Review
Cell Biology
MelissaR Pitman, Martin K. Oehler, Stuart M. Pitson
Summary: Ovarian cancer is a deadly gynaecological malignancy commonly diagnosed at an advanced stage, making treatment challenging. Novel strategies for early detection and therapeutics are urgently needed to improve patient survival, with the sphingolipid pathway showing promise as a potential therapeutic target against chemotherapy-resistant disease.
CELLULAR SIGNALLING
(2021)
Article
Medicine, Research & Experimental
Fangfang Zhu, Jie Gao, Fuling Zeng, Yuling Lai, Xiaofeng Ruan, Gaopi Deng
Summary: This study investigated the protective effects and mechanisms of hyperoside against cyclophosphamide-induced ovarian damage and reduced fertility. The results showed that hyperoside can diminish follicular depletion, prevent excessive hypoxia and autophagy activation, and increase follicular reserve, thereby improving fertility in mice.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Miaoling Lin, Rui Hua, Jing Ma, Yao Zhou, Pei Li, Xiya Xu, Zhiqiang Yu, Song Quan
Summary: This study demonstrated that BPA exposure could significantly decrease human ovarian functions and lead to abnormal folliculogenesis by activating autophagy in GCs through the AMPK/mTOR/ULK1 pathway.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Si Yang, Jie Chen, Bingchun Ma, Jinglei Wang, Jiaxiang Chen
Summary: LPC has been found to inhibit cell viability and induce apoptosis and autophagy in mouse ovarian granulosa cells, with the involvement of oxidative stress and autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Abdel Halim Harrath, Abdulkarem Alrezaki, Maroua Jalouli, Nouf Aldawood, Waleed Aldahmash, Lamjed Mansour, Saleh Alwasel
Summary: Exposure to ethylbenzene caused structural and functional disorders of the ovary by disrupting the normal growth of follicles, altering reproductive hormone balance, inhibiting the expression of key reproductive proteins, and triggering autophagy as well as apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Reproductive Biology
Xin Zhang, Ming Li, Mingguang Huang, Hao Peng, Xingxing Song, Lei Chen, Wen Hu, Wenhao Xu, Rongrong Luo, Dongyang Han, Yan Shi, Yajie Cao, Xun Li, Chuanhuo Hu
Summary: This study investigated the role of RFRP-3 in apoptosis and autophagy in porcine granulosa cells (GCs) and the molecular mechanisms involved. The results showed that RFRP-3 dose-dependently increased the expression of autophagy markers and exhibited a bidirectional effect on the expression of apoptosis markers. The p38MAPK signaling pathway played a critical role in the cellular response of porcine GCs to RFRP-3 by controlling the balance between apoptosis and autophagy.
Article
Medicine, Research & Experimental
Waleed A. I. Khallaf, Ehab E. Sharata, Mina Ezzat Attya, Amira M. Abo-Youssef, Ramadan A. M. Hemeida
Summary: LCZ696 effectively mitigated CP-induced premature ovarian failure, offering promising protection that could be related to its suppression power on NLRP3-induced pyroptosis and TLR4/NF-B P65 pathway.
Article
Biology
Abdulkarem Alrezaki, Nouf Aldawood, Lamjed Mansour, Mukhtar Ahmed, Alexander V. Sirotkin, Saleh Alwasel, Abdel Halim Harrath
Summary: Toluene has been found to be highly toxic to humans and animals, causing damage to various tissues. However, research on its effects on ovarian function is still limited. A study on female Wistar rats showed that toluene exposure decreased ovarian weight, affected ovarian structure, and increased abnormal follicle growth. Additionally, it raised progesterone and testosterone levels and inhibited the expression of genes involved in granulosa cell proliferation and differentiation. The study also demonstrated that toluene exposure induced apoptosis and autophagy, with different effects at various doses.
Article
Biochemistry & Molecular Biology
Zhen Zheng, Wenlong Zuo, Rongrong Ye, Jason William Grunberger, Nitish Khurana, Xianyu Xu, Hamidreza Ghandehari, Fenglei Chen
Summary: This study investigates the relationship between autophagy and apoptosis induced by silica nanoparticles (SNPs) in ovarian granulosa cells. The results show that intratracheal instillation of 25.0 mg/kg body weight (b.w.) of 110 nm spherical Stober SNPs causes ovarian granulosa cell apoptosis in follicles in vivo. In vitro, SNPs mainly internalize into the lumens of lysosomes in primary cultured ovarian granulosa cells. SNPs induce cytotoxicity by decreasing cell viability and increasing apoptosis in a dose-dependent manner, activating autophagy and blocking autophagic flux.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shujuan Liu, Qiqi Bu, Jiashun Tong, Zhanhang Wang, Jiuzeng Cui, Heran Cao, Haidong Ma, Binyun Cao, Xiaopeng An, Yuxuan Song
Summary: This study revealed the differential expression of miR-486 in the ovaries of monotocous dairy goats and its significant effects on the survival, apoptosis, and autophagy of granulosa cells. Further experiments identified and characterized the interaction between miR-486 and SRSF3, demonstrating its regulatory role in granulosa cell function. These findings provide insights into the underlying molecular mechanism of miR-486 in ovarian follicle atresia and its target gene SRSF3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Juan Feng, Wen-Wen Ma, Hui-Xia Li, Xiu-Ying Pei, Shou-Long Deng, Hua Jia, Wen-Zhi Ma
Summary: This study demonstrates that melatonin (Mel) can serve as an adjuvant to protect young female cancer patients from premature ovarian insufficiency (POI) induced by Cyclophosphaty-45mide (Cyc) chemotherapy. Melatonin treatment maintains ovarian hormone levels and inhibits the mitochondrial apoptotic pathway to prevent follicle loss. This has important implications for preserving fertility in cancer patients undergoing chemotherapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Plant Sciences
Xia Liu, Yufan Song, Fanru Zhou, Chu Zhang, Fan Li, Runan Hu, Wenwen Ma, Kunkun Song, Zhouping Tang, Mingmin Zhang
Summary: Si-Wu-Tang (SWT) has been widely used in traditional medicine for supplementing blood and regulating menstruation. This study aimed to investigate the potential effects and underlying mechanisms of SWT on premature ovarian failure (POF) in mice. The results showed that SWT improved ovarian function in POF mice, possibly through inhibiting the PI3K/Akt signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Immunology
Xiaoyan Li, Haifeng Ye, Tie Su, Chuan Hu, Yaoqi Huang, Xinxin Fu, Zhisheng Zhong, Xuelian Du, Yuehui Zheng
Summary: Premature ovarian failure (POF) is a leading cause of infertility in women, with no effective treatment currently available. Research suggests that immune disorders and Chitosan Oligosaccharides (COS) may play important roles in the development and treatment of POF.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Yan Zhao, Wen Wang, Wenying Pan, Yunhai Yu, Wenqian Huang, Jiangang Gao, Ying Zhang, Shiqian Zhang
Summary: The study demonstrated that WWOX can induce apoptosis, inhibit chemoresistance, and suppress autophagy by downregulating autophagic effectors in EOC cells treated with PTX. This mechanism may be achieved through activation of the mTOR signaling pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Obstetrics & Gynecology
Oren Kashi, Hadassa Roness, Itai Spector, Sanaz Derech-Haim, Dror Meirow
Summary: This study found that the combined administration of temsirolimus and c-terminus recombinant anti-Mullerian hormone (rAMH) can completely prevent chemotherapy-induced ovarian reserve loss in mice by suppressing primordial follicle activation and reducing apoptosis.
HUMAN REPRODUCTION
(2023)