Article
Biochemistry & Molecular Biology
Ronghui Yang, Lingkun Zuo, Hui Ma, Ying Zhou, Ping Zhou, Liyong Wang, Miao Wang, Mahrukh Latif, Lu Kong
Summary: In this study, the researchers discovered the importance of nc886 gene in prostate cancer, which affects tumor progression and metastasis by changing cellular morphology and promoting epithelial-to-mesenchymal transition (EMT). They found that nc886 promotes MET by facilitating the degradation of SNAIL protein through ubiquitination. Additionally, they revealed that TGF-beta 1 regulates the transcription of nc886 and its neighboring genes through multiple mechanisms, thus further influencing the EMT process.
Review
Cell Biology
Maoduo Zhang, Ying Yi Zhang, Yongze Chen, Jia Wang, Qiang Wang, Hezhe Lu
Summary: The TGF-beta pathway in cancer has dual roles and is considered a potential new avenue for cancer therapy, but its functions and mechanisms of action require further investigation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Mahshid Deldar Abad Paskeh, Maliheh Entezari, Sepideh Mirzaei, Amirhossein Zabolian, Hossein Saleki, Mohamad Javad Naghdi, Sina Sabet, Mohammad Amin Khoshbakht, Mehrdad Hashemi, Kiavash Hushmandi, Gautam Sethi, Ali Zarrabi, Alan Prem Kumar, Shing Cheng Tan, Marios Papadakis, Athanasios Alexiou, Md Asiful Islam, Ebrahim Mostafavi, Milad Ashrafizadeh
Summary: This review discusses the role of exosomes in cancer progression, therapy, and regulation of the tumor microenvironment. The study found that exosomes can influence cancer cell proliferation and migration rates by modulating components of the tumor microenvironment. Depending on their cargo, exosomes can promote or suppress tumor cell progression and enhance or reduce the response to radiotherapy and chemotherapy. Additionally, exosomes can trigger chronic inflammation and lead to immune evasion and tumor progression by transferring RNA and modulating molecular signaling pathways. Moreover, exosomes can serve as carriers of anti-tumor agents and genetic tools to control cancer progression. Finally, exosomes are valuable diagnostic and prognostic tools in the treatment of cancer patients.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Min Lu, Subo Zhang, Heng Zhou, Xiaoyu Yu, Jianing Li, Boshi Fu, Minjie Wei, Huilin Huang, Huizhe Wu
Summary: Alternative splicing is a common process in eukaryotic gene regulation, and it greatly enriches the complexity and diversity of mRNAs and proteins. Recent studies have found that non-coding RNAs (ncRNAs) are also involved in alternative splicing, and abnormal expression of ncRNAs and ncRNA-related splicing events are implicated in cancer initiation, progression, and drug resistance. Therefore, targeting ncRNAs, splicing factors, and splicing-related antigens may have therapeutic potential in cancer treatment.
Review
Pharmacology & Pharmacy
Feixiang Yang, Jiawei Li, Qintao Ge, Yuchen Zhang, Meng Zhang, Jun Zhou, Haitao Wang, Juan Du, Shenglin Gao, Chaozhao Liang, Jialin Meng
Summary: Prostate cancer is the most common tumor among men, and advanced prostate cancer often leads to death due to resistance to existing treatments. Immunotherapy, particularly immune checkpoint inhibitors (ICIs), has shown great progress in solid tumor treatment, but has limited effectiveness in metastatic castration-resistant prostate cancer (mCRPC). Non-coding RNAs (ncRNAs) have been identified as an ideal class of molecules for cancer treatment, and targeting related ncRNAs presents an opportunity to improve the effectiveness of immunotherapy in mCRPC.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Oncology
Diego de Miguel-Perez, Alessandro Russo, Muthukumar Gunasekaran, Francesco Buemi, Lisa Hester, Xiaoxuan Fan, Brandon A. Carter-Cooper, Rena G. Lapidus, Ariel Peleg, Marisol Arroyo-Hernandez, Andres F. Cardona, Aung Naing, Fred R. Hirsch, Philip C. Mack, Sunjay Kaushal, Maria Jose Serrano, Vincenzo Adamo, Oscar Arrieta, Christian Rolfo
Summary: Immune-checkpoint inhibitors are effective in treating lung cancer, but there is a need for better predictive biomarkers to identify patients who will benefit. This study found that high levels of TGF-beta in extracellular vesicles before treatment were a better predictor of response to ICIs and survival compared to circulating TGF-beta and tissue PD-L1.
