Slc38a9 Deficiency Induces Apoptosis and Metabolic Dysregulation and Leads to Premature Death in Zebrafish

Knock out of specific maternal vitellogenins in zebrafish (Danio rerio) evokes vital changes in egg proteomic profiles that resemble the phenotype of poor quality eggs

(2021) Ozlem Yilmaz et al.   BMC GENOMICS

Zebrafish Heart Failure Models

(2021) Suneeta Narumanchi et al.   Frontiers in Cell and Developmental Biology

SAR1B senses leucine levels to regulate mTORC1 signalling

(2021) Jie Chen et al.   NATURE

Autophagy coordinates chondrocyte development and early joint formation in zebrafish

(2021) Joanna J. Moss et al.   FASEB JOURNAL

A Conformational Change in the N Terminus of SLC38A9 Signals mTORC1 Activation

(2020) Hsiang-Ting Lei et al.   STRUCTURE

SLC38A10 (SNAT10) is Located in ER and Golgi Compartments and Has a Role in Regulating Nascent Protein Synthesis

(2019) Rekha Tripathi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting FBPase is an emerging novel approach for cancer therapy

(2018) Gao-Min Liu et al.   Cancer Cell International

Galectins Control mTOR in Response to Endomembrane Damage

(2018) Jingyue Jia et al.   MOLECULAR CELL

Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state

(2018) Hsiang-Ting Lei et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Zebrafish Heart Failure Model for Assessing Therapeutic Agents

(2018) Xiao-Yu Zhu et al.   Zebrafish

Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state

(2018) Hsiang-Ting Lei et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Environmental and Genetic Variables Influencing Mitochondrial Health and Parkinson’s Disease Penetrance

(2018) Alessandra Zanon et al.   Parkinsons Disease

Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms

(2018) Kuang Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ca2+ concentration–dependent premature death of igfbp5a−/− fish reveals a critical role of IGF signaling in adaptive epithelial growth

(2018) Chengdong Liu et al.   Science Signaling

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

(2017) Brian M. Castellano et al.   SCIENCE

Poor prognosis of hexokinase 2 overexpression in solid tumors of digestive system: a meta-analysis

(2017) Jiayuan Wu et al.   Oncotarget

Development of a Whole Organism Platform for Phenotype-Based Analysis of IGF1R-PI3K-Akt-Tor Action

(2017) Chengdong Liu et al.   Scientific Reports

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

Dietary rescue of altered metabolism gene reveals unexpectedDrosophilamating cues

(2016) François Bousquet et al.   JOURNAL OF LIPID RESEARCH

Impact of maternal malnutrition during the periconceptional period on mammalian preimplantation embryo development

(2015) M.A. Velazquez   DOMESTIC ANIMAL ENDOCRINOLOGY

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation

(2015) K He et al.   ONCOGENE

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Microarray-based detection and expression analysis of ABC and SLC transporters in drug-resistant ovarian cancer cell lines

(2013) Radosław Januchowski et al.   BIOMEDICINE & PHARMACOTHERAPY

An Extended Proteome Map of the Lysosomal Membrane Reveals Novel Potential Transporters

(2013) Agnès Chapel et al.   MOLECULAR & CELLULAR PROTEOMICS

Stress hyperlactataemia: present understanding and controversy

(2013) Mercedes Garcia-Alvarez et al.   Lancet Diabetes & Endocrinology

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Amino Acid Transporter LAT3 Is Required for Podocyte Development and Function

(2009) Y. Sekine et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

The Evolutionary History and Tissue Mapping of Amino Acid Transporters Belonging to Solute Carrier Families SLC32, SLC36, and SLC38

(2008) Björn E. Sundberg et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE