Article
Thermodynamics
D. V. Antonov, R. M. Fedorenko, P. A. Strizhak, S. S. Sazhin
Summary: A new model for heating and evaporation of a droplet on a superhydrophobic surface is proposed, using the analytical solution to the heat transfer equation. The assumptions that heat supplied by conduction and radiation is distributed throughout the droplet volume and that the effects of ambient gas temperature gradient can be ignored, are discussed. The model is validated using experimental data, showing good agreement with the results when the assumptions are satisfied.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2023)
Article
Environmental Sciences
Gizem Ozler, Holger Grosshans
Summary: Research has found that in hot and dry environments, solutes in saliva droplets form a shell on the surface, producing lightweight hollow particles. These hollow particles have a larger cross-sectional area compared to their solid counterparts, allowing them to float longer and travel farther in the air.
ENVIRONMENTAL RESEARCH
(2023)
Article
Thermodynamics
Jianwei Wang, Yueyang Cai, Xiaole Chen, Baobin Sun, Feng Tao
Summary: Inhalation therapy is a common method for treating respiratory diseases, and nebulizers are widely used due to their convenience, high drug delivery efficiency, and low residual volume. However, traditional studies on drug delivery have focused mainly on non-hygroscopic drug particles, neglecting the concentration of nebulized hygroscopic droplet aerosols, which can significantly affect drug deposition efficiency.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2024)
Article
Thermodynamics
Chan Ho Jeong, Hyung Ju Lee, Chang Kyoung Choi, Seong Hyuk Lee
Summary: This study investigates the selective evaporation characteristics of binary mixture droplets and develops a corresponding evaporation rate model. By analyzing the Rayleigh number, a new evaporation rate model is proposed that includes diffusive and convective evaporation effects. This model shows a strong correlation with the observed selective evaporation behavior over the droplet lifetime.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2021)
Article
Biotechnology & Applied Microbiology
Charles F. Dillon, Michael B. Dillon
Summary: Airborne disease transmission is crucial to various scientific fields, but its overall importance is often underestimated, leading to a lack of indexing terms and under-reporting of disease burdens. Studies show that pathogens in the air can cause disease across different distances, but the plausibility and implications of undetected airborne disease transmission are significant.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Physics, Applied
Ming Zhang, Fuyou He, Chuan Li, Jiawei Li, Zhen Zeng, Kexun Yu, Pan Yuan
Summary: The experiments show that frequency, sound power, and lasting time are important factors affecting the acoustic coalescence of droplets. The optimal parameters for cost-effective artificial fog elimination include a frequency of 300 Hz, a sound power of 75 W, and a lasting time of 20 s.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Article
Engineering, Multidisciplinary
S. V. Valiulin, A. A. Onischuk, A. M. Baklanov, S. N. Dubtsov, G. G. Dultseva, S. V. An'kov, T. G. Tolstikova, V. L. Rusinov, V. N. Charushin
Summary: An inhalation setup was developed for studying the effects of inhaled aerosol particles on laboratory mice, including two types of aerosol generators and inhalation chambers, as well as measuring equipment for monitoring particle concentration and size.
Article
Chemistry, Physical
Eloise C. Tredenick, W. Alison Forster, Ravindra Pethiyagoda, Rebecca M. van Leeuwen, Scott W. McCue
Summary: The evaporation of surfactant droplets on different leaf surfaces was studied through experiments and mathematical models, showing that most combinations follow standard evaporation modes except for wheat with high surfactant concentration, where nonstandard evaporation occurs due to additional mechanisms.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Thermodynamics
V. A. Vlasov
Summary: An analytic model of spherical droplet evaporation into surrounding gas is presented without considering Stefan flow and vapor buoyancy. The model is based on diffusion equation and kinetic description, assuming constant droplet temperature. An alternative equation for droplet evaporation rate is obtained, showing three different regimes of evaporation depending on droplet size.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2021)
Article
Pharmacology & Pharmacy
Waiting Tai, Michael Yee Tak Chow, Rachel Yoon Kyung Chang, Patricia Tang, Igor Gonda, Robert B. MacArthur, Hak-Kim Chan, Philip Chi Lip Kwok
Summary: Oral administration of hydroxychloroquine to COVID-19 patients is ineffective, but delivering it by inhalation may be a promising alternative. The isotonic, pH-neutral HCQS solutions exhibit good stability and are suitable for preclinical and clinical studies for potential COVID-19 treatment.