Article
Chemistry, Analytical
Ludmila Moranova, Michal Stanik, Roman Hrstka, Susana Campuzano, Martin Bartosik
Summary: A novel method for detecting prostate cancer by combining electrochemical assay with LAMP technology has been developed, allowing for direct detection of two RNA biomarkers PCA3 and PSA in urine samples. This method demonstrates good sensitivity and specificity, providing a minimally invasive diagnostic format.
Article
Oncology
Ella A. Eklund, Clotilde Wiel, Henrik Fagman, Levent M. Akyurek, Sukanya Raghavan, Jan Nyman, Andreas Hallqvist, Volkan Sayin
Summary: This retrospective study investigated the impact of KRAS mutational status on clinical outcome in patients with metastatic non-small cell lung cancer (NSCLC). The results showed that KRAS(MUT) patients had better response to immune checkpoint blockade (ICB) but worse response to platinum doublet chemotherapy (PT). Additionally, KRAS(WT) patients with high PD-L1 expressing tumors responded better to PT than ICB.
Article
Oncology
Michael R. Conroy, Colum Dennehy, Patrick M. Forde
Summary: Only a minority of lung cancers are resectable at diagnosis, highlighting the need for new approaches to improve cure rates. Checkpoint inhibitor immunotherapy has shown promising results in advanced lung cancer and is being increasingly used in the neoadjuvant setting, but questions remain regarding optimal duration, biomarkers, response assessment, and combination with other therapies.
Article
Cell Biology
Wei Hu, Yanru Wang, Zhixiao Fang, Wei He, Shengli Li
Summary: Through integrated analysis, we found the importance of lncRNA-immune interactions in prostate cancer, especially the impact of the TGF-beta signaling pathway and the key role of lncRNAs in regulating immune response. We also identified LINC00861 as a potential target for immunotherapy in prostate cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yeonsoo Chae, Jungwook Roh, Wanyeon Kim
Summary: Gliomas originate in the central nervous system and are categorized based on both histological and molecular genetic characteristics. Long non-coding RNAs (lncRNAs) play a crucial role in regulating tumorigenesis, tumor progression, and therapeutic resistance in glioma cells. Oncogenic lncRNAs and tumor-suppressive lncRNAs orchestrate signaling pathways that influence the pathogenesis and progression of gliomas, as well as the sensitivity to existing anticancer therapies. This review aims to enhance understanding of the impact of lncRNAs on signaling pathways in gliomas and their role in therapeutic resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Yongyong Yang, Kilia Y. Liu, Qi Liu, Qi Cao
Summary: Prostate cancer is the second leading cause of cancer-related death among men in the United States, with the androgen receptor signaling playing a crucial role in the disease. Advances in high-throughput RNA sequencing techniques have identified a growing number of non-coding RNAs that are involved in prostate cancer progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Jie Guo, Shuang Wang, Zhenzhen Jiang, Le Tang, Zhizhong Liu, Jian Cao, Zhaolan Hu, Xiao Chen, Yanwei Luo, Hao Bo
Summary: In this study, the researchers explored the possibility of using testis-specific long-chain non-coding RNA (lncRNA) Ret finger protein-like 3S (RFPL3S) as a biomarker for the diagnosis, prognosis, and treatment response of testicular germ cell tumor (TGCT). Through analyzing gene expression data in various databases, they found that RFPL3S expression was significantly reduced in TGCT and correlated with patient's disease stage. They also observed that RFPL3S methylation and copy number were associated with disease-free and progression-free intervals. Furthermore, RFPL3S expression was linked to immune cell infiltration and could predict immunotherapy benefits in TGCT patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Hongxu Li, Jie Gao, Long Liu, Shuijun Zhang
Summary: LINC00958, a long non-coding RNA highly expressed in various malignancies, plays a role in enhancing tumor cells' resistance to radiotherapy and chemotherapy, inducing lymphangiogenesis, and facilitating tumor glycolytic metabolism. Additionally, LINC00958 acts as a ceRNA and regulates the malignant behavior of tumor cells through the miRNA-mRNA axis, showcasing potential as a novel biomarker and therapeutic target in cancer diagnosis and treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Zhi Liu, Tiezheng Qi, Xiaowen Li, Yiyan Yao, Belaydi Othmane, Jinbo Chen, Xiongbing Zu, Zhenyu Ou, Jiao Hu
