Review
Reproductive Biology
Kelly J. Baines, Rachel C. West
Summary: Fetal sex influences the immune response of the fetal, placental, and maternal during pregnancy. Male and female have different immune responses, with males prioritizing growth and being more susceptible to adverse outcomes. Male placentas and fetuses also respond to infection and inflammation differently than females. These gender-specific differences in the immune response contribute to increased male perinatal morbidity and mortality. This review explores the genetic and hormonal contributions to the sexual dimorphism of fetal and placental immunity, as well as the impact on fetal and maternal health.
BIOLOGY OF REPRODUCTION
(2023)
Review
Oncology
Yu-Kuan Huang, Rita A. Busuttil, Alex Boussioutas
Summary: This review summarizes recent studies on the roles of innate immune cells in tumor invasion and metastasis, highlighting their interactions with tumor cells and the microenvironment, which contribute to cancer progression.
Review
Immunology
Silvia Carnevale, Irene Di Ceglie, Giovanna Grieco, Anna Rigatelli, Eduardo Bonavita, Sebastien Jaillon
Summary: Neutrophils, the most abundant circulating leukocytes in humans, have been traditionally viewed as short-lived effector cells. However, they are now recognized as diverse immune cells that can adapt to different environmental cues. While neutrophils play a central role in host defense, their presence in pathological contexts such as inflammatory diseases and cancer can lead to detrimental inflammatory responses and poor clinical outcomes. Nevertheless, recent studies have shown that neutrophils may have a beneficial role in certain pathological contexts, including cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Anneloes van Duijn, Sjoerd H. Van der Burg, Ferenc A. Scheeren
Summary: This article focuses on the interactions between myeloid immune cells and anti-tumor immune responses in the tumor microenvironment. Blocking the CD47/SIRP alpha axis can enhance adaptive immune response. The potential therapeutic role of CD47/SIRP alpha axis is discussed in tumors with acquired resistance to classic immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Cell Biology
Edna Ayerim Mandujano-Tinoco, Eliya Sultan, Aner Ottolenghi, Orly Gershoni-Yahalom, Benyamin Rosental
Summary: The evolution of the immune system is aimed at protecting organisms from infections and providing regenerative capacities and tissue maintenance. Despite the diverse range of effector cells, common features and interesting convergent mechanisms can be observed across different animals. The review explores the evolution of phagocytic and cytotoxic immune lineages, highlighting the diverse function plasticity within evolved immune effector cells.
Article
Microbiology
Gabriela Balderrama-Gutierrez, Ana Milovic, Vanessa J. Cook, M. Nurul Islam, Youwen Zhang, Hippokratis Kiaris, John T. Belisle, Ali Mortazavi, Alan G. Barbour
Summary: The study revealed significant differences in responses to infection between white-footed deermice and mice, suggesting that deermice possess adaptive traits to moderate inflammation and better balance infection resistance and tolerance. These findings have implications for studying infection tolerance in other important reservoir species.
Article
Medicine, Research & Experimental
Elizabeth S. Levy, Ryan Chang, Colin R. Zamecnik, Miqdad O. Dhariwala, Lawrence Fong, Tejal A. Desai
Summary: Combining immune agonists and a melanoma-specific peptide in nanoparticles significantly enhances activation of antigen-presenting cells and promotes the development and response of melanoma-sensitized T cells, leading to suppression of tumor growth and reduction of tumor burden in both solid and metastatic tumor models. This biomaterial-based approach provides insights into stimulating multiple activation pathways for promoting tumor regression and delivering combination immunotherapies effectively and safely for cancer treatment.
