
Lanfranco D'Elia, Francesco P. Cappuccio, Maria Masulli, Ersilia La Fata, Domenico Rendina, Ferruccio Galletti
Summary: The systematic review and meta-analysis found that potassium supplementation improves endothelial function and increases flow-mediated dilation. The effect is stronger when urinary potassium excretion is higher than 90 mmol/day.
Article
Peripheral Vascular Disease
Maria Lembo, Wanda Acampa, Maria Assunta Elena Rao, Maria Virginia Manzi, Carmine Morisco, Giovanni Esposito, Roberta Assante, Emilia Zampella, Carmela Nappi, Valeria Gaudieri, Teresa Mannarino, Costantino Mancusi, Giovanni de Simone, Raffaele Izzo, Alberto Cuocolo, Bruno Trimarco
Summary: In hypertensive patients without flow-limiting epicardial coronary artery disease, there may be a relationship between myocardial blood flow and echocardiographic parameters of left ventricular performance. Low MEEi values could detect early left ventricular dysfunction involving both resting and hyperemic myocardial blood flow ratios.
Article
Endocrinology & Metabolism
A. Vergatti, V. Abate, A. Giaquinto, N. Altavilla, L. D'Elia, M. Evangelista, G. De Filippo, G. Piccinocchi, L. Gennari, D. Merlotti, F. Galletti, P. Strazzullo, D. Rendina
Summary: This cross-sectional study aimed to evaluate the association between smoking habits and osteoporosis (Op) in community-dwelling women. The results demonstrated that passive smoke is associated with Op, and the risk of Op from passive smoke exposure is comparable to active smoking.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Peripheral Vascular Disease
Veronica Abate, Anita Vergatti, Antonella Fiore, Angelo Forte, Alessia Attanasio, Nadia Altavilla, Gianpaolo De Filippo, Domenico Rendina, Lanfranco D'Elia
Summary: Hypertension is an important cause of cardiovascular and chronic kidney disease, and it is also an independent risk factor for nephrolithiasis. A diet rich in vegetables and fruits is beneficial for the prevention of both hypertension and nephrolithiasis, and monitoring 24-hour urinary potassium excretion can guide dietary intake. This study demonstrated that higher urinary potassium excretion is associated with a reduced risk of recurrent nephrolithiasis in hypertensive patients.
HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
(2023)
Article
Endocrinology & Metabolism
Veronica Abate, Anita Vergatti, Gianpaolo De Filippo, Vincenzo Damiano, Ciro Menale, Lanfranco D'Elia, Domenico Rendina
Summary: This study compares the clinical characteristics of benign and malignant PMTs inducing TIO. It finds that patients with malignant PMTs are younger and more likely to experience bone pain, functional impairment, and bone deformities. Malignant PMTs also have higher levels of intact FGF23 and a higher mortality rate.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)