Developing Metal-Binding Isosteres of 8-Hydroxyquinoline as Metalloenzyme Inhibitor Scaffolds

Insights of 8-hydroxyquinolines: A novel target in medicinal chemistry

(2021) Rohini Gupta et al.   BIOORGANIC CHEMISTRY

Evaluating Metal–Ligand Interactions of Metal-Binding Isosteres Using Model Complexes

(2021) Hyeonglim Seo et al.   INORGANIC CHEMISTRY

Design, synthesis and biological evaluation of novel glyoxalase I inhibitors possessing diazenylbenzenesulfonamide moiety as potential anticancer agents

(2020) Buthina A. Al-Oudat et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Substituted sulfonamide bioisosteres of 8-hydroxyquinoline as zinc-dependent antibacterial compounds

(2020) John E. McGowan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action

(2020) Alessandro Bonardi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antibacterial study and corrosion inhibition potential of newly synthesis oxathiolan and triazole derivatives of 8-hydroxyquinoline: Experimental and theoretical approach

(2020) M. Rbaa et al.   Surfaces and Interfaces

Design, synthesis and preliminary bioactivity evaluations of 8-hydroxyquinoline derivatives as matrix metalloproteinase (MMP) inhibitors

(2019) Chen Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Metal-Binding Isosteres as New Scaffolds for Metalloenzyme Inhibitors

(2018) Benjamin L. Dick et al.   INORGANIC CHEMISTRY

Inhibition studies on a panel of human carbonic anhydrases with N1-substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails

(2018) Fadi M. Awadallah et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Targeting Metalloenzymes for Therapeutic Intervention

(2018) Allie Y. Chen et al.   CHEMICAL REVIEWS

Synthesis of 8-hydroxyquinoline glycoconjugates and preliminary assay of their β1,4-GalT inhibitory and anti-cancer properties

(2018) Monika Krawczyk et al.   BIOORGANIC CHEMISTRY

A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects

(2015) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Characterisation of selected active agents regarding pKa values, solubility concentrations and pH profiles by SiriusT3

(2015) D. Schönherr et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

8-Hydroxyquinoline: a privileged structure with a broad-ranging pharmacological potential

(2015) Yu'ning Song et al.   MedChemComm

Novel Fluorinated 8-Hydroxyquinoline Based Metal Ionophores for Exploring the Metal Hypothesis of Alzheimer’s Disease

(2015) Steven H. Liang et al.   ACS Medicinal Chemistry Letters

Fluorescent Sensors for Measuring Metal Ions in Living Systems

(2014) Kyle P. Carter et al.   CHEMICAL REVIEWS

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carboxylic Acid (Bio)Isosteres in Drug Design

(2013) Carlo Ballatore et al.   ChemMedChem

Human carbonic anhydrase II as host protein for the creation of artificial metalloenzymes: the asymmetric transfer hydrogenation of imines

(2013) Fabien W. Monnard et al.   Chemical Science

5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation

(2013) Richard J. Hopkinson et al.   Chemical Science

8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications

(2013) Virapong Prachayasittikul et al.   Drug Design Development and Therapy

Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors

(2012) Takashi Chiba et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Investigating chelating sulfonamides and their use in metalloproteinase inhibitors

(2012) Alisa Tanakit et al.   DALTON TRANSACTIONS

Potent inhibition of dinuclear zinc(II) peptidase, an aminopeptidase from Aeromonas proteolytica, by 8-quinolinol derivatives: inhibitor design based on Zn2+ fluorophores, kinetic, and X-ray crystallographic study

(2012) Kengo Hanaya et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Structure–activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI

(2011) Deniz Ekinci et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and activity of benzothiazole-based inhibitors of NO production in LPS-activated macrophages

(2010) Guo Hua Jin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Privileged scaffolds for library design and drug discovery

(2010) Matthew E Welsch et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Identifying Chelators for Metalloprotein Inhibitors Using a Fragment-Based Approach

(2010) Jennifer A. Jacobsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

From Sensors to Silencers: Quinoline- and Benzimidazole-Sulfonamides as Inhibitors for Zinc Proteases

(2010) Matthieu Rouffet et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

(2010) Oliver N. F. King et al.   PLoS One

In Situ Imaging of Metals in Cells and Tissues

(2009) Reagan McRae et al.   CHEMICAL REVIEWS

Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: Particular potency of 1H-indazole-7-carbonitrile

(2008) Betty Cottyn et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Calculation of pKaValues of Nucleobases and the Guanine Oxidation Products Guanidinohydantoin and Spiroiminodihydantoin using Density Functional Theory and a Polarizable Continuum Model

(2008) Vincenzo Verdolino et al.   JOURNAL OF PHYSICAL CHEMISTRY B