Review
Medicine, General & Internal
Amit Akirov, Hiba Masri-Iraqi, Idit Dotan, Ilan Shimon
Summary: The diagnosis, management, and treatment of acromegaly heavily rely on the levels of serum IGF-1, basal GH, and nadir GH following OGTT. However, these hormone concentrations can be influenced by various factors, leading to discordant levels that may require additional monitoring and data. New standards for GH and IGF-1 provide more accurate tools, but limitations should be considered along with clinical history and imaging studies when evaluating patients with acromegaly.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Sabrina Chiloiro, Stefano Frara, Irene Gagliardi, Antonio Bianchi, Antonella Giampietro, Margherita Medici, Agnese Allora, Luigi di Filippo, Maria Rosaria Ambrosio, Alfredo Pontecorvi, Maria Chiara Zatelli, Laura De Marinis, Andrea Giustina
Summary: Skeletal fragility is common in acromegaly patients and can lead to vertebral fractures. This study suggests that cholecalciferol supplementation may reduce the incidence of vertebral fractures in acromegaly.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Li Li, Liheng Meng, Yuping Liu, Rashi Tamrakar, Xi Yang, Xinghuang Liang, Jia Zhou, Jing Xian, Zhenxing Huang, Yingfen Qin
Summary: Mixed pituitary TSH/GH adenomas are rare adenomas that produce both GH and TSH simultaneously, often associated with acromegaly and thyrotoxicosis. Treatment typically involves somatostatin analogs to regulate hormone levels before surgery.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
In-Ho Jung, Seonah Choi, Cheol Ryong Ku, Sang-Guk Lee, Eun Jig Lee, Sun Ho Kim, Eui Hyun Kim
Summary: This study evaluated the reliability of IGF-1 levels as an alternative for disease monitoring after surgical treatment of acromegaly. The results showed that IGF-1 levels can serve as a reliable alternative to OGTT and play a valuable role in monitoring acromegaly status.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Malgorzata Rolla, Aleksandra Jawiarczyk-Przybylowska, Jowita Halupczok-Zyla, Marcin Kaluzny, Bogumil M. Konopka, Izabela Bloniecka, Grzegorz Zielinski, Marek Bolanowski
Summary: Acromegaly patients, predominantly female, commonly suffer from complications such as metabolic disorders, cardiovascular diseases, and endocrine disorders. A majority of patients demonstrate a coexistence of cardiac, metabolic, and endocrine disturbances, with a small percentage being disease-free in these main groups.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Heng Sun, Chunli Wu, Biao Hu, Genqing Xie
Summary: This study is the first to report a high prevalence of radiologic VFs in recently diagnosed CD patients. VFs may represent an early manifestation of CD and may be related to cortisol levels. Therefore, VF assessment should be included in the workup during CD diagnosis.
ANNALS OF MEDICINE
(2023)
Article
Clinical Neurology
Camilla M. Falch, Anne K. Dupont, Nicoleta C. Olarescu, Markus Wiedmann, Daniel Dahlberg, Jens Bollerslev, Jon Berg-Johnsen, Ansgar Heck
Summary: Surgery is necessary for sustained cure of acromegaly. This study aims to estimate the short- and long-term rates of biochemical control after pituitary surgery in acromegaly and identify predictive factors. The findings indicate that the long-term biochemical control rate remains modest in unselected patients with acromegaly.
