Article
Agronomy
Wenhui Guo, Xiang Lu, Bin Liu, He Yan, Juntao Feng
Summary: Plant viral diseases are difficult to control and pose serious threats to the agricultural industry. Biopesticides derived from botanical sources, such as the alkaloids chelerythrine and chelidonine isolated from Chelidonium majus, show significant potential as antiviral agents against tobacco mosaic virus (TMV), providing important evidence for developing new virus disease control measures in agriculture.
PEST MANAGEMENT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yucong Ma, Lu Wang, Aidang Lu, Wei Xue
Summary: A series of oxazinyl flavonoids were synthesized based on flavone and their activities against tobacco mosaic virus (TMV) and plant pathogenic fungi were investigated. The compounds exhibited moderate to excellent antiviral activities against TMV, with some even surpassing commercially available antiviral agents. They also displayed broad-spectrum fungicidal activities against six kinds of plant pathogenic fungi.
Article
Agriculture, Multidisciplinary
Tienan Wang, Lin Li, Yanan Zhou, Aidang Lu, Hongyan Li, Jianxin Chen, Zhongyu Duan, Qingmin Wang
Summary: A series of hamacanthin derivatives were synthesized based on a marine natural product, showing high antiviral and fungicidal activities, with some compounds outperforming existing pesticides. Additionally, the research revealed the antiviral mechanism of one compound.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agronomy
Tie-Nan Wang, Shan Yang, Shao-Yang Shi, Wen-Ying Yuan, Jian-Xin Chen, Zhong-Yu Duan, Ai-Dang Lu, Zi-Wen Wang, Qing-Min Wang
Summary: Plant diseases have been a major issue in agricultural production, impacting crop growth and yields. Marine natural products, specifically pityriacitrin alkaloids, were synthesized and evaluated for their antiviral and fungicidal activities. Compounds 3a and 5f showed promising results as new candidates for antiviral and fungicidal research, providing a new avenue for the development of novel inhibitors against plant viruses and fungi.
PEST MANAGEMENT SCIENCE
(2021)
Article
Agriculture, Multidisciplinary
Ling Li, Jiyong Zou, Changjiang Xu, Shengyong You, Zhaoyang Deng, Guihua Chen, Yuxiu Liu, Qingmin Wang
Summary: By effectively isolating crocin-1 and crocin-2 from Gardeniae fructus and synthesizing a series of crocetin diester derivatives, compound 14 with significantly higher antiviral activities than ribavirin emerged as a new antiviral candidate, demonstrating the potential in developing antiviral agents with an original structure and noticeable effect using natural products as lead compounds.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jia-Meng Dai, Qi-Li Mi, Xue-Mei Li, Du Gang, Guang-Yu Yang, Jian-Duo Zhang, Jin Wang, Yin-Ke Li, Hai-Ying Yang, Dong Miao, Zhen-Jie Li, Qiu-Fen Hu
Summary: This study isolated several new bioactive compounds from the tobacco-derived fungus, and isoaspergilline A and notoamide M showed anti-TMV activities. Molecular docking studies revealed their strong interactions with the residues in the active site of anti-TMV.