Article
Environmental Sciences
Hongmei Liu, Jingping Shao, Wei Jiang, Xuedong Liu
Summary: The differentially weighted operator-splitting Monte Carlo (DWOSMC) method is further developed to describe the dynamic behaviors of droplet aerosols. It considers various processes such as coagulation, deposition, condensation, and evaporation. The results of this method agree well with analytical solutions and other methods, and it can predict the changes in various parameters of droplet aerosol systems.
Article
Chemistry, Multidisciplinary
Geonwoo Yoo, Jung-Hyun Park, Dong-yoon Kwak, Jong-Hyeon Lee
Summary: This study evaluates the evaporation of chemicals in applied chemical products and proposes a Chemical Product Evaporation Model (CPEM) to explain the effect of product mass change. The study finds that the ConsExpo model can be applied to non-volatile materials, while the CPEM can be used for volatile materials.
APPLIED SCIENCES-BASEL
(2022)
Article
Environmental Sciences
Hana Salati, David F. Fletcher, Mehrdad Khamooshi, Jingliang Dong, Kazuhide Ito, Sara Vahaji, Kiao Inthavong
Summary: Understanding the spread of aerosols generated from nasal sneezing is crucial in the context of COVID-19 transmission. This study used computational fluid dynamics to simulate the airflow and aerosol dispersion during nasal sneezing. The results showed that the airflow during nasal sneezing resembles dual jets, resulting in the dispersion of viral-laden aerosols suspended in the air. The study also discovered that the sneeze plume formed a V-shaped pattern with smaller particles in the core region.
AEROSOL AND AIR QUALITY RESEARCH
(2022)
Review
Mechanics
Stephen K. Wilson, Hannah-May D'Ambrosio
Summary: The evaporation of a sessile droplet of liquid is a complex and multifaceted fundamental topic. It has drawn significant multidisciplinary research efforts in recent decades due to its key role in numerous physical and biological processes. This review focuses on the insights gained from simple mathematical models and discusses potential future directions in the field.
ANNUAL REVIEW OF FLUID MECHANICS
(2023)
Article
Thermodynamics
Xue Li, Brandon Murray, Shankar Narayan
Summary: In this study, the evaporation process of water droplets on a thin quartz substrate is analyzed using a numerical model. The model considers mass and heat transfer, as well as interfacial force balance, and agrees well with experimental results. The study highlights the importance of surface wettability in evaporation dynamics.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2023)
Article
Gastroenterology & Hepatology
Antonius T. Otten, Hedwig H. van der Meulen, Maurice Steenhuis, Floris C. Loeff, Daan J. Touw, Jos G. W. Kosterink, Henderik W. Frijlink, Theo Rispens, Gerard Dijkstra, Marijn C. Visschedijk, Arno R. Bourgonje
Summary: A finger prick-based capillary blood self-sampling technique was validated for monitoring infliximab, vedolizumab, and C-reactive protein concentrations in patients with inflammatory bowel disease. The technique received substantial support from patients and demonstrated good tolerability and practicality.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Chemistry, Multidisciplinary
Rick Heida, Renate Akkerman, Paulo H. Jacob Silva, Anke J. Lakerveld, Daniel Ortiz, Chiara Bigogno, Matteo Gasbarri, Puck B. van Kasteren, Francesco Stellacci, Henderik W. Frijlink, Anke L. W. Huckriede, Wouter L. J. Hinrichs
Summary: Respiratory viruses, including RSV, pose a significant global health burden. Entry inhibitors, such as CD-MUS, have shown promise as antiviral drugs that can prevent infection in the respiratory tract. In this study, CD-MUS was shown to be well tolerated when administered to mice's respiratory tract and retained its activity against RSV after spray drying. This research sets the foundation for future in vivo studies on the efficacy of CD-MUS in animal models of RSV infection.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Medicine, General & Internal
Antonius Timotheus Otten, V Peters, I Barth, C. L. Stevens, A. R. Bourgonje, H. W. Frijlink, H. J. M. Harmsen, A. Rehman, M. J. E. Campmans-Kuijpers, G. Dijkstra
Summary: This article describes a nutritional intervention trial on patients with Crohn's disease (CD) and their healthy household members, investigating the effects of an evidence-based anti-inflammatory diet and an ileocolonic-targeted capsule containing vitamin B2, B3, and C. The results of the study will provide valuable evidence for dietary recommendations for CD patients and physicians.
