Review
Endocrinology & Metabolism
Haiyan Zhu, Xin Wang, Shihao Lu, Kongbo Ou
Summary: Clear cell renal cell carcinoma (ccRCC) is a malignancy characterized by metabolic reprogramming, which provides potential targets for therapeutic interventions. This review summarizes recent discoveries of metabolic alterations in ccRCC, including changes in glucose, lipid, and amino acid metabolism. It also discusses the development of metabolic drugs targeting these pathways and proposes future trends in drug development. Overall, this review highlights the potential for developing new treatments for ccRCC based on metabolic alterations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Philip Newsholme, Jordan Rowlands, Roselyn Rose'Meyer, Vinicius Cruzat
Summary: This article summarizes the metabolic adaptations and changes of pancreatic beta-cells required for survival and function under various physiological, pathological, and pharmacological conditions.
Review
Pharmacology & Pharmacy
Jiaxin Li, Xiaoxuan Zhai, Xiao Sun, Shengchuan Cao, Qiuhuan Yuan, Jiali Wang
Summary: This review summarizes recent findings on metabolic reprogramming occurring in different cell types during pulmonary fibrosis, especially those related to glucose, lipid, and amino acid metabolism, with the aim of identifying novel treatment targets for pulmonary fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Environmental Sciences
Yihui Ruan, Xin Fang, Tingyue Guo, Yiting Liu, Yu Hu, Xuening Wang, Yuxin Hu, Lanyue Gao, Yongfang Li, Jingbo Pi, Yuanyuan Xu
Summary: Chronic exposure to arsenic is associated with various cancers, with metabolic reprogramming being a key mechanism. Research has primarily focused on glucose reprogramming induced by arsenic exposure. Apart from enhanced glycolysis, arsenic may also disrupt lipid deposition and induce one-carbon metabolism pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Oncology
Xianlei Cai, Chao Liang, Miaozun Zhang, Yuan Xu, Yihui Weng, Xueying Li, Weiming Yu
Summary: N6-methyladenosine (m6A) modification plays a significant role in the metabolic reprogramming of digestive system malignancies.
Review
Biology
Toshiyuki Murai, Satoru Matsuda
Summary: Alzheimer's disease is characterized by the formation of plaques and tangles in the brain, leading to neuronal cell death. Patients with Alzheimer's disease show a preference for glycolysis instead of normal mitochondrial function, and certain dietary patterns may help prevent the disease. Effective therapies for Alzheimer's disease are still lacking, and researchers are working towards finding novel treatments and understanding the underlying mechanisms of neurodegeneration.
Article
Cell Biology
Hemant Srivastava, Alexander Tate Lasher, Akash Nagarajan, Liou Y. Sun
Summary: Alzheimer's disease (AD) is a prevalent form of dementia that is characterized by cognitive decline with age. Treatment options for AD are limited, making it a significant public health concern. Recent research has shown that metabolic dysfunction and insulin therapy may play a role in the development of AD. In this study, the TgF344-AD rat model was used to examine the relationship between body composition, insulin sensitivity, glucose tolerance, and behavioral assessments of learning, memory, and anxiety. The results showed that female TgF344-AD rats exhibited impaired glucose clearance and reduced insulin sensitivity, while male rats showed no differences or improved glucose clearance. Male rats also displayed impairments in learning and memory, while female rats showed impairments only at a later age. Additionally, female rats displayed increased anxiety at a younger age, but no differences were detected in males. These findings suggest that metabolic impairments occur before or simultaneously with cognitive decline and anxiety, in a sexually dimorphic manner, in the TgF344-AD rat model.
Review
Immunology
Hao-Yun Peng, Jason Lucavs, Darby Ballard, Jugal Kishore Das, Anil Kumar, Liqing Wang, Yijie Ren, Xiaofang Xiong, Jianxun Song
Summary: T cells undergo metabolic reprogramming and various biological processes throughout their lifespan, with the imbalance of ROS generation potentially resulting in severe cellular damage and death. Despite playing an essential role in T cell immunity, ROS can also lead to T cell-related diseases. Recent research has highlighted the effects of ROS on T cell activities within T cell immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Shubhangi Saxena, Neha Dagar, Vishwadeep Shelke, Maciej Lech, Pragyanshu Khare, Anil Bhanudas Gaikwad
Summary: The kidney undergoes metabolic reprogramming in various disease states, and understanding the involved bioenergetic pathways and developing targeted interventions are crucial for addressing the high number of kidney disease cases worldwide. Reprogramming of metabolic pathways has been observed in kidney disease, and therapies targeting these pathways have shown promising results in retarding disease progression. This review focuses on potential pharmacological interventions targeting metabolic reprogramming that have advanced through clinical trials and preclinical studies, with the aim of managing kidney disease effectively in the future.
