Review
Clinical Neurology
Jacqueline Lee, Madelaine Gierc, Fidel Vila-Rodriguez, Eli Puterman, Guy Faulkner
Summary: Exercise combined with standard treatments leads to significantly greater antidepressant effects compared to standard treatment alone, especially for more severe patients. Sensitivity analyses confirmed the significant benefits, indicating that using exercise alongside standard treatments can enhance therapeutic efficacy for depression.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Clinical
Suzanne C. van Bronswijk, Robert J. DeRubeis, Lotte H. J. M. Lemmens, Frenk P. M. L. Peeters, John R. Keefe, Zachary D. Cohen, Marcus J. H. Huibers
Summary: This study aimed to predict long-term depression outcomes in individuals after acute-phase psychotherapy using the Personalized Advantage Index (PAI). Results showed successful identification of a predictor and two moderators, leading to effective prediction of the optimal treatment for individuals and improved treatment outcomes during follow-up. Long-term PAI predictions differed from predictions for acute benefit, with potential implications for enhancing precision medicine in the long term treatment of depressed individuals.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychiatry
Julia Lechinger, Jakob Koch, Sara Lena Weinhold, Mareen Seeck-Hirschner, Karoline Stingele, Cornelia Kropp-Naef, Milena Braun, Henning Johannes Drews, Josef Aldenhoff, Christian Huchzermeier, Robert Goeder
Summary: Research suggests that REM sleep abnormalities may indicate a distinct endophenotype of depression, and pharmacotherapy with SSRI/SSNRI may be more effective than psychotherapy in these patients.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Psychiatry
Toshi A. Furukawa, Kiyomi Shinohara, Ethan Sahker, Eirini Karyotaki, Clara Miguel, Marketa Ciharova, Claudi L. H. Bockting, Josefien J. F. Breedvelt, Aran Tajika, Hissei Imai, Edoardo G. Ostinelli, Masatsugu Sakata, Rie Toyomoto, Sanae Kishimoto, Masami Ito, Yuki Furukawa, Andrea Cipriani, Steven D. Hollon, Pim Cuijpers
Summary: Research indicates that PSY and COM have more enduring effects compared to PHA or STD in treating patients with depression. The advantages of PSY and COM over PHA or STD translate into risk differences ranging from 12 to 16 percentage points.
Review
Clinical Neurology
Priscila R. Toledo, Francisco Lotufo-Neto, Helen Verdeli, Alessandra C. Goulart, Andrea Horvath Marques, Ana Cristina de Oliveira Solis, Yuan-Pang Wang
Summary: The study compared the effects of different interventions on weight loss, binge eating behaviors, and depressive symptoms in patients with overweight/obesity and depression. The results showed that interpersonal psychotherapy (IPT) had some benefits for these patients compared to other interventions.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Clinical
Paul M. Cinciripini, George Kypriotakis, Charles Green, David Lawrence, Robert M. Anthenelli, Jennifer Minnix, Janice A. Blalock, Diane Beneventi, Chad Morris, Maher Karam-Hage
Summary: This study evaluated the safety and efficacy of smoking cessation pharmacotherapy among smokers with major depressive disorder (MDD). The results suggest that varenicline plus counseling may be the best pharmacological option for treating smoking in MDD smokers, including those with recurrent episodes, due to its higher efficacy effect size and similar risk of adverse events.
