期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 190, 期 -, 页码 537-542出版社
ELSEVIER
DOI: 10.1016/j.jad.2015.10.037
关键词
Telomere length; Posttraumatic stress disorder; Major depressive disorder; Cellular ageing; Early traumatic experiences; Positive affect; War veterans
资金
- U.S. Department of Defense [W81XWH-11-2-0223, W81XWH-10-1-0021]
- Mental Illness Research, Education and Clinical Center (MIR-ECC)
- National Center for Advancing Translational Sciences [UL1TR000067]
- Sjobring Foundation
- OM Persson Foundation
- province of Scania (Sweden) state grants (ALF)
Background: Several psychiatric disorders may be characterized by peripheral telomere shortening. However, it is unclear whether telomere shortening is associated with these psychiatric disorders per se or, rather, with underlying dimensional parameters that are often, but not necessarily, associated with them. We explored the association between dimensional psychopathological measures and telomere length (TL) in granulocytes among veterans independent of psychiatric diagnosis. Methods: Seventy-six combat-exposed male veterans (41 psychiatrically healthy, 18 with Posttraumatic Stress Disorder [PTSD] and 17 with concomitant PTSD and Major Depressive Disorder [MDD]) had TL assayed. Assessments included Clinician-Administered PTSD Scale (CAPS), Beck Depression Inventory-II (BDI-II), Early Trauma Inventory (ETI), Symptom Checklist-90-R Global Severity Index (SCL-90-GSI), Perceived Stress Scale (PSS) and Positive and Negative Affect Schedule (PANAS). Correlations were corrected for age, BMI, antidepressants and ethnicity. Results: Across subjects, TL was negatively correlated with early trauma (p <0.001), global psychopathological severity (p=0.044) and perceived stress (p =0.019), positively correlated with positive affect (p=0.026), not significantly correlated with symptom severity of PTSD, depression or negative affect. Across these dimensions, early trauma and positive affect were associated with TL after excluding subjects with somatic illnesses. Limitations: The study was cross-sectional with a moderate sample size and only male combat-exposed subjects. Conclusions: These preliminary findings suggest that early trauma, severity of perceived stress and general psychopathological symptoms are more closely associated with shorter TL than is the severity of core diagnostic symptoms of PTSD or MDD, whereas positive affect is associated with longer TL. Larger-scale studies should assess TL associated with specific psychiatric dimensions, apart from only categorical psychiatric diagnoses, to develop more specific biologically-relevant endophenotypes. (C) 2015 Elsevier By. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据