Review
Pharmacology & Pharmacy
Primawan Putra Nugrahadi, Wouter L. J. Hinrichs, Henderik W. Frijlink, Christian Schoneich, Christina Avanti
Summary: In recent decades, there has been a significant increase in the use of therapeutic peptides. However, peptides are often unstable in aqueous solutions, which affects their stability and bioactivity. This literature review provides an overview of the degradation pathways and formulation strategies to stabilize therapeutic peptides in aqueous solutions. The most practical approaches to peptide stabilization are pH optimization and selecting the appropriate type of buffer, along with other strategies such as co-solvency, air exclusion, viscosity enhancement, PEGylation, and the use of polyol excipients.
Article
Pharmacology & Pharmacy
Renee S. van der Kooij, Martin Beukema, Anke L. W. Huckriede, Johan Zuidema, Rob Steendam, Henderik W. Frijlink, Wouter L. J. Hinrichs
Summary: Although vaccination is important for public health, the increase in vaccination coverage has slowed down. Single-injection vaccines could solve the problem of multiple injections. Researchers developed injectable microspheres that released bovine serum albumin (BSA) over several weeks. In vitro and in vivo studies showed successful sustained release and immunization.
Article
Pharmacology & Pharmacy
Aisha A. Ahmed, Antonius T. Otten, Bahez Gareb, Judith E. Huijmans, Anko C. Eissens, Ateequr Rehman, Gerard Dijkstra, Jos G. W. Kosterink, Henderik W. Frijlink, Reinout C. A. Schellekens
Summary: The development of capsules containing riboflavin, nicotinic acid, and ascorbic acid covered with a pH-sensitive coating (ColoVit) was described to achieve site-specific release in the ileocolon. The capsules met the required specifications and had a lag-time in drug release of 277-283 min, which meets the requirements for ileocolonic release. The production process of the ColoVit formulation was validated and reproducible, and the vitamin blend was stable during the production process and in the finished coated product. ColoVit is intended as an innovative treatment approach for beneficial microbiome modulation and optimization of gut health.
Article
Pharmacology & Pharmacy
Sohaib Mahri, Tobias Wilms, Paul Hagedorm, Marie-Julie Guichard, Kevin Vanvarenberg, Mireille Dumoulin, Henderik Frijlink, Rita Vanbever
Summary: In this study, the effects of PEGylation on the thermodynamic stability of rhDNase were investigated. PEGylation destabilized rhDNase upon denaturation and ethanol exposure, but PEG30-rhDNase remained stable enough to withstand aerosolization stresses. High aerosol output and excellent aerosol characteristics were achieved while preserving protein integrity and enzymatic activity.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Microbiology
Rick Heida, Henderik Frijlink, Wouter Hinrichs
Summary: The pulmonary route of administration plays an important role in the treatment of respiratory virus infections, as it can induce a broader immune response and improve drug bioavailability.