DEPRESSION AND ANXIETY
(2022)
Article
Neurosciences
Pascal Roullet, Guillaume Vaiva, Etienne Very, Axel Bourcier, Antoine Yrondi, Laetitia Dupuch, Pierre Lamy, Claire Thalamas, Laurence Jasse, Wissam El Hage, Philippe Birmes
Summary: The study demonstrated that using propranolol during traumatic memory reactivation can reduce PTSD symptoms, especially for patients with severe symptoms. However, the post-treatment effect may be influenced by the severity of baseline PTSD symptoms.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Ju-Yeon Lee, Robert Stewart, Hee-Ju Kang, Ju-Wan Kim, Min Jhon, Sung-Wan Kim, Il-Seon Shin, Jae-Min Kim
Summary: This study investigated the roles of childhood abuse and social support in predicting short- and long-term pharmacological treatment outcomes in outpatients with depressive disorders. The study found a negative association between childhood abuse and long-term treatment outcomes, and no significant association between social support level and any period outcome. However, in the presence of higher social support, childhood abuse, emotional abuse, and physical abuse were significantly associated with long-term remission rate at 12 months, but not sexual abuse.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Medicine, General & Internal
Qianfang Chen, Yuanyue Zhou, Huifen Lv, Caie Ma
Summary: The study aims to evaluate the efficacy of combined psychotherapy and pharmacological interventions in the treatment of bipolar disorder. Through a meta-analysis of randomized clinical trials, it was found that the combined approach may have advantages in preventing relapse.
Article
Clinical Neurology
Anna Troeger, Clara Miguel, Marketa Ciharova, Nino de Ponti, Gueldehan Durman, Pim Cuijpers, Eirini Karyotaki
Summary: This study aimed to compare the effects of psychotherapy and pharmacotherapy for adult depression and examine the association between baseline depression severity and treatment outcome. The results showed no significant difference between psychotherapy and pharmacotherapy, and baseline depression severity was not significantly associated with treatment outcome.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Psychology, Clinical
Daniel Vigo, Josep Maria Haro, Irving Hwang, Sergio Aguilar-Gaxiola, Jordi Alonso, Guilherme Borges, Ronny Bruffaerts, Jose Miguel Caldas-de-Almeida, Giovanni de Girolamo, Silvia Florescu, Oye Gureje, Elie Karam, Georges Karam, Viviane Kovess-Masfety, Sing Lee, Fernando Navarro-Mateu, Akin Ojagbemi, Jose Posada-Villa, Nancy A. Sampson, Kate Scott, Juan Carlos Stagnaro, Margreet ten Have, Maria Carmen Viana, Chi-Shin Wu, Somnath Chatterji, Pim Cuijpers, Graham Thornicroft, Ronald C. Kessler
Summary: This paper analyzes the gap and critical bottlenecks in treatment coverage for major depressive disorder (MDD). The results show a 90% gap in effective treatment, with lack of utilization and inadequate quality or adherence being the main reasons. Critical bottlenecks include underutilization of psychotherapy, psychopharmacology, inadequate physician monitoring, and inadequate drug-type. Decision-makers need to increase the utilization and quality of pharmacotherapy and psychotherapy.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Clinical Neurology
Marie Crowe, Maree Inder, Jenni Manuel, Dave Carlyle
Summary: This review aimed to identify the characteristics of effective psychotherapy delivered by videoconference for adults in primary care with a primary diagnosis of depression. The findings suggest that teletherapy has similar outcomes to in-person therapy for people with depression, but no evidence was found regarding the superiority of one therapy model over others.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychiatry
Shurui Chen, Hong Wang, Jihui Yue, Nianhong Guan, Xianglan Wang
Summary: This study conducted a systematic review and meta-analysis on the improvement effects of clinical treatments on low heart rate variability (HRV) in patients with major depressive disorder (MDD). The results showed that psychotherapy was effective in improving low HRV in MDD patients, while the effects of pharmacotherapy and physical therapy remained unclear.