ACTA NEUROCHIRURGICA
(2023)
Article
Endocrinology & Metabolism
Charlotte Aagaard, Amanda S. Christophersen, Susanne Finnerup, Christian Rosendal, Helga A. Gulisano, Kare S. Ettrup, Peter Vestergaard, Jesper Karmisholt, Eigil Husted Nielsen, Jakob Dal
Summary: This study investigated the prevalence and patient characteristics of acromegaly over time, as well as the impact of treatment changes on disease control. The study found that the prevalence of acromegaly has increased significantly, with a shift towards a milder clinical phenotype. Modern treatment approaches enable individualized treatment and disease control in the majority of patients with acromegaly.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Hyemi Kwon, Kyung-Do Han, Bong-Sung Kim, Sun Joon Moon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
Summary: In this national cohort study, there was a significantly higher risk of clinical vertebral and hip fractures in patients with acromegaly compared to the controls. The increased fracture risk was time-dependent and observed during the early period of follow-up.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Oncology
Zhengxing Xie, Yan Zhuang, Zongqiang Zhang, Jieping Liu
Summary: This study investigated the prevalence and potential factors associated with cerebral microbleeds (CMBs) in patients with acromegaly. The results showed a higher incidence of CMBs in patients with acromegaly, which may be related to obstructive sleep apnea (OSA) caused by acromegaly. The increase in CMBs could be an important factor contributing to cognitive decline in patients with acromegaly.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Tyler Cardinal, Casey Collet, Michelle Wedemeyer, Peter A. Singer, Martin Weiss, Gabriel Zada, John D. Carmichael
Summary: The study aimed to identify predictive factors for long-term remission of acromegaly after surgical resection of pituitary adenomas. Postoperative GH levels on day 1 and changes in IGF-1 levels postoperatively were found to be useful in predicting hormonal remission. The findings suggest that these factors can help guide clinical follow-up and the need for adjuvant therapy in acromegaly patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Sabrina Chiloiro, Denise Costa, Rosa Lauretta, Valeria Mercuri, Emilia Sbardella, Irene Samperi, Marialuisa Appetecchia, Antonio Bianchi, Antonella Giampietro, Patrizia Gargiulo, Andrea M. Isidori, Maurizio Poggi, Alfredo Pontecorvi, Laura De Marinis
Summary: This study investigated the treatment choices and outcomes for acromegaly patients resistant to first generation somatostatin analogues. The results showed that c-Peg-V and Pasi-Lar were chosen for the treatment of invasive tumors, and partial response to first gen-SSA seemed to be the main determinant for the choice of Pasi-Lar and positively predicted the treatment outcome.
Review
Endocrinology & Metabolism
Joan Gil, Mireia Jorda, Berta Soldevila, Manel Puig-Domingo
Summary: Epithelial-mesenchymal transition is a dynamic process that plays essential roles in both physiological and pathological processes, particularly in the growth and invasion of pituitary tumors. Studies have shown the association of EMT with resistance to somatostatin receptor ligands in the treatment of acromegaly.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Felix Ehret, Markus Kufeld, Christoph Fuerweger, Alfred Haidenberger, Paul Windisch, Susanne Fichte, Ralph Lehrke, Carolin Senger, David Kaul, Daniel Ruess, Maximilian Ruge, Christian Schichor, Joerg-Christian Tonn, Guenter Stalla, Alexander Muacevic
Summary: In addition to surgery and medication, robotic radiosurgery is an effective and safe treatment option for growth hormone-secreting tumors of the pituitary gland infiltrating surrounding tissue structures, achieving biochemical disease control or remission in most patients with decreasing hormone levels. The treatment also demonstrates favorable risk and safety profiles.
Review
Endocrinology & Metabolism
Antonio Bianchi, Sabrina Chiloiro, Antonella Giampietro, Simona Gaudino, Rosalinda Calandrelli, Ciro Mazzarella, Carmelo Caldarella, Mario Rigante, Marco Gessi, Liverana Lauretti, Laura De Marinis, Alessandro Olivi, Alfredo Pontecorvi, Francesco Doglietto
Summary: Growth hormone-secreting adenomas exhibit a wide range of behaviors and outcomes, from mild disease to aggressive neoplasms. Treatment for patients who do not respond to surgery or first-generation somatostatin receptor ligands may involve multiple surgical, medical, and radiation treatments. Currently, there are no markers that can predict the prognosis or aggressiveness of acromegaly. A multidisciplinary approach is necessary to tailor treatment for difficult/aggressive cases, including radiation therapy, chemotherapy, and emerging treatments.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Luigi Albano, Marco Losa, Giorgio Spatola, Pietro Panni, Maria Rosa Terreni, Lina Raffaella Barzaghi, Pietro Mortini
Summary: Sellar melanocytomas are benign, slow-growing tumors with a high risk of recurrence. This study reported two cases treated at the same institute, with one undergoing gross total resection and the other undergoing subtotal resection followed by gamma knife radiosurgery.
BRITISH JOURNAL OF NEUROSURGERY
(2023)
Article
Endocrinology & Metabolism
Luigi di Filippo, Mauro Doga, Stefano Frara, Andrea Giustina
Summary: COVID-19 patients may experience various endocrine manifestations, such as hypocalcemia, vertebral fractures, and vitamin D deficiency, which could negatively impact disease severity, inflammatory response, thrombotic markers, and mortality. Prompt assessment, monitoring, and calcium replacement are recommended to prevent severe complications.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Endocrinology & Metabolism
L. di Filippo, S. La Marca, M. Losa, M. S. Lena, R. Mapelli, G. Incampo, P. Mortini, F. De Cobelli, A. Giustina, R. Lanzi
Summary: This study reports a higher prevalence of ACAs in patients with meningioma and suggests the need for larger studies to confirm and further understand this association.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
Dilek Yazici, Hale Yapici Eser, Sinem Kiyici, Seda Sancak, Havva Sezer, Melin Uygur, Volkan Yumuk
Summary: This review analyzes the effects of GLP-RA's on the complications of obesity, including lowering blood glucose, lowering blood pressure, resolving NASH, improving major cardiovascular events, enhancing fertility and sex hormone levels, improving OSA symptoms and cognitive scores. The effects are not solely due to weight loss but are also attributed to pleiotropic effects such as decreased inflammation, oxidative stress and fibrosis.