Article
Pharmacology & Pharmacy
Rick Heida, Paul Hagedoorn, Melle C. van Meel, Jurrie E. R. Prins, Frederike S. Simonis, Renate Akkerman, Anke L. W. Huckriede, Henderik W. Frijlink, Anne H. de Boer, Wouter L. J. Hinrichs
Summary: A challenge in developing dry powder formulations for inhalation is the poor reproducibility of administration to small laboratory animals. Current devices for delivering dry powder formulations to small rodents often fail to function optimally due to the use of the same puff of air for both powder dispersion and aerosol delivery. A novel aerosol generator was introduced, allowing the administration of a pre-generated aerosol to mice lungs, with controlled powder delivery. Although the emitted aerosol showed favorable size range for lung deposition and reproducibility, in vivo fluorescent imaging revealed significant differences in dose deposition and powder distribution among mice, suggesting inevitable biological variation in lung deposition.
Article
Pharmacology & Pharmacy
Khanh T. T. Nguyen, Daan Zillen, Franca F. M. van Heijningen, Kjeld J. C. van Bommel, Renz J. van Ee, Henderik W. Frijlink, Wouter L. J. Hinrichs
Summary: This study demonstrates the successful production of PBP tablets with smooth surfaces that can be directly coated with the ColoPulse coating, while preserving the stability of the encapsulated biopharmaceutical, BIAP.
Article
Materials Science, Biomaterials
Jihui Lee, Martin Beukema, Oliwia A. Zaplatynska, Conor OMahony, Wouter L. J. Hinrichs, Anke L. W. Huckriede, Joke A. Bouwstra, Koen van der Maaden
Summary: Automatic dispensing system for dMNA production significantly reduces antigen waste and produces dMNAs with excellent physical, mechanical, and immunological properties. Influenza whole inactivated virus (WIV) vaccine-loaded dMNAs fabricated using this method demonstrated stable antigens, high penetration efficiency, and similar immune response as intramuscularly administered vaccine in a mouse study.
BIOMATERIALS SCIENCE
(2023)
Article
Engineering, Chemical
Francisco J. Higuera, Juan Fernandez de la Mora
Summary: This study investigates a particle condensation device that uses cold and warm humid air streams to achieve water vapor condensation. Compared to existing water condensation particle counters, this configuration offers advantages such as variable saturation ratio, accelerated penetration of water vapor, and a relatively uniform saturation field.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Brijal Prajapati, Vishal Dharaiya, Manoranjan Sahu, Chandra Venkatraman, Pratim Biswas, Kajal Yadav, Delwin Pullokaran, Ramya Sunder Raman, Ruqia Bhat, Tanveer Ahmad Najar, Arshid Jehangir
Summary: This study evaluated the performance of a low-cost particulate matter sensor and proposed a physics-based calibration method. The results showed that the physics-based calibration approach performed better compared to statistical models at both observation sites.