Summary: In this study, a TGF-beta signature was constructed and validated to predict prognosis and TME phenotypes for BLCA. The TGF-beta risk score could assist in individual precision treatment for BLCA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Dermatology
Jan Kyselovic, Jozef Masarik, Hayet Kechemir, Eva Koscova, Iva Igracki Turudic, Michael Richard Hamblin
Summary: Infrared light therapy has positive effects on relieving musculoskeletal pain through several mechanisms, including increasing nitric oxide availability and reducing inflammation.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Asmita Deka Dey, Satar Yousefiasl, Arun Kumar, Farnaz Dabbagh Moghaddam, Ilnaz Rahimmanesh, Mohamadmahdi Samandari, Sumit Jamwal, Aziz Maleki, Abbas Mohammadi, Navid Rabiee, Ana Claudia Paiva-Santos, Ali Tamayol, Esmaeel Sharifi, Pooyan Makvandi
Summary: MicroRNAs (miRNAs) have shown significant effectiveness in treating acute and chronic wounds. However, their limited stability and intracellular delivery pose challenges in the design of miRNA and its delivery system. This review discusses the roles of miRNAs in different stages of wound healing and highlights recent advances in nanotechnology and biomaterials for developing new strategies. The challenges and opportunities for translating miRNA-based strategies into clinical applications are also discussed.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Hamed Kowsari, Amirhossein Davoodvandi, Fatemeh Dashti, Seyed Mohamad Ali Mirazimi, Zahra Razaghi Bahabadi, Michael Aschner, Amirhossein Sahebkar, Hamid Reza Gilasi, Michael R. Hamblin, Hamed Mirzaei
Summary: Acute liver injury (ALI) is a critical and fatal disorder associated with excessive alcohol consumption. Despite advances in the early diagnosis and treatment of breast cancer, it remains a leading cause of cancer-related death in women worldwide. Phytochemicals, such as resveratrol, have shown promise in preventing and treating breast cancer. While resveratrol can affect various signaling pathways in vitro, its efficacy in animal models of breast cancer has been disappointing.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Milad Ashrafizadeh, Ali Zarrabi, Hassan Karimi-Maleh, Afshin Taheriazam, Sepideh Mirzaei, Mehrdad Hashemi, Kiavash Hushmandi, Pooyan Makvandi, Ehsan Nazarzadeh Zare, Esmaeel Sharifi, Arul Goel, Lingzhi Wang, Jun Ren, Yavuz Nuri Ertas, Alan Prem Kumar, Yuzhuo Wang, Navid Rabiee, Gautam Sethi, Zhaowu Ma
Summary: Nanomedicine has great potential in the treatment of bladder cancer, including improving drug efficacy, regulating gene expression, providing photodynamic and photothermal therapy, remodeling tumor microenvironment and infiltration of immune cells, timely diagnosis, and targeted therapy for bladder cancer.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Ming Zhong, Ghanbar Mahmoodi Chalbatani, Meifang Deng, Qiuyi Li, Elahe Gharagouzloo, Michael R. Hamblin, Eloah Rabello Suarez, Lili Hu, Dingding Wang
Summary: This study investigates the potential of CAR-T cells modified with a chimeric antigen receptor (CAR) targeting the vascular endothelial growth factor 2 receptor/kinase insert domain receptor (KDR) to destroy tumors. The results demonstrate the effectiveness of this CAR construct in inhibiting the growth of lung cancer and suggest its applicability as a new treatment strategy for other vascularized solid tumors.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Mohammad Arad Zandieh, Melika Heydari Farahani, Romina Rajabi, Shamim Tavakkoli Avval, Kimia Karimi, Parham Rahmanian, Mehrnaz Razzazan, Salar Javanshir, Sepideh Mirzaei, Mahshid Deldar Abad Paskeh, Shokooh Salimimoghadam, Kiavash Hushmandi, Afshin Taheriazam, Vijay Pandey, Mehrdad Hashemi
Summary: This review evaluates the role of non-coding RNAs in regulating autophagy in gastrointestinal tumors, and finds that the ncRNA/autophagy axis can reduce/increase tumor proliferation through the glycolysis mechanism, and affect tumor growth, invasion, and therapy response, as well as metastasis pathways and the response to chemotherapy and radiotherapy.