MOLECULAR PHARMACEUTICS
(2021)
Review
Immunology
Edries Yousaf Hajam, Patricia Panikulam, Chung-Ching Chu, Haarshadri Jayaprakash, Amitabha Majumdar, Colin Jamora
Summary: As the interface between the body and the environment, the skin not only acts as a physical barrier, but also as an immunologically active organ. Regulatory T cells (T-regs) play a crucial role in maintaining homeostasis, clearing pathogens, and promoting wound healing. Recent studies have uncovered non-lymphoid functions of cutaneous T-regs, suggesting that they have executive control over various biological activities in the skin. These findings highlight the importance of T-regs and their potential role in future discoveries in the field of regenerative medicine.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Trevor Ung, Nakisha S. Rutledge, Adam M. Weiss, Aaron P. Esser-Kahn, Peter Deak
Summary: This article summarizes the recent advancements in immunology and chemistry in targeted vaccine technology, including cellular targets, methods of targeting, and their effects on immune responses. The relationships between vaccine targets and subsequent adaptive immune responses are crucial for effective vaccine design, potentially leading to more effective, disease-specific vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Tianmeng Yan, Zhenying Zhang
Summary: Bullous pemphigoid (BP) is an autoimmune blistering disease primarily affecting elderly individuals. It presents with heterogeneous manifestations, typically characterized by microscopically subepidermal separation and mixed inflammatory infiltrate. The development mechanism of BP remains unclear. B cells are involved in pathogenic autoantibody production, and other immune cells such as T cells, type II inflammatory cytokines, eosinophils, mast cells, neutrophils, and keratinocytes also contribute to the pathogenesis of BP. This review focuses on the roles and crosstalk between innate and adaptive immune cells in BP.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Shir Eliachar, Grace Ann Snyder, Shany Klara Barkan, Shani Talice, Aner Otolenghi, Adrian Jaimes-Becerra, Ton Sharoni, Eliya Sultan, Uzi Hadad, Oren Levy, Yehu Moran, Orly Gershoni-Yahalom, Nikki Traylor-Knowles, Benyamin Rosental
Summary: Climate change-induced heat stress leads to increased coral bleaching events. This study explored the immune response during heat stress using two sea anemone models. The results showed enhanced immune cell activity during heat stress, which was not influenced by the presence of algal symbionts.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Ghada Tafesh-Edwards, Ananda Kalukin, Dean Bunnell, Stanislava Chtarbanova, Ioannis Eleftherianos
Summary: By studying a Drosophila mutant, researchers have found that temperature variability plays a key role in Zika virus pathogenesis, leading to host mortality and motor dysfunction. They also discovered that the virus primarily targets the brain and activates RNAi and apoptotic immune responses. These findings provide an in vivo model to study host innate immune responses and highlight the importance of evaluating neurodegenerative deficits as potential comorbidities in Zika virus-infected adults.
Review
Immunology
George W. Burke III, Alla Mitrofanova, Antonio Fontanella, Gaetano Ciancio, David Roth, Phil Ruiz, Carolyn Abitbol, Jayanthi Chandar, Sandra Merscher, Alessia Fornoni
Summary: This article focuses on the podocyte as the target of circulating factors causing recurrent proteinuria in patients with FSGS after kidney transplantation. Studies involving pre- and post-reperfusion biopsies, as well as in vitro podocyte liquid biopsies/assays, have provided insights into new pathways and potential therapeutic targets. The successful use of immunomodulating agents, such as rituximab and abatacept, suggests direct effects on the podocyte beyond immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Multidisciplinary Sciences
Hongliang Zhang, Jie Gao, Yujie Tang, Tengchuan Jin, Jinhui Tao
Summary: Inflammasomes play a crucial role in both the innate and adaptive immune systems, acting as a bridge between these two components to maintain a fine balance in immune responses. Understanding the function of inflammasomes in lymphocytes can provide new insights into the mechanisms and treatment of various diseases, including autoimmune diseases and tumors.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Immunology
Michelle Felicia Lee, Guan Zhong Voon, Hui Xuan Lim, Mun Lok Chua, Chit Laa Poh
Summary: Dengue is a mosquito-borne disease that poses significant public health concerns in tropical and subtropical countries. The dengue virus has evolved various strategies to manipulate the host's immune responses, and miRNAs and DENV non-structural proteins (NS) are promising targets for anti-dengue therapeutics.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Binbin Chang, Zhang Wang, Hui Cheng, Tingyuan Xu, Jieyu Chen, Wan Wu, Yizhi Li, Yong Zhang
Summary: Acacetin can attenuate sepsis-induced ALI by inhibiting the inflammatory response and promoting macrophage polarization. This study is of great significance for the development of new treatments for sepsis-induced ALI.
Review
Biochemistry & Molecular Biology
Nikoleta Bizymi, Andreas M. Matthaiou, Irene Mavroudi, Aristea Batsali, Helen A. Papadaki
Summary: Myeloid-derived suppressor cells (MDSCs) are innate immune cells that have immunomodulatory properties. They interact extensively with other innate or adaptive immune cells and can either enhance or attenuate immune responses depending on the triggering conditions. However, their positive role in host defense mechanisms is rarely discussed in the literature.