JOURNAL OF AEROSOL SCIENCE
(2024)
Correction
Engineering, Chemical
N. Searle, K. Kaur, K. Kelly
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Tianyu Cen, Laura Torrent, Andrea Testino, Christian Ludwig
Summary: In this study, a hyphenated setup consisting of a rotating disk diluter (RDD) with spICP-MS (RDDspICP-MS) was used for online sampling and characterization of metallic nanoparticles (NPs) in ambient pressure aerosols. The RDD allowed for constant flow rate sampling of aerosols and adjusting the dilution ratio for different particle number concentrations (PNCs). The feasibility of this setup was tested with different sizes of AuNPs in argon-based and air-based aerosols, and the results showed a lower limit of detection for number concentration. The capability of the setup to accurately investigate multi-modal samples and the interference of ionic species was also demonstrated.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
A. Valenzuela, E. Bazo, R. A. Rica, L. Alados-Arboledas, F. J. Olmo-Reyes
Summary: This article introduces a method to measure the extinction cross section of levitated particles using an electrodynamic trap and double-cavity ring down spectroscopy technique, and demonstrates the potential of this method in 1,2,6-hexanetriol particles through simulations and experiments. Unlike traditional methods, this technique provides crucial information about the extinction cross section of sodium chloride particles during dehydration and hydration processes.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Shadi Yaqoubi, Mohaddese Sokuti, Sahand Mazloum-Ravasan, Kofi Asare-Addo, Hamed Hamishehkar, Ali Nokhodchi
Summary: In this study, a modified version of ultrasonic spray pyrolysis was used to prepare salbutamol sulfate dry powder. The engineered particles showed suitable characteristics for effective drug delivery to the lungs and demonstrated acceptable aerosolization performance. This newly introduced method appears to be capable of producing dry powder formulations of different drugs without the need for surfactants or stabilizers.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Ashley L. Nord, Patrice Dosset, Pierre Slangen, Manouk Abkarian
Summary: Phonation has been found to be a potent transmission route for the COVID-19 virus. To control transmission, it is important to measure the amount of aerosols produced by speech. Researchers used digital in-line holography to overcome experimental challenges and successfully imaged the formation and deformation of saliva filaments in the mouth during speech, as well as the resulting aerosolized droplets.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Yating Wang, Yiyang Zhang, Zhu Fang, Xinxin Wu
Summary: The research investigates the energy dissipation in particle-wall collision with roughness using the finite element method. The results show that the presence of surface roughness leads to lower viscoelastic dissipation and higher restitution coefficient compared to a smooth surface. The collision time is identified as a key factor in predicting the energy dissipation.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Shaamrit Balendra, Akshay Kale, Julie Pongetti, Mohsen Kazemimanesh, Molly Haugen, Lee Weller, Adam Boies
Summary: The measurement of airborne particles is important for detecting and characterising air pollution, emissions, fire detection, occupational and climate impacts. However, current optical particle counters (OPCs) cannot measure ultrafine particles. This study explores the limitations of miniaturising a condensation particle counter (CPC) growth chamber and provides a toolkit for optimising the design of miniaturised CPC-GCs.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Markus Snellman, Namsoon Eom, Maria E. Messing, Knut Deppert, Chris Hogan
Summary: Segregated bimetallic nanoparticles, such as core-shell nanoparticles, have attracted widespread interest in various fields like biomedicine, catalysis, and optoelectronics. Aerosol technology provides an optimal platform for controlling the size, structure, and composition of nanoparticles, which are crucial parameters for tuning the material performance for specific applications. In this study, researchers developed a novel evaporator design that allows on-line coating of core particles with a shell directly in the gas phase. By utilizing a local heater, the researchers were able to decouple the heating process of the evaporating material from the aerosol particles, thereby limiting core-shell alloying. The resulting core-shell particle formation with controllable shell thickness was demonstrated using evaporation of zinc onto core particles of gold, tin, and bismuth. Simple models were also discussed to explain the observed growth process inside the evaporator and the formation of the shell.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Kentaro Misawa, Yuto Kasai
Summary: In this study, the laser-induced fluorescence technique was used to observe scattered and fluorescent signals from fluorescent polystyrene latex particles. The ratio of fluorescence to scattered signal intensities was found to be almost equal for particles of the same size, allowing for the separate observation of mixed-size fluorescent particles. Relative fluorescence intensities were obtained by incorporating ratios of fluorescence to scattered signal and relative scattered signal intensities.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Engineering, Chemical
Sripriya Nannu Shankar, William B. Vass, John A. Lednicky, Tracey Logan, Rebeccah L. Messcher, Arantzazu Eiguren-Fernandez, Stavros Amanatidis, Tara Sabo-Attwood, Chang-Yu Wu
Summary: This study introduces a testing system that allows for direct exposure of aerosolized viruses onto host cells. By collecting particles of different sizes and analyzing them, researchers obtained information on the concentration and viability of the virus at different particle sizes.
JOURNAL OF AEROSOL SCIENCE
(2024)