PHARMACOLOGICAL RESEARCH
(2023)
Correction
Nanoscience & Nanotechnology
Marzieh Ramezani Farani, Maryam Azarian, Hamid Heydari Sheikh Hossein, Zohreh Abdolvahabi, Zahra Mohammadi Abgarmi, Arash Moradi, Seyyedeh Maedeh Mousavi, Milad Ashrafizadeh, Pooyan Makvandi, Mohammad Reza Saeb, Navid Rabiee
ACS APPLIED BIO MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Minmin Shao, Ashkan Bigham, Satar Yousefiasl, Cynthia K. Y. Yiu, Yarabahally R. Girish, Matineh Ghomi, Esmaeel Sharifi, Serap Sezen, Ehsan Nazarzadeh Zare, Ali Zarrabi, Navid Rabiee, Ana Claudia Paiva-Santos, Serena Del Turco, Baolin Guo, Xiangdong Wang, Virgilio Mattoli, Aimin Wu
Summary: Oxidative damage and infection can hinder tissue repair, and infection aggravates the production of reactive oxygen species (ROS), exacerbating the condition of wounds. Therefore, there is a need for antioxidant and antibacterial agents in tissue regeneration. This article summarizes the principles of antioxidant and antibacterial activity, discussing the biological aspects of tissue barriers against infection, the chemistry and mechanism of action of dual-function antioxidant and antibacterial materials. The article also highlights future prospects and challenges for these biomaterials, aiming to inspire advanced designs and pave the way for their clinical application.
Review
Genetics & Heredity
Alireza Farokhian, Ali Rajabi, Amirhossein Sheida, Amirhossein Abdoli, Moein Rafiei, Zahra Hadian Jazi, Sahar Ahmadi Asouri, Mohammad Amin Morshedi, Michael R. Hamblin, Parisa Adib-Hajbagheri, Hamed Mirzaei
Summary: ncRNAs, particularly miRNAs, lncRNAs, and circRNAs, play a significant role in regulating gene expression and affecting multiple cellular processes, especially apoptosis. Apoptosis has recently gained great interest as a therapeutic target to improve myocardial infarction outcomes. This review summarizes studies on ncRNAs that can promote or suppress apoptosis in the context of myocardial infarction, potentially introducing new therapeutic targets for its treatment.
Editorial Material
Biotechnology & Applied Microbiology
Ali Zarrabi
BIOENGINEERING-BASEL
(2023)
Article
Oncology
Amanda Ramos da Cunha, Kelly Compton, Rixing Xu, Rashmi Mishra, Mark Thomas Drangsholt, Jose Leopoldo Ferreira Antunes, Alexander R. Kerr, Alistair R. Acheson, Dan Lu, Lindsey E. Wallace, Jonathan M. Kocarnik, Weijia Fu, Frances E. Dean, Alyssa Pennini, Hannah Jacqueline Henrikson, Tahiya Alam, Emad Ababneh, Sherief Abd-Elsalam, Meriem Abdoun, Hassan Abidi, Hiwa Abubaker Ali, Eman Abu-Gharbieh, Tigist Demssew Adane, Isaac Yeboah Addo, Aqeel Ahmad, Sajjad Ahmad, Tarik Ahmed Rashid, Maxwell Akonde, Hanadi Al Hamad, Fares Alahdab, Yousef Alimohamadi, Vahid Alipour, Sadeq Ali Al-Maweri, Ubai Alsharif, Alireza Ansari-Moghaddam, Sumadi Lukman Anwar, Anayochukwu Edward Anyasodor, Jalal Arabloo, Aleksandr Y. Aravkin, Raphael Taiwo Aruleba, Malke Asaad, Tahira Ashraf, Seyyed Shamsadin Athari, Sameh Attia, Sina Azadnajafabad, Mohammadreza Azangou-Khyavy, Muhammad Badar, Nayereh Baghcheghi, Maciej Banach, Mainak Bardhan, Hiba Jawdat Barqawi, Nasir Z. Bashir, Azadeh Bashiri, Habib Benzian, Eduardo Bernabe, Devidas S. Bhagat, Vijayalakshmi S. Bhojaraja, Tone Bjorge, Souad Bouaoud, Dejana Braithwaite, Nikolay Ivanovich Briko, Daniela Calina, Giulia Carreras, Promit Ananyo Chakraborty, Vijay Kumar Chattu, Akhilanand