COMPREHENSIVE PSYCHIATRY
(2022)
Review
Endocrinology & Metabolism
Karim Kheniser, David R. Saxon, Sangeeta R. Kashyap
Summary: Obesity is a chronic disease that requires holistic therapy, including lifestyle changes, cognitive behavioral therapy, pharmacotherapy, and bariatric surgery. Lifestyle interventions can lead to weight loss but may also result in weight regain, highlighting the importance of multifactorial maintenance programs that integrate diet, exercise, and medication. Behavioral therapy can complement maintenance programs effectively.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Clinical Neurology
Evrim Anik, Robert M. West, Alastair G. Cardno, Ghazala Mir
Summary: The review included 15 studies on culturally adapted psychotherapies, with Cognitive Behavioural Therapy and Behavior Activation being common approaches. The studies showed significant benefits of CAPs in reducing symptoms of depression, especially for the majority ethnic group in a population.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Psychology, Clinical
Darin Pauley, Pim Cuijpers, Davide Papola, Clara Miguel, Eirini Karyotaki
Summary: This systematic review and meta-analysis found that digital interventions are effective for anxiety disorders. Digital interventions showed a larger effect size compared to wait-list and care-as-usual controls, supporting their application in the treatment of anxiety disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Psychology, Developmental
Pim Cuijpers, Eirini Karyotaki, Marketa Ciharova, Clara Miguel, Hisashi Noma, Yvonne Stikkelbroek, John R. Weisz, Toshi A. Furukawa
Summary: Meta-analyses demonstrate the effectiveness of psychotherapies in treating depression in children and adolescents. However, more than 60% of youth receiving therapy do not respond, highlighting the need for more effective treatments and strategies.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Review
Psychology, Clinical
Ruiying Zhao, Arpana Amarnath, Eirini Karyotaki, Sascha Y. Struijs, Pim Cuijpers
Summary: Although many individuals with depression do not actively seek help, psychological treatments have been found to be effective. A meta-analysis of 52 randomized trials showed that psychological treatments have a moderate to high effect on reducing depressive symptoms. Additionally, only 13% of patients who completed a screening questionnaire met the inclusion criteria and participated in the clinical trial.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Lynn Verweij, Genevieve I. C. G. Ector, Yolba Smit, Bas van Vlijmen, Bert A. van der Reijden, Rosella P. M. G. Hermens, Nicole M. A. Blijlevens
Summary: CMyLife is an eHealth innovation co-created with and for chronic myeloid leukemia (CML) patients to improve their care, leading to increased quality of life and the opportunity for hospital-free care. It explores the effectiveness of CMyLife in terms of information provision, patient empowerment, medication compliance, molecular monitoring, and quality of life.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Mathematical & Computational Biology
Michael Seo, Toshi A. Furukawa, Eirini Karyotaki, Orestis Efthimiou
Summary: Clinical prediction models are widely used in modern clinical practice. This study compares different approaches for developing prediction models when there are different sets of predictors available from multiple studies. The results show that multiple imputation methods and a new approach that synthesizes all predictions outperform a restrict predictors approach.
RESEARCH SYNTHESIS METHODS
(2023)
Article
Medicine, General & Internal
Davide Papola, Eirini Karyotaki, Marianna Purgato, Marit Sijbrandij, Federico Tedeschi, Pim Cuijpers, Efthimiou Orestis, Toshi A. Furukawa, Vikram Patel, Corrado Barbui
Summary: Common mental disorders, such as depression and anxiety, are leading causes of disability worldwide. In low-resource settings, psychosocial interventions delivered through task-sharing modalities have been proven effective in expanding access to mental healthcare. However, the specific components of these interventions that are most efficacious in reducing symptoms of common mental disorders, and for whom, have yet to be substantiated by evidence.
Review
Psychiatry
Pim Cuijpers, Clara Miguel, Mathias Harrer, Marketa Ciharova, Eirini Karyotaki
Summary: This study investigated the interaction between psychotherapy and pharmacotherapy for adult depression and found no significant interaction. Patients can start with psychotherapy without fearing that it will reduce the effects of the treatment.
EUROPEAN PSYCHIATRY
(2023)
Review
Psychiatry
Constantin Yves Plessen, Eirini Karyotaki, Clara Miguel, Marketa Ciharova, Pim Cuijpers
Summary: Through a multiverse meta-analysis, the study found that psychotherapies for depression have overall robustness in terms of effectiveness. Meta-analyses that included studies with a high risk of bias, compared the intervention with wait-list control groups, and did not correct for publication bias produced larger effect sizes.