Article
Agriculture, Multidisciplinary
Ling Li, Jiyong Zou, Changjiang Xu, Shengyong You, Yongqiang Li, Qingmin Wang
Summary: The structure-activity relationship of gossypol was further studied through the design and synthesis of hemigossypol and its derivatives, which exhibited strong anti-tobacco mosaic virus and fungicidal activities. Hemigossypol acid lactone showed stability and higher insecticidal activity compared to commercial species.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agriculture, Multidisciplinary
Yu-Bin Bai, Meng Zhang, Ding Li, Yu Zhao, Liang-Zhu Huang, Jin-Ming Gao
Summary: Researchers synthesized 39 diversified griseofulvin derivatives and found that compounds 5h and 5l exhibited excellent antifungal activity against two phytopathogenic fungi. Compounds 9, 10, 11, and 12 also showed potential antifungal activity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Plant Sciences
Leandro Ferrini, Juan Pablo Rodriguez, Juan Pablo Melana Colavita, Gabriela Olea, Gonzalo Adrian Ojeda, Gabriela Ricciardi, Ana Maria Torres, Maria Victoria Aguirre
Summary: The ethanolic extract of Nectandra angustifolia has a high content of flavonoids and possesses antioxidant and anti-inflammatory properties as demonstrated by multiparametric analyses from in vitro assays and an in vivo model of inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wei Luo, Kaiyue Wang, Jingyi Luo, Yingchen Liu, Jiawen Tong, Mengting Qi, Yue Jiang, Yong Wang, Zhiqing Ma, Juntao Feng, Bin Lei, He Yan
Summary: The main component of orange peel essential oil, limonene, has antibacterial, antiseptic, and antitumor activity, and is of great value in agriculture. It has been found that limonene exhibits excellent antiviral activity against tobacco mosaic virus (TMV), and it triggers a hypersensitive response in tobacco. Limonene also enhances defense enzyme activity and the expression of defense-related genes, as well as the accumulation of salicylic acid. Furthermore, it has been shown to induce plant resistance against various pathogens in pot experiments.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Thomas C. Sparks, Stephen O. Duke
Summary: Natural products have a long history as sources of compounds for crop protection, and have also served as models for the discovery and development of synthetic crop protection compounds. The simplification of natural product structures is key for the development of future agrochemicals focused on fungicides, herbicides, and insecticides.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Xin-Hui Zhang, Qian Guo, Heng-Ying Wang, Yi-Han Li, Mussa Yussuf Khamis, Li-Ying Ma, Bo Wang, Hong-Min Liu
Summary: A pharmacophore fusion strategy was used to design and synthesize new indole-azole hybrids based on the structure of gramine, aiming to enhance its anti-gastric cancer activity. Terminal alkyne group was found to play a crucial role in improving the inhibitory effect, with compound 16h showing the best antiproliferative activity against MGC803 cells. Additionally, compound 16h induced mitochondria-mediated apoptosis, caused cell cycle arrest at G2/M phase, and inhibited the metastasis ability of MGC803 cells.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Wataru Miyanishi, Makoto Ojika, Dai Akase, Misako Aida, Yasuhiro Igarashi, Yukishige Ito, Yu Nakagawa
Summary: The study found that attachment of 2-aminoethanol to the carboxy group of PRM-A significantly suppressed aggregation, and the prepared amide derivatives not only bound to Man without aggregation but also exhibited antifungal activity.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Yan-Yan Ding, Han Zhou, Bao-Qi Peng-Deng, Bao-Qi Zhang, Zhi-Jun Zhang, Guang-Han Wang, Shao-Yong Zhang, Zheng-Rong Wu, Yi-Rong Wang, Ying-Qian Liu
Summary: Since the isolation of the first natural carbazole alkaloid, murrayanine, from Mwraya Spreng, carbazole alkaloid derivatives have attracted wide attention for their anti-tumor, anti-viral, and anti-bacterial activities. Recent research has shown that carbazole alkaloids and their derivatives exhibit diverse biological activities. This study provides the first comprehensive description of the antifungal and antibacterial activities of carbazole alkaloids in the past decade (2012-2022), including both natural and partially synthesized compounds. The challenges and problems faced by this class of alkaloids are also summarized. This paper will facilitate further exploration of carbazole alkaloids.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Xue Bai, Yong Shen, Tiehua Zhang, Rizeng Meng, Yan Zhang, Yanhong Deng, Na Guo
Summary: This study aimed to evaluate the anti-biofilm effects of natural product biochanin A against Staphylococcus aureus. Results showed that biochanin A effectively eradicated established S. aureus biofilms on different food-contact materials. Molecular docking also demonstrated that biochanin A conducted strong interactions with biofilm-related proteins.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)