The challenge of targeting metastasis

Vascular-Promoting Therapy Reduced Tumor Growth and Progression by Improving Chemotherapy Efficacy

(2015) Esther Bridges et al.   CANCER CELL

Dual-Action Combination Therapy Enhances Angiogenesis while Reducing Tumor Growth and Spread

(2015) Ping-Pui Wong et al.   CANCER CELL

Astrocytes facilitate melanoma brain metastasis via secretion of IL-23

(2015) Anat Klein et al.   JOURNAL OF PATHOLOGY

Targeting Vascular Pericytes in Hypoxic Tumors Increases Lung Metastasis via Angiopoietin-2

(2015) Doruk Keskin et al.   Cell Reports

Reactive Astrocytes Protect Melanoma Cells from Chemotherapy by Sequestering Intracellular Calcium through Gap Junction Communication Channels

(2015) Qingtang Lin et al.   NEOPLASIA

Astrocytes Upregulate Survival Genes in Tumor Cells and Induce Protection from Chemotherapy

(2015) Sun-Jin Kim et al.   NEOPLASIA

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Cancer Stem Cells: Constantly Evolving and Functionally Heterogeneous Therapeutic Targets

(2014) T. Yang et al.   CANCER RESEARCH

Heterogeneity of Pancreatic Cancer Metastases in a Single Patient Revealed by Quantitative Proteomics

(2014) Min-Sik Kim et al.   MOLECULAR & CELLULAR PROTEOMICS

Role of the endothelin axis in astrocyte- and endothelial cell-mediated chemoprotection of cancer cells

(2014) Seung Wook Kim et al.   NEURO-ONCOLOGY

Plasticity of epithelial stem cells in tissue regeneration

(2014) C. Blanpain et al.   SCIENCE

Antivascular Therapy for Multidrug-Resistant Ovarian Tumors by Macitentan, a Dual Endothelin Receptor Antagonist

(2014) Sun-Jin Kim et al.   Translational Oncology

Combining Radiation and Immunotherapy: A New Systemic Therapy for Solid Tumors?

(2014) C. Tang et al.   Cancer Immunology Research

Bevacizumab-Induced Normalization of Blood Vessels in Tumors Hampers Antibody Uptake

(2013) M. Arjaans et al.   CANCER RESEARCH

Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers

(2013) Rakesh K. Jain   JOURNAL OF CLINICAL ONCOLOGY

The causes and consequences of genetic heterogeneity in cancer evolution

(2013) Rebecca A. Burrell et al.   NATURE

Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

(2013) L. M. Coussens et al.   SCIENCE

Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells

(2013) M. A. Nieto   SCIENCE

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Vessel co-option in primary human tumors and metastases: an obstacle to effective anti-angiogenic treatment?

(2013) Tom Donnem et al.   Cancer Medicine

Rapid Decrease in Delivery of Chemotherapy to Tumors after Anti-VEGF Therapy: Implications for Scheduling of Anti-Angiogenic Drugs

(2012) Astrid A.M. Van der Veldt et al.   CANCER CELL

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Why Your New Cancer Biomarker May Never Work: Recurrent Patterns and Remarkable Diversity in Biomarker Failures

(2012) S. E. Kern   CANCER RESEARCH

Anti-VEGF/VEGFR Therapy for Cancer: Reassessing the Target

(2012) B. Sitohy et al.   CANCER RESEARCH

Heterogeneity of the tumor vasculature: the need for new tumor blood vessel type-specific targets

(2012) Janice A. Nagy et al.   CLINICAL & EXPERIMENTAL METASTASIS

Antiangiogenic therapy—evolving view based on clinical trial results

(2012) Gordon C. Jayson et al.   Nature Reviews Clinical Oncology

Circulating Epithelial Cells in Patients with Benign Colon Diseases

(2011) K. Pantel et al.   CLINICAL CHEMISTRY

The seed and soil hypothesis revisited-The role of tumor-stroma interactions in metastasis to different organs

(2011) Robert R. Langley et al.   INTERNATIONAL JOURNAL OF CANCER

Tumour evolution inferred by single-cell sequencing

(2011) Nicholas Navin et al.   NATURE

Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis

(2011) E. S. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective

(2010) J. E. Talmadge et al.   CANCER RESEARCH

The role of genetic diversity in cancer

(2010) Lauren M.F. Merlo et al.   JOURNAL OF CLINICAL INVESTIGATION

The platelet contribution to cancer progression

(2010) N. M. BAMBACE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Signatures of mutation and selection in the cancer genome

(2010) Graham R. Bignell et al.   NATURE

Finding the tumor copycat: Therapy fails, patients don't

(2010) Lee M Ellis et al.   NATURE MEDICINE

The role of the organ microenvironment in brain metastasis

(2010) Isaiah J. Fidler   SEMINARS IN CANCER BIOLOGY

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

(2009) John M.L. Ebos et al.   CANCER CELL

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Taming Vessels to Treat Cancer

(2009) Rakesh K. Jain   SCIENTIFIC AMERICAN

Intratumoral Heterogeneity for Expression of Tyrosine Kinase Growth Factor Receptors in Human Colon Cancer Surgical Specimens and Orthotopic Tumors

(2008) Toshio Kuwai et al.   AMERICAN JOURNAL OF PATHOLOGY

Yin-Yang Activities and Vicious Cycles in the Tumor Microenvironment

(2008) I. P. Witz   CANCER RESEARCH

Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression

(2008) R. F. Hwang et al.   CANCER RESEARCH

Osteosarcoma: The Addition of Muramyl Tripeptide to Chemotherapy Improves Overall Survival—A Report From the Children's Oncology Group

(2008) Paul A. Meyers et al.   JOURNAL OF CLINICAL ONCOLOGY