Article
Endocrinology & Metabolism
Mario Detomas, Katrin Ritzel, Isabella Nasi-Kordhishti, Marie Helene Schernthaner-Reiter, Marco Losa, Viola Troeger, Barbara Altieri, Matthias Kroiss, Ralph Kickuth, Martin Fassnacht, Alexander Micko, Juergen Honegger, Martin Reincke, Timo Deutschbein
Summary: This multicenter study confirmed the diagnostic accuracy of BIPSS in differentiating between CD and ECS. It also suggests that measuring prolactin levels may further improve the diagnostic performance of this test.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Jacqueline Trouillas, Pia Burman, Marco Losa, Ann McCormack, Stephan Petersenn, Vera Popovic, Marily Theodoropoulou, Olaf M. Dekkers, Gerald Raverot
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Andrea Giustina, Luigi di Filippo, Agnese Allora, Daniel D. D. Bikle, Giulia Martina Cavestro, David Feldman, Giovanni Latella, Salvatore Minisola, Nicola Napoli, Silvia Trasciatti, Melin Uygur, John P. P. Bilezikian
Summary: This paper is a result of the 5th International Conference Controversies in Vitamin D, which aims to discuss controversial issues about vitamin D. The paper focuses on the relationship between vitamin D and malabsorptive gastrointestinal conditions. The participants reviewed literature and presented their findings, highlighting the bidirectional relationship between vitamin D and these conditions. The paper emphasizes the importance of regularly assessing and supplementing vitamin D in patients with these conditions.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Review
Endocrinology & Metabolism
Meliha Melin Uygur, Stefano Frara, Luigi di Filippo, Andrea Giustina
Summary: Pituitary hormones play a role in regulating bone health, and high levels can lead to bone remodeling and changes in bone microstructure. Vertebral fractures are an early sign of impaired bone health in pituitary adenoma patients, but they cannot be accurately predicted by bone mineral density. A morphometric approach is considered the gold standard in evaluating bone health, and new tools have been proposed for predicting fractures in pituitary-driven osteopathies. This review focuses on potential biomarkers and diagnostic methods for bone fragility in acromegaly, prolactinomas, and Cushing's disease, including their pathophysiological, clinical, radiological, and therapeutic implications.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Correction
Endocrinology & Metabolism
Andrea Giustina, Luigi di Filippo, Antonio Facciorusso, Robert A. Adler, Neil Binkley, Jens Bollerslev, Roger Bouillon, Felipe F. Casanueva, Giulia Martina Cavestro, Marlene Chakhtoura, Caterina Conte, Lorenzo M. Donini, Peter R. Ebeling, Angelo Fassio, Stefano Frara, Claudia Gagnon, Giovanni Latella, Claudio Marcocci, Jeffrey I. Mechanick, Salvatore Minisola, Rene Rizzoli, Ferruccio Santini, Joseph L. Shaker, Christopher Sempos, Fabio Massimo Ulivieri, Jyrki K. Virtanen, Nicola Napoli, Anne L. Schafer, John P. Bilezikian
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Endocrinology & Metabolism
Luigi di Filippo, Melin Uygur, Massimo Locatelli, Fabrizio Nannipieri, Stefano Frara, Andrea Giustina
Summary: This study evaluated the levels of vitamin D in COVID-19 patients and control subjects, and found a higher prevalence of vitamin D deficiency in COVID-19 patients. The levels of vitamin D were correlated with disease worsening, suggesting that vitamin D levels may have an impact on the outcomes of COVID-19.
Article
Endocrinology & Metabolism
Andrea Giustina, Luigi di Filippo, Melin M. Uygur, Stefano Frara
Summary: A personalized approach to acromegaly treatment, utilizing novel clinical and molecular biomarkers, has shown promising results in predicting responsiveness to second-line medical treatments. Integrating these findings into existing guidelines may significantly improve the management of difficult acromegaly patients.