Chaurasia, Meng Xuan Chen, William C. S. Cho, Dinh-Toi Chu, Isaac Sunday Chukwu, Eunice Chung, Natalia Cruz-Martins, Omid Dadras, Xiaochen Dai, Lalit Dandona, Rakhi Dandona, Parnaz Daneshpajouhnejad, Reza Darvishi Cheshmeh Soltani, Aso Mohammad Darwesh, Sisay Abebe Debela, Meseret Derbew Molla, Fikadu Nugusu Dessalegn, Mostafa Dianati-Nasab, Lankamo Ena Digesa, Shilpi Gupta Dixit, Abhinav Dixit, Shirin Djalalinia, Iman El Sayed, Maha El Tantawi, Daniel Berhanie Enyew, Daniel Asfaw Erku, Rana Ezzeddini, Adeniyi Francis Fagbamigbe, Luca Falzone, Getahun Fetensa, Takeshi Fukumoto, Piyada Gaewkhiew, Silvano Gallus, Mesfin Gebrehiwot, Ahmad Ghashghaee, Paramjit Singh Gill, Mahaveer Golechha, Pouya Goleij, Ricardo Santiago Gomez, Giuseppe Gorini, Andre Luiz Sena Guimaraes, Bhawna Gupta, Sapna Gupta, Veer Bala Gupta, Vivek Kumar Gupta, Arvin Haj-Mirzaian, Esam S. Halboub, Rabih Halwani, Asif Hanif, Ninuk Hariyani, Mehdi Harorani, Hamidreza Hasani, Abbas M. Hassan, Soheil Hassanipour, Mohammed Bheser Hassen, Simon I. Hay, Khezar Hayat, Brenda Yuliana Herrera-Serna, Ramesh Holla, Nobuyuki Horita, Mehdi Hosseinzadeh, Salman Hussain, Olayinka Stephen Ilesanmi, Irena M. Ilic, Milena D. Ilic, Gaetano Isola, Abhishek Jaiswal, Chinmay T. Jani, Tahereh Javaheri, Umesh Jayarajah, Shubha Jayaram, Nitin Joseph, Vidya Kadashetti, Eswar Kandaswamy, Shama D. Karanth, Ibraheem M. Karaye, Joonas H. Kauppila, Harkiran Kaur, Mohammad Keykhaei, Yousef Saleh Khader, Himanshu Khajuria, Javad Khanali, Mahalaqua Nazli Khatib, Hamid Reza Khayat Kashani, Mohammad Amin Khazeei Tabari, Min Seo Kim, Farzad Kompani, Hamid Reza Koohestani, G. Anil Kumar, Om P. Kurmi, Carlo La Vecchia, Dharmesh Kumar Lal, Ivan Landires, Savita Lasrado, Caterina Ledda, Yo Han Lee, Massimo Libra, Stephen S. Lim, Stefan Listl, Platon D. Lopukhov, Ahmad R. Mafi, Rashidul Alam Mahumud, Ahmad Azam Malik, Manu Raj Mathur, Sazan Qadir Maulud, Jitendra Kumar Meena, Entezar Mehrabi Nasab, Tomislav Mestrovic, Reza Mirfakhraie, Awoke Misganaw, Sanjeev Misra, Prasanna Mithra, Yousef Mohammad, Mokhtar Mohammadi, Esmaeil Mohammadi, Ali H. Mokdad, Mohammad Ali Moni, Paula Moraga, Shane Douglas Morrison, Hamid Reza Mozaffari, Sumaira Mubarik, Christopher J. L. Murray, Tapas Sadasivan Nair, Sreenivas Narasimha Swamy, Aparna Ichalangod Narayana, Hasan Nassereldine, Zuhair S. Natto, Biswa Prakash Nayak, Serban Mircea Negru, Haruna Asura Nggada, Hasti Nouraei, Virginia Nunez-Samudio, Bogdan Oancea, Andrew T. Olagunju, Ahmed Omar Bali, Alicia Padron-Monedero, Jagadish Rao Padubidri, Anamika Pandey, Shahina Pardhan, Jay Patel, Raffaele Pezzani, Zahra Zahid Piracha, Navid Rabiee, Venkatraman Radhakrishnan, Raghu Anekal Radhakrishnan, Amir Masoud Rahmani, Vahid Rahmanian, Chythra R. Rao, Sowmya J. Rao, Goura Kishor Rath, David Laith Rawaf, Salman Rawaf, Reza Rawassizadeh, Mohammad Sadegh Razeghinia, Nazila Rezaei, Negar Rezaei, Nima Rezaei, Aziz Rezapour, Abanoub Riad, Thomas J. Roberts, Esperanza Romero-Rodriguez, Gholamreza Roshandel, S. Manjula, S. N. Chandan, Basema Saddik, Mohammad Reza Saeb, Umar Saeed, Mohsen Safaei, Maryam Sahebazzamani, Amirhossein Sahebkar, Amir Salek Farrokhi, Abdallah M. Samy, Milena M. Santric-Milicevic, Brijesh Sathian, Maheswar Satpathy, Mario Sekerija, Subramanian Senthilkumaran, Allen Seylani, Omid Shafaat, Hamid R. Shahsavari, Erfan Shamsoddin, Mequannent Melaku Sharew, Javad