Review
Psychiatry
Eirini Karyotaki, Marit Sijbrandij, Marianna Purgato, Ceren Acarturk, Daniel Lakin, Della Bailey, Emily Peckham, Ersin Uygun, Federico Tedeschi, Johannes Wancata, Jura Augustinavicius, Kenneth Carswell, Maritta Valimaki, Mark van Ommeren, Markus Koesters, Mariana Popa, Marx Ronald Leku, Minna Anttila, Rachel Churchill, Ross G. White, Sarah Al-Hashimi, Tella Lantta, Teresa Au, Thomas Klein, Wietse A. Tol, Pim Cuijpers, Corrado Barbui
Summary: The study compared the effects of Self-Help Plus (SH+) and Enhanced Care as Usual (ECAU) on reducing depressive symptoms among refugees and asylum seekers. Results showed no significant difference between SH+ and ECAU post-intervention, but SH+ was more effective for unemployed and lower mental well-being participants, and improvements were observed at midterm follow-up.
Correction
Psychiatry
Yaara Sadeh, Anna Denejkina, Eirini Karyotaki, Lonneke I. M. Lenferink, Nancy Kassam-Adams
CAMBRIDGE PRISMS-GLOBAL MENTAL HEALTH
(2023)
Review
Psychiatry
Yaara Sadeh, Anna Denejkina, Eirini Karyotaki, Lonneke I. M. Lenferink, Nancy Kassam-Adams
Summary: Optimizing global mental health research is crucial in addressing the high burden of mental health challenges and mental illness. Data sharing and reuse have proven valuable in advancing science and knowledge development. The FAIR Guiding Principles provide a framework to improve research transparency and impact. This review explores ethical and equity considerations in data sharing and reuse, discusses the application of FAIR principles in mental health research, and examines the current state of FAIR data practices, identifying challenges and opportunities.
CAMBRIDGE PRISMS-GLOBAL MENTAL HEALTH
(2023)
Article
Primary Health Care
Elke Elzinga, Derek P. de Beurs, Aartjan T. F. Beekman, Otto R. Maarsingh, Renske Gilissen
Summary: This study aimed to assess the effectiveness of an intervention using pop-up screens to nudge General Practitioners (GPs) to explore suicidal thoughts more frequently. The findings showed that GPs were 50% more likely to explore suicidal thoughts in the second year compared to the first year. However, the effect of the pop-up screens disappeared after adjusting for patients' gender and age. Further research is needed to test whether implementing these nudges alongside other interventions will lead to a stronger effect, and to include more variables to better understand the effects on GPs' behavior.
Article
Psychiatry
Remco F. P. de Winter, Connie M. Meijer, Anne T. Van den Bos, Nienke Kool-Goudzwaard, John H. Enterman, Manuela A. M. L. Gemen, Chani Nuij, Mirjam C. Hazewinkel, Danielle Steentjes, Gabrielle E. van Son, Derek P. de Beurs, Marieke H. de Groot
Summary: This study aims to examine the usability and feasibility of a four-type model of suicidality in clinical practice. The results show promising reliability and accuracy of the model and the SUICIDI-2 instrument in identifying and classifying subtypes.
Letter
Psychiatry
Rene Freichel, Reinout Wiers, Brian O'Shea, Richard J. McNally, Derek de Beurs
PSYCHIATRY RESEARCH
(2023)
Review
Psychiatry
Eirini Karyotaki, Clara Miguel, Olga M. Panagiotopoulou, Mathias Harrer, Nadine Seward, Marit Sijbrandij, Ricardo Araya, Vikram Patel, Pim Cuijpers
Summary: Digital interventions can effectively reduce symptoms of common mental disorders, improve quality of life, and have a lasting impact in low- and middle-income countries. However, further research is needed to determine the specific magnitude of the effects of digital interventions.
CAMBRIDGE PRISMS-GLOBAL MENTAL HEALTH
(2023)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)