DRUG DISCOVERY TODAY
(2023)
Review
Biochemistry & Molecular Biology
Rongrong Han, Jing Liang, Bing Zhou
Summary: Glucose is the main energy substrate for the adult brain and plays a crucial role in neuronal function. Dysregulation of glucose metabolism is commonly observed in neurodegenerative diseases, highlighting the importance of understanding metabolic adaptation mechanisms and potential interventions. Mitochondrial dysfunction, decreased glucose uptake, and hypoxia are key factors in neurodegeneration and may serve as targets for therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Shulan Qiu, Sijia He, Jianing Wang, Hu Wang, Anindita Bhattacharjee, Xin Li, Moawiz Saeed, Jeffrey L. Dupree, Xianlin Han
Summary: The interaction between obesity and central nervous system (CNS) neurological dysfunction is well recognized. Evidence shows that obesity is a risk factor for CNS neuroinflammation and cognitive impairment. This study investigates how CNS sulfatide deficiency affects peripheral metabolism, considering sex- and age-specific effects. Results show that female sulfatide-deficient mice gained more body weight, had higher basal glucose levels, and were glucose intolerant compared to controls, while male sulfatide-deficient mice only showed glucose intolerance at a later age compared to females. Increased body weight was associated with increased food intake and elevated neuroinflammation in a sex-specific manner, suggesting that CNS sulfatide deficiency leads to sex-specific alterations in energy homeostasis via dysregulated hypothalamic control of food intake.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Ling Tao, Myrthala Moreno-Smith, Rodrigo Ibarra-Garcia-Padilla, Giorgio Milazzo, Nathan A. Drolet, Blanca E. Hernandez, Young S. Oh, Ivanshi Patel, Jean J. Kim, Barry Zorman, Tajhal Patel, Abu Hena Mostafa Kamal, Yanling Zhao, John Hicks, Sanjeev A. Vasudevan, Nagireddy Putluri, Cristian Coarfa, Pavel Sumazin, Giovanni Perini, Ronald J. Parchem, Rosa A. Uribe, Eveline Barbieri
Summary: This study shows that CHAF1A gain-of-function supports cell malignancy, blocks neuronal differentiation, and promotes NB oncogenesis. Mechanistically, CHAF1A upregulates polyamine metabolism, which blocks neuronal differentiation and promotes cell cycle progression.
Article
Microbiology
Gloria Griffante, Weronika Hewelt-Belka, Camilla Albano, Francesca Gugliesi, Selina Pasquero, Sergio Fernando Castillo Pacheco, Greta Bajetto, Paolo Ettore Porporato, Erica Mina, Marta Vallino, Christian Krapp, Martin Roelsgaard Jakobsen, John Purdy, Jens von Einem, Santo Landolfo, Valentina Dell'Oste, Matteo Biolatti
Summary: Human cytomegalovirus (HCMV) utilizes host cell resources for new virion assembly, including inducing cellular metabolism changes to favor virion production. However, the host defense factor IFI16 can counteract HCMV-induced metabolic reprogramming, limiting virion infectivity by downregulating glucose transporter 4 and reducing lipogenic enzyme transcription. This discovery unveils a potential target for novel antiviral therapies.
Article
Oncology
Lingzhi Wang, Yanling Lin, Xiaohan Zhou, Yuting Chen, Xueying Li, Wenxiao Luo, Yingtong Zhou, Longmei Cai
Summary: CYLD inhibits glycolysis in nasopharyngeal carcinoma by regulating p53 and FZR1, delaying tumor growth and progression, and serving as a biomarker for poor prognosis.
Article
Neurosciences
Yang Hyun Lee, Seun Jeon, Han Soo Yoo, Seok Jong Chung, Jin Ho Jung, Kyoungwon Baik, Young H. Sohn, Phil Hyu Lee, Mijin Yun, Alan C. Evans, Byoung Seok Ye
Summary: The study investigated the relationship among amyloid-beta deposition, cortical metabolism, and clinical diagnosis in AD and LBD patients. Results showed that AD and LBD patients commonly exhibited hypometabolism in specific brain regions. Combining clinical and metabolic evaluations may enhance the diagnostic accuracy of AD, LBD, and mixed disease cases.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Polymer Science
Linyan Duan, Xingfan Li, Rong Ji, Zhizhong Hao, Mingyue Kong, Xuejun Wen, Fangxia Guan, Shanshan Ma
Summary: Neurodegenerative diseases are common incurable neurological disorders that lead to impairments in memory, movement, language, and intelligence, threatening the lives and health of patients worldwide. Nanoparticles can be used as drug transport carriers, known as nanoparticle-based drug delivery systems, which increase drug stability, facilitate drug penetration through the blood-brain barrier, and improve efficacy.
Review
Polymer Science
Xingfan Li, Linyan Duan, Mingyue Kong, Xuejun Wen, Fangxia Guan, Shanshan Ma
Summary: Traumatic brain injury (TBI) is a serious global neurotrauma that affects the quality of life of patients and imposes burdens on families, healthcare institutions, and society. Hydrogels, especially stimuli-responsive hydrogels, have shown great potential in the treatment of TBI due to their biodegradability and similarity to the natural extracellular matrix. This review examines the applications and therapeutic effects of stimuli-responsive hydrogels in TBI, including promoting neurogenesis, reducing inflammation and apoptosis, preventing oxidative stress, and promoting angiogenesis.