期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 64, 期 17, 页码 3422-3429出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.6b00931
关键词
phenolic acid grafting chitosan; nanocomplexes; EGCG; antioxidant activity; controlled release
资金
- National Natural Science Foundation of China [31501488]
- Natural Science Foundation of Jiangsu Province, China [BK2012367]
- Fundamental Research Funds for the Central Universities [KJQN201648, KYLH201601]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20120097120001]
Modification of chitosan (CS) through grafting with caffeic acid (CA, CA-g-CS) and ferulic acid (FA, FA-g-CS) significantly improved its solubility under neutral and alkaline environments. Spherical and physicochemically stable nanocomplexes assembled from the phenolic acid grafting CS and caseinophosphopeptide (CPP) were obtained with particle size <300 nm and zeta potential of <+30 mV. The net polymer nanocomplexes composed with the phenolic acid grafting CS and CPP showed strong antioxidant activity. The encapsulation efficiencies of epigallocatechin-3-gallate (EGCG) in the CA-g-CS CPP nanocomplexes and FA-g-CS CPP nanocomplexes were 88.1 +/- 6.7 and 90.4 +/- 4.2%, respectively. Improved delivery properties of EGCG were achieved after loading with the antioxidant nanocomplexes, including controlling release of EGCG under simulated gastric environments and preventing its degradation under neutral and alkaline environments.
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