Sharifi-Rad, Jeevan K. Shetty, K. M. Shivakumar, Parnian Shobeiri, Seyed Afshin Shorofi, Sunil Shrestha, Sudeep K. Siddappa Malleshappa, Paramdeep Singh, Jasvinder A. Singh, Garima Singh, Dhirendra Narain Sinha, Yonatan Solomon, Muhammad Suleman, Rizwan Suliankatchi Abdulkader, Yasaman Taheri Abkenar, Iman M. Talaat, Ker-Kan Tan, Abdelghani Tbakhi, Arulmani Thiyagarajan, Amir Tiyuri, Marcos Roberto Tovani-Palone, Bhaskaran Unnikrishnan, Bay Vo, Simona Ruxandra Volovat, Cong Wang, Ronny Westerman, Nuwan Darshana Wickramasinghe, Hong Xiao, Chuanhua Yu, Deniz Yuce, Ismaeel Yunusa, Vesna Zadnik, Iman Zare, Zhi-Jiang Zhang, Mohammad Zoladl, Lisa M. Force, Fernando N. Hugo
Summary: Lip, oral, and pharyngeal cancers are significant contributors to the global cancer burden. This study analyzed their total and risk-attributable burden across different regions and identified disparities based on Socio-demographic Index (SDI). The findings highlight the substantial impact of tobacco and alcohol use on these types of cancers.
Review
Pharmacology & Pharmacy
Shahla Ranjbar, Abbasali Emamjomeh, Fatemeh Sharifi, Atefeh Zarepour, Kian Aghaabbasi, Ali Dehshahri, Azadeh Mohammadi Sepahvand, Ali Zarrabi, Hamid Beyzaei, Mohammad Mehdi Zahedi, Reza Mohammadinejad
Summary: Herbal chemicals with a long history in medicine, such as flavonolignans and flavonoids, have various therapeutic capabilities. However, their hydrophobic properties limit their bioavailability and application. To overcome this challenge, lipid-based nanocarriers have been introduced to improve the delivery of these compounds, enhancing their bioavailability and reducing side effects.
Article
Biochemistry & Molecular Biology
Mahshid Deldar Abad Paskeh, Nahid Babaei, Mehrdad Hashemi, Abbas Doosti, Kiavash Hushmandi, Maliheh Entezari, Saeed Samarghandian
Summary: The combination of curcumin, vitamins D and E with Fe2O3-NPs and MnO2-NPs has shown to improve semen parameters and reduce apoptosis in germ cells in rats with testicular hyperthermia. This study suggests that this combination therapy may have a positive effect on fertility and decreasing the toxic effects of nanoparticles.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Review
Chemistry, Multidisciplinary
Bahareh Farasati Far, Navid Rabiee, Siavash Iravani
Summary: Metal-organic frameworks (MOFs) and MXenes have great potential in biomedical applications, but their environmental implications and biosafety issues need to be carefully considered. While there have been studies exploring their toxicity and biocompatibility, further systematic research is required. Efforts should be made to minimize the environmental impact during synthesis and manufacturing, and the potential release into the environment during biomedical applications should be evaluated.
Article
Chemistry, Physical
Maziyar Kazemi, Mohammad Zirak, Hassan Alehdaghi, Mehdi Baghayeri, Marzieh Nodehi, Javad Baedi, Navid Rabiee
Summary: The preparation of high-performance BiVO4 thin films using a straightforward and cost-effective hot spin coating method is described in this work. The optimized parameters resulted in uniform mesoporous films with high adhesion. The method was also capable of preparing large-scale superhydrophilic BiVO4 layers, exhibiting stable photo-current density in a photoelectrochemical cell.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
