期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 64, 期 34, 页码 6630-6640出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.6b02656
关键词
bisphenol S; oxidative stress; catalase; hepatocyte; renal cell; spectroscopy
资金
- NSFC [21277081, 21477067, 21507071, 201577083]
- Cultivation Fund of the Key Scientific and Technical Innovation Project
- Research Fund for the Doctoral Program of Higher Education and Ministry of Education of China [20130131110016]
- Science and Technology Development Plan of Shandong Province [2014GSF117027]
- Fundamental Research Funds of Shandong University [2014BT013, 2015JC010, 2015JC030]
Bisphenol S (BPS) is present in multitudinous consumer products and detected in both food and water. It also has been a main substitute for bisphenol A (BPA) in the food-packaging industry. Yet, the toxicity of BPS is not fully understood. The present study of the toxicity of BPS was divided into two parts. First, oxidative stress, cell viability, apoptosis level, and catalase (CAT) activity in mouse hepatocytes and renal cells were investigated after BPS exposure. After 12 h of incubation with BPS, all of these parameters of hepatocytes and renal cells changed by >15% as the concentration of BPS ranged from 0.1 to 1 mM. Second, the direct interaction between BPS and CAT on the molecule level was investigated by multiple spectral methods and molecular docking investigations. BPS changed the structure and the activity of CAT through binding to the Gly 117 residue on the substrate channel of the enzyme. The main binding forces were hydrogen bond and hydrophobic force.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据